메뉴 건너뛰기




Volumn 6, Issue 7, 2011, Pages

Reduced cAMP, Akt activation and p65-c-Rel dimerization: Mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytes

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; DIMER; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR AGONIST; PROTEIN KINASE B; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; 4 AMINHO 2 THIABICYCLO(3.1.0)HEXANE 4,6 DICARBOXYLIC ACID; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; 4-AMINHO-2-THIABICYCLO(3.1.0)HEXANE-4,6-DICARBOXYLIC ACID; AMINO ACID; FUSED HETEROCYCLIC RINGS; GLIAL FIBRILLARY ACIDIC PROTEIN; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 2; SULFOXIDE;

EID: 79960340621     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022235     Document Type: Article
Times cited : (27)

References (49)
  • 1
    • 25844440561 scopus 로고    scopus 로고
    • Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous system
    • Benarroch EE, (2005) Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous system. Mayo Clin Proc 80: 1326-1338.
    • (2005) Mayo Clin Proc , vol.80 , pp. 1326-1338
    • Benarroch, E.E.1
  • 2
    • 34748907751 scopus 로고    scopus 로고
    • Activation of melanocortin 4 receptor reduces the inflammatory response and prevents apoptosis induced by lipopolisaccharide and interferon-gamma in astrocytes
    • Caruso C, Durand D, Schiöth HB, Rey R, Seilicovich A, et al. (2007) Activation of melanocortin 4 receptor reduces the inflammatory response and prevents apoptosis induced by lipopolisaccharide and interferon-gamma in astrocytes. Endocrinology 148: 4918-4926.
    • (2007) Endocrinology , vol.148 , pp. 4918-4926
    • Caruso, C.1    Durand, D.2    Schiöth, H.B.3    Rey, R.4    Seilicovich, A.5
  • 3
    • 72849135960 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes
    • Durand D, Caruso C, Carniglia L, Lasaga M, (2010) Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes. J Neurochem 112: 420-433.
    • (2010) J Neurochem , vol.112 , pp. 420-433
    • Durand, D.1    Caruso, C.2    Carniglia, L.3    Lasaga, M.4
  • 4
    • 0032834028 scopus 로고    scopus 로고
    • Pharmacological agents acting at subtypes of metabotropic glutamate receptors
    • Schoepp DD, Jane DE, Monn JA, (1999) Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38: 1431-76.
    • (1999) Neuropharmacology , vol.38 , pp. 1431-1476
    • Schoepp, D.D.1    Jane, D.E.2    Monn, J.A.3
  • 5
    • 34247525137 scopus 로고    scopus 로고
    • Cellular localization of mGluR3 and mGluR5 mRNAs in normal and injured rat brain
    • Mudo G, Trovato-Salinaro A, Caniglia G, Cheng Q, Condorelli DF, (2007) Cellular localization of mGluR3 and mGluR5 mRNAs in normal and injured rat brain. Brain Res 1149: 1-13.
    • (2007) Brain Res , vol.1149 , pp. 1-13
    • Mudo, G.1    Trovato-Salinaro, A.2    Caniglia, G.3    Cheng, Q.4    Condorelli, D.F.5
  • 6
    • 0032791811 scopus 로고    scopus 로고
    • Neuroprotection by metabotropic glutamate receptor agonists: LY354740, LY379268 and LY389795
    • Kingston AE, O'Neill MJ, Lam A, Bales KR, Monn JA, et al. (1999) Neuroprotection by metabotropic glutamate receptor agonists: LY354740, LY379268 and LY389795. Eur J Pharmacol 377: 155-165.
    • (1999) Eur J Pharmacol , vol.377 , pp. 155-165
    • Kingston, A.E.1    O'Neill, M.J.2    Lam, A.3    Bales, K.R.4    Monn, J.A.5
  • 7
    • 0032403407 scopus 로고    scopus 로고
    • Neuroprotection by glial metabotropic glutamate receptor is mediated by transforming growth factor-beta
    • Bruno V, Battaglia G, Casabona G, Copani A, Caciagli F, et al. (1998) Neuroprotection by glial metabotropic glutamate receptor is mediated by transforming growth factor-beta. J Neurosci 18: 9594-9600.
    • (1998) J Neurosci , vol.18 , pp. 9594-9600
    • Bruno, V.1    Battaglia, G.2    Casabona, G.3    Copani, A.4    Caciagli, F.5
  • 8
    • 34247524153 scopus 로고    scopus 로고
    • Molecular signaling mediating the protective effect of A1 adenosine and mGluR3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes
    • Ciccarelli R, D'Alimonte I, Ballerini P, D'Auro M, Nargi E, et al. (2007) Molecular signaling mediating the protective effect of A1 adenosine and mGluR3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes. Mol Pharmacol 71: 1369-1380.
    • (2007) Mol Pharmacol , vol.71 , pp. 1369-1380
    • Ciccarelli, R.1    D'Alimonte, I.2    Ballerini, P.3    D'Auro, M.4    Nargi, E.5
  • 9
    • 44749092463 scopus 로고    scopus 로고
    • Activation of NF-κB p65/c-Rel dimer is associated with neuroprotection elicited by mGlu5 receptor agonists against MPP+ toxicity in SK-N-SH cells
    • Sarnico I, Boroni F, Benarese M, Sigala S, Lanzillotta A, et al. (2008) Activation of NF-κB p65/c-Rel dimer is associated with neuroprotection elicited by mGlu5 receptor agonists against MPP+ toxicity in SK-N-SH cells. J Neural Transm 115: 669-676.
    • (2008) J Neural Transm , vol.115 , pp. 669-676
    • Sarnico, I.1    Boroni, F.2    Benarese, M.3    Sigala, S.4    Lanzillotta, A.5
  • 10
    • 17844376201 scopus 로고    scopus 로고
    • Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways
    • D'Onofrio M, Cuomo L, Battaglia G, Ngomba RT, Storto M, et al. (2001) Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways. J Neurochem 78: 435-445.
    • (2001) J Neurochem , vol.78 , pp. 435-445
    • D'Onofrio, M.1    Cuomo, L.2    Battaglia, G.3    Ngomba, R.T.4    Storto, M.5
  • 11
    • 2542442420 scopus 로고    scopus 로고
    • The anti-apoptotic effect of guanosine is mediated by the activation of the PI3-kinase/Akt/PKB pathway in cultured rat astrocytes
    • Di Iorio P, Ballerini P, Traversa U, Nicoletti F, D'Alimonte I, et al. (2004) The anti-apoptotic effect of guanosine is mediated by the activation of the PI3-kinase/Akt/PKB pathway in cultured rat astrocytes. Glia 46: 356-368.
    • (2004) Glia , vol.46 , pp. 356-368
    • Di Iorio, P.1    Ballerini, P.2    Traversa, U.3    Nicoletti, F.4    D'Alimonte, I.5
  • 12
    • 0031053586 scopus 로고    scopus 로고
    • Regulation of neuronal survival by the serine-threonine protein kinase Akt
    • Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, et al. (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (Wash DC) 275: 661-665.
    • (1997) Science (Wash DC) , vol.275 , pp. 661-665
    • Dudek, H.1    Datta, S.R.2    Franke, T.F.3    Birnbaum, M.J.4    Yao, R.5
  • 13
    • 3242756910 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats
    • Caruso C, Mohn C, Karara AL, Rettori V, Watanobe H, et al. (2004) Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats. Neuroendocrinology 79: 278-86.
    • (2004) Neuroendocrinology , vol.79 , pp. 278-286
    • Caruso, C.1    Mohn, C.2    Karara, A.L.3    Rettori, V.4    Watanobe, H.5
  • 14
    • 0030742222 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor expression in cultured rat astrocytes and human gliomas
    • Condorelli DF, Dell'Albani P, Corsaro M, Giuffrida R, Caruso A, et al. (1997) Metabotropic glutamate receptor expression in cultured rat astrocytes and human gliomas. Neurochem Res 22: 1127-1133.
    • (1997) Neurochem Res , vol.22 , pp. 1127-1133
    • Condorelli, D.F.1    Dell'Albani, P.2    Corsaro, M.3    Giuffrida, R.4    Caruso, A.5
  • 15
    • 85016872313 scopus 로고    scopus 로고
    • Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5
    • Ferraguti F, Corti C, Valerio E, Mion S, Xuereb J, (2001) Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5. Exp Brain Res 137: 1-11.
    • (2001) Exp Brain Res , vol.137 , pp. 1-11
    • Ferraguti, F.1    Corti, C.2    Valerio, E.3    Mion, S.4    Xuereb, J.5
  • 16
    • 0027190384 scopus 로고
    • Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat
    • Ohishi H, Shigemoto R, Nakanishi S, Mizuno N, (1993a) Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat. Neuroscience 53: 1009-1018.
    • (1993) Neuroscience , vol.53 , pp. 1009-1018
    • Ohishi, H.1    Shigemoto, R.2    Nakanishi, S.3    Mizuno, N.4
  • 17
    • 0027168754 scopus 로고
    • Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study
    • Ohishi H, Shigemoto R, Nakanishi S, Mizuno N, (1993b) Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study. J Comp Neurol 335: 252-266.
    • (1993) J Comp Neurol , vol.335 , pp. 252-266
    • Ohishi, H.1    Shigemoto, R.2    Nakanishi, S.3    Mizuno, N.4
  • 18
    • 0033571654 scopus 로고    scopus 로고
    • mGluR3 and mGluR5 are the predominant metabotropic glutamate receptor mRNAs expressed in hippocampal astrocytes acutely isolated from young rats
    • Schools GP, Kimelberg HK, (1999) mGluR3 and mGluR5 are the predominant metabotropic glutamate receptor mRNAs expressed in hippocampal astrocytes acutely isolated from young rats. J Neurosci Res 58: 533-543.
    • (1999) J Neurosci Res , vol.58 , pp. 533-543
    • Schools, G.P.1    Kimelberg, H.K.2
  • 19
    • 0032190403 scopus 로고    scopus 로고
    • N-Acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes
    • Wroblewska B, Santi MR, Neale JH, (1998) N-Acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes. Glia 24: 172-179.
    • (1998) Glia , vol.24 , pp. 172-179
    • Wroblewska, B.1    Santi, M.R.2    Neale, J.H.3
  • 20
    • 0031539216 scopus 로고    scopus 로고
    • Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture
    • Ciccarelli R, Sureda FX, Casabona G, Di Iorio P, Caruso A, et al. (1997) Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and-5 on astrocyte proliferation in culture. Glia 21: 390-398.
    • (1997) Glia , vol.21 , pp. 390-398
    • Ciccarelli, R.1    Sureda, F.X.2    Casabona, G.3    Di Iorio, P.4    Caruso, A.5
  • 21
    • 0034972413 scopus 로고    scopus 로고
    • Glutamate receptor subunit expression in primary neuronal and secondary glial cultures
    • Janssens N, Lesage ASJ, (2001) Glutamate receptor subunit expression in primary neuronal and secondary glial cultures. J Neurochem 77: 1457-1474.
    • (2001) J Neurochem , vol.77 , pp. 1457-1474
    • Janssens, N.1    Lesage, A.S.J.2
  • 22
    • 0033602516 scopus 로고    scopus 로고
    • Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors
    • Monn JA, Matthew JV, Massey SM, Hansen MM, Kress TJ, et al. (1999) Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem 42: 1027-1040.
    • (1999) J Med Chem , vol.42 , pp. 1027-1040
    • Monn, J.A.1    Matthew, J.V.2    Massey, S.M.3    Hansen, M.M.4    Kress, T.J.5
  • 23
    • 33947415606 scopus 로고    scopus 로고
    • Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039)
    • Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, et al. (2007) Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039). J Pharmacol Exp Ther 321: 308-317.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 308-317
    • Rorick-Kehn, L.M.1    Johnson, B.G.2    Burkey, J.L.3    Wright, R.A.4    Calligaro, D.O.5
  • 24
    • 21744444009 scopus 로고    scopus 로고
    • NF-κB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid β-peptide toxicity
    • Pizzi M, Sarnico I, Boroni F, Benarese M, Steimberg N, et al. (2005) NF-κB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid β-peptide toxicity. Cell Death Differ 12: 761-772.
    • (2005) Cell Death Differ , vol.12 , pp. 761-772
    • Pizzi, M.1    Sarnico, I.2    Boroni, F.3    Benarese, M.4    Steimberg, N.5
  • 25
    • 57549112366 scopus 로고    scopus 로고
    • NF-κB p50/RelA and c-Rel-containing dimmers: opposite regulators of neuron vulnerability to ischaemia
    • Sarnico I, Lanzillotta A, Boroni F, Benarese M, Alghisi M, et al. (2009) NF-κB p50/RelA and c-Rel-containing dimmers: opposite regulators of neuron vulnerability to ischaemia. J Neurochem 108: 475-485.
    • (2009) J Neurochem , vol.108 , pp. 475-485
    • Sarnico, I.1    Lanzillotta, A.2    Boroni, F.3    Benarese, M.4    Alghisi, M.5
  • 27
    • 33645105623 scopus 로고    scopus 로고
    • Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes
    • Wroblewska B, Wegorzewska I, Bzdega T, Olszewski R, Neal J, (2006) Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes. J Neurochem 96: 1071-1077.
    • (2006) J Neurochem , vol.96 , pp. 1071-1077
    • Wroblewska, B.1    Wegorzewska, I.2    Bzdega, T.3    Olszewski, R.4    Neal, J.5
  • 29
    • 1242329363 scopus 로고    scopus 로고
    • Mode of action of endotoxin: role of free radicals and antioxidants
    • Bhattacharyya J, Biswas S, Datta AG, (2004) Mode of action of endotoxin: role of free radicals and antioxidants. Curr Med Chem 11: 359-368.
    • (2004) Curr Med Chem , vol.11 , pp. 359-368
    • Bhattacharyya, J.1    Biswas, S.2    Datta, A.G.3
  • 30
    • 33845770235 scopus 로고    scopus 로고
    • Multiple inhibitory pathways for lipopolisaccharide- and pro-inflammatory cytokine-induced nitric oxide production in cultured astrocytes
    • Kozuka N, Kudo Y, Morita M, (2007) Multiple inhibitory pathways for lipopolisaccharide- and pro-inflammatory cytokine-induced nitric oxide production in cultured astrocytes. Neuroscience 144: 911-919.
    • (2007) Neuroscience , vol.144 , pp. 911-919
    • Kozuka, N.1    Kudo, Y.2    Morita, M.3
  • 31
    • 0029360606 scopus 로고
    • Cytokine-induced expression of type II nitric oxide synthase in astrocytes is downregulated by ATP and glutamate
    • Murphy S, Lin HL, Park SK, (1995) Cytokine-induced expression of type II nitric oxide synthase in astrocytes is downregulated by ATP and glutamate. Glia 15: 77-82.
    • (1995) Glia , vol.15 , pp. 77-82
    • Murphy, S.1    Lin, H.L.2    Park, S.K.3
  • 32
    • 0031435749 scopus 로고    scopus 로고
    • Control of NF-kappa B activity by the I kappa B beta inhibitor
    • Weil R, Whiteside ST, Israël A, (1997) Control of NF-kappa B activity by the I kappa B beta inhibitor. Immunobiology 198: 14-23.
    • (1997) Immunobiology , vol.198 , pp. 14-23
    • Weil, R.1    Whiteside, S.T.2    Israël, A.3
  • 33
    • 0028986194 scopus 로고
    • I kappa B-beta regulates the persistent response in a biphasic activation of NFkappaB
    • Thompson JE, Phillips RJ, Erdjument-Bromage H, Tempst P, Ghosh S, (1995) I kappa B-beta regulates the persistent response in a biphasic activation of NFkappaB. Cell 80: 573-582.
    • (1995) Cell , vol.80 , pp. 573-582
    • Thompson, J.E.1    Phillips, R.J.2    Erdjument-Bromage, H.3    Tempst, P.4    Ghosh, S.5
  • 34
    • 0033538340 scopus 로고    scopus 로고
    • Differential IκB kinase activation and IκBα degradation by interleukin-1β and tumor necrosis factor-α in human U937 monocytic cells
    • Nasuhara Y, Adcock IM, Catley M, Barnes PJ, Newton R, (1999) Differential IκB kinase activation and IκBα degradation by interleukin-1β and tumor necrosis factor-α in human U937 monocytic cells. J Biol Chem 274: 19965-19972.
    • (1999) J Biol Chem , vol.274 , pp. 19965-19972
    • Nasuhara, Y.1    Adcock, I.M.2    Catley, M.3    Barnes, P.J.4    Newton, R.5
  • 35
    • 0037036405 scopus 로고    scopus 로고
    • Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta
    • Pizzi M, Goffi F, Boroni F, Benarese M, Perkins SE, et al. (2002) Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta. J Biol Chem 277: 20717-20723.
    • (2002) J Biol Chem , vol.277 , pp. 20717-20723
    • Pizzi, M.1    Goffi, F.2    Boroni, F.3    Benarese, M.4    Perkins, S.E.5
  • 36
    • 4143053661 scopus 로고    scopus 로고
    • S100B potently activates p65/c-Rel transcriptional complexes in hippocampal neurons: clinical implications for the role of S100B in excitotoxic brain injury
    • Kögel D, Peters M, König HG, Hashemi SM, Bui NT, et al. (2004) S100B potently activates p65/c-Rel transcriptional complexes in hippocampal neurons: clinical implications for the role of S100B in excitotoxic brain injury. Neuroscience 127: 913-920.
    • (2004) Neuroscience , vol.127 , pp. 913-920
    • Kögel, D.1    Peters, M.2    König, H.G.3    Hashemi, S.M.4    Bui, N.T.5
  • 37
    • 60549099917 scopus 로고    scopus 로고
    • Leptin is induced in the ischemic cerebral cortex and exerts neuroprotection through NF-κB/c-Rel-dependent transcription
    • Valerio A, Dossena M, Bertolotti P, Boroni F, Sarnico I, et al. (2009) Leptin is induced in the ischemic cerebral cortex and exerts neuroprotection through NF-κB/c-Rel-dependent transcription. Stroke 40: 610-617.
    • (2009) Stroke , vol.40 , pp. 610-617
    • Valerio, A.1    Dossena, M.2    Bertolotti, P.3    Boroni, F.4    Sarnico, I.5
  • 38
    • 6344278016 scopus 로고    scopus 로고
    • The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma
    • Giri S, Rattan R, Singh AK, Singh I, (2004) The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. J Immunol 173: 5196-5208.
    • (2004) J Immunol , vol.173 , pp. 5196-5208
    • Giri, S.1    Rattan, R.2    Singh, A.K.3    Singh, I.4
  • 39
    • 0031407416 scopus 로고    scopus 로고
    • Neuroprotective effects of group III mGluR in traumatic neuronal injury
    • Faden AI, Ivanova SA, Yakovlev AG, Mukhin AG, (1997) Neuroprotective effects of group III mGluR in traumatic neuronal injury. J Neurotrauma 14: 885-895.
    • (1997) J Neurotrauma , vol.14 , pp. 885-895
    • Faden, A.I.1    Ivanova, S.A.2    Yakovlev, A.G.3    Mukhin, A.G.4
  • 40
    • 0031813790 scopus 로고    scopus 로고
    • Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase
    • Srivastava RK, Srivastava AR, Korsmeyer SJ, Nesterova M, Cho-Chung YS, et al. (1998) Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol Cell Biol 18: 3509-3517.
    • (1998) Mol Cell Biol , vol.18 , pp. 3509-3517
    • Srivastava, R.K.1    Srivastava, A.R.2    Korsmeyer, S.J.3    Nesterova, M.4    Cho-Chung, Y.S.5
  • 41
    • 0035918149 scopus 로고    scopus 로고
    • Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1
    • Kim S, Jee K, Kim D, Koh H, Chung J, (2001) Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1. J Biol Chem 276: 12864-12870.
    • (2001) J Biol Chem , vol.276 , pp. 12864-12870
    • Kim, S.1    Jee, K.2    Kim, D.3    Koh, H.4    Chung, J.5
  • 42
    • 17744364870 scopus 로고    scopus 로고
    • Regulation of MAP kianse-dependent apoptotic pathway: implication of reactive oxygen and nitrogen species
    • Sumbayev VV, Yasinska IM, (2005) Regulation of MAP kianse-dependent apoptotic pathway: implication of reactive oxygen and nitrogen species. Arch Biochem Biophys 436: 406-412.
    • (2005) Arch Biochem Biophys , vol.436 , pp. 406-412
    • Sumbayev, V.V.1    Yasinska, I.M.2
  • 43
    • 76949092145 scopus 로고    scopus 로고
    • Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung
    • Peng XQ, Damarla M, Skirball J, Nonas S, Wang XY, et al. (2010) Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung. Acta Pharmacol Sin 31: 175-183.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 175-183
    • Peng, X.Q.1    Damarla, M.2    Skirball, J.3    Nonas, S.4    Wang, X.Y.5
  • 44
    • 78649727068 scopus 로고    scopus 로고
    • Exercise improves the dilatation function of mesenteric arteries in postmyocardial infarction rats via a PI3K/Akt/eNOS pathway-mediated mechanism
    • Wang Y, Wang S, Wier WG, Zhang Q, Jiang H, et al. (2010) Exercise improves the dilatation function of mesenteric arteries in postmyocardial infarction rats via a PI3K/Akt/eNOS pathway-mediated mechanism. Am J Physiol Heart Circ Physiol 299: 097-106.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , pp. 097-106
    • Wang, Y.1    Wang, S.2    Wier, W.G.3    Zhang, Q.4    Jiang, H.5
  • 45
    • 30644476464 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases (MAPKs) mediate SIN-1/glucose deprivation-induced death in rat primary astrocytes
    • Yoo K, Choi JW, Choi MS, Ryu MK, Park GH, et al. (2005) Mitogen-activated protein kinases (MAPKs) mediate SIN-1/glucose deprivation-induced death in rat primary astrocytes. Arch Pharm Res 28: 942-947.
    • (2005) Arch Pharm Res , vol.28 , pp. 942-947
    • Yoo, K.1    Choi, J.W.2    Choi, M.S.3    Ryu, M.K.4    Park, G.H.5
  • 46
    • 33847203682 scopus 로고    scopus 로고
    • MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes
    • Fernandes A, Falcao AS, Silva RF, Brito MA, Brites D, (2007) MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes. Eur J Neurosci 25: 1058-1068.
    • (2007) Eur J Neurosci , vol.25 , pp. 1058-1068
    • Fernandes, A.1    Falcao, A.S.2    Silva, R.F.3    Brito, M.A.4    Brites, D.5
  • 47
    • 39149122831 scopus 로고    scopus 로고
    • Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation
    • Chen SH, Lin JK, Liu SH, Liang YC, Lin-Shiau SY, (2008) Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation. Toxicol Sci 102: 138-149.
    • (2008) Toxicol Sci , vol.102 , pp. 138-149
    • Chen, S.H.1    Lin, J.K.2    Liu, S.H.3    Liang, Y.C.4    Lin-Shiau, S.Y.5
  • 48
    • 13244277800 scopus 로고    scopus 로고
    • Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for phosphatidylinositol 3-kinase inhibition
    • Perez V, Bouschet T, Fernandez C, Bockaert J, Journot L, (2005) Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for phosphatidylinositol 3-kinase inhibition. Eur J Neurosci 21: 26-32.
    • (2005) Eur J Neurosci , vol.21 , pp. 26-32
    • Perez, V.1    Bouschet, T.2    Fernandez, C.3    Bockaert, J.4    Journot, L.5
  • 49
    • 74449090245 scopus 로고    scopus 로고
    • Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling
    • Salminen A, Kaarniranta K, (2010) Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling. Cell Signal 22: 573-577.
    • (2010) Cell Signal , vol.22 , pp. 573-577
    • Salminen, A.1    Kaarniranta, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.