Evidence for the Involvement of a Pulmonary First-Pass Effect via Carboxylesterase in the Disposition of a Propranolol Ester Derivative after Intravenous Administration

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 3, 2003, Pages 1234-1242

  Imai, Teruko ^a   Yoshigae, Yasushi ^a   Hosokawa, Masakiyo ^b   Chiba, Kan ^b   Otagiri, Masaki ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLESTERASE; O BUTYRYLPROPRANOLOL; PROPRANOLOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; DRUG CLEARANCE; DRUG DISPOSITION; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG STRUCTURE; ENZYME SPECIFICITY; FIRST PASS EFFECT; KIDNEY; LIVER BLOOD FLOW; LUNG BLOOD FLOW; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SPECIES DIFFERENCE; TIME SERIES ANALYSIS; TISSUE LEVEL;

ADRENERGIC BETA-ANTAGONISTS; ALGORITHMS; ANIMALS; ANTIBODIES, BLOCKING; AREA UNDER CURVE; CARBOXYLIC ESTER HYDROLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOSOL; DOGS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; HYDROLYSIS; INJECTIONS, INTRA-ARTERIAL; INJECTIONS, INTRAVENOUS; ISOENZYMES; LUNG; MALE; MICROSOMES; NITROPHENOLS; PROPRANOLOL; RATS; RATS, WISTAR; SPECIES SPECIFICITY; STEREOISOMERISM;

EID: 0344304751     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.056499     Document Type: Article

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