RTD-1 mimic containing γPNA scaffold exhibits broad-spectrum antibacterial activities

Journal of the American Chemical Society

Volumn 134, Issue 9, 2012, Pages 4041-4044

  Rapireddy, Srinivas ^a   Nhon, Linda ^a   Meehan, Robert E ^a,d   Franks, Jonathan ^b   Stolz, Donna Beer ^b   Tran, Dat ^c   Selsted, Michael E ^c   Ly, Danith H ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-BACTERIAL ACTIVITY; CROSS LINKAGES; CYCLIC PEPTIDES; DEFENSINS; DISULFIDE BRIDGE; ENZYMATIC STABILITY; HIGH PURITY; INNATE IMMUNITY; MACROCYCLICS; MOLECULAR THERAPY; NON-HUMAN PRIMATE; NONCOVALENT; SPATIAL ARRANGEMENTS;

BIOACTIVITY; CHEMICAL STABILITY; COVALENT BONDS; HYDROGEN BONDS; MAMMALS; PEPTIDES; SCAFFOLDS; SULFUR COMPOUNDS;

PLANTS (BOTANY);

ANTIBIOTIC AGENT; CYCLIC RTD 1 MIMIC; DISULFIDE; GAMMA PEPTIDE NUCLEIC ACID; HYDROGEN; PEPTIDE NUCLEIC ACID; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CYCLOPEPTIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL ENGINEERING; CROSS LINKING; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME STABILITY; HYDROGEN BOND; INNATE IMMUNITY; MOLECULAR THERAPY; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ESCHERICHIA COLI; MICROBIOLOGICAL EXAMINATION; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PEPTIDE NUCLEIC ACIDS; PEPTIDES, CYCLIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857883452     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja211867j     Document Type: Article

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