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Volumn 239, Issue 1, 2013, Pages 28-37

Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease

Author keywords

Alzheimer's disease; Astrocytes; Environmental enrichment; GFAP; Hippocampus; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN;

EID: 84867775830     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.09.009     Document Type: Article
Times cited : (143)

References (84)
  • 2
    • 0033557386 scopus 로고    scopus 로고
    • Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease
    • Akiyama H., Mori H., Saido T., Kondo H., Ikeda K., McGeer P.L. Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease. Glia 1999, 25:324-331.
    • (1999) Glia , vol.25 , pp. 324-331
    • Akiyama, H.1    Mori, H.2    Saido, T.3    Kondo, H.4    Ikeda, K.5    McGeer, P.L.6
  • 3
    • 4043147336 scopus 로고    scopus 로고
    • Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition
    • Arendash G.W., Garcia M.F., Costa D.A., Cracchiolo J.R., Wefes I.M., Potter H. Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition. Neuroreport 2004, 15:1751-1754.
    • (2004) Neuroreport , vol.15 , pp. 1751-1754
    • Arendash, G.W.1    Garcia, M.F.2    Costa, D.A.3    Cracchiolo, J.R.4    Wefes, I.M.5    Potter, H.6
  • 4
    • 80052840457 scopus 로고    scopus 로고
    • Effect of environmental enrichment on the immunoendocrine aging of male and female triple-transgenic 3xTg-AD mice for Alzheimer's disease
    • Arranz L., De Castro N.M., Baeza I., Gimenez-Llort L., la FM De Effect of environmental enrichment on the immunoendocrine aging of male and female triple-transgenic 3xTg-AD mice for Alzheimer's disease. J. Alzheimers Dis. 2011, 25:727-737.
    • (2011) J. Alzheimers Dis. , vol.25 , pp. 727-737
    • Arranz, L.1    De Castro, N.M.2    Baeza, I.3    Gimenez-Llort, L.4    de la, F.M.5
  • 5
    • 0024824922 scopus 로고
    • Patterns of gliosis in Alzheimer's disease and aging cerebrum
    • Beach T.G., Walker R., McGeer E.G. Patterns of gliosis in Alzheimer's disease and aging cerebrum. Glia 1989, 2:420-436.
    • (1989) Glia , vol.2 , pp. 420-436
    • Beach, T.G.1    Walker, R.2    McGeer, E.G.3
  • 6
    • 78649725008 scopus 로고    scopus 로고
    • Short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice
    • Beauquis J., Roig P., De Nicola A.F., Saravia F. Short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice. PLoS One 2010, 5:e13993.
    • (2010) PLoS One , vol.5
    • Beauquis, J.1    Roig, P.2    De Nicola, A.F.3    Saravia, F.4
  • 7
    • 10044242541 scopus 로고    scopus 로고
    • Ballistic labeling and dynamic imaging of astrocytes in organotypic hippocampal slice cultures
    • Benediktsson A.M., Schachtele S.J., Green S.H., Dailey M.E. Ballistic labeling and dynamic imaging of astrocytes in organotypic hippocampal slice cultures. J. Neurosci. Methods 2005, 141:41-53.
    • (2005) J. Neurosci. Methods , vol.141 , pp. 41-53
    • Benediktsson, A.M.1    Schachtele, S.J.2    Green, S.H.3    Dailey, M.E.4
  • 8
    • 33845190338 scopus 로고    scopus 로고
    • Short-term exposure to an enriched environment enhances dendritic branching but not brain-derived neurotrophic factor expression in the hippocampus of rats with ventral subicular lesions
    • Bindu B., Alladi P.A., Mansooralikhan B.M., Srikumar B.N., Raju T.R., Kutty B.M. Short-term exposure to an enriched environment enhances dendritic branching but not brain-derived neurotrophic factor expression in the hippocampus of rats with ventral subicular lesions. Neuroscience 2007, 144:412-423.
    • (2007) Neuroscience , vol.144 , pp. 412-423
    • Bindu, B.1    Alladi, P.A.2    Mansooralikhan, B.M.3    Srikumar, B.N.4    Raju, T.R.5    Kutty, B.M.6
  • 9
    • 33748790666 scopus 로고    scopus 로고
    • Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus
    • Boekhoorn K., Joels M., Lucassen P.J. Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiol. Dis. 2006, 24:1-14.
    • (2006) Neurobiol. Dis. , vol.24 , pp. 1-14
    • Boekhoorn, K.1    Joels, M.2    Lucassen, P.J.3
  • 10
    • 0031596284 scopus 로고    scopus 로고
    • Evolution of neuronal changes in the course of Alzheimer's disease
    • Braak H., Braak E. Evolution of neuronal changes in the course of Alzheimer's disease. J. Neural Transm. Suppl. 1998, 53:127-140.
    • (1998) J. Neural Transm. Suppl. , vol.53 , pp. 127-140
    • Braak, H.1    Braak, E.2
  • 11
    • 64849088876 scopus 로고    scopus 로고
    • Environmental experience modulates ischemia-induced amyloidogenesis and enhances functional recovery
    • Briones T.L., Rogozinska M., Woods J. Environmental experience modulates ischemia-induced amyloidogenesis and enhances functional recovery. J. Neurotrauma 2009, 26:613-625.
    • (2009) J. Neurotrauma , vol.26 , pp. 613-625
    • Briones, T.L.1    Rogozinska, M.2    Woods, J.3
  • 12
    • 84855369203 scopus 로고    scopus 로고
    • Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG
    • Carter S.F., Scholl M., Almkvist O., Wall A., Engler H., Langstrom B., Nordberg A. Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG. J. Nucl. Med. 2012, 53:37-46.
    • (2012) J. Nucl. Med. , vol.53 , pp. 37-46
    • Carter, S.F.1    Scholl, M.2    Almkvist, O.3    Wall, A.4    Engler, H.5    Langstrom, B.6    Nordberg, A.7
  • 14
    • 81355133149 scopus 로고    scopus 로고
    • Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice
    • Cotel M.C., Jawhar S., Christensen D.Z., Bayer T.A., Wirths O. Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice. Neurobiol. Aging 2012, 33:96-107.
    • (2012) Neurobiol. Aging , vol.33 , pp. 96-107
    • Cotel, M.C.1    Jawhar, S.2    Christensen, D.Z.3    Bayer, T.A.4    Wirths, O.5
  • 16
    • 0030660554 scopus 로고    scopus 로고
    • Neuropathological diagnosis of Alzheimer's disease: a perspective from longitudinal clinicopathological studies
    • Dickson D.W. Neuropathological diagnosis of Alzheimer's disease: a perspective from longitudinal clinicopathological studies. Neurobiol. Aging 1997, 18:S21-S26.
    • (1997) Neurobiol. Aging , vol.18
    • Dickson, D.W.1
  • 17
    • 84869204157 scopus 로고    scopus 로고
    • Exercise improves motor deficits and alters striatal GFAP expression in a 6-OHDA-induced rat model of Parkinson's disease
    • Dutra M.F., Jaeger M., Ilha J., Kalil-Gaspar P.I., Marcuzzo S., Achaval M. Exercise improves motor deficits and alters striatal GFAP expression in a 6-OHDA-induced rat model of Parkinson's disease. Neurol. Sci. 2012, 33(5):1137-1144.
    • (2012) Neurol. Sci. , vol.33 , Issue.5 , pp. 1137-1144
    • Dutra, M.F.1    Jaeger, M.2    Ilha, J.3    Kalil-Gaspar, P.I.4    Marcuzzo, S.5    Achaval, M.6
  • 18
    • 77955281765 scopus 로고    scopus 로고
    • Activated astroglia during chronic inflammation in Alzheimer's disease-do they neglect their neurosupportive roles?
    • Fuller S., Steele M., Munch G. Activated astroglia during chronic inflammation in Alzheimer's disease-do they neglect their neurosupportive roles?. Mutat. Res. 2010, 690:40-49.
    • (2010) Mutat. Res. , vol.690 , pp. 40-49
    • Fuller, S.1    Steele, M.2    Munch, G.3
  • 20
    • 0018119845 scopus 로고
    • Hypertrophy of astroglial processes in the dentate gyrus of the senescent rat
    • Geinisman Y., Bondareff W., Dodge J.T. Hypertrophy of astroglial processes in the dentate gyrus of the senescent rat. Am. J. Anat. 1978, 153:537-543.
    • (1978) Am. J. Anat. , vol.153 , pp. 537-543
    • Geinisman, Y.1    Bondareff, W.2    Dodge, J.T.3
  • 22
    • 0023760665 scopus 로고
    • The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis
    • Gundersen H.J., Bagger P., Bendtsen T.F., Evans S.M., Korbo L., Marcussen N., Moller A., et al. The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988, 96:857-881.
    • (1988) APMIS , vol.96 , pp. 857-881
    • Gundersen, H.J.1    Bagger, P.2    Bendtsen, T.F.3    Evans, S.M.4    Korbo, L.5    Marcussen, N.6    Moller, A.7
  • 23
    • 0000152483 scopus 로고
    • The effects of early experience on problem-solving at maturity
    • Hebb D.O. The effects of early experience on problem-solving at maturity. Am. Psychol. 1947, 2:306-307.
    • (1947) Am. Psychol. , vol.2 , pp. 306-307
    • Hebb, D.O.1
  • 25
    • 38349147618 scopus 로고    scopus 로고
    • Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice
    • Herring A., Yasin H., Ambree O., Sachser N., Paulus W., Keyvani K. Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice. Brain Pathol. 2008, 18:32-39.
    • (2008) Brain Pathol. , vol.18 , pp. 32-39
    • Herring, A.1    Yasin, H.2    Ambree, O.3    Sachser, N.4    Paulus, W.5    Keyvani, K.6
  • 26
    • 80855123772 scopus 로고    scopus 로고
    • The effects of amyloid-beta42 oligomer on the proliferation and activation of astrocytes in vitro
    • Hou L., Liu Y., Wang X., Ma H., He J., Zhang Y., Yu C., et al. The effects of amyloid-beta42 oligomer on the proliferation and activation of astrocytes in vitro. In Vitro Cell. Dev. Biol. Anim. 2011, 47:573-580.
    • (2011) In Vitro Cell. Dev. Biol. Anim. , vol.47 , pp. 573-580
    • Hou, L.1    Liu, Y.2    Wang, X.3    Ma, H.4    He, J.5    Zhang, Y.6    Yu, C.7
  • 28
    • 0344305380 scopus 로고    scopus 로고
    • Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease
    • Jankowsky J.L., Xu G., Fromholt D., Gonzales V., Borchelt D.R. Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J. Neuropathol. Exp. Neurol. 2003, 62:1220-1227.
    • (2003) J. Neuropathol. Exp. Neurol. , vol.62 , pp. 1220-1227
    • Jankowsky, J.L.1    Xu, G.2    Fromholt, D.3    Gonzales, V.4    Borchelt, D.R.5
  • 30
    • 79953231162 scopus 로고    scopus 로고
    • Regional and laminar differences in antigen profiles and spatial distributions of astrocytes in the mouse hippocampus, with reference to aging
    • Jinno S. Regional and laminar differences in antigen profiles and spatial distributions of astrocytes in the mouse hippocampus, with reference to aging. Neuroscience 2011, 180:41-52.
    • (2011) Neuroscience , vol.180 , pp. 41-52
    • Jinno, S.1
  • 31
    • 0030937293 scopus 로고    scopus 로고
    • More hippocampal neurons in adult mice living in an enriched environment
    • Kempermann G., Kuhn H., Gage F. More hippocampal neurons in adult mice living in an enriched environment. Nature 1997, 386:493-495.
    • (1997) Nature , vol.386 , pp. 493-495
    • Kempermann, G.1    Kuhn, H.2    Gage, F.3
  • 32
    • 0032080116 scopus 로고    scopus 로고
    • Experience-induced neurogenesis in the senescent dentate gyrus
    • Kempermann G., Kuhn H.G., Gage F.H. Experience-induced neurogenesis in the senescent dentate gyrus. J. Neurosci. 1998, 18:3206-3212.
    • (1998) J. Neurosci. , vol.18 , pp. 3206-3212
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 33
    • 0035297712 scopus 로고    scopus 로고
    • Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
    • Klein W.L., Krafft G.A., Finch C.E. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?. Trends Neurosci. 2001, 24:219-224.
    • (2001) Trends Neurosci. , vol.24 , pp. 219-224
    • Klein, W.L.1    Krafft, G.A.2    Finch, C.E.3
  • 34
    • 77955973836 scopus 로고    scopus 로고
    • Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer's disease
    • pii:732806
    • Krause D.L., Muller N. Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer's disease. Int. J. Alzheimers Dis. 2010, pii:732806.
    • (2010) Int. J. Alzheimers Dis.
    • Krause, D.L.1    Muller, N.2
  • 35
    • 0001437008 scopus 로고
    • Relations between chemistry and problem-solving among rats raised in enriched and impoverished environments
    • Krech D., Rosenzweig M.R., Bennett E.L. Relations between chemistry and problem-solving among rats raised in enriched and impoverished environments. J. Comp. Physiol. Psychol. 1962, 55:801-807.
    • (1962) J. Comp. Physiol. Psychol. , vol.55 , pp. 801-807
    • Krech, D.1    Rosenzweig, M.R.2    Bennett, E.L.3
  • 36
    • 61349096009 scopus 로고    scopus 로고
    • Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice
    • Kuchibhotla K.V., Lattarulo C.R., Hyman B.T., Bacskai B.J. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science 2009, 323:1211-1215.
    • (2009) Science , vol.323 , pp. 1211-1215
    • Kuchibhotla, K.V.1    Lattarulo, C.R.2    Hyman, B.T.3    Bacskai, B.J.4
  • 38
    • 0030872412 scopus 로고    scopus 로고
    • Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression
    • Li S., Mallory M., Alford M., Tanaka S., Masliah E. Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression. J. Neuropathol. Exp. Neurol. 1997, 56:901-911.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 901-911
    • Li, S.1    Mallory, M.2    Alford, M.3    Tanaka, S.4    Masliah, E.5
  • 39
    • 0032888131 scopus 로고    scopus 로고
    • Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
    • Lue L.F., Kuo Y.M., Roher A.E., Brachova L., Shen Y., Sue L., Beach T., et al. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 1999, 155:853-862.
    • (1999) Am. J. Pathol. , vol.155 , pp. 853-862
    • Lue, L.F.1    Kuo, Y.M.2    Roher, A.E.3    Brachova, L.4    Shen, Y.5    Sue, L.6    Beach, T.7
  • 40
    • 0029811226 scopus 로고    scopus 로고
    • Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease
    • Masliah E., Alford M., DeTeresa R., Mallory M., Hansen L. Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann. Neurol. 1996, 40:759-766.
    • (1996) Ann. Neurol. , vol.40 , pp. 759-766
    • Masliah, E.1    Alford, M.2    DeTeresa, R.3    Mallory, M.4    Hansen, L.5
  • 41
    • 80054923695 scopus 로고    scopus 로고
    • Pharmacological treatment of Alzheimer disease
    • Massoud F., Leger G.C. Pharmacological treatment of Alzheimer disease. Can. J. Psychiatry 2011, 56:579-588.
    • (2011) Can. J. Psychiatry , vol.56 , pp. 579-588
    • Massoud, F.1    Leger, G.C.2
  • 42
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature 2004, 430:631-639.
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 43
    • 77953522402 scopus 로고    scopus 로고
    • Clinical practice. Early Alzheimer's disease
    • Mayeux R. Clinical practice. Early Alzheimer's disease. N. Engl. J. Med. 2010, 362:2194-2201.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 2194-2201
    • Mayeux, R.1
  • 44
    • 69349090064 scopus 로고    scopus 로고
    • Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease
    • Mirochnic S., Wolf S., Staufenbiel M., Kempermann G. Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease. Hippocampus 2009, 19:1008-1018.
    • (2009) Hippocampus , vol.19 , pp. 1008-1018
    • Mirochnic, S.1    Wolf, S.2    Staufenbiel, M.3    Kempermann, G.4
  • 45
    • 0034213718 scopus 로고    scopus 로고
    • High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation
    • Mucke L., Masliah E., Yu G.Q., Mallory M., Rockenstein E.M., Tatsuno G., Hu K., et al. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 2000, 20:4050-4058.
    • (2000) J. Neurosci. , vol.20 , pp. 4050-4058
    • Mucke, L.1    Masliah, E.2    Yu, G.Q.3    Mallory, M.4    Rockenstein, E.M.5    Tatsuno, G.6    Hu, K.7
  • 46
    • 84856221835 scopus 로고    scopus 로고
    • The effect of amyloid associated proteins on the expression of genes involved in amyloid-beta clearance by adult human astrocytes
    • Mulder S.D., Veerhuis R., Blankenstein M.A., Nielsen H.M. The effect of amyloid associated proteins on the expression of genes involved in amyloid-beta clearance by adult human astrocytes. Exp. Neurol. 2012, 233:373-379.
    • (2012) Exp. Neurol. , vol.233 , pp. 373-379
    • Mulder, S.D.1    Veerhuis, R.2    Blankenstein, M.A.3    Nielsen, H.M.4
  • 47
    • 0023200840 scopus 로고
    • Functional receptors for neurotransmitters on astroglial cells
    • Murphy S., Pearce B. Functional receptors for neurotransmitters on astroglial cells. Neuroscience 1987, 22:381-394.
    • (1987) Neuroscience , vol.22 , pp. 381-394
    • Murphy, S.1    Pearce, B.2
  • 48
    • 83755182724 scopus 로고    scopus 로고
    • The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases
    • Murray A.D., Staff R.T., McNeil C.J., Salarirad S., Ahearn T.S., Mustafa N., Whalley L.J. The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases. Brain 2011, 134:3687-3696.
    • (2011) Brain , vol.134 , pp. 3687-3696
    • Murray, A.D.1    Staff, R.T.2    McNeil, C.J.3    Salarirad, S.4    Ahearn, T.S.5    Mustafa, N.6    Whalley, L.J.7
  • 49
    • 2542481651 scopus 로고    scopus 로고
    • Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease
    • Nagele R.G., Wegiel J., Venkataraman V., Imaki H., Wang K.C., Wegiel J. Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease. Neurobiol. Aging 2004, 25:663-674.
    • (2004) Neurobiol. Aging , vol.25 , pp. 663-674
    • Nagele, R.G.1    Wegiel, J.2    Venkataraman, V.3    Imaki, H.4    Wang, K.C.5    Wegiel, J.6
  • 50
    • 20344394153 scopus 로고    scopus 로고
    • Role of glial cells in cerebral ischemia
    • Nedergaard M., Dirnagl U. Role of glial cells in cerebral ischemia. Glia 2005, 50:281-286.
    • (2005) Glia , vol.50 , pp. 281-286
    • Nedergaard, M.1    Dirnagl, U.2
  • 51
    • 34248223082 scopus 로고    scopus 로고
    • An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach
    • Newman S.F., Sultana R., Perluigi M., Coccia R., Cai J., Pierce W.M., Klein J.B., et al. An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach. J. Neurosci. Res. 2007, 85:1506-1514.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 1506-1514
    • Newman, S.F.1    Sultana, R.2    Perluigi, M.3    Coccia, R.4    Cai, J.5    Pierce, W.M.6    Klein, J.B.7
  • 52
    • 33747613561 scopus 로고    scopus 로고
    • Enriched environments, experience-dependent plasticity and disorders of the nervous system
    • Nithianantharajah J., Hannan A.J. Enriched environments, experience-dependent plasticity and disorders of the nervous system. Nat. Rev. Neurosci. 2006, 7:697-709.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 697-709
    • Nithianantharajah, J.1    Hannan, A.J.2
  • 53
    • 33847011405 scopus 로고    scopus 로고
    • Truncated TrkB-T1 regulates the morphology of neocortical layer I astrocytes in adult rat brain slices
    • Ohira K., Funatsu N., Homma K.J., Sahara Y., Hayashi M., Kaneko T., Nakamura S. Truncated TrkB-T1 regulates the morphology of neocortical layer I astrocytes in adult rat brain slices. Eur. J. Neurosci. 2007, 25:406-416.
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 406-416
    • Ohira, K.1    Funatsu, N.2    Homma, K.J.3    Sahara, Y.4    Hayashi, M.5    Kaneko, T.6    Nakamura, S.7
  • 54
    • 77952573750 scopus 로고    scopus 로고
    • Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
    • Olabarria M., Noristani H.N., Verkhratsky A., Rodriguez J.J. Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease. Glia 2010, 58:831-838.
    • (2010) Glia , vol.58 , pp. 831-838
    • Olabarria, M.1    Noristani, H.N.2    Verkhratsky, A.3    Rodriguez, J.J.4
  • 55
    • 33645103788 scopus 로고    scopus 로고
    • Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways
    • Olson A.K., Eadie B.D., Ernst C., Christie B.R. Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways. Hippocampus 2006, 16:250-260.
    • (2006) Hippocampus , vol.16 , pp. 250-260
    • Olson, A.K.1    Eadie, B.D.2    Ernst, C.3    Christie, B.R.4
  • 56
    • 84862657672 scopus 로고    scopus 로고
    • Neuroglia at the crossroads of homeostasis, metabolism and signaling: evolution of the concept
    • Parpura V., Verkhratsky A. Neuroglia at the crossroads of homeostasis, metabolism and signaling: evolution of the concept. ASN Neuro 2012, 4(4):201-205.
    • (2012) ASN Neuro , vol.4 , Issue.4 , pp. 201-205
    • Parpura, V.1    Verkhratsky, A.2
  • 57
    • 20344398223 scopus 로고    scopus 로고
    • Astrocyte activation and reactive gliosis
    • Pekny M., Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005, 50:427-434.
    • (2005) Glia , vol.50 , pp. 427-434
    • Pekny, M.1    Nilsson, M.2
  • 59
    • 33845924454 scopus 로고    scopus 로고
    • S100B expression defines a state in which GFAP-expressing cells lose their neural stem cell potential and acquire a more mature developmental stage
    • Raponi E., Agenes F., Delphin C., Assard N., Baudier J., Legraverend C., Deloulme J.C. S100B expression defines a state in which GFAP-expressing cells lose their neural stem cell potential and acquire a more mature developmental stage. Glia 2007, 55:165-177.
    • (2007) Glia , vol.55 , pp. 165-177
    • Raponi, E.1    Agenes, F.2    Delphin, C.3    Assard, N.4    Baudier, J.5    Legraverend, C.6    Deloulme, J.C.7
  • 60
    • 34248181511 scopus 로고    scopus 로고
    • Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
    • Roberson E.D., Scearce-Levie K., Palop J.J., Yan F., Cheng I.H., Wu T., Gerstein H., et al. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 2007, 316:750-754.
    • (2007) Science , vol.316 , pp. 750-754
    • Roberson, E.D.1    Scearce-Levie, K.2    Palop, J.J.3    Yan, F.4    Cheng, I.H.5    Wu, T.6    Gerstein, H.7
  • 62
    • 79956212740 scopus 로고    scopus 로고
    • Amyloid-beta protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease
    • Rolyan H., Feike A.C., Upadhaya A.R., Waha A., Van Dooren T., Haass C., Birkenmeier G., et al. Amyloid-beta protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. J. Neural Transm. 2011, 118:699-712.
    • (2011) J. Neural Transm. , vol.118 , pp. 699-712
    • Rolyan, H.1    Feike, A.C.2    Upadhaya, A.R.3    Waha, A.4    Van Dooren, T.5    Haass, C.6    Birkenmeier, G.7
  • 63
    • 34247611481 scopus 로고    scopus 로고
    • Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
    • Scheff S.W., Price D.A., Schmitt F.A., DeKosky S.T., Mufson E.J. Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology 2007, 68:1501-1508.
    • (2007) Neurology , vol.68 , pp. 1501-1508
    • Scheff, S.W.1    Price, D.A.2    Schmitt, F.A.3    DeKosky, S.T.4    Mufson, E.J.5
  • 64
    • 0034516988 scopus 로고    scopus 로고
    • Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein
    • Selkoe D.J. Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann. N. Y. Acad. Sci. 2000, 924:17-25.
    • (2000) Ann. N. Y. Acad. Sci. , vol.924 , pp. 17-25
    • Selkoe, D.J.1
  • 65
    • 3543144446 scopus 로고
    • Dendritic organization in the neurons of the visual and motor cortices of the cat
    • Sholl D.A. Dendritic organization in the neurons of the visual and motor cortices of the cat. J. Anat. 1953, 87:387-406.
    • (1953) J. Anat. , vol.87 , pp. 387-406
    • Sholl, D.A.1
  • 66
    • 80051576621 scopus 로고    scopus 로고
    • Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype
    • Simpson J.E., Ince P.G., Shaw P.J., Heath P.R., Raman R., Garwood C.J., Gelsthorpe C., et al. Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype. Neurobiol. Aging 2011, 32:1795-1807.
    • (2011) Neurobiol. Aging , vol.32 , pp. 1795-1807
    • Simpson, J.E.1    Ince, P.G.2    Shaw, P.J.3    Heath, P.R.4    Raman, R.5    Garwood, C.J.6    Gelsthorpe, C.7
  • 67
    • 0025974547 scopus 로고
    • Plasticity of GFAP-immunoreactive astrocyte size and number in visual cortex of rats reared in complex environments
    • Sirevaag A.M., Greenough W.T. Plasticity of GFAP-immunoreactive astrocyte size and number in visual cortex of rats reared in complex environments. Brain Res. 1991, 540:273-278.
    • (1991) Brain Res. , vol.540 , pp. 273-278
    • Sirevaag, A.M.1    Greenough, W.T.2
  • 68
    • 77956305343 scopus 로고    scopus 로고
    • Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
    • Spilman P., Podlutskaya N., Hart M.J., Debnath J., Gorostiza O., Bredesen D., Richardson A., et al. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 2010, 5:e9979.
    • (2010) PLoS One , vol.5
    • Spilman, P.1    Podlutskaya, N.2    Hart, M.J.3    Debnath, J.4    Gorostiza, O.5    Bredesen, D.6    Richardson, A.7
  • 69
    • 82755161978 scopus 로고    scopus 로고
    • Reactive astrocytes give neurons less support: implications for Alzheimer's disease
    • Steele M.L., Robinson S.R. Reactive astrocytes give neurons less support: implications for Alzheimer's disease. Neurobiol. Aging 2012, 33(2):423.e1-13.
    • (2012) Neurobiol. Aging , vol.33 , Issue.2
    • Steele, M.L.1    Robinson, S.R.2
  • 70
    • 1842763123 scopus 로고    scopus 로고
    • Differential regulation of gliogenesis in the context of adult hippocampal neurogenesis in mice
    • Steiner B., Kronenberg G., Jessberger S., Brandt M.D., Reuter K., Kempermann G. Differential regulation of gliogenesis in the context of adult hippocampal neurogenesis in mice. Glia 2004, 46:41-52.
    • (2004) Glia , vol.46 , pp. 41-52
    • Steiner, B.1    Kronenberg, G.2    Jessberger, S.3    Brandt, M.D.4    Reuter, K.5    Kempermann, G.6
  • 71
    • 84861687100 scopus 로고    scopus 로고
    • The role of astrocytes in amyloid beta-protein toxicity and clearance
    • Thal D.R. The role of astrocytes in amyloid beta-protein toxicity and clearance. Exp. Neurol. 2012, 236:1-5.
    • (2012) Exp. Neurol. , vol.236 , pp. 1-5
    • Thal, D.R.1
  • 72
    • 0033774694 scopus 로고    scopus 로고
    • Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex
    • Thal D.R., Schultz C., Dehghani F., Yamaguchi H., Braak H., Braak E. Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex. Acta Neuropathol. 2000, 100:608-617.
    • (2000) Acta Neuropathol. , vol.100 , pp. 608-617
    • Thal, D.R.1    Schultz, C.2    Dehghani, F.3    Yamaguchi, H.4    Braak, H.5    Braak, E.6
  • 74
    • 77950617631 scopus 로고    scopus 로고
    • A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo
    • Tomiyama T., Matsuyama S., Iso H., Umeda T., Takuma H., Ohnishi K., Ishibashi K., et al. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J. Neurosci. 2010, 30:4845-4856.
    • (2010) J. Neurosci. , vol.30 , pp. 4845-4856
    • Tomiyama, T.1    Matsuyama, S.2    Iso, H.3    Umeda, T.4    Takuma, H.5    Ohnishi, K.6    Ishibashi, K.7
  • 75
    • 79951789939 scopus 로고    scopus 로고
    • Short-term environmental enrichment rescues adult neurogenesis and memory deficits in APP(Sw, Ind) transgenic mice
    • Valero J., Espana J., Parra-Damas A., Martin E., Rodriguez-Alvarez J., Saura C.A. Short-term environmental enrichment rescues adult neurogenesis and memory deficits in APP(Sw, Ind) transgenic mice. PLoS One 2011, 6:e16832.
    • (2011) PLoS One , vol.6
    • Valero, J.1    Espana, J.2    Parra-Damas, A.3    Martin, E.4    Rodriguez-Alvarez, J.5    Saura, C.A.6
  • 77
    • 84868099665 scopus 로고    scopus 로고
    • Transient enriched housing before amyloidosis onset sustains cogni-tive improvement in Tg2576 mice
    • in press. (Electronic publication ahead of print).
    • Verret, L., Krezymon, A., Halley, H., Trouche, S., Zerwas, M., Lazouret, M., Lassalle, J.M., et al., in press. Transient enriched housing before amyloidosis onset sustains cogni-tive improvement in Tg2576 mice. Neurobiol Aging. (Electronic publication ahead of print). http://dx.doi.org/10.1016/j.neurobiolaging.2012.05.013.
    • Neurobiol Aging
    • Verret, L.1    Krezymon, A.2    Halley, H.3    Trouche, S.4    Zerwas, M.5    Lazouret, M.6    Lassalle, J.M.7
  • 81
    • 34347240979 scopus 로고    scopus 로고
    • Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain
    • Wilcock D.M., Gordon M.N., Morgan D. Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain. Nat. Protoc. 2006, 1:1591-1595.
    • (2006) Nat. Protoc. , vol.1 , pp. 1591-1595
    • Wilcock, D.M.1    Gordon, M.N.2    Morgan, D.3
  • 82
    • 84857194991 scopus 로고    scopus 로고
    • Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus
    • Williamson L.L., Chao A., Bilbo S.D. Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus. Brain Behav. Immun. 2012, 26:500-510.
    • (2012) Brain Behav. Immun. , vol.26 , pp. 500-510
    • Williamson, L.L.1    Chao, A.2    Bilbo, S.D.3
  • 83
    • 0034744296 scopus 로고    scopus 로고
    • TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice
    • Wyss-Coray T., Lin C., Yan F., Yu G.Q., Rohde M., McConlogue L., Masliah E., et al. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat. Med. 2001, 7:612-618.
    • (2001) Nat. Med. , vol.7 , pp. 612-618
    • Wyss-Coray, T.1    Lin, C.2    Yan, F.3    Yu, G.Q.4    Rohde, M.5    McConlogue, L.6    Masliah, E.7
  • 84
    • 84856990170 scopus 로고    scopus 로고
    • Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease
    • Yeh C.Y., Vadhwana B., Verkhratsky A., Rodriguez J.J. Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease. ASN Neuro 2011, 3:271-279.
    • (2011) ASN Neuro , vol.3 , pp. 271-279
    • Yeh, C.Y.1    Vadhwana, B.2    Verkhratsky, A.3    Rodriguez, J.J.4


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