Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage

Neuropharmacology

Volumn 79, Issue , 2014, Pages 180-189

  Durand, Daniela ^a   Carniglia, Lila ^a   Beauquis, Juan ^b,c   Caruso, Carla ^a   Saravia, Flavia ^b,c   Lasaga, Mercedes ^a  

^a Universidad de Buenos Aires   (Argentina)

^b Laboratorio de Neurobiologia de la Memoria   (Argentina)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Amyloid precursor protein; Astrocytes; Hippocampus; Keywords; Metabotropic glutamate receptor 3; PDAPP J20 mice; Secretases

Indexed keywords

ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN ADAM17; UNCLASSIFIED DRUG; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; AMINO ACID; AMINO ACID RECEPTOR STIMULATING AGENT; APP PROTEIN, HUMAN; FUSED HETEROCYCLIC RINGS; METABOTROPIC RECEPTOR; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR UPREGULATION; AGING; AGONISTS; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; GENETICS; HIPPOCAMPUS; HUMAN; METABOLISM; MUTATION; TRANSGENIC MOUSE; WISTAR RAT;

AGING; AMINO ACIDS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASTROCYTES; BICYCLO COMPOUNDS, HETEROCYCLIC; CELLS, CULTURED; EXCITATORY AMINO ACID AGONISTS; FEMALE; HIPPOCAMPUS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 84890539489     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.11.015     Document Type: Article

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