Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 3, 2012, Pages 1259-1270

  Hegazy, Gehan H ^a   Ali, Hamed I ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b Ein Helwan   (Egypt)

Author keywords

Cox; Ibuprofen; Mefenamic acid; Molecular docking; NSAIDs

Indexed keywords

4 (4 BROMO BENZYLIDENEAMINO)PHENYL 2 (2,4 DIMETHYLPHENYLAMINO)BENZOATE; 4 (4 BROMO BENZYLIDENEAMINO)PHENYL 2 (4 ISOBUTYLPHENYL)PROPANOATE; 4 (4 METHOXY BENZYLIDENEAMINO)PHENYL 2 (2,4 DIMETHYLPHENYLAMINO)BENZOATE; 4 (4 METHOXY BENZYLIDENEAMINO)PHENYL 2 (4 ISOBUTYLPHENYL)PROPANOATE; 4 (4 NITRO BENZYLIDENEAMINO)PHENYL 2 (2,4 DIMETHYLPHENYLAMINO)BENZOATE; 4 (4 NITRO BENZYLIDENEAMINO)PHENYL 2 (4 ISOBUTYLPHENYL)PROPANOATE; 4 (4 SUBSTITUTED BENZYLIDENEAMINO)PHENOL; 4 (4 SUBSTITUTED BENZYLIDENEAMINO)PHENYL 2 (2,4 DIMETHYLPHENYL AMINO)BENZOATE; 4 (4 SUBSTITUTED BENZYLIDENEAMINO)PHENYL 2 (4 ISOBUTYLPHENYL)PROPANOATE; 4 [4 (DIMETHYLAMINO)BENZYLIDENEAMINO]PHENYL 2 (2,4 DIMETHYLPHENYLAMINO)BENZOATE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IBUPROFEN; MEFENAMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GASTROINTESTINAL TOXICITY; HOT PLATE TEST; MALE; MOLECULAR DOCKING; NONHUMAN; PAW EDEMA; RAT; TOXICITY TESTING;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; DRUG DESIGN; EDEMA; IBUPROFEN; MALE; MEFENAMIC ACID; MODELS, MOLECULAR; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; RATS; RATS, WISTAR; STOMACH ULCER;

EID: 84856228291     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.030     Document Type: Article

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