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Volumn 85, Issue 4, 2009, Pages 664-672

Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells

Author keywords

Innate immunity; Regulation; Transcription factors

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 12P70; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; STAT PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR ALPHA; LIGAND; MESSENGER RNA;

EID: 65249164025     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0808503     Document Type: Article
Times cited : (137)

References (46)
  • 1
    • 33745847180 scopus 로고    scopus 로고
    • TLRs, NLRs and RLRs: A trinity of pathogen sensors that co-operate in innate immunity
    • Creagh, E. M., O'Neill, L. A. (2006) TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol. 27, 352-357.
    • (2006) Trends Immunol. , vol.27 , pp. 352-357
    • Creagh, E.M.1    O'Neill, L.A.2
  • 2
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira, S., Uematsu, S., Takeuchi, O. (2006) Pathogen recognition and innate immunity. Cell 124, 783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 3
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domain-containing adaptors in Toll-like receptor signaling
    • O'Neill, L. A., Bowie, A. G. (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signaling. Nat. Rev. Immunol. 7, 353-364.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 5
    • 23944489407 scopus 로고    scopus 로고
    • Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1 -polarizing program in dendritic cells
    • DOI 10.1038/ni1223, PII N1223
    • Napolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F., Lanzavecchia, A. (2005) Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat. Immunol. 6, 769-776. (Pubitemid 43090462)
    • (2005) Nature Immunology , vol.6 , Issue.8 , pp. 769-776
    • Napolitani, G.1    Rinaldi, A.2    Bertoni, F.3    Sallusto, F.4    Lanzavecchia, A.5
  • 6
    • 33846207958 scopus 로고    scopus 로고
    • MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists
    • Bagchi, A., Herrup, E. A., Warren, H. S., Trigilio, J., Shin, H. S., Valentine, C., Hellman, J. (2007) MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J. Immunol. 178, 1164-1171. (Pubitemid 46095190)
    • (2007) Journal of Immunology , vol.178 , Issue.2 , pp. 1164-1171
    • Bagchi, A.1    Herrup, E.A.2    Warren, H.S.3    Trigilio, J.4    Shin, H.-S.5    Valentine, C.6    Hellman, J.7
  • 9
    • 35648991998 scopus 로고    scopus 로고
    • Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses
    • Bohnenkamp, H. R., Papazisis, K. T., Burchell, J. M., Taylor-Papadimitriou, J. (2007) Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses. Cell. Immunol. 247, 72-84.
    • (2007) Cell. Immunol. , vol.247 , pp. 72-84
    • Bohnenkamp, H.R.1    Papazisis, K.T.2    Burchell, J.M.3    Taylor-Papadimitriou, J.4
  • 10
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
    • Manetti, R., Parronchi, P., Giudizi, M. G., Piccinni, M. P., Maggi, E., Trinchieri, G., Romagnani, S. (1993) Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177, 1199-1204. (Pubitemid 23097410)
    • (1993) Journal of Experimental Medicine , vol.177 , Issue.4 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Giudizi, M.G.3    Piccinni, M.-P.4    Maggi, E.5    Trinchieri, G.6    Romagnani, S.7
  • 11
    • 2342614855 scopus 로고    scopus 로고
    • Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1-type cytokines and chemokines in human monocyte-derived dendritic cells
    • DOI 10.1189/jlb.1003461
    • Veckman, V., Miettinen, M., Pirhonen, J., Siren, J., Matikainen, S., Julkunen, I. (2004) Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1-type cytokines and chemokines in human monocyte-derived dendritic cells. J. Leukoc. Biol. 75, 764-771. (Pubitemid 38580056)
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.5 , pp. 764-771
    • Veckman, V.1    Miettinen, M.2    Pirhonen, J.3    Siren, J.4    Matikainen, S.5    Julkunen, I.6
  • 12
    • 22544477862 scopus 로고    scopus 로고
    • Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells
    • DOI 10.1128/JVI.79.15.9608-9617.2005
    • Österlund, P., Veckman, V., Siren, J., Klucher, K. M., Hiscott, J., Matikainen, S., Julkunen, I. (2005) Gene expression and antiviral activity of α/β interferons and interleukin-29 in virus-infected human myeloid dendritic cells. J. Virol. 79, 9608-9617. (Pubitemid 41022304)
    • (2005) Journal of Virology , vol.79 , Issue.15 , pp. 9608-9617
    • Osterlund, P.1    Veckman, V.2    Siren, J.3    Klucher, K.M.4    Hiscott, J.5    Matikainen, S.6    Julkunen, I.7
  • 13
    • 0029908573 scopus 로고    scopus 로고
    • Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells
    • Matikainen, S., Ronni, T., Hurme, M., Pine, R., Julkunen, I. (1996) Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells. Blood 88, 114-123. (Pubitemid 26230678)
    • (1996) Blood , vol.88 , Issue.1 , pp. 114-123
    • Matikainen, S.1    Ronni, T.2    Hurme, M.3    Pine, R.4    Julkunen, I.5
  • 14
    • 33845930736 scopus 로고    scopus 로고
    • Multiple NF-κB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells
    • Pietilä, T. E., Veckman, V., Lehtonen, A., Lin, R., Hiscott, J., Julkunen, I. (2007) Multiple NF-κB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells. J. Immunol. 178, 253-261. (Pubitemid 46033608)
    • (2007) Journal of Immunology , vol.178 , Issue.1 , pp. 253-261
    • Pietila, T.E.1    Veckman, V.2    Lehtonen, A.3    Lin, R.4    Hiscott, J.5    Julkunen, I.6
  • 15
    • 30844433763 scopus 로고    scopus 로고
    • TNF-α and IFN-α enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells
    • DOI 10.1016/j.virol.2005.09.043, PII S0042682205006100
    • Veckman, V., Österlund, P., Fagerlund, R., Melen, K., Matikainen, S., Julkunen, I. (2006) TNF-α and IFN-α enhance influenza-A-virus- induced chemokine gene expression in human A549 lung epithelial cells. Virology 345, 96-104. (Pubitemid 43107575)
    • (2006) Virology , vol.345 , Issue.1 , pp. 96-104
    • Veckman, V.1    Osterlund, P.2    Fagerlund, R.3    Melen, K.4    Matikainen, S.5    Julkunen, I.6
  • 16
    • 31544456342 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- And TLR3-induced IL-12p35 gene activation
    • DOI 10.1182/blood-2005-06-2416
    • Goriely, S., Molle, C., Nguyen, M., Albarani, V., Haddou, N. O., Lin, R., De Wit, D., Flamand, V., Willems, F., Goldman, M. (2006) Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation. Blood 107, 1078-1084. (Pubitemid 43156308)
    • (2006) Blood , vol.107 , Issue.3 , pp. 1078-1084
    • Goriely, S.1    Molle, C.2    Nguyen, M.3    Albarani, V.4    Haddou, N.O.5    Lin, R.6    De Wit, D.7    Flamand, V.8    Willems, F.9    Goldman, M.10
  • 17
    • 11244336489 scopus 로고    scopus 로고
    • Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein
    • DOI 10.1074/jbc.M406565200
    • Liu, J., Guan, X., Tamura, T., Ozato, K., Ma, X. (2004) Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein. J. Biol. Chem. 279, 55609-55617. (Pubitemid 40066565)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.53 , pp. 55609-55617
    • Liu, J.1    Guan, X.2    Tamura, T.3    Ozato, K.4    Ma, X.5
  • 18
    • 0142156744 scopus 로고    scopus 로고
    • Differential Regulation of Interleukin (IL)-12 p35 and p40 Gene Expression and Interferon (IFN)-γ-primed IL-12 Production by IFN Regulatory Factor 1
    • DOI 10.1084/jem.20030026
    • Liu, J., Cao, S., Herman, L. M., Ma, X. (2003) Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-γ-primed IL-12 production by IFN regulatory factor 1. J. Exp. Med. 198, 1265-1276. (Pubitemid 37323391)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.8 , pp. 1265-1276
    • Liu, J.1    Cao, S.2    Herman, L.M.3    Ma, X.4
  • 19
    • 27744509044 scopus 로고    scopus 로고
    • Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages
    • Lehtonen, A., Veckman, V., Nikula, T., Lahesmaa, R., Kinnunen, L., Matikainen, S., Julkunen, I. (2005) Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages. J. Immunol. 175, 6570-6579. (Pubitemid 41598899)
    • (2005) Journal of Immunology , vol.175 , Issue.10 , pp. 6570-6579
    • Lehtonen, A.1    Veckman, V.2    Nikula, T.3    Lahesmaa, R.4    Kinnunen, L.5    Matikainen, S.6    Julkunen, I.7
  • 20
    • 34548448100 scopus 로고    scopus 로고
    • Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells
    • DOI 10.1189/jlb.0307194
    • Lehtonen, A., Ahlfors, H., Veckman, V., Miettinen, M., Lahesmaa, R., Julkunen, I. (2007) Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells. J. Leukoc. Biol. 82, 710-720. (Pubitemid 47367163)
    • (2007) Journal of Leukocyte Biology , vol.82 , Issue.3 , pp. 710-720
    • Lehtonen, A.1    Ahlfors, H.2    Veckman, V.3    Miettinen, M.4    Lahesmaa, R.5    Julkunen, I.6
  • 21
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • DOI 10.1042/0264-6021:3510095
    • Davies, S. P., Reddy, H., Caivano, M., Cohen, P. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105. (Pubitemid 30781561)
    • (2000) Biochemical Journal , vol.351 , Issue.1 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 23
    • 0029043582 scopus 로고
    • How MAP kinases are regulated
    • Cobb, M. H., Goldsmith, E. J. (1995) How MAP kinases are regulated. J. Biol. Chem. 270, 14843-14846.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14843-14846
    • Cobb, M.H.1    Goldsmith, E.J.2
  • 25
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphyatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos, C. J., Matter, W. F., Hui, K. Y., Brown, R. F. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (LY294002). J. Biol. Chem. 269, 5241-5248. (Pubitemid 2045363)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.7 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 26
    • 0026590541 scopus 로고
    • Dithiocarbamates as potent inhibitors of nuclear factor κ B activation in intact cells
    • Schreck, R., Meier, B., Mannel, D. N., Droge, W., Baeuerle, P. A. (1992) Dithiocarbamates as potent inhibitors of nuclear factor κ B activation in intact cells. J. Exp. Med. 175, 1181-1194.
    • (1992) J. Exp. Med. , vol.175 , pp. 1181-1194
    • Schreck, R.1    Meier, B.2    Mannel, D.N.3    Droge, W.4    Baeuerle, P.A.5
  • 29
    • 41849101964 scopus 로고    scopus 로고
    • Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells
    • Hirata, N., Yanagawa, Y., Ebihara, T., Seya, T., Uematsu, S., Akira, S., Hayashi, F., Iwabuchi, K., Onoe, K. (2008) Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells. Mol. Immunol. 45, 2734-2742.
    • (2008) Mol. Immunol. , vol.45 , pp. 2734-2742
    • Hirata, N.1    Yanagawa, Y.2    Ebihara, T.3    Seya, T.4    Uematsu, S.5    Akira, S.6    Hayashi, F.7    Iwabuchi, K.8    Onoe, K.9
  • 30
    • 33745945647 scopus 로고    scopus 로고
    • Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo
    • DOI 10.1182/blood-2005-10-4015
    • Warger, T., Osterloh, P., Rechtsteiner, G., Fassbender, M., Heib, V., Schmid, B., Schmitt, E., Schild, H., Radsak, M. P. (2006) Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo. Blood 108, 544-550. (Pubitemid 44061354)
    • (2006) Blood , vol.108 , Issue.2 , pp. 544-550
    • Warger, T.1    Osterloh, P.2    Rechtsteiner, G.3    Fassbender, M.4    Heib, V.5    Schmid, B.6    Schmitt, E.7    Schild, H.8    Radsak, M.P.9
  • 31
    • 34548209246 scopus 로고    scopus 로고
    • TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells
    • DOI 10.1016/j.molimm.2007.02.021, PII S016158900700079X
    • Theiner, G., Rossner, S., Dalpke, A., Bode, K., Berger, T., Gessner, A., Lutz, M. B. (2008) TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells. Mol. Immunol. 45, 244-252. (Pubitemid 47331637)
    • (2008) Molecular Immunology , vol.45 , Issue.1 , pp. 244-252
    • Theiner, G.1    Rossner, S.2    Dalpke, A.3    Bode, K.4    Berger, T.5    Gessner, A.6    Lutz, M.B.7
  • 32
    • 0002958069 scopus 로고    scopus 로고
    • Macrophages exposed continuously to lipopolysaccharide and other agonists that act via Toll-like receptors exhibit a sustained and additive activation state
    • Hume, D. A., Underhill, D. M., Sweet, M. J., Ozinsky, A. O., Liew, F. Y., Aderem, A. (2001) Macrophages exposed continuously to lipopolysaccharide and other agonists that act via Toll-like receptors exhibit a sustained and additive activation state. BMC Immunol. 2, 11.
    • (2001) BMC Immunol. , vol.2 , pp. 11
    • Hume, D.A.1    Underhill, D.M.2    Sweet, M.J.3    Ozinsky, A.O.4    Liew, F.Y.5    Aderem, A.6
  • 33
    • 0035163566 scopus 로고    scopus 로고
    • Lipopolysaccharide and CpG DNA synergize for tumor necrosis factor-α production through activation of NF-κB
    • Yi, A. K., Yoon, J. G., Hong, S. C., Redford, T. W., Krieg, A. M. (2001) Lipopolysaccharide and CpG DNA synergize for tumor necrosis factor-α production through activation of NF-κB. Int. Immunol. 13, 1391-1404. (Pubitemid 33049123)
    • (2001) International Immunology , vol.13 , Issue.11 , pp. 1391-1404
    • Yi, A.-K.1    Yoon, J.-G.2    Hong, S.-C.3    Redford, T.W.4    Krieg, A.M.5
  • 34
    • 0034671772 scopus 로고    scopus 로고
    • Synergy and cross-tolerance between Toll-like receptor (TLR) 2- And TLR4-mediated signaling pathways
    • Sato, S., Nomura, F., Kawai, T., Takeuchi, O., Muhlradt, P. F., Takeda, K., Akira, S. (2000) Synergy and cross-tolerance between Toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J. Immunol. 165, 7096-7101. (Pubitemid 32001184)
    • (2000) Journal of Immunology , vol.165 , Issue.12 , pp. 7096-7101
    • Sato, S.1    Nomura, F.2    Kawai, T.3    Takeuchi, O.4    Muhlradt, P.F.5    Takeda, K.6    Akira, S.7
  • 35
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • DOI 10.1038/nri1001
    • Trinchieri, G. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3, 133-146. (Pubitemid 37328691)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.2 , pp. 133-146
    • Trinchieri, G.1
  • 36
    • 33744539146 scopus 로고    scopus 로고
    • IRF-8/interferon (IFN) consensus sequence-binding protein is involved in toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-γ signaling pathways
    • DOI 10.1074/jbc.M507788200
    • Zhao, J., Kong, H. J., Li, H., Huang, B., Yang, M., Zhu, C., Bogunovic, M., Zheng, F., Mayer, L., Ozato, K., Unkeless, J., Xiong, H. (2006) IRF-8/ interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-γ signaling pathways. J. Biol. Chem. 281, 10073-10080. (Pubitemid 43864542)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.15 , pp. 10073-10080
    • Zhao, J.1    Hee, J.K.2    Li, H.3    Huang, B.4    Yang, M.5    Zhu, C.6    Bogunovic, M.7    Zheng, F.8    Mayer, L.9    Ozato, K.10    Unkeless, J.11    Xiong, H.12
  • 38
    • 40949134086 scopus 로고    scopus 로고
    • TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
    • Kagan, J. C., Su, T., Horng, T., Chow, A., Akira, S., Medzhitov, R. (2008) TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β. Nat. Immunol. 9, 361-368.
    • (2008) Nat. Immunol. , vol.9 , pp. 361-368
    • Kagan, J.C.1    Su, T.2    Horng, T.3    Chow, A.4    Akira, S.5    Medzhitov, R.6
  • 39
    • 10844273239 scopus 로고    scopus 로고
    • Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells
    • DOI 10.1093/intimm/dxh171
    • Nakahara, T., Uchi, H., Urabe, K., Chen, Q., Furue, M., Moroi, Y. (2004) Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells. Int. Immunol. 16, 1701-1709. (Pubitemid 40003858)
    • (2004) International Immunology , vol.16 , Issue.12 , pp. 1701-1709
    • Nakahara, T.1    Uchi, H.2    Urabe, K.3    Chen, Q.4    Furue, M.5    Moroi, Y.6
  • 40
    • 0035869634 scopus 로고    scopus 로고
    • A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-α, and contact sensitizers
    • Arrighi, J. F., Rebsamen, M., Rousset, F., Kindler, V., Hauser, C. (2001) A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-α, and contact sensitizers. J. Immunol. 166, 3837-3845. (Pubitemid 32224909)
    • (2001) Journal of Immunology , vol.166 , Issue.6 , pp. 3837-3845
    • Arrighi, J.-F.1    Rebsamen, M.2    Rousset, F.3    Kindler, V.4    Hauser, C.5
  • 41
    • 0035496927 scopus 로고    scopus 로고
    • Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells
    • Puig-Kroger, A., Relloso, M., Fernandez-Capetillo, O., Zubiaga, A., Silva, A., Bernabeu, C., Corbi, A. L. (2001) Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 98, 2175-2182.
    • (2001) Blood , vol.98 , pp. 2175-2182
    • Puig-Kroger, A.1    Relloso, M.2    Fernandez-Capetillo, O.3    Zubiaga, A.4    Silva, A.5    Bernabeu, C.6    Corbi, A.L.7
  • 42
    • 0242580118 scopus 로고    scopus 로고
    • Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos
    • Agrawal, S., Agrawal, A., Doughty, B., Gerwitz, A., Blenis, J., Van Dyke, T., Pulendran, B. (2003) Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J. Immunol. 171, 4984-4989. (Pubitemid 37432777)
    • (2003) Journal of Immunology , vol.171 , Issue.10 , pp. 4984-4989
    • Agrawal, S.1    Agrawal, A.2    Doughty, B.3    Gerwitz, A.4    Blenis, J.5    Van Dyke, T.6    Pulendran, B.7
  • 44
  • 45
    • 0037629646 scopus 로고    scopus 로고
    • PI3K and negative regulation of TLR signaling
    • DOI 10.1016/S1471-4906(03)00139-X
    • Fukao, T., Koyasu, S. (2003) PI3K and negative regulation of TLR signaling. Trends Immunol. 24, 358-363. (Pubitemid 36830961)
    • (2003) Trends in Immunology , vol.24 , Issue.7 , pp. 358-363
    • Fukao, T.1    Koyasu, S.2


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