Application of structure-metabolism relationships in the identification of a selective endothelin A antagonist, BMS-193884, with favourable pharmacokinetic properties

Xenobiotica

Volumn 33, Issue 11, 2003, Pages 1109-1123

  Humphreys, W G ^a   Obermeier, M T ^a   Barrish, J C ^a   Chong, S ^a   Marino, A M ^a   Murugesan, N ^a   Wang Iverson, D ^a   Morrison, R A ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' AMINO N (3,4 DIMETHYL 5 ISOXAZOLYL) 4' (2 METHYLPROPYL) 1,1' BIPHENYL 2 SULFONAMIDE; 2' AMINO N (3,4 DIMETHYL 5 ISOXAZOLYL) 4' ISOBUTYLBIPHENYL 2 SULFONAMIDE; 5 DIMETHYLAMINO N (3,4 DIMETHYL 5 ISOXAZOLYL) 1 NAPHTHALENESULFONAMIDE; BMS 193884; ENDOTHELIN; ENDOTHELIN A RECEPTOR ANTAGONIST; N [[2' [[(3,4 DIMETHYL 5 ISOXAZOLYL)AMINO]SULFONYL] 4 (2 OXAZOLYL) 1,1' BIPHENYL 2 YL]METHYL]ACETAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; BINDING AFFINITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CLEARANCE; DRUG DISPOSITION; DRUG METABOLISM; DRUG POTENCY; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG TRANSFORMATION; DRUG TRANSPORT; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BILE DUCTS; BIOTRANSFORMATION; BLOOD PROTEINS; DRUG DESIGN; HUMANS; MALE; MICROSOMES, LIVER; OXAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

ANIMALIA;

EID: 0344629208     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250310001609147     Document Type: Article

References (22)

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