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Volumn 40, Issue 17, 2001, Pages 5172-5180

Structural analysis of NSAID binding by prostaglandin H2 synthase: Time-dependent and time-independent inhibitors elicit identical enzyme conformations

(4) Selinsky, B S a Gupta, K b Sharkey, C T c Loll, P J b

a VILLANOVA UNIVERSITY (United States)

b UNIVERSITY OF PENNSYLVANIA (United States)

c ROYAL COLLEGE OF SURGEONS IN IRELAND (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CORRELATION METHODS; DRUG PRODUCTS; HYDROGEN BONDS; STATISTICAL TESTS; STRUCTURAL ANALYSIS;

ANTIINFLAMMATORY DRUGS;

ENZYME INHIBITION;

ALCLOFENAC; FLURBIPROFEN; IBUPROFEN; METHYLFLURBIPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; PROSTANOID; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; HYDROGEN BOND; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; REACTION TIME;

EID: 0035339905 PISSN: 00062960 EISSN: None Source Type: Journal
DOI: 10.1021/bi010045s Document Type: Article

Times cited : (264)

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