Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: Structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs

Journal of Medicinal Chemistry

Volumn 39, Issue 26, 1996, Pages 5267-5275

  Genin, Michael J ^a   Poel, Toni J ^a   Yagi, Yoshihiko ^a   Biles, Carolyn ^a   Althaus, Irene ^a   Keiser, Barbara J ^a   Kopta, Laurice A ^a   Friis, Jan M ^a   Reusser, Fritz ^a   Adams, Wade J ^a   Olmsted, Robert A ^a   Voorman, Richard L ^a   Thomas, Richard C ^a   Romero, Donna L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATEVIRDINE; DELAVIRDINE; PIPERAZINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG METABOLISM; DRUG STABILITY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; HIV-1; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSOMES, LIVER; PIPERAZINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 5544231319     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960269m     Document Type: Article

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