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Volumn 2, Issue 1, 2003, Pages 19-25

GPCRs: An update on structural approaches to drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIORHODOPSIN; G PROTEIN COUPLED RECEPTOR; OCTREOTIDE; RHODOPSIN; SENSORY RHODOPSIN; SEROTONIN 2C AGONIST; UROTENSIN;

EID: 3042832379     PISSN: 17418372     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1477-3627(02)02283-3     Document Type: Review
Times cited : (35)

References (45)
  • 2
    • 0018711707 scopus 로고
    • Buprenorphine: A review of its pharmacological properties and therapeutic efficacy
    • Heel, R.C. et al. (1979) Buprenorphine: a review of its pharmacological properties and therapeutic efficacy. Drugs 17, 81-110
    • (1979) Drugs , vol.17 , pp. 81-110
    • Heel, R.C.1
  • 4
    • 0025726621 scopus 로고
    • The 1990 Lilly Prize Lecture. A way of looking at agonism and antagonism: Lessons from salbutamol, salmeterol and other β-adrenoceptor agonists
    • Jack, D. (1991) The 1990 Lilly Prize Lecture. A way of looking at agonism and antagonism : lessons from salbutamol, salmeterol and other β-adrenoceptor agonists. Br. J. Clin. Pharmacol. 31, 501-514
    • (1991) Br. J. Clin. Pharmacol. , vol.31 , pp. 501-514
    • Jack, D.1
  • 5
    • 0019756323 scopus 로고
    • Antihypertensive agents 1969-1980
    • Schier, O. and Marxer, A. (1981) Antihypertensive agents 1969-1980. Prog. Drug Res. 25, 9-132
    • (1981) Prog. Drug Res. , vol.25 , pp. 9-132
    • Schier, O.1    Marxer, A.2
  • 6
    • 0017742180 scopus 로고
    • Antihypertensive drugs: Clinical pharmacology and therapeutic use
    • Wollam, G.L. et al. (1977) Antihypertensive drugs: clinical pharmacology and therapeutic use. Drugs 14, 420-460
    • (1977) Drugs , vol.14 , pp. 420-460
    • Wollam, G.L.1
  • 7
    • 0019170539 scopus 로고
    • The pharmacology of prazosin, a novel antihypertensive agent
    • Cavero, I. and Roach, A.G. (1980) The pharmacology of prazosin, a novel antihypertensive agent. Life Sci. 27, 1525-1540
    • (1980) Life Sci. , vol.27 , pp. 1525-1540
    • Cavero, I.1    Roach, A.G.2
  • 8
    • 0019861787 scopus 로고
    • 1980 Award in medicinal chemistry: Medicinal chemistry and dynamic structure-activity analysis in the discovery of drugs acting at histamine H2 receptors
    • Ganellin, R. (1981) 1980 Award in medicinal chemistry: medicinal chemistry and dynamic structure-activity analysis in the discovery of drugs acting at histamine H2 receptors. J. Med. Chem. 24, 913-920
    • (1981) J. Med. Chem. , vol.24 , pp. 913-920
    • Ganellin, R.1
  • 9
    • 0001752768 scopus 로고    scopus 로고
    • The Cambridge structural database: A quarter of a million crystal structures and rising
    • Allen, F.H. (2002) The Cambridge structural database: a quarter of a million crystal structures and rising. Acta Crystallogr. 58, 380-388
    • (2002) Acta Crystallogr. , vol.58 , pp. 380-388
    • Allen, F.H.1
  • 13
    • 0003675575 scopus 로고    scopus 로고
    • Pharmacophore perception, development and use in drug design
    • International University Line
    • Guner, O.F. (ed.) (2000) Pharmacophore perception, development and use in drug design. In IUL Biotechnology Series 2, International University Line
    • (2000) IUL Biotechnology Series 2
    • Guner, O.F.1
  • 14
    • 0034604451 scopus 로고    scopus 로고
    • Crystal structure of rhodopsin: A G protein-coupled receptor
    • Palczewski, K. et al. (2000) Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289, 739-745
    • (2000) Science , vol.289 , pp. 739-745
    • Palczewski, K.1
  • 15
    • 0035800032 scopus 로고    scopus 로고
    • Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs)
    • Teller, D.C. et al. (2001) Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry 40, 7761-7772
    • (2001) Biochemistry , vol.40 , pp. 7761-7772
    • Teller, D.C.1
  • 16
    • 0034801665 scopus 로고    scopus 로고
    • G protein-coupled receptor drug discovery: Implications from the crystal structure of rhodopsin
    • Ballesteros, J. and Palczewski, K. (2001) G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin. Curr. Opin. Drug Discov. Dev. 4, 561-574
    • (2001) Curr. Opin. Drug Discov. Dev. , vol.4 , pp. 561-574
    • Ballesteros, J.1    Palczewski, K.2
  • 17
    • 0030864048 scopus 로고    scopus 로고
    • X-ray structure of bacteriorhodopsin at 2.5 Å from microcrystals grown in lipidic cubic phases
    • Pebay-Peyroula, E. et al. (1997) X-ray structure of bacteriorhodopsin at 2.5 Å from microcrystals grown in lipidic cubic phases. Science 277, 1676-1681
    • (1997) Science , vol.277 , pp. 1676-1681
    • Pebay-Peyroula, E.1
  • 18
    • 0033567092 scopus 로고    scopus 로고
    • Protein, lipid and water organization in bacteriorhodopsin crystals: A molecular view of the purple membrane at 1.9 Å resolution
    • Belrhali, H. et al. (1999) Protein, lipid and water organization in bacteriorhodopsin crystals: a molecular view of the purple membrane at 1.9 Å resolution. Structure Fold. Des. 7, 909-917
    • (1999) Structure Fold. Des. , vol.7 , pp. 909-917
    • Belrhali, H.1
  • 19
    • 0028961335 scopus 로고
    • SCOP: A structural classification of proteins database for the investigation of sequences and structures
    • Murzin, A.G. et al. (1995) SCOP: a structural classification of proteins database for the investigation of sequences and structures. J. Mol. Biol. 247, 536-540
    • (1995) J. Mol. Biol. , vol.247 , pp. 536-540
    • Murzin, A.G.1
  • 20
    • 0032059717 scopus 로고    scopus 로고
    • Highly selective separation of rhodopsin from bovine rod outer segment membranes using combination of divalent cation and alkyl(thio)glucoside
    • Okada, T. et al. (1998) Highly selective separation of rhodopsin from bovine rod outer segment membranes using combination of divalent cation and alkyl(thio)glucoside. Photochem. Photobiol. 67, 495-499
    • (1998) Photochem. Photobiol. , vol.67 , pp. 495-499
    • Okada, T.1
  • 21
    • 0037109074 scopus 로고    scopus 로고
    • Structure and function in rhodopsin: High-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line
    • Reeves, P.J. et al. (2002) Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line. Proc. Natl. Acad. Sci. U. S. A. 99, 13419-13424
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 13419-13424
    • Reeves, P.J.1
  • 22
    • 0035964365 scopus 로고    scopus 로고
    • X-ray structure of sensory rhodopsin II at 2.1 Å resolution
    • Royant, A. et al. (2001) X-ray structure of sensory rhodopsin II at 2.1 Å resolution. Proc. Natl. Acad. Sci. U. S. A. 98, 10131-10136
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 10131-10136
    • Royant, A.1
  • 23
    • 0035671430 scopus 로고    scopus 로고
    • Solubilization and purification of the human ETB endothelin receptor produced by high-level fermentation in Pichia pastoris
    • Schiller, H. et al. (2001) Solubilization and purification of the human ETB endothelin receptor produced by high-level fermentation in Pichia pastoris. Receptors Channels 7, 453-469
    • (2001) Receptors Channels , vol.7 , pp. 453-469
    • Schiller, H.1
  • 24
    • 15744369685 scopus 로고
    • The photosynthetic reaction center from the purple bacterium Rhodopseudomonas viridis
    • Deisenhofer, J. and Michel, H. (1988) The photosynthetic reaction center from the purple bacterium Rhodopseudomonas viridis. In Nobel Lectures Chemistry, pp. 526-565
    • (1988) Nobel Lectures Chemistry , pp. 526-565
    • Deisenhofer, J.1    Michel, H.2
  • 25
    • 0036261591 scopus 로고    scopus 로고
    • Structural genomics on GPCRs: The MePNet approach
    • Lundstrom, K. (2002) Structural genomics on GPCRs: the MePNet approach. Curr. Drug Discov. May, 29-33
    • (2002) Curr. Drug Discov. , vol.MAY , pp. 29-33
    • Lundstrom, K.1
  • 26
    • 0036667741 scopus 로고    scopus 로고
    • Crystallisation of membrane proteins mediated by antibody fragments
    • Hunte, C. and Michel, H. (2002) Crystallisation of membrane proteins mediated by antibody fragments. Curr. Opin. Struct. Biol. 12, 503-508
    • (2002) Curr. Opin. Struct. Biol. , vol.12 , pp. 503-508
    • Hunte, C.1    Michel, H.2
  • 27
    • 0036099405 scopus 로고    scopus 로고
    • Interaction of a non-peptide agonist with angiotensin II AT1 receptor mutants
    • Costa-Neto, C.M. et al. (2002) Interaction of a non-peptide agonist with angiotensin II AT1 receptor mutants. Can. J. Physiol. Pharmacol. 80, 413-417
    • (2002) Can. J. Physiol. Pharmacol. , vol.80 , pp. 413-417
    • Costa-Neto, C.M.1
  • 28
    • 0000243829 scopus 로고
    • PROCHECK: A program to check the stereochemical quality of protein structures
    • Laskowski, R.A. et al. (1993) PROCHECK: a program to check the stereochemical quality of protein structures. J. Appl. Crystallogr. 26, 283
    • (1993) J. Appl. Crystallogr. , vol.26 , pp. 283
    • Laskowski, R.A.1
  • 29
    • 0034954455 scopus 로고    scopus 로고
    • Mutation of Asp-171 and Asp-262 of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100
    • Hatse, S. et al. (2001) Mutation of Asp-171 and Asp-262 of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. Mol. Pharmacol. 60, 164-173
    • (2001) Mol. Pharmacol. , vol.60 , pp. 164-173
    • Hatse, S.1
  • 30
    • 0034062515 scopus 로고    scopus 로고
    • Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists
    • De Clercq, E. (2000) Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists. Mol. Pharmacol. 57, 833-839
    • (2000) Mol. Pharmacol. , vol.57 , pp. 833-839
    • De Clercq, E.1
  • 31
    • 0033602128 scopus 로고    scopus 로고
    • Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl] indoles: Potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor
    • Sternfeld, F. et al. (1999) Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor. J. Med. Chem. 42, 677-690
    • (1999) J. Med. Chem. , vol.42 , pp. 677-690
    • Sternfeld, F.1
  • 32
    • 0037215651 scopus 로고    scopus 로고
    • Rhodopsin crystal: New template yielding realistic models of G-protein-coupled receptors?
    • Archer, E. et al. (2003) Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors? Trends Pharmacol. Sci. 24, 36-40
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 36-40
    • Archer, E.1
  • 33
    • 0034886035 scopus 로고    scopus 로고
    • Modeling the 3D structure of GPCRs from sequence
    • Shacham, S. et al. (2001) Modeling the 3D structure of GPCRs from sequence. Med. Res. Rev. 21, 472-483
    • (2001) Med. Res. Rev. , vol.21 , pp. 472-483
    • Shacham, S.1
  • 34
    • 0028854034 scopus 로고
    • Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation
    • Jones, G. et al. (1995) Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation. J. Mol. Biol. 245, 43-53
    • (1995) J. Mol. Biol. , vol.245 , pp. 43-53
    • Jones, G.1
  • 35
    • 0031552362 scopus 로고    scopus 로고
    • Development and validation of a genetic algorithm for flexible docking
    • Jones, G. et al. (1997) Development and validation of a genetic algorithm for flexible docking J. Mol. Biol. 267, 727-748
    • (1997) J. Mol. Biol. , vol.267 , pp. 727-748
    • Jones, G.1
  • 36
    • 0028198851 scopus 로고
    • Structure-activity studies of glucagon-like peptide-1
    • Adelhorst, K. et al. (1994) Structure-activity studies of glucagon-like peptide-1. J. Biol. Chem. 269, 6275-6278
    • (1994) J. Biol. Chem. , vol.269 , pp. 6275-6278
    • Adelhorst, K.1
  • 37
    • 0034256051 scopus 로고    scopus 로고
    • Can peptides be mimicked?
    • Beeley, N.R.A. (2000) Can peptides be mimicked? Drug Discov. Today 5, 354-363
    • (2000) Drug Discov. Today , vol.5 , pp. 354-363
    • Beeley, N.R.A.1
  • 38
    • 18244370299 scopus 로고    scopus 로고
    • Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule
    • Gadek, T.R. et al. (2002) Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule. Science 295, 1086-1089
    • (2002) Science , vol.295 , pp. 1086-1089
    • Gadek, T.R.1
  • 39
    • 0028550028 scopus 로고
    • Chemical function queries for 3D database search
    • Greene, J. et al. (1994) Chemical function queries for 3D database search. J. Chem. Inf. Comput. Sci. 34, 1297-1308
    • (1994) J. Chem. Inf. Comput. Sci. , vol.34 , pp. 1297-1308
    • Greene, J.1
  • 40
    • 0025161031 scopus 로고
    • Recognition by goby intestine of a somatostatin analog, SMS 201-995
    • Loretz, C.A. (1990) Recognition by goby intestine of a somatostatin analog, SMS 201-995. J. Exp. Zool. (Suppl. 4), 31-36
    • (1990) J. Exp. Zool. , Issue.4 SUPPL. , pp. 31-36
    • Loretz, C.A.1
  • 41
    • 0023751431 scopus 로고
    • Comparative molecular field analysis (CoMFA). Effect of shape on binding of steroids to carrier proteins
    • Cramer, R.D., III et al. (1988) Comparative molecular field analysis (CoMFA). Effect of shape on binding of steroids to carrier proteins. J. Am. Chem. Soc. 110, 5959
    • (1988) J. Am. Chem. Soc. , vol.110 , pp. 5959
    • Cramer III, R.D.1
  • 42
    • 0038568057 scopus 로고    scopus 로고
    • 2c receptor modulators: Progress in development of new CNS medicines
    • 2c receptor modulators: progress in development of new CNS medicines. Ann. Rep. Med. Chem. 37, 21-30
    • (2002) Ann. Rep. Med. Chem. , vol.37 , pp. 21-30
    • Fitzgerald, L.W.1    Ennis, M.D.2
  • 43
    • 15744379396 scopus 로고    scopus 로고
    • ROCS (Rapid Overlay of Chemical Structures) OpenEye Scientific, Santa Fe, NM, USA
    • ROCS (Rapid Overlay of Chemical Structures) OpenEye Scientific, Santa Fe, NM, USA
  • 44
    • 0036688175 scopus 로고    scopus 로고
    • The use of constitutively active GPCRs in drug discovery and functional genomics
    • Chalmers, D.T. and Behan, D.P. (2002) The use of constitutively active GPCRs in drug discovery and functional genomics. Nat. Rev. Drug. Discov. 1, 599-608
    • (2002) Nat. Rev. Drug. Discov. , vol.1 , pp. 599-608
    • Chalmers, D.T.1    Behan, D.P.2
  • 45
    • 0028198301 scopus 로고
    • Tools for investigating functional interactions between ligands and G-protein-coupled receptors
    • Lerner, M.R. (1994) Tools for investigating functional interactions between ligands and G-protein-coupled receptors. Trends Neurosci. 17, 142-146
    • (1994) Trends Neurosci. , vol.17 , pp. 142-146
    • Lerner, M.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.