Synthesis of new ibuprofen derivatives with their in silico and in vitro cyclooxygenase-2 inhibitions

Bioorganic Chemistry

Volumn 52, Issue , 2014, Pages 8-15

  Gundogdu Hizliates, Cevher ^a   Alyuruk, Hakan ^a   Gocmenturk, Mustafa ^a   Ergun, Yavuz ^a   Cavas, Levent ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

Cyclooxygenase 2; Ibuprofen; Molecular docking; Molecular modeling; Selective inhibitor

Indexed keywords

2 (4 ISOBUTYLPHENYL) N' (THIOPHEN 2 YLMETHYLENE)PROPANEHYDRAZIDE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; IBUPROFEN; IBUPROFEN DERIVATIVE; N (2,2 DIMETHOXYETHYL) 2 (4 ISOBUTYLPHENYL) N METHYLPROPANAMIDE; N (2,2 DIMETHOXYETHYL) 2 (4 ISOBUTYLPHENYL)PROPANAMIDE; N (4,4 DIETHOXYBUTYL) 2 (4 ISOBUTYLPHENYL)PROPANAMIDE; N [(1H INDOL 3 YL)METHYLENE] 2 (4 ISOBUTYLPHENYL)PROPANEHYDRAZIDE; N [(9 HEXYL 9H CARBAZOL 3 YL)METHYLENE] 2 (4 ISOBUTYLPHENYL)PROPANEHYDRAZIDE; N' (FURAN 2 YLMETHYLENE) 2 (4 ISOBUTYLPHENYL)PROPANEHYDRAZIDE; N' [2 (4 ISOBUTYLPHENYL)PROPANOYL]ISONICOTINOHYDRAZIDE; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL;

CYCLOOXYGENASE-2; IBUPROFEN; MOLECULAR DOCKING; MOLECULAR MODELING; SELECTIVE INHIBITOR;

AMINO ACID SEQUENCE; COMPUTER SIMULATION; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DRUG EVALUATION, PRECLINICAL; IBUPROFEN; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA;

EID: 84888266493     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2013.10.002     Document Type: Article

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