CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 4, 2012, Pages 1228-1232

  Hawley, Kelly L ^a   Olson, Chris M ^a   Iglesias Pedraz, Juan M ^a   Navasa, Nicolás ^a   Cervantes, Jorge L ^b   Caimano, Melissa J ^b   Izadi, Hooman ^a   Ingalls, Robin R ^c   Pal, Utpal ^d   Salazar, Juan C ^b,e   Radol, Justin D ^b   Anguita, Juan ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

^e Farmington   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; COMPLEMENT RECEPTOR 3; MYELOID DIFFERENTIATION FACTOR 88; RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BORRELIA BURGDORFERI; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; LYME DISEASE; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN INTERACTION;

BACTERIA (MICROORGANISMS); BORRELIA BURGDORFERI; MURINAE; SPIROCHAETALES;

EID: 84856390837     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1112078109     Document Type: Article

References (39)

1. Shapiro ED (2008) Lyme disease. Adv Exp Med Biol 609:185-195.
2. Olson CM, Jr., et al. (2009) Local production of IFN-ã by invariant NKT cells modulates acute Lyme carditis. J Immunol 182:3728-3734.
3. Montgomery RR, et al. (2007) Recruitment of macrophages and polymorphonuclear leukocytes in Lyme carditis. Infect Immun 75:613-620. (Pubitemid 46203423)
4. Aliprantis AO, et al. (1999) Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285:736-739.
5. Hirschfeld M, et al. (1999) Cutting edge: Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J Immunol 163:2382-2386. (Pubitemid 29399155)
6. Alexopoulou L, et al. (2002) Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med 8:878-884.
7. Sellati TJ, et al. (1999) Activation of human monocytic cells by Borrelia burgdorferi and Treponema pallidum is facilitated by CD14 and correlates with surface exposure of spirochetal lipoproteins. J Immunol 163:2049-2056. (Pubitemid 29382209)
8. Wooten RM, et al. (1998) The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi. J Immunol 160:5485-5492. (Pubitemid 28267840)
9. Moore MW, et al. (2007) Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces γ interferon production. Infect Immun 75:2046-2062. (Pubitemid 46559474)
10. Cervantes JL, et al. (2011) Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-β. Proc Natl Acad Sci USA 108:3683-3688.
11. Salazar JC, et al. (2009) Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-β. PLoS Pathog 5:e1000444.
12. Petzke MM, Brooks A, Krupna MA, Mordue D, Schwartz I (2009) Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells. J Immunol 183:5279-5292.
13. Sahay B, et al. (2009) CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance. PLoS Pathog 5:e1000687.
14. Shin OS, et al. (2008) Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction. Infect Immun 76: 2341-2351.
15. Shin OS, et al. (2009) Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K. J Immunol 183:491-498.
16. Humphries JD, Byron A, Humphries MJ (2006) Integrin ligands at a glance. J Cell Sci 119:3901-3903. (Pubitemid 44650863)
17. Ben Nasr A, et al. (2006) Critical role for serum opsonins and complement receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in phagocytosis of Francisella tularensis by human dendritic cells (DC): Uptake of Francisella leads to activation of immature DC and intracellular survival of the bacteria. J Leukoc Biol 80:774-786.
18. Mobberley-Schuman PS, Weiss AA (2005) Influence of CR3 (CD11b/CD18) expression on phagocytosis of Bordetella pertussis by human neutrophils. Infect Immun 73: 7317-7323. (Pubitemid 41587632)
19. Le Cabec V, Cols C, Maridonneau-Parini I (2000) Nonopsonic phagocytosis of zymosan and Mycobacterium kansasii by CR3 (CD11b/CD18) involves distinct molecular determinants and is or is not coupled with NADPH oxidase activation. Infect Immun 68: 4736-4745. (Pubitemid 30497748)
20. Sendide K, et al. (2005) Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: Regulation by phosphatidylinositol 3-kinase and cytohesin-1. J Immunol 174:4210-4219. (Pubitemid 40396001)
21. Oliva C, Turnbough CL, Jr., Kearney JF (2009) CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages. Proc Natl Acad Sci USA 106: 13957-13962.
22. Harokopakis E, Hajishengallis G (2005) Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase. Eur J Immunol 35:1201-1210. (Pubitemid 40542227)
23. Cinco M, Murgia R, Perticarari S, Presani G (1998) Surface receptors of neutrophils towards B. burgdorferi. Wien Klin Wochenschr 110:866-869. (Pubitemid 29067789)
24. Cinco M, Murgia R, Presani G, Perticarari S (1997) Integrin CR3 mediates the binding of nonspecifically opsonized Borrelia burgdorferi to human phagocytes and mammalian cells. Infect Immun 65:4784-4789. (Pubitemid 27463257)
25. Dunham-Ems SM, et al. (2009) Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks. J Clin Invest 119:3652-3665.
26. 1stimulates production of pro-inflammatory mediators in primary human chondrocytes. Cell Microbiol 10:320-331.
27. 3) recognition. Infect Immun 69:3455-3459.
28. Garcia RC, Murgia R, Cinco M (2005) Complement receptor 3 binds the Borrelia burgdorferi outer surface proteins OspA and OspB in an iC3b-independent manner. Infect Immun 73:6138-6142. (Pubitemid 41193053)
29. Amiel E, Acker JL, Collins RM, Berwin B (2009) Uncoupling scavenger receptor A-mediated phagocytosis of bacteria from endotoxic shock resistance. Infect Immun 77:4567-4573.
30. Medvedev AE, et al. (1998) Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls. J Immunol 160:4535-4542. (Pubitemid 28217313)
31. Golenbock DT, Liu Y, Millham FH, Freeman MW, Zoeller RA (1993) Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin. J Biol Chem 268:22055-22059. (Pubitemid 23320715)
32. Heine H, et al. (1999) Cutting edge: Cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J Immunol 162:6971-6975. (Pubitemid 29277661)
33. Loiarro M, et al. (2005) Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-κB. J Biol Chem 280:15809-15814. (Pubitemid 40616701)
34. Liddington RC, Ginsberg MH (2002) Integrin activation takes shape. J Cell Biol 158: 833-839. (Pubitemid 35001074)
35. Vachon E, et al. (2007) CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages. Blood 110:4492-4502. (Pubitemid 351377816)
36. Hristov M, Gümbel D, Lutgens E, Zernecke A, Weber C (2010) Soluble CD40 ligand impairs the function of peripheral blood angiogenic outgrowth cells and increases neointimal formation after arterial injury. Circulation 121:315-324.
37. Benhnia MR, et al. (2005) Signaling through CD14 attenuates the inflammatory response to Borrelia burgdorferi, the agent of Lyme disease. J Immunol 174:1539-1548.
38. + T helper 1 cells facilitate regression of murine Lyme carditis. Infect Immun 69:5264-5269.
39. Fan ST, Edgington TS (1993) Integrin regulation of leukocyte inflammatory functions. CD11b/CD18 enhancement of the tumor necrosis factor-alpha responses of monocytes. J Immunol 150:2972-2980.