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Volumn , Issue , 2010, Pages 163-216

Improving Drug Design: Considerations for the Structural Modification Process

Author keywords

Drug design improvement for structural modification process; Reactive intermediate theory and idiosyncratic reactions toxic effects; Toxicity problems, idiosyncratic conditions late stages of drug development

Indexed keywords


EID: 84888730833     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470890387.ch4     Document Type: Chapter
Times cited : (2)

References (117)
  • 1
    • 48249092512 scopus 로고
    • Amsterdam, Elsevier Scientifi c Publishing Company
    • Ariens EJ et al. 1982 Strategy in Drug Research Amsterdam, Elsevier Scientifi c Publishing Company
    • (1982) Strategy in Drug Research
    • Ariens, E.J.1
  • 2
    • 0029863135 scopus 로고    scopus 로고
    • Chemical and immunochemical comparison of protein adduct formation of four carboxylate drugs in rat liver and plasma
    • Bailey MJ et al. 1996 Chemical and immunochemical comparison of protein adduct formation of four carboxylate drugs in rat liver and plasma Chem Res Toxicol 9, 659-666
    • (1996) Chem Res Toxicol , vol.9 , pp. 659-666
    • Bailey, M.J.1
  • 3
    • 0029129057 scopus 로고
    • Drug safety discontinuations in the United Kingdom, the United States and Spain from 1974 through 1993 A regulatory perspective
    • Bakke OM et al. 1995 Drug safety discontinuations in the United Kingdom, the United States and Spain from 1974 through 1993: A regulatory perspective Clin Pharmacol Ther 58 ( 1 ): 108-117
    • (1995) Clin Pharmacol Ther , vol.58 , Issue.1 , pp. 108-117
    • Bakke, O.M.1
  • 4
    • 0026765423 scopus 로고
    • In vitro activity of clarithromycin and its 14-hydroxy-metabolite against 203 strains of Haemophilus infl uenzae
    • Bergeron MG., Bernier M., L ' Ecuyer J 1992 In vitro activity of clarithromycin and its 14 - hydroxy - metabolite against 203 strains of Haemophilus infl uenzae Infection 20, 164-167
    • (1992) Infection , vol.20 , pp. 164-167
    • Bergeron, M.G.1    Bernier, M.2    L'Ecuyer, J.3
  • 5
    • 0031604723 scopus 로고    scopus 로고
    • Discovery of bioavailable inhibitors of secretory phospholipase A2
    • Blanchard SG et al. 1998 Discovery of bioavailable inhibitors of secretory phospholipase A2 Pharm Biotechnol 11, 445-463
    • (1998) Pharm Biotechnol , vol.11 , pp. 445-463
    • Blanchard, S.G.1
  • 6
    • 0021210779 scopus 로고
    • Soft drugs: Principles and methods for the design of safe drugs
    • Bodor N 1984 Soft drugs: Principles and methods for the design of safe drugs Med Res Rev 4, 449-469
    • (1984) Med Res Rev , vol.4 , pp. 449-469
    • Bodor, N.1
  • 7
    • 0033966357 scopus 로고    scopus 로고
    • Soft drug design: General principles and recent applications
    • Bodor N., Buchwald P 2000 Soft drug design: General principles and recent applications Med Res Rev 20, 58-101
    • (2000) Med Res Rev , vol.20 , pp. 58-101
    • Bodor, N.1    Buchwald, P.2
  • 8
    • 3042687583 scopus 로고    scopus 로고
    • Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites
    • Bodor N., Buchwald P 2004 Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites Mol Biotechnol 26, 123-132
    • (2004) Mol Biotechnol , vol.26 , pp. 123-132
    • Bodor, N.1    Buchwald, P.2
  • 9
    • 0018908788 scopus 로고
    • Soft drugs: 2. Soft alkylating compounds as potential antitumor agents
    • Bodor N., Kaminski JJ 1980 Soft drugs: 2. Soft alkylating compounds as potential antitumor agents J Med Chem 23, 566-569
    • (1980) J Med Chem , vol.23 , pp. 566-569
    • Bodor, N.1    Kaminski, J.J.2
  • 10
    • 0041854179 scopus 로고    scopus 로고
    • Tolcapone-related liver dysfunction: Implications for use in Parkinson ' s disease therapy
    • Borges N et al. 2000 Tolcapone - related liver dysfunction: Implications for use in Parkinson ' s disease therapy Drug Saf 26 ( 11 ): 743-747
    • (2000) Drug Saf , vol.26 , Issue.11 , pp. 743-747
    • Borges, N.1
  • 12
    • 0030833366 scopus 로고    scopus 로고
    • Improving the in vivo duration of 5-lipoxygenase inhibitors: application of an in vitro glucuronosyltransferase assay
    • Bouska JJ et al. 1997 Improving the in vivo duration of 5 - lipoxygenase inhibitors: application of an in vitro glucuronosyltransferase assay Drug Metab Dispos 25 ( 9 ): 1032-1038
    • (1997) Drug Metab Dispos , vol.25 , Issue.9 , pp. 1032-1038
    • Bouska, J.J.1
  • 13
    • 0030833366 scopus 로고    scopus 로고
    • Improving the in vivo duration of 5-lipoxygenase inhibitors: Application of an in vitro glucuronosyltransferase assay
    • Bouska JJ., Bell RL., Goodfellow CL., Stewart AO., Brooks CD., Carter GW 1997 Improving the in vivo duration of 5 - lipoxygenase inhibitors: Application of an in vitro glucuronosyltransferase assay Drug Metab Dispos 25, 1032-1038
    • (1997) Drug Metab Dispos , vol.25 , pp. 1032-1038
    • Bouska, J.J.1    Bell, R.L.2    Goodfellow, C.L.3    Stewart, A.O.4    Brooks, C.D.5    Carter, G.W.6
  • 14
    • 0025202686 scopus 로고
    • Minoxidil sulfate is the active metabolite that stimulates hair follicles
    • Buhl AE., Waldon DJ., Baker CA., Johnson GA 1990 Minoxidil sulfate is the active metabolite that stimulates hair follicles J Invest Dermatol 95, 553-557
    • (1990) J Invest Dermatol , vol.95 , pp. 553-557
    • Buhl, A.E.1    Waldon, D.J.2    Baker, C.A.3    Johnson, G.A.4
  • 15
    • 0037434510 scopus 로고    scopus 로고
    • Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors: Development of an orally bioavailable series containing P1 and P3 pyridines
    • Burgey CS et al. 2003 Metabolism - directed optimization of 3 - aminopyrazinone acetamide thrombin inhibitors: Development of an orally bioavailable series containing P1 and P3 pyridines J Med Chem 46, 461-473
    • (2003) J Med Chem , vol.46 , pp. 461-473
    • Burgey, C.S.1
  • 16
    • 0036990101 scopus 로고    scopus 로고
    • Single -and multiple-dose pharmacokinetics of oral moxifl oxacin and clarithromycin, and concentrations in serum, saliva and faeces
    • Burkhardt O., Borner K., Stass H., Beyer G., Allewelt M., Nord C., Lode H 2002 Single -and multiple - dose pharmacokinetics of oral moxifl oxacin and clarithromycin, and concentrations in serum, saliva and faeces Scand J Infect Dis 34, 898-903
    • (2002) Scand J Infect Dis , vol.34 , pp. 898-903
    • Burkhardt, O.1    Borner, K.2    Stass, H.3    Beyer, G.4    Allewelt, M.5    Nord, C.6    Lode, H.7
  • 17
    • 0028075679 scopus 로고
    • Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro. IV: Implications for the development of agranulocytosis
    • Coleman MD et al. 1994 Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro. IV: Implications for the development of agranulocytosis Biochem Pharmacol 48 ( 7 ): 1349-1354
    • (1994) Biochem Pharmacol , vol.48 , Issue.7 , pp. 1349-1354
    • Coleman, M.D.1
  • 18
    • 0026552198 scopus 로고
    • Sulfamethoxazole is metabolized to the hydroxylamine in humans
    • Cribb AE et al. 1992 Sulfamethoxazole is metabolized to the hydroxylamine in humans Clin Pharmacol Ther 51, 522-526
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 522-526
    • Cribb, A.E.1
  • 19
    • 0026021849 scopus 로고
    • The activity of clarithromycin and its 14-hydroxy metabolite against Haemophilus infl uenzae. determined by in-vitro and serum bactericidal tests
    • Dabernat H., Delmas C., Seguy M., Fourtillan JB., Girault J., Lareng MB 1991 The activity of clarithromycin and its 14 - hydroxy metabolite against Haemophilus infl uenzae., determined by in - vitro and serum bactericidal tests J Antimicrob Chemother 27, 19-30
    • (1991) J Antimicrob Chemother , vol.27 , pp. 19-30
    • Dabernat, H.1    Delmas, C.2    Seguy, M.3    Fourtillan, J.B.4    Girault, J.5    Lareng, M.B.6
  • 20
    • 0037058251 scopus 로고    scopus 로고
    • Mechanisms of idiosyncratic drug reactions: The case of felbamate
    • Dieckhaus CM et al. 2002 Mechanisms of idiosyncratic drug reactions: The case of felbamate Chem Biol Interact 142 ( 1-2 ): 99-117
    • (2002) Chem Biol Interact , vol.142 , Issue.1-2 , pp. 99-117
    • Dieckhaus, C.M.1
  • 21
    • 10744228371 scopus 로고    scopus 로고
    • Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors: 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics
    • Dragovich P et al. 2003 Structure - based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors: 8. Pharmacological optimization of orally bioavailable 2 - pyridone - containing peptidomimetics J Med Chem 46 ( 21 ): 4572-4585
    • (2003) J Med Chem , vol.46 , Issue.21 , pp. 4572-4585
    • Dragovich, P.1
  • 22
    • 0018604964 scopus 로고
    • Pharmacokinetics of ampicillin and its prodrugs bacampicillin and pivampicillin in man
    • Ehrnebo M., Nilsson SO., Boreus LO 1979 Pharmacokinetics of ampicillin and its prodrugs bacampicillin and pivampicillin in man J Pharmacokinet Biopharm 7, 429-451
    • (1979) J Pharmacokinet Biopharm , vol.7 , pp. 429-451
    • Ehrnebo, M.1    Nilsson, S.O.2    Boreus, L.O.3
  • 23
    • 0030018764 scopus 로고    scopus 로고
    • Oral bioavailability and in vitro stability of pivampicillin, bacampicillin, talampicillin, and ampicillin in horses
    • Ensink JM., Vulto AG., van Miert AS., Tukker JJ., Winkel MB., Fluitman MA 1996 Oral bioavailability and in vitro stability of pivampicillin, bacampicillin, talampicillin, and ampicillin in horses Am J Vet Res 57, 1021-1024
    • (1996) Am J Vet Res , vol.57 , pp. 1021-1024
    • Ensink, J.M.1    Vulto, A.G.2    van Miert, A.S.3    Tukker, J.J.4    Winkel, M.B.5    Fluitman, M.A.6
  • 24
    • 1642281756 scopus 로고    scopus 로고
    • Drug-protein adducts: An industry perspective on minimizing the potential for drug bioactivation in drug discovery and development
    • Evans DC 2004 Drug - protein adducts: An industry perspective on minimizing the potential for drug bioactivation in drug discovery and development Chem Res Toxicol 17 ( 1 ): 3-16
    • (2004) Chem Res Toxicol , vol.17 , Issue.1 , pp. 3-16
    • Evans, D.C.1
  • 25
    • 0035020110 scopus 로고    scopus 로고
    • Bioactivation of tamoxifen to metabolite E quinone methide: Reaction with glutathione and DNA
    • Fan PW et al. 2001 Bioactivation of tamoxifen to metabolite E quinone methide: Reaction with glutathione and DNA Drug Metab Dispos 29, 891-896
    • (2001) Drug Metab Dispos , vol.29 , pp. 891-896
    • Fan, P.W.1
  • 26
    • 0033783227 scopus 로고    scopus 로고
    • Bisphosphonates induce breast cancer cell death in vitro
    • Fromigue O., Lagneaux L., Body JJ 2000 Bisphosphonates induce breast cancer cell death in vitro J Bone Miner Res 15, 2211-2221
    • (2000) J Bone Miner Res , vol.15 , pp. 2211-2221
    • Fromigue, O.1    Lagneaux, L.2    Body, J.J.3
  • 27
    • 0018081952 scopus 로고
    • Plasma propranolol levels in beagle dogs after administration of propranolol hemisuccinate ester
    • Garceau Y., Davis I., Hasegawa J 1978 Plasma propranolol levels in beagle dogs after administration of propranolol hemisuccinate ester J Pharm Sci 67, 1360-1363
    • (1978) J Pharm Sci , vol.67 , pp. 1360-1363
    • Garceau, Y.1    Davis, I.2    Hasegawa, J.3
  • 28
    • 5544231319 scopus 로고    scopus 로고
    • Synthesis and bioactivity of novel bis(heteroaryl)piperazine reverse transcriptase inhibitors: Structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs
    • Genin M et al. 1996 Synthesis and bioactivity of novel bis(heteroaryl)piperazine reverse transcriptase inhibitors: Structure - activity relationships and increased metabolic stability of novel substituted pyridine analogs J Med Chem 39 ( 26 ): 5267-5275
    • (1996) J Med Chem , vol.39 , Issue.26 , pp. 5267-5275
    • Genin, M.1
  • 29
    • 0034464153 scopus 로고    scopus 로고
    • Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat
    • Godessart N et al. 1999 Role of COX - 2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat Adv Exp Med Biol 469, 157-163
    • (1999) Adv Exp Med Biol , vol.469 , pp. 157-163
    • Godessart, N.1
  • 30
    • 0025986938 scopus 로고
    • Trapping of reactive intermediates by incorporation of 14C-sodium cyanide during microsomal oxidation
    • Gorrod JW., Whittesea CMC., Lam SP 1991 Trapping of reactive intermediates by incorporation of 14C - sodium cyanide during microsomal oxidation Adv Exp Med Biol 283, 657-664
    • (1991) Adv Exp Med Biol , vol.283 , pp. 657-664
    • Gorrod, J.W.1    Whittesea, C.M.C.2    Lam, S.P.3
  • 31
    • 0037204541 scopus 로고    scopus 로고
    • Computer systems for the prediction of toxicity: An update
    • Greene N et al. 2002 Computer systems for the prediction of toxicity: An update Adv Drug Deliv Rev 54 ( 3 ): 417-431
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.3 , pp. 417-431
    • Greene, N.1
  • 32
    • 0031896913 scopus 로고    scopus 로고
    • Severe neutropenia associated with oral terbinafi ne therapy
    • Gupta AK et al. 1998 Severe neutropenia associated with oral terbinafi ne therapy J Am Acad Dermatol 38, 765-767
    • (1998) J Am Acad Dermatol , vol.38 , pp. 765-767
    • Gupta, A.K.1
  • 33
    • 0034876276 scopus 로고    scopus 로고
    • Effect of alpha-fl uorination of valproic acid on valproyl-S-acyl -CoA formation in vivo in rats
    • Grillo MP et al. 2001 Effect of alpha - fl uorination of valproic acid on valproyl - S - acyl -CoA formation in vivo in rats Drug Metab Dispos 29, 1210-1215
    • (2001) Drug Metab Dispos , vol.29 , pp. 1210-1215
    • Grillo, M.P.1
  • 34
    • 0041882102 scopus 로고    scopus 로고
    • Toxic rise of clozapine plasma concentrations in relation to infl ammation
    • Haack MJ et al. 2003 Toxic rise of clozapine plasma concentrations in relation to infl ammation Eur Neuropsychopharmacol 13 ( 5 ): 381-385
    • (2003) Eur Neuropsychopharmacol , vol.13 , Issue.5 , pp. 381-385
    • Haack, M.J.1
  • 35
    • 0020045205 scopus 로고
    • Benoxaprofen: Side-effect profi le in 300 patients
    • Halsey JP et al. 1982 Benoxaprofen: Side - effect profi le in 300 patients Br Med J (Clin Res Ed) 284, 1365-1368
    • (1982) Br Med J (Clin Res Ed) , vol.284 , pp. 1365-1368
    • Halsey, J.P.1
  • 36
    • 0142105935 scopus 로고    scopus 로고
    • Design, pharmacokinetic, and pharmacodynamic evaluation of a new class of soft anticholinergics
    • Huang F., Browne CE., Wu WM., Juhasz A., Ji F., Bodor N 2003 Design, pharmacokinetic, and pharmacodynamic evaluation of a new class of soft anticholinergics Pharm Res 20, 1681-1689
    • (2003) Pharm Res , vol.20 , pp. 1681-1689
    • Huang, F.1    Browne, C.E.2    Wu, W.M.3    Juhasz, A.4    Ji, F.5    Bodor, N.6
  • 37
    • 0026646828 scopus 로고
    • Role of metabolism and pharmacokinetic studies in the discovery of new drugs - Present and future perspectives
    • Humphrey MJ., Smith DA 1992 Role of metabolism and pharmacokinetic studies in the discovery of new drugs - Present and future perspectives Xenobiotica 22 ( 7 ): 743-755
    • (1992) Xenobiotica , vol.22 , Issue.7 , pp. 743-755
    • Humphrey, M.J.1    Smith, D.A.2
  • 38
    • 0344629208 scopus 로고    scopus 로고
    • Application of structure-metabolism relationships in the identification of a selective endothelin A antagonist, BMS-193884, with favourable pharmacokinetic properties
    • Humphreys WG., Obermeier MT., Barrish JC., Chong S., Marino AM., Murugesan N., Wang - Iverson D., Morrison RA 2003 Application of structure - metabolism relationships in the identification of a selective endothelin A antagonist, BMS - 193884, with favourable pharmacokinetic properties Xenobiotica 33, 1109-1123
    • (2003) Xenobiotica , vol.33 , pp. 1109-1123
    • Humphreys, W.G.1    Obermeier, M.T.2    Barrish, J.C.3    Chong, S.4    Marino, A.M.5    Murugesan, N.6    Wang-Iverson, D.7    Morrison, R.A.8
  • 39
    • 0023264053 scopus 로고
    • Improvement of the oral bioavailability of naltrexone in dogs: A prodrug approach
    • Hussain MA., Koval CA., Myers MJ., Shami EG., Shefter E 1987 Improvement of the oral bioavailability of naltrexone in dogs: A prodrug approach J Pharm Sci 76, 356-358
    • (1987) J Pharm Sci , vol.76 , pp. 356-358
    • Hussain, M.A.1    Koval, C.A.2    Myers, M.J.3    Shami, E.G.4    Shefter, E.5
  • 40
    • 0017617998 scopus 로고
    • Agranulocytosis during treatment with chlozapine
    • Idanpaan - Heikkila J et al. 1977 Agranulocytosis during treatment with chlozapine Eur J Clin Pharmacol 11, 193-198
    • (1977) Eur J Clin Pharmacol , vol.11 , pp. 193-198
    • Idanpaan-Heikkila, J.1
  • 41
    • 0344304751 scopus 로고    scopus 로고
    • Evidence for the involvement of a pulmonary fi rst-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration
    • Imai T., Yoshigae Y., Hosokawa M., Chiba K., Otagiri M 2003 Evidence for the involvement of a pulmonary fi rst - pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration J Pharmacol Exp Ther 307, 1234-1242
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 1234-1242
    • Imai, T.1    Yoshigae, Y.2    Hosokawa, M.3    Chiba, K.4    Otagiri, M.5
  • 42
    • 0023883393 scopus 로고
    • Blood disorders and suicide in patients taking mianserin or amitriptyline
    • Inman WH et al. 1988 Blood disorders and suicide in patients taking mianserin or amitriptyline Lancet 2 ( 8602 ): 90-92
    • (1988) Lancet , vol.2 , Issue.8602 , pp. 90-92
    • Inman, W.H.1
  • 43
    • 0033195237 scopus 로고    scopus 로고
    • Index of suspicion: Case 3. Acetaminophen overdose
    • Isaacson J et al. 1999 Index of suspicion: Case 3. Acetaminophen overdose Pediatr Rev 20, 309-310., 312-313
    • (1999) Pediatr Rev , vol.20 , Issue.309-310 , pp. 312-313
    • Isaacson, J.1
  • 44
    • 0037150549 scopus 로고    scopus 로고
    • Hodgkin ' s disease following methotrexate therapy for rheumatoid arthritis
    • Jardine DL 2002 Hodgkin ' s disease following methotrexate therapy for rheumatoid arthritis N Z Med J 115 ( 1156 ): 293-294
    • (2002) N Z Med J , vol.115 , Issue.1156 , pp. 293-294
    • Jardine, D.L.1
  • 45
    • 0032912536 scopus 로고    scopus 로고
    • Detection of 2-hydroxyiminostilbene in the urine of patients taking carbamazepine and its oxidation to a reactive iminoquinone intermediate
    • Ju C et al. 1999 Detection of 2 - hydroxyiminostilbene in the urine of patients taking carbamazepine and its oxidation to a reactive iminoquinone intermediate J Pharmacol Exp Ther 288, 51-56
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 51-56
    • Ju, C.1
  • 46
    • 0344233243 scopus 로고    scopus 로고
    • Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry
    • Kantharaj E et al. 2003 Simultaneous measurement of drug metabolic stability and identification of metabolites using ion - trap mass spectrometry Rapid Commun Mass Spectrom 17 ( 23 ): 2661-2668
    • (2003) Rapid Commun Mass Spectrom , vol.17 , Issue.23 , pp. 2661-2668
    • Kantharaj, E.1
  • 47
    • 17744394481 scopus 로고    scopus 로고
    • Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission
    • Kassahun K et al. 2001 Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission Chem Res Toxicol 14, 62-70
    • (2001) Chem Res Toxicol , vol.14 , pp. 62-70
    • Kassahun, K.1
  • 48
    • 0008583584 scopus 로고    scopus 로고
    • Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical effi cacy
    • Kempf D et al. 1998 Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical effi cacy J Med Chem 41 ( 4 ): 602-617
    • (1998) J Med Chem , vol.41 , Issue.4 , pp. 602-617
    • Kempf, D.1
  • 49
    • 1542346871 scopus 로고    scopus 로고
    • Systemic exposure to morphine and the risk of acute chest syndrome in sickle cell disease
    • Kopecky EA., Jacobson S., Joshi P., Koren G 2004 Systemic exposure to morphine and the risk of acute chest syndrome in sickle cell disease Clin Pharmacol Ther 75, 140-146
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 140-146
    • Kopecky, E.A.1    Jacobson, S.2    Joshi, P.3    Koren, G.4
  • 50
    • 0037649064 scopus 로고    scopus 로고
    • Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies
    • Kostiainen R et al. 2003 Liquid chromatography/atmospheric pressure ionization - mass spectrometry in drug metabolism studies J Mass Spectrom 38 ( 4 ): 357-372
    • (2003) J Mass Spectrom , vol.38 , Issue.4 , pp. 357-372
    • Kostiainen, R.1
  • 51
    • 0017647476 scopus 로고
    • Quantitative structure-activity relationships: 7. The bilinear model, a new model for nonlinear dependence of biological activity on hydrophobic character
    • Kubinyi H et al. 1977 Quantitative structure - activity relationships: 7. The bilinear model, a new model for nonlinear dependence of biological activity on hydrophobic character J Med Chem 20, 625-629
    • (1977) J Med Chem , vol.20 , pp. 625-629
    • Kubinyi, H.1
  • 52
    • 0036570099 scopus 로고    scopus 로고
    • Timing of new black box warnings and withdrawals for prescription medications
    • Lasser KE et al. 2002 Timing of new black box warnings and withdrawals for prescription medications J Am Med Assoc 287 ( 17 ): 2215-2220
    • (2002) J Am Med Assoc , vol.287 , Issue.17 , pp. 2215-2220
    • Lasser, K.E.1
  • 53
    • 0034491130 scopus 로고    scopus 로고
    • Optimizing the science of drug development: Opportunities for better candidate selection and accelerated evaluation in humans
    • Lesko LL et al. 2000 Optimizing the science of drug development: Opportunities for better candidate selection and accelerated evaluation in humans Pharmaceutical Res 14, 1335-1343
    • (2000) Pharmaceutical Res , vol.14 , pp. 1335-1343
    • Lesko, L.L.1
  • 54
    • 0037058253 scopus 로고    scopus 로고
    • A review of the common properties of drugs with idiosyncratic hepatotoxicity and the " multiple determinant hypothesis " for the manifestation of idiosyncratic drug toxicity
    • Li AP et al. 2002 A review of the common properties of drugs with idiosyncratic hepatotoxicity and the " multiple determinant hypothesis " for the manifestation of idiosyncratic drug toxicity Chem Biol Interact 142 ( 1-2 ): 7-23
    • (2002) Chem Biol Interact , vol.142 , Issue.1-2 , pp. 7-23
    • Li, A.P.1
  • 55
    • 77949320496 scopus 로고    scopus 로고
    • The danger hypothesis applied to idiosyncratic drug reactions
    • Li J., Uetrecht JP 2010 The danger hypothesis applied to idiosyncratic drug reactions Handb Exp Pharmacol 196, 493-509
    • (2010) Handb Exp Pharmacol , vol.196 , pp. 493-509
    • Li, J.1    Uetrecht, J.P.2
  • 56
    • 0028814504 scopus 로고
    • Oxidation of 5-aminosalicylic acid by hypochlorous acid to a reactive iminoquinone. Possible role in the treatment of infl ammatory bowel diseases
    • Liu ZC et al. 1995 Oxidation of 5 - aminosalicylic acid by hypochlorous acid to a reactive iminoquinone. Possible role in the treatment of infl ammatory bowel diseases Drug Metab Dispos 23, 246-250
    • (1995) Drug Metab Dispos , vol.23 , pp. 246-250
    • Liu, Z.C.1
  • 57
    • 0000140208 scopus 로고    scopus 로고
    • Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties
    • Lin NH et al. 1997 Structure - activity studies on 2 - methyl - 3 - (2(S) - pyrrolidinylmethoxy) pyridine (ABT - 089): an orally bioavailable 3 - pyridyl ether nicotinic acetylcholine receptor ligand with cognition - enhancing properties J Med Chem 40 ( 3 ): 385-390
    • (1997) J Med Chem , vol.40 , Issue.3 , pp. 385-390
    • Lin, N.H.1
  • 58
    • 0027326685 scopus 로고
    • An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes
    • Madden S et al. 1993 An investigation into the formation of stable, protein - reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes Biochem Pharmacol 46, 13-20
    • (1993) Biochem Pharmacol , vol.46 , pp. 13-20
    • Madden, S.1
  • 59
    • 0023248472 scopus 로고
    • Differential effects of a new dibenzo-epine neuroleptic compared with haloperidol. Results of an open and crossover study
    • Mann K et al. 1987 Differential effects of a new dibenzo - epine neuroleptic compared with haloperidol. Results of an open and crossover study Pharmacopsychiat 20, 155-159
    • (1987) Pharmacopsychiat , vol.20 , pp. 155-159
    • Mann, K.1
  • 60
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger P et al. 2002 The danger model: A renewed sense of self Science 296 ( 5566 ): 301-305
    • (2002) Science , vol.296 , Issue.5566 , pp. 301-305
    • Matzinger, P.1
  • 61
    • 0034742510 scopus 로고    scopus 로고
    • Fatal hepatoxicity secondary to nimesulide
    • Merlani G et al. 2001 Fatal hepatoxicity secondary to nimesulide Eur J Clin Pharmacol 57, 321-326
    • (2001) Eur J Clin Pharmacol , vol.57 , pp. 321-326
    • Merlani, G.1
  • 62
    • 0034042841 scopus 로고    scopus 로고
    • An ABC of drug-related problems
    • Meyboom RHB et al. 2000 An ABC of drug - related problems Drug Saf 22 ( 6 ): 415-423
    • (2000) Drug Saf , vol.22 , Issue.6 , pp. 415-423
    • Meyboom, R.H.B.1
  • 63
    • 0037621502 scopus 로고    scopus 로고
    • Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses
    • Miyamoto Y et al. 2003 Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses Biol Chem 384 ( 4 ): 567-574
    • (2003) Biol Chem , vol.384 , Issue.4 , pp. 567-574
    • Miyamoto, Y.1
  • 64
    • 10344263365 scopus 로고    scopus 로고
    • Progesterone receptor by immunohistochemistry and clinical outcome in breast cancer: A validation study
    • Mohsin SK et al. 2004 Progesterone receptor by immunohistochemistry and clinical outcome in breast cancer: A validation study Mod Pathol 17 ( 12 ): 1545-1554
    • (2004) Mod Pathol , vol.17 , Issue.12 , pp. 1545-1554
    • Mohsin, S.K.1
  • 65
    • 0033135344 scopus 로고    scopus 로고
    • Severe hepatotoxicity associated with bromfenac sodium
    • Moses PL et al. 1999 Severe hepatotoxicity associated with bromfenac sodium Am J Gastroenterol 94 ( 5 ): 1393-1396
    • (1999) Am J Gastroenterol , vol.94 , Issue.5 , pp. 1393-1396
    • Moses, P.L.1
  • 66
    • 0030869281 scopus 로고    scopus 로고
    • Bioactivation of phenytoin by human cytochrome P450: Characterization of the mechanism and targets of covalent adduct formation
    • Munns AJ et al. 1997 Bioactivation of phenytoin by human cytochrome P450: Characterization of the mechanism and targets of covalent adduct formation Chem Res Toxicol 10, 1049-1058
    • (1997) Chem Res Toxicol , vol.10 , pp. 1049-1058
    • Munns, A.J.1
  • 67
    • 84888668063 scopus 로고    scopus 로고
    • Minimizing the potential for drug bioactivation of drug candidates to success in clinical development In
    • ed. Nassar A-EF., Hollenberg P., Scatina J Hoboken, NJ, John Wiley & Sons
    • Nassar A - EF 2009 Minimizing the potential for drug bioactivation of drug candidates to success in clinical development In Drug Metabolism Handbook: Concepts and Applications., ed. Nassar A - EF., Hollenberg P., Scatina J Hoboken, NJ, John Wiley & Sons
    • (2009) Drug Metabolism Handbook: Concepts and Applications
    • Nassar, A.-E.1
  • 68
    • 0042090318 scopus 로고    scopus 로고
    • Metabolite characterization in drug discovery utilizing robotic liquid-handling, quadrupole time-of-fl ight mass spectrometry and in-silico prediction
    • Nassar A - EF et al. 2003a Metabolite characterization in drug discovery utilizing robotic liquid - handling, quadrupole time - of - fl ight mass spectrometry and in - silico prediction Curr Drug Metab 4, 259-271
    • (2003) Curr Drug Metab , vol.4 , pp. 259-271
    • Nassar, A.-E.1
  • 69
    • 0141718553 scopus 로고    scopus 로고
    • Online hydrogen-deuterium exchange and a tandem quadrupole time-of-fl ight mass spectrometer coupled with liquid chromatography for metabolite identification in drug metabolism
    • Nassar A - EF et al. 2003b Online hydrogen - deuterium exchange and a tandem quadrupole time - of - fl ight mass spectrometer coupled with liquid chromatography for metabolite identification in drug metabolism J Chromatog Science 41, 398-404
    • (2003) J Chromatog Science , vol.41 , pp. 398-404
    • Nassar, A.-E.1
  • 70
    • 2942593914 scopus 로고    scopus 로고
    • Strategies for dealing with reactive intermediates in drug discovery and development
    • Nassar AF et al. 2004a Strategies for dealing with reactive intermediates in drug discovery and development Curr Opin Drug Discov Devel 7, 126-136
    • (2004) Curr Opin Drug Discov Devel , vol.7 , pp. 126-136
    • Nassar, A.F.1
  • 71
    • 1642368205 scopus 로고    scopus 로고
    • Strategies for dealing with metabolite elucidation in drug discovery and development
    • Nassar A - EF et al. 2004b Strategies for dealing with metabolite elucidation in drug discovery and development Drug Discov Today 9, 317-327
    • (2004) Drug Discov Today , vol.9 , pp. 317-327
    • Nassar, A.-E.1
  • 72
    • 4344595784 scopus 로고    scopus 로고
    • Detecting and minimizing reactive intermediates in R & D
    • July
    • Nassar AE et al. 2004c Detecting and minimizing reactive intermediates in R & D Curr Drug Discov July, 20-25
    • (2004) Curr Drug Discov , pp. 20-25
    • Nassar, A.E.1
  • 73
    • 0032733974 scopus 로고    scopus 로고
    • Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecifi c binding to microsomes
    • Obach RS et al. 1999a Prediction of human clearance of twenty - nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half - life approach and nonspecifi c binding to microsomes Drug 27 ( 11 ): 1350-1359
    • (1999) Drug , vol.27 , Issue.11 , pp. 1350-1359
    • Obach, R.S.1
  • 74
    • 0031466149 scopus 로고    scopus 로고
    • Nonspecifi c binding to microsomes: Impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol
    • Obach RS et al. 1999b Nonspecifi c binding to microsomes: Impact on scale - up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol Drug Metabolism 25 ( 12 ): 1359-1369
    • (1999) Drug Metabolism , vol.25 , Issue.12 , pp. 1359-1369
    • Obach, R.S.1
  • 75
    • 0037019271 scopus 로고    scopus 로고
    • Synthesis, SAR, and biological evaluation of oximino-piperidino -piperidine amides: 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity
    • Palani A et al. 2002 Synthesis, SAR, and biological evaluation of oximino - piperidino -piperidine amides: 1. Orally bioavailable CCR5 receptor antagonists with potent anti - HIV activity J Medicinal Chemistry 45 ( 14 ): 3143-3160
    • (2002) J Medicinal Chemistry , vol.45 , Issue.14 , pp. 3143-3160
    • Palani, A.1
  • 76
    • 85033533360 scopus 로고    scopus 로고
    • Activation of CGS 12094 (prinomide metabolite) to 1,4-benzoquinone by myeloperoxidase: Implications for human idiosyncratic agranulocytosis
    • Parrish DD et al. 1997 Activation of CGS 12094 (prinomide metabolite) to 1,4 - benzoquinone by myeloperoxidase: Implications for human idiosyncratic agranulocytosis Fundam Appl Toxicol 35, 197-204
    • (1997) Fundam Appl Toxicol , vol.35 , pp. 197-204
    • Parrish, D.D.1
  • 77
    • 0032565185 scopus 로고    scopus 로고
    • Adverse drug reactions
    • Pirmohamed M et al. 1998 Adverse drug reactions Br Med J 316 ( 7140 ): 1295-1298
    • (1998) Br Med J , vol.316 , Issue.7140 , pp. 1295-1298
    • Pirmohamed, M.1
  • 78
    • 0345095459 scopus 로고    scopus 로고
    • Use of liquid chromatography/time-of-fl ight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fl uids
    • Plumb RS et al. 2003 Use of liquid chromatography/time - of - fl ight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fl uids Rapid Commun Mass Spectrom 17 ( 23 ): 2632-2638
    • (2003) Rapid Commun Mass Spectrom , vol.17 , Issue.23 , pp. 2632-2638
    • Plumb, R.S.1
  • 79
    • 0022917633 scopus 로고
    • Effects of non-narcotic analgesics on the liver
    • Prescott LF et al. 1986 Effects of non - narcotic analgesics on the liver Drugs 32 ( 4 ): 129-147
    • (1986) Drugs , vol.32 , Issue.4 , pp. 129-147
    • Prescott, L.F.1
  • 80
    • 0022382297 scopus 로고
    • Use of high-performance liquid chromatography to detect hydroxyl and superoxide radicals generated from mitomycin C
    • Pritsos CA., Constantinides PP., Tritton TR., Heimbrook DC., Sartorelli AC 1985 Use of high - performance liquid chromatography to detect hydroxyl and superoxide radicals generated from mitomycin C Anal Biochem 150 ( 2 ): 294-299
    • (1985) Anal Biochem , vol.150 , Issue.2 , pp. 294-299
    • Pritsos, C.A.1    Constantinides, P.P.2    Tritton, T.R.3    Heimbrook, D.C.4    Sartorelli, A.C.5
  • 81
    • 0017335453 scopus 로고
    • Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance
    • Rane A et al. 1977 Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance J Pharmacol Exp Ther 200 ( 2 ): 420-424
    • (1977) J Pharmacol Exp Ther , vol.200 , Issue.2 , pp. 420-424
    • Rane, A.1
  • 82
    • 0024839964 scopus 로고
    • Disposition and pharmacokinetics of naltrexone after intravenous and oral administration in rhesus monkeys
    • Reuning RH., Ashcraft SB., Wiley JN., Morrison BE 1989 Disposition and pharmacokinetics of naltrexone after intravenous and oral administration in rhesus monkeys Drug Metab Dispos 17, 583-589
    • (1989) Drug Metab Dispos , vol.17 , pp. 583-589
    • Reuning, R.H.1    Ashcraft, S.B.2    Wiley, J.N.3    Morrison, B.E.4
  • 83
    • 0032565550 scopus 로고    scopus 로고
    • Structure-based methods for predicting mutagenicity and carcinogenicity: are we there yet ?
    • Richard AM et al. 1998 Structure - based methods for predicting mutagenicity and carcinogenicity: are we there yet ? Mutat Res 400 ( 1-2 ): 493-507
    • (1998) Mutat Res , vol.400 , Issue.1-2 , pp. 493-507
    • Richard, A.M.1
  • 84
    • 0028920789 scopus 로고
    • The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse
    • Ruscoe JE et al. 1995 The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse J Pharmacol Exp Ther 273, 393-404
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 393-404
    • Ruscoe, J.E.1
  • 85
    • 0027464929 scopus 로고
    • Acute agranulocytosis after prolonged high-dose usage of intravenous dipyrone - A different mechanism of dipyrone toxicity ?
    • Sabbaga J et al. 1993 Acute agranulocytosis after prolonged high - dose usage of intravenous dipyrone - A different mechanism of dipyrone toxicity ? Ann Hematol 66 ( 3 ): 153-155
    • (1993) Ann Hematol , vol.66 , Issue.3 , pp. 153-155
    • Sabbaga, J.1
  • 86
    • 0021838250 scopus 로고
    • The role of metabolite-specific antibodies in nomifensine -dependent immune hemolytic anemia
    • Salama A et al. 1983 The role of metabolite - specific antibodies in nomifensine -dependent immune hemolytic anemia N Engl J Med 313, 469-474
    • (1983) N Engl J Med , vol.313 , pp. 469-474
    • Salama, A.1
  • 87
    • 0034020193 scopus 로고    scopus 로고
    • Measurements of free radicals in isolated, ischemic lungs and lung mitochondria
    • Sanders SP., Bassett DJ., Harrison SJ., Pearse D., Zweier JL., Becker PM 2000 Measurements of free radicals in isolated, ischemic lungs and lung mitochondria Lung 178 ( 2 ): 105-118
    • (2000) Lung , vol.178 , Issue.2 , pp. 105-118
    • Sanders, S.P.1    Bassett, D.J.2    Harrison, S.J.3    Pearse, D.4    Zweier, J.L.5    Becker, P.M.6
  • 88
    • 0033528331 scopus 로고    scopus 로고
    • Angioedema induced by ACE inhibitors and angiotensin II-receptor antagonists: Analysis of 98 cases
    • Schuster C., Reinhart WH., Hartmann K., Kuhn M 1999 Angioedema induced by ACE inhibitors and angiotensin II - receptor antagonists: Analysis of 98 cases Schweiz Med Wochenschr 129, 362-369
    • (1999) Schweiz Med Wochenschr , vol.129 , pp. 362-369
    • Schuster, C.1    Reinhart, W.H.2    Hartmann, K.3    Kuhn, M.4
  • 89
    • 0004955433 scopus 로고
    • Kinetics of unireactant enzymes In
    • ed. Segel IH., 18-89 New York, John Wiley & Sons, Inc
    • Segel IH et al. 1993 Kinetics of unireactant enzymes In Enzyme Kinetics., ed. Segel IH., 18-89 New York, John Wiley & Sons, Inc
    • (1993) Enzyme Kinetics
    • Segel, I.H.1
  • 90
    • 0030789930 scopus 로고    scopus 로고
    • Seizures and hepatotoxicity following sulphasalazine administration
    • Senturk T et al. 1997 Seizures and hepatotoxicity following sulphasalazine administration Rheumatol Int 17 ( 2 ): 75-77
    • (1997) Rheumatol Int , vol.17 , Issue.2 , pp. 75-77
    • Senturk, T.1
  • 91
    • 0027278061 scopus 로고
    • An in-vitro and in-vivo correlative approach to the evaluation of ester prodrugs to improve oral delivery of propranolol
    • Shameem M., Imai T., Otagiri M 1993 An in - vitro and in - vivo correlative approach to the evaluation of ester prodrugs to improve oral delivery of propranolol J Pharm Pharmacol 45, 246-452
    • (1993) J Pharm Pharmacol , vol.45 , pp. 246-452
    • Shameem, M.1    Imai, T.2    Otagiri, M.3
  • 92
    • 0030824857 scopus 로고    scopus 로고
    • Comparative safety of tetracycline, minocycline, and doxycycline
    • Shapiro LE et al. 1997 Comparative safety of tetracycline, minocycline, and doxycycline Arch Dermatol 133, 1224-1230
    • (1997) Arch Dermatol , vol.133 , pp. 1224-1230
    • Shapiro, L.E.1
  • 93
    • 0017876048 scopus 로고
    • Pharmacokinetics of bacampicillin compared with those of ampicillin, pivampicillin, and amoxycillin
    • Sjövall J., Magni L., Bergan T 1978 Pharmacokinetics of bacampicillin compared with those of ampicillin, pivampicillin, and amoxycillin Antimicrob Agents Chemother 13, 90-96
    • (1978) Antimicrob Agents Chemother , vol.13 , pp. 90-96
    • Sjövall, J.1    Magni, L.2    Bergan, T.3
  • 94
    • 0033011853 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of bromfenac
    • Skjodt NM et al. 1999 Clinical pharmacokinetics and pharmacodynamics of bromfenac Clin Pharmacokinet 36 ( 6 ): 399-408
    • (1999) Clin Pharmacokinet , vol.36 , Issue.6 , pp. 399-408
    • Skjodt, N.M.1
  • 95
    • 0035987890 scopus 로고    scopus 로고
    • The pharmacokinetics of a thiazole benzenesulfonamide beta 3-adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: Improving oral bioavailability
    • Stearns RA et al. 2002 The pharmacokinetics of a thiazole benzenesulfonamide beta 3 - adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: Improving oral bioavailability Drug Metab Dispos 30, 771-777
    • (2002) Drug Metab Dispos , vol.30 , pp. 771-777
    • Stearns, R.A.1
  • 96
    • 0021558916 scopus 로고
    • Aminoglutethimide in the treatment of advanced breast cancer
    • Stuart - Harris RC et al. 1984 Aminoglutethimide in the treatment of advanced breast cancer Cancer Treat Rep 11, 189-204
    • (1984) Cancer Treat Rep , vol.11 , pp. 189-204
    • Stuart-Harris, R.C.1
  • 97
    • 0035846070 scopus 로고    scopus 로고
    • Piperazine-based CCR5 antagonists as HIV-1 inhibitors: II.Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4-methyl-4-[3(S)-methyl-4 -[1(S)-[4-(trifl uoromethyl)phenyl]ethyl]-1-piperazinyl]-piperidine N1-oxide (Sch -350634), an orally bioavailable, potent CCR5 antagonist
    • Tagat JR et al. 2001 Piperazine - based CCR5 antagonists as HIV - 1 inhibitors: II.Discovery of 1 - [(2,4 - dimethyl - 3 - pyridinyl)carbonyl] - 4 - methyl - 4 - [3(S) - methyl - 4 -[1(S) - [4 - (trifl uoromethyl)phenyl]ethyl] - 1 - piperazinyl] - piperidine N1 - oxide (Sch -350634), an orally bioavailable, potent CCR5 antagonist J Medicinal Chemistry 44 ( 21 ): 3343-3346
    • (2001) J Medicinal Chemistry , vol.44 , Issue.21 , pp. 3343-3346
    • Tagat, J.R.1
  • 98
    • 0027489228 scopus 로고
    • Oxidative damage to mitochondria is mediated by the Ca(2 ??) -dependent inner-membrane permeability transition
    • Takeyama N et al. 1993 Oxidative damage to mitochondria is mediated by the Ca(2 ??) -dependent inner - membrane permeability transition Biochem J 15 ( 294 ): 719-725
    • (1993) Biochem J , vol.15 , Issue.294 , pp. 719-725
    • Takeyama, N.1
  • 99
    • 0036645750 scopus 로고    scopus 로고
    • Accelerating the drug optimization process: identification, structure elucidation, and quantification of in vivo metabolites using stable isotopes with LC/MSn and the chemiluminescent nitrogen detector
    • Taylor EW et al. 2002 Accelerating the drug optimization process: identification, structure elucidation, and quantification of in vivo metabolites using stable isotopes with LC/MSn and the chemiluminescent nitrogen detector Anal Chem 74 ( 13 ): 3232-3238
    • (2002) Anal Chem , vol.74 , Issue.13 , pp. 3232-3238
    • Taylor, E.W.1
  • 100
    • 0025251932 scopus 로고
    • Drug metabolism and pharmacokinetics: Implications for drug design
    • Testa B et al. 1990 Drug metabolism and pharmacokinetics: Implications for drug design Acta Pharm Jugosl 40 ( 3 ): 315-350
    • (1990) Acta Pharm Jugosl , vol.40 , Issue.3 , pp. 315-350
    • Testa, B.1
  • 101
    • 0034868665 scopus 로고    scopus 로고
    • Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo
    • Tettey JN et al. 2001 Enzyme - induction dependent bioactivation of troglitazone and troglitazone quinone in vivo Chem Res Toxicol 14 ( 8 ): 965-974
    • (2001) Chem Res Toxicol , vol.14 , Issue.8 , pp. 965-974
    • Tettey, J.N.1
  • 102
    • 0029849184 scopus 로고    scopus 로고
    • Synthesis and in vitro reactivity of 3-carbamoyl-2 -phenylpropionaldehyde and 2-phenylpropenal: Putative reactive metabolites of felbamate
    • Thompson CD et al. 1996 Synthesis and in vitro reactivity of 3 - carbamoyl - 2 -phenylpropionaldehyde and 2 - phenylpropenal: Putative reactive metabolites of felbamate Chem Res Toxicol 9, 1225-1229
    • (1996) Chem Res Toxicol , vol.9 , pp. 1225-1229
    • Thompson, C.D.1
  • 103
    • 0035983382 scopus 로고    scopus 로고
    • Liquid chromatography/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process
    • Tiller PR et al. 2002 Liquid chromatography/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process Rapid Commun Mass Spectrom 16, 1225-1231
    • (2002) Rapid Commun Mass Spectrom , vol.16 , pp. 1225-1231
    • Tiller, P.R.1
  • 104
    • 0344604498 scopus 로고    scopus 로고
    • Trapping of free radicals with direct in vivo EPR detection: a comparison of 5,5-dimethyl-1-pyrroline -N-oxide and 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide as spin traps for HO * and SO4
    • Timmins GS., Liu KJ., Bechara EJ., Kotake Y., Swartz HM 1999 Trapping of free radicals with direct in vivo EPR detection: a comparison of 5,5 - dimethyl - 1 - pyrroline -N - oxide and 5 - diethoxyphosphoryl - 5 - methyl - 1 - pyrroline - N - oxide as spin traps for HO * and SO4 Free Radic Biol Med 27 ( 3-4 ): 329-333
    • (1999) Free Radic Biol Med , vol.27 , Issue.3-4 , pp. 329-333
    • Timmins, G.S.1    Liu, K.J.2    Bechara, E.J.3    Kotake, Y.4    Swartz, H.M.5
  • 105
    • 38949104743 scopus 로고    scopus 로고
    • Idiosyncratic drug reactions: Past, present, and future
    • Uetrecht J 2008 Idiosyncratic drug reactions: Past, present, and future Chem Res Toxicol 21 ( 1 ): 84-92
    • (2008) Chem Res Toxicol , vol.21 , Issue.1 , pp. 84-92
    • Uetrecht, J.1
  • 106
    • 0028090231 scopus 로고
    • Metabolism of vesnarinone by activated neutrophils: implications for vesnarinone-induced agranulocytosis
    • Uetrecht JP et al. 1994 Metabolism of vesnarinone by activated neutrophils: implications for vesnarinone - induced agranulocytosis J Pharmacol Exp Ther 270, 865-872
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 865-872
    • Uetrecht, J.P.1
  • 107
    • 0028911862 scopus 로고
    • Oxidation of aminopyrine by hypochlorite to a reactive dication: Possible implications for aminopyrine-induced agranulocytosis
    • Uetrecht JP et al. 1995 Oxidation of aminopyrine by hypochlorite to a reactive dication: Possible implications for aminopyrine - induced agranulocytosis Chem Res Toxicol 8 ( 2 ): 226-233
    • (1995) Chem Res Toxicol , vol.8 , Issue.2 , pp. 226-233
    • Uetrecht, J.P.1
  • 108
    • 0042831348 scopus 로고    scopus 로고
    • Screening for the potential of a drug candidate to cause idiosyncratic drug reactions
    • Uetrecht JP et al. 2002 Screening for the potential of a drug candidate to cause idiosyncratic drug reactions Drug Discov Today 5, 832-837
    • (2002) Drug Discov Today , vol.5 , pp. 832-837
    • Uetrecht, J.P.1
  • 109
    • 0017685967 scopus 로고
    • Dantrolene-associated hepatic injury: Incidence and character
    • Utili R et al. 1977 Dantrolene - associated hepatic injury: Incidence and character J Gastroenterol 72, 610-616
    • (1977) J Gastroenterol , vol.72 , pp. 610-616
    • Utili, R.1
  • 110
    • 0030920759 scopus 로고    scopus 로고
    • Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime
    • Victor F et al. 1997 Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime J Med Chem 40 ( 10 ): 1511-1518
    • (1997) J Med Chem , vol.40 , Issue.10 , pp. 1511-1518
    • Victor, F.1
  • 111
    • 0031937084 scopus 로고    scopus 로고
    • Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: Possible role in allergic reactions
    • Ware JA et al. 1998 Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: Possible role in allergic reactions Chem Res Toxicol 11, 164-171
    • (1998) Chem Res Toxicol , vol.11 , pp. 164-171
    • Ware, J.A.1
  • 112
    • 0037277751 scopus 로고    scopus 로고
    • Metabolite identification in drug discovery
    • Watt AP 2003 Metabolite identification in drug discovery Curr Opin Drug Discov Devel 6 ( 1 ): 57-65
    • (2003) Curr Opin Drug Discov Devel , vol.6 , Issue.1 , pp. 57-65
    • Watt, A.P.1
  • 113
    • 0018099670 scopus 로고
    • Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome
    • Woosley RL et al. 1978 Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome N Engl J Med 298, 1157-1159
    • (1978) N Engl J Med , vol.298 , pp. 1157-1159
    • Woosley, R.L.1
  • 114
    • 0019074051 scopus 로고
    • Chloramphenicol toxicity: Pathogenetic mechanisms and the role of the p-NO2 in aplastic anemia
    • Yunis AA et al. 1980 Chloramphenicol toxicity: Pathogenetic mechanisms and the role of the p - NO2 in aplastic anemia Clin Toxicol 17 ( 3 ): 359-373
    • (1980) Clin Toxicol , vol.17 , Issue.3 , pp. 359-373
    • Yunis, A.A.1
  • 115
    • 10544245022 scopus 로고    scopus 로고
    • Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3 -d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity
    • Zhao Z et al. 1996a Bioactivation of 6,7 - dimethyl - 2,4 - di - 1 - pyrrolidinyl - 7H - pyrrolo[2,3 -d]pyrimidine (U - 89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity Chem Res Toxicol 9 ( 8 ): 1230-1239
    • (1996) Chem Res Toxicol , vol.9 , Issue.8 , pp. 1230-1239
    • Zhao, Z.1
  • 116
    • 0030066506 scopus 로고    scopus 로고
    • In vitro and in vivo biotransformation of 6,7-dimethyl-2,4-di-1 -pyrrolidinyl-7H-pyrrolo[2,3-D]pyrimidine (U-89843) in the rat
    • Zhao Z et al. 1996b In vitro and in vivo biotransformation of 6,7 - dimethyl - 2,4 - di - 1 -pyrrolidinyl - 7H - pyrrolo[2,3 - D]pyrimidine (U - 89843) in the rat Drug Metab Dispos 24 ( 2 ): 187-198
    • (1996) Drug Metab Dispos , vol.24 , Issue.2 , pp. 187-198
    • Zhao, Z.1
  • 117
    • 0031893482 scopus 로고    scopus 로고
    • Isoindol- 1- one analogues of 4-(2 '?- methoxyphenyl)-1-[2 '?- [N-(2 ??-pyridyl) -p-iodobenzamido]ethyl]pipera zine (p-MPPI) as 5-HT1A receptor ligands
    • Zhuang ZP et al. 1998. Isoindol- 1- one analogues of 4-(2 '?- methoxyphenyl) - 1 - [2 '?- [N - (2 ??-pyridyl) -p - iodobenzamido]ethyl]pipera zine (p - MPPI) as 5 - HT1A receptor ligands J Med Chem 41 ( 2 ): 157-166
    • (1998) J Med Chem , vol.41 , Issue.2 , pp. 157-166
    • Zhuang, Z.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.