Design, synthesis and in vitro evaluation of thiazole derivatives of ibuprofen as cyclooxygenase-2 inhibitors

Chinese Chemical Letters

Volumn 17, Issue 3, 2006, Pages 325-328

  Guo, Chang Bin ^a   Cai, Zhe Feng ^a   Guo, Zong Ru ^a   Feng, Zhi Qiang ^a   Chu, Feng Ming ^a   Cheng, Gui Fang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cyclooxygenase 2 (COX 2) inhibitor; Ibuprofen; Thiazole derivative

Indexed keywords

EID: 33645338716     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. R. G. Kurumbail, A. M. Stevens, J. K. Gierse, et al., Nature, 1996, 384(6610), 644.
2. B. S. Selinsky, K. Gupta, C. T. Sharkey, et al., Biochemistry, 2001, 40(17), 5172.
3. K. W. Woods, R. W. McCroskey, M. R. Michaelides, et al., Bioorg. Med. Chem. Lett., 2001, 11, 1325.
4. A. S. Kalgutkar, A. B. Marnett, B. C. Crews, et al., J. Med. Chem., 2000, 43, 2860.
5. A. S. Kalgutkar, B. C. Crews, S. W. Rowlinson, et al., Science, 1998, 280(5367), 1268.
6. C. I. Bayly, W. C. Black, S. Leger, et al., Bioorg. Med. Chem. Lett., 1999, 9(3), 307.
7. T. D. Warner, F. Giuliano, I. Vojnovic, et al., Proc. Nat. Acad. Sci. U.S.A., 1999, 96, 7563.
8. S. Raucher, P. Klein, J. Org. Chem., 1981, 46(17), 3558.
9. B. S. Friedman, M. Sparks, R. Adams, J. Am. Chem. Soc. , 1937, 59(2), 2262.
10. Y. Wang, F. S. Guziec, J. Org. Chem., 2001, 66(25), 8293.
11. T. Goslinski, B. Golankiewicz, E. D. Clercq, et al., J. Med. Chem., 2002, 45(23), 5052.
12. C. H. Park, R. S. Givens, J. Am. Chem. Soc., 1997, 119(10), 2453.
13. P. A. Levene, Bromoacetone, Org. Synth. Coll. Vol. 2, 1943, 88.