Isoindol-1-one analogues of 4-(2'-methoxyphenyl)-1-[2'-[N-(2'-pyridyl)- p-iodobenzamido]ethyl]piperazine (p-MPPI) as 5-HT1(A) receptor ligands

Journal of Medicinal Chemistry

Volumn 41, Issue 2, 1998, Pages 157-166

  Zhuang, Zhi Ping ^a   Kung, Mei Ping ^a   Mu, Mu ^a   Kung, Hank F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 2 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 2,3 DIHYDROISOINDOL 1 ONE; 2 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 6 NITRO 3 PHENYL 2,3 DIHYDROISOINDOL 1 ONE; 3 HYDROXY 6 IODO 2 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 3 PHENYL 2,3 DIHYDROISOINDOL 1 ONE; 5 (4 BROMOPHENYL) 1 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL]PYRROLIDIN 2 ONE; 5 (4 IODOPHENYL) 1 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL]PYRROLIDIN 2 ONE; 6 IODO 2 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 3 PHENYL 2,3 DIHYDROISOINDOL 1 ONE; AMIDE; IODINE 123; IODINE 125; ISOINDOLE DERIVATIVE; LIGAND; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG BINDING; DRUG DISTRIBUTION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; LIPOPHILICITY; LIVER MICROSOME; MALE; METABOLISM; NONHUMAN; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYNTHESIS;

AMINOPYRIDINES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HETEROCYCLIC COMPOUNDS; HIPPOCAMPUS; HUMANS; INDOLES; IODINE RADIOISOTOPES; KINETICS; LIGANDS; MALE; MICROSOMES, LIVER; MODELS, CHEMICAL; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN ANTAGONISTS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0031893482     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970296s     Document Type: Article

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