Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes

Journal of Leukocyte Biology

Volumn 94, Issue 6, 2013, Pages 1231-1241

  Cervantes, Jorge L ^a   La Vake, Carson J ^a   Weinerman, Bennett ^a   Luu, Stephanie ^a   O'Connell, Caitlin ^c   Verardi, Paulo H ^c   Salazar, Juan C ^a,b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b Farmington   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Bacterial RNA borrelia burgdorferi human monocytes; TLR8

Indexed keywords

BACTERIAL DNA; BACTERIAL RNA; BACTERIUM LYSATE; BETA INTERFERON; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; POLYETHYLENEIMINE; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BORRELIA BURGDORFERI; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; LEUKOCYTE ACTIVATION; MONOCYTE; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA ANALYSIS;

BACTERIAL RNA; BORRELIA BURGDORFERI; HUMAN MONOCYTES; TLR8;

BORRELIA BURGDORFERI; FEMALE; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; INTERFERON-BETA; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LYME DISEASE; MALE; MONOCYTES; MYELOID DIFFERENTIATION FACTOR 88; PHAGOSOMES; RNA, BACTERIAL; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; TRANSCRIPTION, GENETIC;

EID: 84888792095     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.0413206     Document Type: Article

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