-
2
-
-
0037677695
-
Increased islet volume but unchanged islet number in ob/ob mice
-
Bock T, Pakkenberg B, Buschard K. Increased islet volume but unchanged islet number in ob/ob mice. Diabetes 52: 1716-1722, 2003.
-
(2003)
Diabetes
, vol.52
, pp. 1716-1722
-
-
Bock, T.1
Pakkenberg, B.2
Buschard, K.3
-
3
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52: 102-110, 2003.
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
5
-
-
0030874158
-
Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes
-
Cockburn BN, Ostrega DM, Sturis J, Kubstrup C, Polonsky KS, Bell GI. Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes. Diabetes 46: 1434-1439, 1997.
-
(1997)
Diabetes
, vol.46
, pp. 1434-1439
-
-
Cockburn, B.N.1
Ostrega, D.M.2
Sturis, J.3
Kubstrup, C.4
Polonsky, K.S.5
Bell, G.I.6
-
6
-
-
0033972763
-
Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats
-
Corsetti JP, Sparks JD, Peterson RG, Smith RL, Sparks CE. Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats. Atherosclerosis 148: 231-241, 2000.
-
(2000)
Atherosclerosis
, vol.148
, pp. 231-241
-
-
Corsetti, J.P.1
Sparks, J.D.2
Peterson, R.G.3
Smith, R.L.4
Sparks, C.E.5
-
7
-
-
0035042679
-
Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death
-
Finegood DT, McArthur MD, Kojwang D, Thomas MJ, Topp BG, Leonard T, Buckingham RE. Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death. Diabetes 50: 1021-1029, 2001.
-
(2001)
Diabetes
, vol.50
, pp. 1021-1029
-
-
Finegood, D.T.1
McArthur, M.D.2
Kojwang, D.3
Thomas, M.J.4
Topp, B.G.5
Leonard, T.6
Buckingham, R.E.7
-
8
-
-
0036381998
-
Adipose tissue as a buffer for daily lipid flux
-
Frayn KN. Adipose tissue as a buffer for daily lipid flux. Diabetologia 45: 1201-1210, 2002.
-
(2002)
Diabetologia
, vol.45
, pp. 1201-1210
-
-
Frayn, K.N.1
-
9
-
-
0035149733
-
A genetic defect in beta-cell gene expression segregates independently from the fa locus in the ZDF rat
-
Griffen SC, Wang J, German MS. A genetic defect in beta-cell gene expression segregates independently from the fa locus in the ZDF rat. Diabetes 50: 63-68, 2001.
-
(2001)
Diabetes
, vol.50
, pp. 63-68
-
-
Griffen, S.C.1
Wang, J.2
German, M.S.3
-
10
-
-
0029920943
-
Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes
-
Hirose H, Lee YH, Inman LR, Nagasawa Y, Johnson JH, Unger RH. Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes. J Biol Chem 271: 5633-5637, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 5633-5637
-
-
Hirose, H.1
Lee, Y.H.2
Inman, L.R.3
Nagasawa, Y.4
Johnson, J.H.5
Unger, R.H.6
-
11
-
-
0030907293
-
Parallel reduction of pancreas insulin content and insulin secretion in 48-h tolbutamide-infused normoglycemic rats
-
Hosokawa YA, Leahy JL. Parallel reduction of pancreas insulin content and insulin secretion in 48-h tolbutamide-infused normoglycemic rats. Diabetes 46: 808-813, 1997.
-
(1997)
Diabetes
, vol.46
, pp. 808-813
-
-
Hosokawa, Y.A.1
Leahy, J.L.2
-
12
-
-
0034094064
-
Roles of insulin resistance and obesity in regulation of plasma insulin concentrations
-
Jones CN, Abbasi F, Carantoni M, Polonsky KS, Reaven GM. Roles of insulin resistance and obesity in regulation of plasma insulin concentrations. Am J Physiol Endocrinol Metab 278: E501-E508, 2000.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.278
-
-
Jones, C.N.1
Abbasi, F.2
Carantoni, M.3
Polonsky, K.S.4
Reaven, G.M.5
-
13
-
-
0029783411
-
Impaired β-cell JL. function with chronic hyperglycaemia: "overworked β-cell" hypothesis
-
Leahy Impaired β-cell JL. function with chronic hyperglycaemia: "overworked β-cell" hypothesis. Diabetes Rev 4: 298-319, 1996.
-
(1996)
Diabetes Rev
, vol.4
, pp. 298-319
-
-
Leahy1
-
14
-
-
0027947379
-
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
-
Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci USA 91: 10878-10882, 1994.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10878-10882
-
-
Lee, Y.1
Hirose, H.2
Ohneda, M.3
Johnson, J.H.4
McGarry, J.D.5
Unger, R.H.6
-
15
-
-
0033859232
-
β-Cell adaptation in 60% pancreatectomy rats that preserves normoinsulinemia and normoglycemia
-
Liu YQ, Nevin PW, Leahy JL. β-Cell adaptation in 60% pancreatectomy rats that preserves normoinsulinemia and normoglycemia. Am J Physiol Endocrinol Metab 279: E68-E73, 2000.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.279
-
-
Liu, Y.Q.1
Nevin, P.W.2
Leahy, J.L.3
-
16
-
-
0037131246
-
beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats
-
Liu YQ, Jetton TL, Leahy JL. beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats. J Biol Chem 277: 39163-39168, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 39163-39168
-
-
Liu, Y.Q.1
Jetton, T.L.2
Leahy, J.L.3
-
17
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man
-
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DT, Turner RC. Homeostasis model assessment: insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
Naylor, B.A.4
Treacher, D.T.5
Turner, R.C.6
-
18
-
-
0036092239
-
Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
-
McGarry JD. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51: 7-18, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 7-18
-
-
McGarry, J.D.1
-
19
-
-
0028985060
-
Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids
-
Milburn JL Jr, Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, Beltrandelrio H, Newgard CB, Johnson JH, Unger RH. Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J Biol Chem 270: 1295-1299, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 1295-1299
-
-
Milburn Jr, J.L.1
Hirose, H.2
Lee, Y.H.3
Nagasawa, Y.4
Ogawa, A.5
Ohneda, M.6
Beltrandelrio, H.7
Newgard, C.B.8
Johnson, J.H.9
Unger, R.H.10
-
20
-
-
0025598902
-
Evidence that downregulation of β-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia
-
Orci L, Ravazzola M, Baetens D, Inman L, Amherdt M, Peterson RG, Newgard CB, Johnson JH, Unger RH. Evidence that downregulation of β-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia. Proc Natl Acad Sci USA 87: 9953-9957, 1990.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 9953-9957
-
-
Orci, L.1
Ravazzola, M.2
Baetens, D.3
Inman, L.4
Amherdt, M.5
Peterson, R.G.6
Newgard, C.B.7
Johnson, J.H.8
Unger, R.H.9
-
21
-
-
0031913829
-
Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat
-
Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes 47: 358-364, 1998.
-
(1998)
Diabetes
, vol.47
, pp. 358-364
-
-
Pick, A.1
Clark, J.2
Kubstrup, C.3
Levisetti, M.4
Pugh, W.5
Bonner-Weir, S.6
Polonsky, K.S.7
-
22
-
-
0036153256
-
Minireview: Secondary beta-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity
-
Poitout V, Robertson RP. Minireview: Secondary beta-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity. Endocrinology 143: 339-342, 2002.
-
(2002)
Endocrinology
, vol.143
, pp. 339-342
-
-
Poitout, V.1
Robertson, R.P.2
-
23
-
-
0032478314
-
Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
-
Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 95: 2498-2502, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2498-2502
-
-
Shimabukuro, M.1
Zhou, Y.T.2
Levi, M.3
Unger, R.H.4
-
24
-
-
0028874383
-
Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat
-
Tokuyama Y, Sturis J, DePaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS, Bell GI. Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 44: 1447-1457, 1995.
-
(1995)
Diabetes
, vol.44
, pp. 1447-1457
-
-
Tokuyama, Y.1
Sturis, J.2
DePaoli, A.M.3
Takeda, J.4
Stoffel, M.5
Tang, J.6
Sun, X.7
Polonsky, K.S.8
Bell, G.I.9
-
25
-
-
0034699781
-
A model of beta-cell insulin, and glucose kinetics: Pathways to diabetes
-
Topp BG, Promislow K, deVries G, Miura RM, Finegood DT. A model of beta-cell insulin, and glucose kinetics: pathways to diabetes. J Theor Biol 206: 605-619, 2000.
-
(2000)
J Theor Biol
, vol.206
, pp. 605-619
-
-
Topp, B.G.1
Promislow, K.2
deVries, G.3
Miura, R.M.4
Finegood, D.T.5
-
26
-
-
37149053401
-
Estimation of insulin sensitivity from fasting glucose and insulin levels: Glucose is irrelevant except when insulin is low (Abstract)
-
Topp BG, Finegood DT. Estimation of insulin sensitivity from fasting glucose and insulin levels: glucose is irrelevant except when insulin is low (Abstract). Diabetes 50, Suppl 2: A523, 2001.
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 2
-
-
Topp, B.G.1
Finegood, D.T.2
-
27
-
-
5644251769
-
Metabolic adaptations to chronic glucose infusion in rats
-
Topp BG, McArthur MD, Finegood DT. Metabolic adaptations to chronic glucose infusion in rats. Diabetologia 47: 1602-1610, 2004.
-
(2004)
Diabetologia
, vol.47
, pp. 1602-1610
-
-
Topp, B.G.1
McArthur, M.D.2
Finegood, D.T.3
-
28
-
-
0021961644
-
Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: Implications for the management of diabetes
-
Unger RH, Grundy S. Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 28: 119-121, 1985.
-
(1985)
Diabetologia
, vol.28
, pp. 119-121
-
-
Unger, R.H.1
Grundy, S.2
-
29
-
-
0029151863
-
-
Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Geneticand clinical implications. Diabetes 44: 863-870, 1995.
-
Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Geneticand clinical implications. Diabetes 44: 863-870, 1995.
-
-
-
-
30
-
-
0032993726
-
Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: Role of enhanced fuel metabolism
-
Zhou YP, Cockburn BN, Pugh W, Polonsky KS. Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism. Metabolism 48: 857-864, 1999.
-
(1999)
Metabolism
, vol.48
, pp. 857-864
-
-
Zhou, Y.P.1
Cockburn, B.N.2
Pugh, W.3
Polonsky, K.S.4
|