Regioselective reaction: Synthesis and pharmacological study of Mannich bases containing ibuprofen moiety

European Journal of Medicinal Chemistry

Volumn 44, Issue 9, 2009, Pages 3697-3702

  Sujith, K V ^a   Rao, Jyothi N ^a   Shetty, Prashanth ^b   Kalluraya, Balakrishna ^a  

^a MANGALORE UNIVERSITY   (India)

^b NITTE DEEMED TO BE UNIVERSITY   (India)

Author keywords

Analgesic agents; Anti inflammatory agents; Ibuprofen; Mannich base; Schiff base

Indexed keywords

DICLOFENAC; IBUPROFEN; IBUPROFEN DERIVATIVE; MANNICH BASE; SCHIFF BASE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MANNICH REACTION; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; STEREOCHEMISTRY;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPERGILLUS; EDEMA; ESCHERICHIA COLI; IBUPROFEN; INFLAMMATION; MANNICH BASES; MICE; PAIN; RATS; RATS, WISTAR; SCHIFF BASES; STAPHYLOCOCCUS AUREUS; TRIAZOLES;

EID: 67650409733     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.044     Document Type: Article

References (28)

1. Kawail S., Kojima F., and Kusunoki N. Allergol. Int. 54 (2005) 209-215
2. Klasser G.D., and Epstein J. J. Can. Dent. Assoc. 71 (2005) 575-580
3. Adams S.S. Inflammopharmacology 7 (1999) 191-197
4. Palaska E., Sahin G., Kelicen P., Durlu N.T., and Altinok G. Il Farmaco 57 (2002) 101-107
5. Hla T., and Neilson K. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 7384-7388
6. Marnett L., and Kalgutkar A.S. Trends Pharmacol. Sci. 20 (1999) 465-469
7. Dannhardt G., and Kiefer W. Eur. J. Med. Chem. 36 (2001) 109-126
8. Almansa C., Alfon J., De Arriba A., Cavalcanti F., Escamilla I., Gomez L., Miralles A., Soliva R., Bartolli J., Carceller E., Merlos M., and Garcia-Rafanell J. J. Med. Chem. 46 (2003) 3463-3475
9. Jackson L., and Hawkey C. Exp. Opin. Invest. Drugs 8 (1999) 963-973
10. Allison M., Howatson A., Torrance C., Lee F., and Russell R.N. Engl. J. Med. 327 (1992) 749-754
11. Kimmey M.B. NSAID, ulcers and prostaglandins. J. Rheumatol. 19 (1992) 68-73
12. Tally J.J., Bertenshaw R.S., Brown D.L., Carter J.S., Graneto M.J., Kellogg M.S., Kobolt C.M., Yuan J., Zhang Y.Y., and Seibert K. J. Med. Chem. 43 (2000) 1661-1663
13. Lanza F.L. Am. J. Gastroenterol. 93 (1998) 2037-2046
14. Hawkey C., Laine L., Simon T., Beaulieu A., Maldonado-Cocco J., Acevedo E., Shahane A., Quan H., Bolognese J., and Mortensen E. Arthritis Rheum. 43 (2000) 370-377
15. Kalgutkar A.S., Marnett A.B., Crews B.C., Remmel R.P., and Marnett L.J. J. Med. Chem. 43 (2000) 2860-2870
16. Duflos M., Nourrisson M.R., Brelet J., Courant J., Le Baut G., Grimaud N., and Petit J.Y. Eur. J. Med. Chem. 36 (2001) 545-553
17. Maxwell J.R., Wasdahl D.A., Wolfson A.C., and Stenberg V.I. J. Med. Chem. 27 (1984) 1565-1570
18. Turan-Zitouni G., Kaplancikli Z.A., Erol K., and Kilic F.S. Il Farmaco 54 (1999) 218-223
19. Holla B.S., Veerendra B., Shivananda M.K., and Poojary B. Eur. J. Med. Chem. 38 (2003) 759-767
20. Malinka W., Swiatek P., Filipek B., Sapa J., Jerierska A., and Koll A. Il Farmaco 60 (2005) 961-968
21. Ashok M., Holla B.S., and Poojary B. Eur. J. Med. Chem. 42 (2007) 1095-1101
22. Dolle R.E., and Nelson K.H. J. Comb. Chem. 1 (1999) 235-282
23. Kalluraya B., Isloor A.M., Chimbalkar R., and Shenoy S. Indian J. Heterocycl. Chem. 10 (2001) 239-240
24. Tramontini M., and Angliolini L. Tetrahedron 46 (1990) 1791-1837
25. Haijian S., Zhongyi W., and Haoxina S. Synth. Commun. 28 (1998) 3973-3982
26. Metwally K.A., Yaseen S.H., Lashine E.M., El-Fayomi H.M., and El-Sadek M.E. Eur. J. Med. Chem. 42 (2007) 152-160
27. Reid J.R., and Heindel N.D. J. Heterocycl. Chem. 13 (1976) 925-926
28. Winter C.A., Risley E.A., and Nuss G.N. Proc. Soc. Exp. Biol. 111 (1962) 544-547