Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells

Biochemical Pharmacology

Volumn 52, Issue 7, 1996, Pages 1113-1125

  Kargman, Stacia ^a   Wong, Elizabeth ^a   Greig, Gillian M ^a   Falgueyret, Jean Pierre ^a   Cromlish, Wanda ^a   Ethier, Diane ^a   Yergey, Jim A ^a   Riendeau, Denis ^a   Evans, Jilly F ^a   Kennedy, Brian ^a   Tagari, Philip ^a   Francis, Donna A ^a   O'Neill, Gary P ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

cyclooxygenase; inflammation; NSAID; phospholipase A2; prostaglandin; prostaglandin G H synthase

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; 6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CALCIMYCIN; CALCIUM IONOPHORE; COMPLEMENTARY DNA; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DICLOFENAC; FLURBIPROFEN; IBUPROFEN; INDOMETACIN; ISOENZYME; KETOROLAC; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIFLUMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; SALICYLIC ACID;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL FREE SYSTEM; CHO CELL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; GENE EXPRESSION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION;

EID: 0030580035     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00462-5     Document Type: Article

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