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Volumn 16, Issue 12, 2002, Pages 1225-1231
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Liquid chromatography/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process
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Author keywords
[No Author keywords available]
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Indexed keywords
CHROMATOGRAPHIC ANALYSIS;
DRUG PRODUCTS;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
MASS SPECTROMETRY;
CHROMATOGRAPHIC METHODS;
DRUG DISCOVERY PROCESS;
DRUG METABOLISMS;
HIGH-FLOW RATE;
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY;
LINEAR GRADIENTS;
METABOLITE SCREENING;
PHARMACOKINETIC STUDIES;
TANDEM MASS SPECTROMETRIC;
ULTRA-FAST;
METABOLITES;
ANTIDIABETIC AGENT;
CARDIOVASCULAR AGENT;
DRUG METABOLITE;
GLUCURONIDE;
ANIMAL;
ANIMAL CELL;
ARTICLE;
BIOTRANSFORMATION;
CELL CULTURE;
CHEMISTRY;
CONTROLLED STUDY;
DOG;
DRUG DESIGN;
DRUG SCREENING;
HAPLORHINI;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HUMAN;
HUMAN CELL;
INCUBATION TIME;
INSTRUMENTATION;
LIVER CELL;
LIVER MICROSOME;
MASS SPECTROMETRY;
METABOLISM;
METHODOLOGY;
MOUSE;
NONHUMAN;
PHARMACEUTICS;
PHARMACOKINETICS;
QUANTITATIVE ANALYSIS;
RAT;
SPECIES DIFFERENCE;
TANDEM MASS SPECTROMETRY;
ELECTROSPRAY MASS SPECTROMETRY;
ANIMALS;
BIOPHARMACEUTICS;
BIOTRANSFORMATION;
CARDIOVASCULAR AGENTS;
CELLS, CULTURED;
CHEMISTRY, PHARMACEUTICAL;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
DOGS;
DRUG DESIGN;
DRUG EVALUATION, PRECLINICAL;
GLUCURONIDES;
HAPLORHINI;
HEPATOCYTES;
HUMANS;
HYPOGLYCEMIC AGENTS;
MICE;
MICROSOMES, LIVER;
PHARMACOKINETICS;
RATS;
SPECIES SPECIFICITY;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
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EID: 0035983382
PISSN: 09514198
EISSN: None
Source Type: Journal
DOI: 10.1002/rcm.708 Document Type: Article |
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Times cited : (64)
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References (10)
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