The cyclic cystine ladder in β-defensins is important for structure and stability, but not antibacterial activity

Journal of Biological Chemistry

Volumn 288, Issue 15, 2013, Pages 10830-10840

  Conibear, Anne C ^a   Rosengren, K Johan ^a   Daly, Norelle L ^a   Henriques, Sónia Troeira ^a   Craik, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-BACTERIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; DEFENSINS; DISULFIDE BONDS; PEPTIDE DRUGS;

BIOCHEMISTRY; BIOLOGY;

COVALENT BONDS;

CYSTINE; DEFENSIN; DISULFIDE; MELITTIN; THETA DEFENSIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DISULFIDE BOND; DRUG DETERMINATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG STRUCTURE; GROWTH INHIBITION; HEMOLYSIS; HUMAN; HUMAN CELL; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; THERMOSTABILITY;

ALPHA-DEFENSINS; AMINO ACID MOTIFS; CYSTINE; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY;

EID: 84876206211     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.451047     Document Type: Article

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