Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3- d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity

Chemical Research in Toxicology

Volumn 9, Issue 8, 1996, Pages 1230-1239

  Zhao, Zhiyang ^a   Koeplinger, Kenneth A ^a   Padbury, Guy E ^a   Hauer, Michael J ^a   Bundy, Gordon L ^a   Banitt, Lee S ^a   Schwartz, Theresa M ^a   Zimmermann, David C ^a   Harbach, Philip R ^a   Mayo, Judy K ^a   Aaron, C Sidney ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CYTOCHROME P450; GLUTATHIONE; METHANOL; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; U 107634; U 89843; U 97924; UNCLASSIFIED DRUG;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DIMERIZATION; GENOTOXICITY; HUMAN; HUMAN CELL; HYDROXYLATION; LIVER MICROSOME METABOLISM; MACROMOLECULE; MALE; NONHUMAN; RAT; UNSCHEDULED DNA SYNTHESIS;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA REPAIR; DOGS; FREE RADICAL SCAVENGERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HAPLORHINI; HUMANS; MALE; MICROSOMES, LIVER; MUTAGENS; PROTEIN BINDING; PYRIMIDINES; PYRROLES; RATS; RATS, INBRED F344; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROPHOTOMETRY, ULTRAVIOLET;

ANIMALIA;

EID: 10544245022     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx960092z     Document Type: Article

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