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Volumn 9, Issue 6, 2012, Pages 434-438

TLR8: The forgotten relative revindicated

Author keywords

Human monocytes; TLR8; Type I interferon

Indexed keywords

BACTERIAL RNA; BETA INTERFERON; CYTOKINE; DOUBLE STRANDED RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; NUCLEIC ACID; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR;

EID: 84868598029     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2012.38     Document Type: Review
Times cited : (193)

References (64)
  • 1
    • 68849085894 scopus 로고    scopus 로고
    • A cell biological view of Toll-like receptor function: Regulation through compartmentalization
    • Barton GM, Kagan JC. A cell biological view of Toll-like receptor function: Regulation through compartmentalization. Nat Rev Immunol 2009; 9: 535-542.
    • (2009) Nat Rev Immunol , vol.9 , pp. 535-542
    • Barton, G.M.1    Kagan, J.C.2
  • 3
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-Recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-Recognition receptors in innate immunity: Update on Toll-like receptors. Nat Immunol 2010; 11: 373-384.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 4
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • DOI 10.1016/j.cell.2006.02.015, PII S0092867406001905
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124: 783-801. (Pubitemid 43261452)
    • (2006) Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 6
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 2011; 34: 637-650.
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 7
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol 2011; 30: 16-34.
    • (2011) Int Rev Immunol , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 8
    • 84859986329 scopus 로고    scopus 로고
    • Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
    • Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L et al. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 2012; 36: 561-571.
    • (2012) Immunity , vol.36 , pp. 561-571
    • Jin, T.1    Perry, A.2    Jiang, J.3    Smith, P.4    Curry, J.A.5    Unterholzner, L.6
  • 11
    • 55449113946 scopus 로고    scopus 로고
    • Genetic association and expression studies indicate a role of Toll-like receptor 8 in pulmonary tuberculosis
    • Davila S, Hibberd ML, Hari Dass R, Wong HE, Sahiratmadja E, Bonnard C et al. Genetic association and expression studies indicate a role of Toll-like receptor 8 in pulmonary tuberculosis. Plos Genet 2008; 4: E1000218.
    • (2008) Plos Genet , vol.4
    • Davila, S.1    Hibberd, M.L.2    Hari Dass, R.3    Wong, H.E.4    Sahiratmadja, E.5    Bonnard, C.6
  • 13
    • 79952750092 scopus 로고    scopus 로고
    • Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-Beta
    • Cervantes JL, Dunham-Ems SM, la Vake CJ, Petzke MM, Sahay B, Sellati TJ et al. Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-Beta. Proc Natl Acad Sci USA 2011; 108: 3683-3688.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 3683-3688
    • Cervantes, J.L.1    Dunham-Ems, S.M.2    La Vake, C.J.3    Petzke, M.M.4    Sahay, B.5    Sellati, T.J.6
  • 14
    • 84868565711 scopus 로고    scopus 로고
    • Human TLR8 Is activated upon recognition of borrelia burgdorferi rna in the phagosome of human monocytes
    • Cervantes JL, la Vake CJ, Salazar JC. Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes. Cytokine [Abstract]. 2011; 56: 107.
    • (2011) Cytokine [Abstract , vol.56 , pp. 107
    • Cervantes, J.L.1    La Vake, C.J.2    Salazar, J.C.3
  • 15
    • 42149167357 scopus 로고    scopus 로고
    • TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages
    • Gantier MP, Tong S, Behlke MA, Xu D, Phipps S, Foster PS et al. TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. J Immunol 2008; 180: 2117-2124.
    • (2008) J Immunol , vol.180 , pp. 2117-2124
    • Gantier, M.P.1    Tong, S.2    Behlke, M.A.3    Xu, D.4    Phipps, S.5    Foster, P.S.6
  • 16
    • 77949940198 scopus 로고    scopus 로고
    • Intracellular toll-like receptors
    • Blasius AL, Beutler B. Intracellular toll-like receptors. Immunity 2010; 32: 305-315.
    • (2010) Immunity , vol.32 , pp. 305-315
    • Blasius, A.L.1    Beutler, B.2
  • 18
    • 12444341806 scopus 로고    scopus 로고
    • Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8
    • Gorden KB, Gorski KS, Gibson SJ, Kedl RM, Kieper WC, Qiu X et al. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol 2005; 174: 1259-1268.
    • (2005) J Immunol , vol.174 , pp. 1259-1268
    • Gorden, K.B.1    Gorski, K.S.2    Gibson, S.J.3    Kedl, R.M.4    Kieper, W.C.5    Qiu, X.6
  • 22
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002; 168: 4531-4537. (Pubitemid 34441357)
    • (2002) Journal of Immunology , vol.168 , Issue.9 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 23
    • 38149021578 scopus 로고    scopus 로고
    • The covalent modification and regulation of TLR8 in HEK-293 cells stimulated with imidazoquinoline agonists
    • Rajagopal R, Waller AS, Mendoza JD, Wightman PD. The covalent modification and regulation of TLR8 in HEK-293 cells stimulated with imidazoquinoline agonists. Biochem J 2008; 409: 275-287.
    • (2008) Biochem J. , vol.409 , pp. 275-287
    • Rajagopal, R.1    Waller, A.S.2    Mendoza, J.D.3    Wightman, P.D.4
  • 24
    • 40749098665 scopus 로고    scopus 로고
    • UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
    • DOI 10.1038/nature06726, PII NATURE06726
    • Kim YM, Brinkmann MM, Paquet ME, Ploegh HL. UNC93B1 delivers nucleotidesensing toll-like receptors to endolysosomes. Nature 2008; 452: 234-238. (Pubitemid 351380247)
    • (2008) Nature , vol.452 , Issue.7184 , pp. 234-238
    • Kim, Y.-M.1    Brinkmann, M.M.2    Paquet, M.-E.3    Ploegh, H.L.4
  • 25
    • 82555187209 scopus 로고    scopus 로고
    • UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling
    • Itoh H, Tatematsu M, Watanabe A, Iwano K, Funami K, Seya T et al. UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling. Plos One 2011; 6: E28500.
    • (2011) Plos One , vol.6
    • Itoh, H.1    Tatematsu, M.2    Watanabe, A.3    Iwano, K.4    Funami, K.5    Seya, T.6
  • 26
    • 67349187318 scopus 로고    scopus 로고
    • Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells
    • Mancuso G, Gambuzza M, Midiri A, Biondo C, Papasergi S, Akira S et al. Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells. Nat Immunol 2009; 10: 587-594.
    • (2009) Nat Immunol , vol.10 , pp. 587-594
    • Mancuso, G.1    Gambuzza, M.2    Midiri, A.3    Biondo, C.4    Papasergi, S.5    Akira, S.6
  • 27
    • 70349245386 scopus 로고    scopus 로고
    • Bacterial RNA is recognized by different sets of immunoreceptors
    • Eberle F, Sirin M, Binder M, Dalpke AH. Bacterial RNA is recognized by different sets of immunoreceptors. Eur J Immunol 2009; 39: 2537-2547.
    • (2009) Eur J Immunol , vol.39 , pp. 2537-2547
    • Eberle, F.1    Sirin, M.2    Binder, M.3    Dalpke, A.H.4
  • 28
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
    • DOI 10.1016/j.immuni.2005.06.008, PII S1074761305002116
    • Kariko K, Buckstein M, Ni H, Weissman D. Suppression ofRNArecognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 2005; 23: 165-175. (Pubitemid 41169286)
    • (2005) Immunity , vol.23 , Issue.2 , pp. 165-175
    • Kariko, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 29
    • 67249115186 scopus 로고    scopus 로고
    • Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-Beta
    • Salazar JC, Duhnam-Ems S, la Vake C, Cruz AR, Moore MW, Caimano MJ et al. Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-Beta. Plos Pathog 2009; 5: E1000444.
    • (2009) Plos Pathog , vol.5
    • Salazar, J.C.1    Duhnam-Ems, S.2    La Vake, C.3    Cruz, A.R.4    Moore, M.W.5    Caimano, M.J.6
  • 30
    • 75749141369 scopus 로고    scopus 로고
    • Intrinsic cellular defenses against virus infection by antiviral type I interferon
    • Boo KH, Yang JS. Intrinsic cellular defenses against virus infection by antiviral type I interferon. Yonsei Med J 2010; 51: 9-17.
    • (2010) Yonsei Med J. , vol.51 , pp. 9-17
    • Boo, K.H.1    Yang, J.S.2
  • 31
    • 84863115824 scopus 로고    scopus 로고
    • The 29-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition
    • Jockel S, Nees G, Sommer R, Zhao Y, Cherkasov D, Hori H et al. The 29-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition. J Exp Med 2012; 209: 235-241.
    • (2012) J Exp Med , vol.209 , pp. 235-241
    • Jockel, S.1    Nees, G.2    Sommer, R.3    Zhao, Y.4    Cherkasov, D.5    Hori, H.6
  • 32
    • 43449132981 scopus 로고    scopus 로고
    • Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod
    • Zhu J, Lai K, Brownile R, Babiuk LA, Mutwiri GK. Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod. Mol Immunol 2008; 45: 3238-3243.
    • (2008) Mol Immunol , vol.45 , pp. 3238-3243
    • Zhu, J.1    Lai, K.2    Brownile, R.3    Babiuk, L.A.4    Mutwiri, G.K.5
  • 33
    • 44649137559 scopus 로고    scopus 로고
    • Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses
    • Forsbach A, Nemorin JG, Montino C, Muller C, Samulowitz U, Vicari AP et al. Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses. J Immunol 2008; 180: 3729-3738.
    • (2008) J Immunol , vol.180 , pp. 3729-3738
    • Forsbach, A.1    Nemorin, J.G.2    Montino, C.3    Muller, C.4    Samulowitz, U.5    Vicari, A.P.6
  • 34
    • 33750823681 scopus 로고    scopus 로고
    • Cutting edge: Activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides
    • Gorden KK, Qiu XX, Binsfeld CC, Vasilakos JP, Alkan SS. Cutting edge: Activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides. J Immunol 2006; 177: 6584-6587. (Pubitemid 44715019)
    • (2006) Journal of Immunology , vol.177 , Issue.10 , pp. 6584-6587
    • Gorden, K.K.B.1    Qiu, X.X.2    Binsfeld, C.C.A.3    Vasilakos, J.P.4    Alkan, S.S.5
  • 35
    • 77950883727 scopus 로고    scopus 로고
    • Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA
    • Martinez J, Huang X, Yang Y. Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA. Proc Natl Acad Sci USA 2010; 107: 6442-6447.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6442-6447
    • Martinez, J.1    Huang, X.2    Yang, Y.3
  • 37
    • 34250011263 scopus 로고    scopus 로고
    • TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-α
    • DOI 10.1016/j.intimp.2007.04.006, PII S1567576907001099
    • Ghosh TK, Mickelson DJ, Solberg JC, Lipson KE, Inglefield JR, Alkan SS. TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha. Int Immunopharmacol 2007; 7: 1111-1121. (Pubitemid 46891328)
    • (2007) International Immunopharmacology , vol.7 , Issue.8 , pp. 1111-1121
    • Ghosh, T.K.1    Mickelson, D.J.2    Solberg, J.C.3    Lipson, K.E.4    Inglefield, J.R.5    Alkan, S.S.6
  • 38
    • 23944489407 scopus 로고    scopus 로고
    • Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1 -polarizing program in dendritic cells
    • DOI 10.1038/ni1223, PII N1223
    • Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-Polarizing program in dendritic cells. Nat Immunol 2005; 6: 769-776. (Pubitemid 43090462)
    • (2005) Nature Immunology , vol.6 , Issue.8 , pp. 769-776
    • Napolitani, G.1    Rinaldi, A.2    Bertoni, F.3    Sallusto, F.4    Lanzavecchia, A.5
  • 39
    • 65249164025 scopus 로고    scopus 로고
    • Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells
    • Makela SM, Strengell M, Pietila TE, Osterlund P, Julkunen I. Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells. J Leukoc Biol 2009; 85: 664-672.
    • (2009) J Leukoc Biol , vol.85 , pp. 664-672
    • Makela, S.M.1    Strengell, M.2    Pietila, T.E.3    Osterlund, P.4    Julkunen, I.5
  • 40
    • 84875257261 scopus 로고    scopus 로고
    • TLR8 and NOD signaling synergistically induce the production of IL-1beta and IL-23 in monocytederived DCs and enhance the expression of the feedback inhibitor SOCS2
    • Schwarz H, Posselt G, Wurm P, Ulbing M, Duschl A, Horejs-Hoeck J. TLR8 and NOD signaling synergistically induce the production of IL-1beta and IL-23 in monocytederived DCs and enhance the expression of the feedback inhibitor SOCS2. Immunobiology 2012.
    • (2012) Immunobiology
    • Schwarz, H.1    Posselt, G.2    Wurm, P.3    Ulbing, M.4    Duschl, A.5    Horejs-Hoeck, J.6
  • 41
    • 77954759074 scopus 로고    scopus 로고
    • Exposure To HIV-1-encoded toll-like receptor 8 ligands enhances monocyte response to microbial encoded tolllike receptor 24 ligands
    • Mureith MW, Chang JJ, Lifson JD, Ndung9u T, Altfeld M. Exposure to HIV-1-encoded Toll-like receptor 8 ligands enhances monocyte response to microbial encoded Tolllike receptor 2/4 ligands. AIDS 2010; 24: 1841-8.
    • (2010) AIDS , vol.24 , pp. 1841-1848
    • Mureith, M.W.1    Chang, J.J.2    Lifson, J.D.3    Ndungu, T.4    Altfeld, M.5
  • 42
    • 80054020359 scopus 로고    scopus 로고
    • The TLR7/8 ligand resiquimod targets monocyte-derived dendritic cell differentiation via TLR8 and augments functional dendritic cell generation
    • Hackstein H, Knoche A, Nockher A, Poeling J, Kubin T, JurkMet al. The TLR7/8 ligand resiquimod targets monocyte-derived dendritic cell differentiation via TLR8 and augments functional dendritic cell generation. Cell Immunol 2011; 271: 401-412.
    • (2011) Cell Immunol , vol.271 , pp. 401-412
    • Hackstein, H.1    Knoche, A.2    Nockher, A.3    Poeling, J.4    Kubin, T.5    Jurk, M.6
  • 43
    • 0033566734 scopus 로고    scopus 로고
    • Activation of human monocytic cells by Borrelia burgdorferi and Treponema pallidum is facilitated by CD14 and correlates with surface exposure of spirochetal lipoproteins
    • Sellati TJ, Bouis DA, Caimano MJ, Feulner JA, Ayers C, Lien E et al. Activation of human monocytic cells by Borrelia burgdorferi and TrepOnema pallidum is facilitated by CD14 and correlates with surface exposure of spirochetal lipoproteins. J Immunol 1999; 163: 2049-2056. (Pubitemid 29382209)
    • (1999) Journal of Immunology , vol.163 , Issue.4 , pp. 2049-2056
    • Sellati, T.J.1    Bouis, D.A.2    Caimano, M.J.3    Feulner, J.A.4    Ayers, C.5    Lien, E.6    Radolf, J.D.7
  • 44
    • 0033618630 scopus 로고    scopus 로고
    • Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    • Aliprantis AO, Yang RB, Mark MR, Suggett S, Devaux B, Radolf JD et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 1999; 285: 736-739.
    • (1999) Science , vol.285 , pp. 736-739
    • Aliprantis, A.O.1    Yang, R.B.2    Mark, M.R.3    Suggett, S.4    Devaux, B.5    Radolf, J.D.6
  • 46
    • 78650542756 scopus 로고    scopus 로고
    • Association between tolllike receptor expression and human papillomavirus type 16 persistence
    • Daud II, Scott ME, Ma Y, Shiboski S, Farhat S, Moscicki AB. Association between tolllike receptor expression and human papillomavirus type 16 persistence. Int J Cancer 2011; 128: 879-886.
    • (2011) Int J Cancer , vol.128 , pp. 879-886
    • Daud, I.I.1    Scott, M.E.2    Ma, Y.3    Shiboski, S.4    Farhat, S.5    Moscicki, A.B.6
  • 50
    • 0034457684 scopus 로고    scopus 로고
    • Cloning and characterization of a sub-family of human Toll-like receptors: HTLR7, hTLR8 and hTLR9
    • Chuang TH, Ulevitch RJ. Cloning and characterization of a sub-family of human tolllike receptors: HTLR7, hTLR8 and hTLR9. Eur Cytokine Netw 2000; 11: 372-378. (Pubitemid 32268894)
    • (2000) European Cytokine Network , vol.11 , Issue.3 , pp. 372-378
    • Chuang, T.-H.1    Ulevitch, R.J.2
  • 51
    • 0034456693 scopus 로고    scopus 로고
    • Three novel mammalian toll-like receptors: Gene structure, expression, and evolution
    • Du X, Poltorak A, Wei Y, Beutler B. Three novel mammalian toll-like receptors: Gene structure, expression, and evolution. Eur Cytokine Netw 2000; 11: 362-371. (Pubitemid 32268893)
    • (2000) European Cytokine Network , vol.11 , Issue.3 , pp. 362-371
    • Du, X.1    Poltorak, A.2    Wei, Y.3    Beutler, B.4
  • 52
    • 50949083798 scopus 로고    scopus 로고
    • A functional toll-like receptor 8 variant is associated with HIV disease restriction
    • Oh DY, Taube S, Hamouda O, Kucherer C, Poggensee G, Jessen H et al. A functional toll-like receptor 8 variant is associated with HIV disease restriction. J Infect Dis 2008; 198: 701-709.
    • (2008) J Infect Dis , vol.198 , pp. 701-709
    • Oh, D.Y.1    Taube, S.2    Hamouda, O.3    Kucherer, C.4    Poggensee, G.5    Jessen, H.6
  • 53
    • 33847789122 scopus 로고    scopus 로고
    • The CD14+ CD16+ blood monocytes: Their role in infection and inflammation
    • DOI 10.1189/jlb.0806510
    • Ziegler-Heitbrock L. The CD141CD161 blood monocytes: Their role in infection and inflammation. J Leukoc Biol 2007; 81: 584-592. (Pubitemid 46393535)
    • (2007) Journal of Leukocyte Biology , vol.81 , Issue.3 , pp. 584-592
    • Ziegler-Heitbrock, L.1
  • 54
    • 84865032889 scopus 로고    scopus 로고
    • New developments in Toll-like receptor targeted therapeutics
    • Connolly DJ, O'Neill LA. New developments in Toll-like receptor targeted therapeutics. Curr Opin Pharmacol 2012; 12: 510-518.
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 510-518
    • Connolly, D.J.1    O'Neill, L.A.2
  • 56
    • 77955656853 scopus 로고    scopus 로고
    • TLR8 agonists stimulate newly recruited monocyte-derived cells into potent APCs that enhance HBsAg immunogenicity
    • Du J, Wu Z, Ren S, Wei Y, Gao M, Randolph GJ et al. TLR8 agonists stimulate newly recruited monocyte-derived cells into potent APCs that enhance HBsAg immunogenicity. Vaccine 2010; 28: 6273-6281.
    • (2010) Vaccine , vol.28 , pp. 6273-6281
    • Du, J.1    Wu, Z.2    Ren, S.3    Wei, Y.4    Gao, M.5    Randolph, G.J.6
  • 57
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • DOI 10.1038/nm1589, PII NM1589
    • Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007; 13: 552-559. (Pubitemid 46830615)
    • (2007) Nature Medicine , vol.13 , Issue.5 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 59
    • 79958832035 scopus 로고    scopus 로고
    • VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis
    • Horak F. VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis. Expert Opin Investig Drugs 2011; 20: 981-986.
    • (2011) Expert Opin Investig Drugs , vol.20 , pp. 981-986
    • Horak, F.1
  • 61
    • 84855756265 scopus 로고    scopus 로고
    • R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes
    • Nian H, Geng WQ, Cui HL, Bao MJ, Zhang ZN, Zhang M et al. R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes. BMC Infect Dis 2012; 12: 5.
    • (2012) BMC Infect Dis , vol.12 , pp. 5
    • Nian, H.1    Geng, W.Q.2    Cui, H.L.3    Bao, M.J.4    Zhang, Z.N.5    Zhang, M.6
  • 62
    • 79959242498 scopus 로고    scopus 로고
    • Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
    • Sander LE, Davis MJ, Boekschoten MV, Amsen D, Dascher CC, RyffelBet al. Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature 2011; 474: 385-389.
    • (2011) Nature , vol.474 , pp. 385-389
    • Sander, L.E.1    Davis, M.J.2    Boekschoten, M.V.3    Amsen, D.4    Dascher, C.C.5    Ryffel, B.6
  • 63
    • 74549167783 scopus 로고    scopus 로고
    • Regulation of adaptive immunity by the innate immune system
    • Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science 2010; 327: 291-295.
    • (2010) Science , vol.327 , pp. 291-295
    • Iwasaki, A.1    Medzhitov, R.2
  • 64
    • 37649018614 scopus 로고    scopus 로고
    • Toll-like receptors and autoimmunity
    • Hurst J, von Landenberg P. Toll-like receptors and autoimmunity. Autoimmun Rev 2008; 7: 204-208
    • (2008) Autoimmun Rev , vol.7 , pp. 204-208
    • Hurst, J.1    Von Landenberg, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.