Invariant gly residue is important for α-defensin folding, dimerization, and function: A case study of the human neutrophil α-defensin HNP1

Journal of Biological Chemistry

Volumn 287, Issue 23, 2012, Pages 18900-18912

  Zhao, Le ^a   Ericksen, Bryan ^b   Wu, Xueji ^b   Zhan, Changyou ^b   Yuan, Weirong ^b   Li, Xu ^a   Pazgier, Marzena ^a,b   Lu, Wuyuan ^a,b  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE PEPTIDES; ANTI-BACTERIAL ACTIVITY; COLONY COUNTS; D-AMINO ACID; DEFENSINS; HUMAN NEUTROPHIL; IN-VIVO; INHIBITORY ACTIVITY; INHIBITORY CONCENTRATION; L-ALANINE; L-AMINO ACIDS; LETHAL DOSE; LETHAL FACTOR; MAIN CHAINS; NATIVE CHEMICAL LIGATION; SELF-ASSOCIATIONS; SIDE-CHAINS; STAPHYLOCOCCUS AUREUS; SURFACE PLASMONS; TORSION ANGLE; WILD TYPES;

ASSOCIATION REACTIONS; BACTERIA; DIMERIZATION; ESCHERICHIA COLI; MAMMALS; PEPTIDES;

AMINO ACIDS;

ALANINE; ALPHA DEFENSIN; AMINO ACID; ARGININE; CYANOGEN BROMIDE; GLYCINE; MONOMER; MUTANT PROTEIN; PHENYLALANINE; PROTEIN HNP1; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTHRAX; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS CEREUS; CONTROLLED STUDY; DIMERIZATION; ESCHERICHIA COLI; IC 50; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STAPHYLOCOCCUS AUREUS; SURFACE PLASMON RESONANCE; WILD TYPE;

ALPHA-DEFENSINS; AMINO ACID SUBSTITUTION; ANTI-INFECTIVE AGENTS; BACTERIA; CRYSTALLOGRAPHY, X-RAY; GLYCINE; HUMANS; MUTATION, MISSENSE; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

BACILLUS CEREUS; ESCHERICHIA COLI; MAMMALIA; STAPHYLOCOCCUS AUREUS;

EID: 84861724380     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.355255     Document Type: Article

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