Arginine in α-defensins: Differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior

Journal of Biological Chemistry

Volumn 287, Issue 26, 2012, Pages 21866-21872

  Schmidt, Nathan W ^a   Tai, Kenneth P ^b   Kamdar, Karishma ^b   Mishra, Abhijit ^a,c   Lai, Ghee Hwee ^a   Zhao, Kun ^a   Ouellette, André J ^b   Wong, Gerard C L ^a  

^a Department of Civil and Environmental Engineering   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c INDIAN INSTITUTE OF TECHNOLOGY GANDHINAGAR   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERICIDAL ACTIVITY; BIOLOGICAL EFFECTS; DEFENSINS; DIFFERENTIAL EFFECT; LIPID COMPOSITION; MEMBRANE CURVATURE; MEMBRANE DESTABILIZATION; NANO-POROUS; PEPTIDE-LIPID SYSTEM; PRIMARY STRUCTURES; SMALL ANGLE X-RAY SCATTERING;

AMINO ACIDS; BACTERICIDES; BIOACTIVITY; MUTAGENESIS; X RAY SCATTERING;

PEPTIDES;

ALPHA DEFENSIN; ARGININE; BACTERIAL PROTEIN; CRYPTDIN 4; LYSINE; PEPTIDE; RHEUSUS MYELOID ALPHA DEFENSIN 4; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL CELL; BACTERICIDAL ACTIVITY; CELL SURVIVAL; CONTROLLED STUDY; ESCHERICHIA COLI; LIPID COMPOSITION; LISTERIA MONOCYTOGENES; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SALMONELLA ENTERICA; STAPHYLOCOCCUS AUREUS; VIBRIO CHOLERAE;

ALPHA-DEFENSINS; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; ARGININE; DEFENSINS; ESCHERICHIA COLI; IMMUNITY, INNATE; LIPIDS; LYSINE; MICE; NORMAL DISTRIBUTION; PEPTIDES; PROTEIN PRECURSORS; SCATTERING, RADIATION; X-RAYS;

EID: 84862646898     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.358721     Document Type: Article

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