ER stress in rodent islets of langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes

Nutrition and Diabetes

Volumn 3, Issue OCTOBER, 2013, Pages

  Omikorede, O ^a   Qi, C ^a   Gorman, T ^b   Chapman, P ^b   Yu, A ^b   Smith, D M ^c   Herbert, T P ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

ER stress; Obesity; Pancreatic b cell; Type 2 diabetes; Unfolded protein response

Indexed keywords

BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 1C; FAS ANTIGEN; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE REGULATED PROTEIN 78; GLUCOSE TRANSPORTER 2; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN 40; INSULIN; PROTEIN ATFX; PROTEIN CREBP2; PROTEIN DDIT1; PROTEIN DFNA14; PROTEIN DNAJ; PROTEIN ERDJ4; PROTEIN FHC; PROTEIN FKBP19; PROTEIN LAP; PROTEIN MODY2; PROTEIN MODY4; PROTEIN P58; PROTEIN P72; PROTEIN PEK; PROTEIN PERK; PROTEIN PRAD1; PROTEIN SLC25A8; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENDOPLASMIC RETICULUM STRESS; LIPID DIET; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PANCREAS INSUFFICIENCY; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RODENT; UNFOLDED PROTEIN RESPONSE; ZUCKER DIABETIC FATTY RAT;

EID: 84888274198     PISSN: None     EISSN: 20444052     Source Type: Journal    
DOI: 10.1038/nutd.2013.35     Document Type: Article

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