-
1
-
-
84862522237
-
-
(accessed February 24
-
o 297. http://www. who. int/mediacenter/factsheets/fs297/en/(accessed February 24, 2012).
-
(2012)
Fact Sheet
-
-
-
2
-
-
78649284256
-
Overcoming drug resistance by regulating nuclear receptors
-
Chen, T. Overcoming drug resistance by regulating nuclear receptors. Adv. Drug Deliv. Rev. 2010, 62 (13), 1257-1264.
-
(2010)
Adv. Drug Deliv. Rev
, vol.62
, Issue.13
, pp. 1257-1264
-
-
Chen, T.1
-
3
-
-
0033799839
-
Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs
-
Krishna, R.; Mayer, L. D. Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur. J. Pharm. Sci. 2000, 11 (4), 265-283.
-
(2000)
Eur. J. Pharm. Sci
, vol.11
, Issue.4
, pp. 265-283
-
-
Krishna, R.1
Mayer, L.D.2
-
4
-
-
84867419830
-
Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression
-
Nobili, S.; Landini, I.; Mazzei, T.; Mini, E. Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression. Med. Res. Rev. 2012, 32 (6), 1220-1262.
-
(2012)
Med. Res. Rev
, vol.32
, Issue.6
, pp. 1220-1262
-
-
Nobili, S.1
Landini, I.2
Mazzei, T.3
Mini, E.4
-
5
-
-
79251517383
-
Mechanism of multidrug resistance of human small cell lung cancer cell line H446/VP
-
Wang, Y. L.; Yan, Y. L.; Zhou, N. J.; Han, S.; Zhao, J. X.; Cao, C. L.; Lu, Y. H. Mechanism of multidrug resistance of human small cell lung cancer cell line H446/VP. Chin. Med. J. (Engl) 2010, 123 (22), 3299-3303.
-
(2010)
Chin. Med. J. (Engl)
, vol.123
, Issue.22
, pp. 3299-3303
-
-
Wang, Y.L.1
Yan, Y.L.2
Zhou, N.J.3
Han, S.4
Zhao, J.X.5
Cao, C.L.6
Lu, Y.H.7
-
6
-
-
0036232692
-
Induction of multidrug resistance in MOLT-4 cells by anticancer agents is closely related to increased expression of functional Pglycoprotein and MDR1 mRNA
-
Liu, Z. L.; Onda, K.; Tanaka, S.; Toma, T.; Hirano, T.; Oka, K. Induction of multidrug resistance in MOLT-4 cells by anticancer agents is closely related to increased expression of functional Pglycoprotein and MDR1 mRNA. Cancer Chemother. Pharmacol. 2002, 49 (5), 391-397.
-
(2002)
Cancer Chemother. Pharmacol
, vol.49
, Issue.5
, pp. 391-397
-
-
Liu, Z.L.1
Onda, K.2
Tanaka, S.3
Toma, T.4
Hirano, T.5
Oka, K.6
-
7
-
-
33646568511
-
Mechanisms and strategies to overcome multiple drug resistance in cancer
-
Ozben, T. Mechanisms and strategies to overcome multiple drug resistance in cancer. FEBS Lett. 2006, 580 (12), 2903-2909.
-
(2006)
FEBS Lett
, vol.580
, Issue.12
, pp. 2903-2909
-
-
Ozben, T.1
-
8
-
-
34547650721
-
Involvement of CtBP1 in the transcriptional activation of the MDR1 gene in human multidrug resistant cancer cells
-
Jin, W.; Scotto, K. W.; Hait, W. N.; Yang, J. M. Involvement of CtBP1 in the transcriptional activation of the MDR1 gene in human multidrug resistant cancer cells. Biochem. Pharmacol. 2007, 74 (6), 851-859.
-
(2007)
Biochem. Pharmacol
, vol.74
, Issue.6
, pp. 851-859
-
-
Jin, W.1
Scotto, K.W.2
Hait, W.N.3
Yang, J.M.4
-
9
-
-
0037427122
-
NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells
-
Bentires-Alj, M.; Barbu, V.; Fillet, M.; Chariot, A.; Relic, B.; Jacobs, N.; Gielen, J.; Merville, M. P.; Bours, V. NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene 2003, 22 (1), 90-97.
-
(2003)
Oncogene
, vol.22
, Issue.1
, pp. 90-97
-
-
Bentires-Alj, M.1
Barbu, V.2
Fillet, M.3
Chariot, A.4
Relic, B.5
Jacobs, N.6
Gielen, J.7
Merville, M.P.8
Bours, V.9
-
10
-
-
0032427211
-
Transcriptional regulation of MDR genes
-
Scotto, K. W.; Egan, D. A. Transcriptional regulation of MDR genes. Cytotechnology 1998, 27 (1-3), 257-269.
-
(1998)
Cytotechnology
, vol.27
, Issue.1-3
, pp. 257-269
-
-
Scotto, K.W.1
Egan, D.A.2
-
11
-
-
0034936354
-
ABC drug transporters: Hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2
-
Kerb, R.; Hoffmeyer, S.; Brinkmann, U. ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2. Pharmacogenomics 2001, 2 (1), 51-64.
-
(2001)
Pharmacogenomics
, vol.2
, Issue.1
, pp. 51-64
-
-
Kerb, R.1
Hoffmeyer, S.2
Brinkmann, U.3
-
12
-
-
1642523162
-
Polymorphisms in human MDR1 (P-glycoprotein): Recent advances and clinical relevance
-
Marzolini, C.; Paus, E.; Buclin, T.; Kim, R. B. Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin. Pharmacol. Ther. 2004, 75 (1), 13-33.
-
(2004)
Clin. Pharmacol. Ther
, vol.75
, Issue.1
, pp. 13-33
-
-
Marzolini, C.1
Paus, E.2
Buclin, T.3
Kim, R.B.4
-
13
-
-
47349110179
-
Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
-
Zhou, S. F. Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition. Xenobiotica 2008, 38 (7-8), 802-832.
-
(2008)
Xenobiotica
, vol.38
, Issue.7-8
, pp. 802-832
-
-
Zhou, S.F.1
-
14
-
-
0345688182
-
Transcriptional regulation of ABC drug transporters
-
Scotto, K. W. Transcriptional regulation of ABC drug transporters. Oncogene 2003, 22 (47), 7496-7511.
-
(2003)
Oncogene
, vol.22
, Issue.47
, pp. 7496-7511
-
-
Scotto, K.W.1
-
15
-
-
55249108934
-
Redox Regulation of Multidrug Resistance in Cancer Chemotherapy: Molecular Mechanisms and Therapeutic Opportunities
-
Kuo, M. T. Redox Regulation of Multidrug Resistance in Cancer Chemotherapy: Molecular Mechanisms and Therapeutic Opportunities. Antioxid. Redox Signal. 2009, 11 (1), 99-133.
-
(2009)
Antioxid. Redox Signal
, vol.11
, Issue.1
, pp. 99-133
-
-
Kuo, M.T.1
-
16
-
-
77958099641
-
Multiple drug resistance mechanisms in cancer
-
Baguley, B. C. Multiple drug resistance mechanisms in cancer. Mol. Biotechnol. 2010, 46 (3), 308-316.
-
(2010)
Mol. Biotechnol
, vol.46
, Issue.3
, pp. 308-316
-
-
Baguley, B.C.1
-
17
-
-
79959764016
-
Toward a better pharmacophore description of P-glycoprotein modulators, based on macrocyclic diterpenes from Euphorbia species
-
Ferreira, R. J.; dos Santos, D. J.; Ferreira, M. J.; Guedes, R. C. Toward a better pharmacophore description of P-glycoprotein modulators, based on macrocyclic diterpenes from Euphorbia species. J. Chem. Inf. Model 2011, 51 (6), 1315-1324.
-
(2011)
J. Chem. Inf. Model
, vol.51
, Issue.6
, pp. 1315-1324
-
-
Ferreira, R.J.1
dos Santos, D.J.2
Ferreira, M.J.3
Guedes, R.C.4
-
18
-
-
84862203273
-
Insights on PGlycoprotein's Efflux Mechanism Obtained by Molecular Dynamics Simulations
-
Ferreira, R. J.; Ferreira, M. J. U.; dos Santos, D. Insights on PGlycoprotein's Efflux Mechanism Obtained by Molecular Dynamics Simulations. J. Chem. Theory Comput. 2012, 8 (6), 1853-1864.
-
(2012)
J. Chem. Theory Comput
, vol.8
, Issue.6
, pp. 1853-1864
-
-
Ferreira, R.J.1
Ferreira, M.J.U.2
dos Santos, D.3
-
19
-
-
73649111071
-
Understanding polyspecificity of multidrug ABC transporters: Closing in on the gaps in ABCB1
-
Gutmann, D. A.; Ward, A.; Urbatsch, I. L.; Chang, G.; van Veen, H. W. Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1. Trends Biochem. Sci. 2010, 35 (1), 36-42.
-
(2010)
Trends Biochem. Sci
, vol.35
, Issue.1
, pp. 36-42
-
-
Gutmann, D.A.1
Ward, A.2
Urbatsch, I.L.3
Chang, G.4
van Veen, H.W.5
-
20
-
-
84855757480
-
-
Chemical Computing Group Inc.: Montreal, QC, Canada
-
Molecular Operating Environment (MOE), 2009. 10, Chemical Computing Group Inc.: Montreal, QC, Canada, 2010.
-
(2010)
Molecular Operating Environment
-
-
-
21
-
-
33745746815
-
Pharmacological strategies for overcoming multidrug resistance
-
Nobili, S.; Landini, I.; Giglioni, B.; Mini, E. Pharmacological strategies for overcoming multidrug resistance. Curr. Drug Targets 2006, 7 (7), 861-879.
-
(2006)
Curr. Drug Targets
, vol.7
, Issue.7
, pp. 861-879
-
-
Nobili, S.1
Landini, I.2
Giglioni, B.3
Mini, E.4
-
22
-
-
84860535245
-
Three decades of P-gp inhibitors: Skimming through several generations and scaffolds
-
Palmeira, A.; Sousa, E.; Vasconcelos, M. H.; Pinto, M. M. Three decades of P-gp inhibitors: skimming through several generations and scaffolds. Curr. Med. Chem. 2012, 19 (13), 1946-2025.
-
(2012)
Curr. Med. Chem
, vol.19
, Issue.13
, pp. 1946-2025
-
-
Palmeira, A.1
Sousa, E.2
Vasconcelos, M.H.3
Pinto, M.M.4
-
23
-
-
84860689257
-
Drug resistance: Still a daunting challenge to the successful treatment of AML
-
Shaffer, B. C.; Gillet, J. P.; Patel, C.; Baer, M. R.; Bates, S. E.; Gottesman, M. M. Drug resistance: still a daunting challenge to the successful treatment of AML. Drug Resist. Updat. 2012, 15 (1-2), 62-69.
-
(2012)
Drug Resist. Updat
, vol.15
, Issue.1-2
, pp. 62-69
-
-
Shaffer, B.C.1
Gillet, J.P.2
Patel, C.3
Baer, M.R.4
Bates, S.E.5
Gottesman, M.M.6
-
24
-
-
84860669151
-
Targeting MDR in breast and lung cancer: Discriminating its potential importance from the failure of drug resistance reversal studies
-
Amiri-Kordestani, L.; Basseville, A.; Kurdziel, K.; Fojo, A. T.; Bates, S. E. Targeting MDR in breast and lung cancer: discriminating its potential importance from the failure of drug resistance reversal studies. Drug Resist. Updat. 2012, 15 (1-2), 50-61.
-
(2012)
Drug Resist. Updat
, vol.15
, Issue.1-2
, pp. 50-61
-
-
Amiri-Kordestani, L.1
Basseville, A.2
Kurdziel, K.3
Fojo, A.T.4
Bates, S.E.5
-
25
-
-
51049115157
-
Overcoming multidrug resistance in human carcinoma cells by an antisense oligodeoxynucleotide--doxorubicin conjugate in vitro and in vivo
-
Ren, Y.; Wang, Y.; Zhang, Y.; Wei, D. Overcoming multidrug resistance in human carcinoma cells by an antisense oligodeoxynucleotide--doxorubicin conjugate in vitro and in vivo. Mol. Pharm. 2008, 5 (4), 579-587.
-
(2008)
Mol. Pharm
, vol.5
, Issue.4
, pp. 579-587
-
-
Ren, Y.1
Wang, Y.2
Zhang, Y.3
Wei, D.4
-
26
-
-
79960016661
-
Role of nanomedicine in reversing drug resistance mediated by ATP binding cassette transporters and P-glycoprotein in melanoma
-
Kanwar, J. R.; Singh, N.; Kanwar, R. K. Role of nanomedicine in reversing drug resistance mediated by ATP binding cassette transporters and P-glycoprotein in melanoma. Nanomedicine (Lond) 2011, 6 (4), 701-714.
-
(2011)
Nanomedicine (Lond)
, vol.6
, Issue.4
, pp. 701-714
-
-
Kanwar, J.R.1
Singh, N.2
Kanwar, R.K.3
-
27
-
-
84862615963
-
Delivery of P-glycoprotein substrates using chemosensitizers and nanotechnology for selective and efficient therapeutic outcomes
-
Nieto Montesinos, R.; Beduneau, A.; Pellequer, Y.; Lamprecht, A. Delivery of P-glycoprotein substrates using chemosensitizers and nanotechnology for selective and efficient therapeutic outcomes. J. Control Release 2012, 161 (1), 50-61.
-
(2012)
J. Control Release
, vol.161
, Issue.1
, pp. 50-61
-
-
Nieto Montesinos, R.1
Beduneau, A.2
Pellequer, Y.3
Lamprecht, A.4
-
28
-
-
65649147504
-
Interaction of ABC multidrug transporters with anticancer protein kinase inhibitors: Substrates and/or inhibitors?
-
Hegedus, C.; Ozvegy-Laczka, C.; Szakacs, G.; Sarkadi, B. Interaction of ABC multidrug transporters with anticancer protein kinase inhibitors: substrates and/or inhibitors? Curr. Cancer Drug Targets 2009, 9 (3), 252-272.
-
(2009)
Curr. Cancer Drug Targets
, vol.9
, Issue.3
, pp. 252-272
-
-
Hegedus, C.1
Ozvegy-Laczka, C.2
Szakacs, G.3
Sarkadi, B.4
-
29
-
-
84862811607
-
Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance
-
Shukla, S.; Chen, Z. S.; Ambudkar, S. V. Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance. Drug Resist. Updat. 2012, 15 (1-2), 70-80.
-
(2012)
Drug Resist. Updat
, vol.15
, Issue.1-2
, pp. 70-80
-
-
Shukla, S.1
Chen, Z.S.2
Ambudkar, S.V.3
-
30
-
-
84860671176
-
Collateral sensitivity as a strategy against cancer multidrug resistance
-
Pluchino, K. M.; Hall, M. D.; Goldsborough, A. S.; Callaghan, R.; Gottesman, M. M. Collateral sensitivity as a strategy against cancer multidrug resistance. Drug Resist. Updat. 2012, 15 (1-2), 98-105.
-
(2012)
Drug Resist. Updat
, vol.15
, Issue.1-2
, pp. 98-105
-
-
Pluchino, K.M.1
Hall, M.D.2
Goldsborough, A.S.3
Callaghan, R.4
Gottesman, M.M.5
-
31
-
-
70349176240
-
Is resistance useless? Multidrug resistance and collateral sensitivity
-
Hall, M. D.; Handley, M. D.; Gottesman, M. M. Is resistance useless? Multidrug resistance and collateral sensitivity. Trends Pharmacol. Sci. 2009, 30 (10), 546-556.
-
(2009)
Trends Pharmacol. Sci
, vol.30
, Issue.10
, pp. 546-556
-
-
Hall, M.D.1
Handley, M.D.2
Gottesman, M.M.3
-
32
-
-
84860687790
-
Immunotherapy: A useful strategy to help combat multidrug resistance
-
Curiel, T. J. Immunotherapy: a useful strategy to help combat multidrug resistance. Drug Resist. Updat. 2012, 15 (1-2), 106-113.
-
(2012)
Drug Resist. Updat
, vol.15
, Issue.1-2
, pp. 106-113
-
-
Curiel, T.J.1
-
33
-
-
84860650725
-
Cellular senescence and cancer chemotherapy resistance
-
Gordon, R. R.; Nelson, P. S. Cellular senescence and cancer chemotherapy resistance. Drug Resist. Updat. 2012, 15 (1-2), 123-131.
-
(2012)
Drug Resist. Updat
, vol.15
, Issue.1-2
, pp. 123-131
-
-
Gordon, R.R.1
Nelson, P.S.2
-
34
-
-
84860697028
-
The tumor microenvironment is a dominant force in multidrug resistance
-
Correia, A. L.; Bissell, M. J. The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist. Updat. 2012, 15 (1-2), 39-49.
-
(2012)
Drug Resist. Updat
, vol.15
, Issue.1-2
, pp. 39-49
-
-
Correia, A.L.1
Bissell, M.J.2
-
35
-
-
84862821594
-
Starvation, detoxification, and multidrug resistance in cancer therapy
-
Lee, C.; Raffaghello, L.; Longo, V. D. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist. Updat. 2012, 15 (1-2), 114-122.
-
(2012)
Drug Resist. Updat
, vol.15
, Issue.1-2
, pp. 114-122
-
-
Lee, C.1
Raffaghello, L.2
Longo, V.D.3
-
36
-
-
78651367221
-
ATP-binding cassette transporters in primary central nervous system lymphoma: Decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells
-
Sakata, S.; Fujiwara, M.; Ohtsuka, K.; Kamma, H.; Nagane, M.; Sakamoto, A.; Fujioka, Y. ATP-binding cassette transporters in primary central nervous system lymphoma: decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells. Oncol. Rep. 2011, 25 (2), 333-339.
-
(2011)
Oncol. Rep
, vol.25
, Issue.2
, pp. 333-339
-
-
Sakata, S.1
Fujiwara, M.2
Ohtsuka, K.3
Kamma, H.4
Nagane, M.5
Sakamoto, A.6
Fujioka, Y.7
-
37
-
-
0005582691
-
Transcription of the multidrug resistance gene MDR1: A therapeutic target
-
Scotto, K. W.; Johnson, R. A. Transcription of the multidrug resistance gene MDR1: a therapeutic target. Mol. Interv. 2001, 1 (2), 117-125.
-
(2001)
Mol. Interv
, vol.1
, Issue.2
, pp. 117-125
-
-
Scotto, K.W.1
Johnson, R.A.2
-
38
-
-
77950192396
-
Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin
-
Gao, A.; Wang, X.; Xiang, W.; Liang, H.; Gao, J.; Yan, Y. Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin. J. Pharm. Pharmacol. 2010, 62 (3), 393-399.
-
(2010)
J. Pharm. Pharmacol
, vol.62
, Issue.3
, pp. 393-399
-
-
Gao, A.1
Wang, X.2
Xiang, W.3
Liang, H.4
Gao, J.5
Yan, Y.6
-
39
-
-
79961092091
-
Poloxamines display a multiple inhibitory activity of ATP-binding cassette (ABC) transporters in cancer cell lines
-
Cuestas, M. L.; Sosnik, A.; Mathet, V. L. Poloxamines display a multiple inhibitory activity of ATP-binding cassette (ABC) transporters in cancer cell lines. Mol. Pharm. 2011, 8 (4), 1152-1164.
-
(2011)
Mol. Pharm
, vol.8
, Issue.4
, pp. 1152-1164
-
-
Cuestas, M.L.1
Sosnik, A.2
Mathet, V.L.3
-
40
-
-
34447506459
-
Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
-
Limtrakul, P.; Chearwae, W.; Shukla, S.; Phisalphong, C.; Ambudkar, S. V. Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. Mol. Cell Biochem. 2007, 296 (1-2), 85-95.
-
(2007)
Mol. Cell Biochem
, vol.296
, Issue.1-2
, pp. 85-95
-
-
Limtrakul, P.1
Chearwae, W.2
Shukla, S.3
Phisalphong, C.4
Ambudkar, S.V.5
-
41
-
-
79954447132
-
Effect of MDR modulators verapamil and promethazine on gene expression levels of MDR1 and MRP1 in doxorubicin-resistant MCF-7 cells
-
Donmez, Y.; Akhmetova, L.; Iseri, O. D.; Kars, M. D.; Gunduz, U. Effect of MDR modulators verapamil and promethazine on gene expression levels of MDR1 and MRP1 in doxorubicin-resistant MCF-7 cells. Cancer Chemother. Pharmacol. 2011, 67 (4), 823-828.
-
(2011)
Cancer Chemother. Pharmacol
, vol.67
, Issue.4
, pp. 823-828
-
-
Donmez, Y.1
Akhmetova, L.2
Iseri, O.D.3
Kars, M.D.4
Gunduz, U.5
-
42
-
-
84859376472
-
Molecular pathways: Regulation and therapeutic implications of multidrug resistance
-
Chen, K. G.; Sikic, B. I. Molecular pathways: regulation and therapeutic implications of multidrug resistance. Clin. Cancer Res. 2012, 18 (7), 1863-1869.
-
(2012)
Clin. Cancer Res
, vol.18
, Issue.7
, pp. 1863-1869
-
-
Chen, K.G.1
Sikic, B.I.2
-
43
-
-
0035808413
-
2-acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway
-
Deng, L.; Lin-Lee, Y. C.; Claret, F. X.; Kuo, M. T. 2-acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway. J. Biol. Chem. 2001, 276 (1), 413-420.
-
(2001)
J. Biol. Chem
, vol.276
, Issue.1
, pp. 413-420
-
-
Deng, L.1
Lin-Lee, Y.C.2
Claret, F.X.3
Kuo, M.T.4
-
44
-
-
0037150228
-
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling
-
Kuo, M. T.; Liu, Z.; Wei, Y.; Lin-Lee, Y. C.; Tatebe, S.; Mills, G. B.; Unate, H. Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling. Oncogene 2002, 21 (13), 1945-1954.
-
(2002)
Oncogene
, vol.21
, Issue.13
, pp. 1945-1954
-
-
Kuo, M.T.1
Liu, Z.2
Wei, Y.3
Lin-Lee, Y.C.4
Tatebe, S.5
Mills, G.B.6
Unate, H.7
-
45
-
-
1542405935
-
Reactive oxygen species (ROS), troublemakers between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK)
-
Zhang, Y.; Chen, F. Reactive oxygen species (ROS), troublemakers between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK). Cancer Res. 2004, 64 (6), 1902-1905.
-
(2004)
Cancer Res
, vol.64
, Issue.6
, pp. 1902-1905
-
-
Zhang, Y.1
Chen, F.2
-
46
-
-
84862736573
-
Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells
-
Cheng, Z.; Yang, N.; Liang, W.; Yan, X.; Li, L.; Pan, L. Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells. Leuk. Lymphoma 2012, 53 (7), 1383-1389.
-
(2012)
Leuk. Lymphoma
, vol.53
, Issue.7
, pp. 1383-1389
-
-
Cheng, Z.1
Yang, N.2
Liang, W.3
Yan, X.4
Li, L.5
Pan, L.6
-
47
-
-
17144410320
-
Differential regulation of MDR1 transcription by the p53 family members. Role of the DNA binding domain
-
Johnson, R. A.; Shepard, E. M.; Scotto, K. W. Differential regulation of MDR1 transcription by the p53 family members. Role of the DNA binding domain. J. Biol. Chem. 2005, 280 (14), 13213-13219.
-
(2005)
J. Biol. Chem
, vol.280
, Issue.14
, pp. 13213-13219
-
-
Johnson, R.A.1
Shepard, E.M.2
Scotto, K.W.3
-
48
-
-
79955137781
-
Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma
-
Shen, H.; Xu, W.; Luo, W.; Zhou, L.; Yong, W.; Chen, F.; Wu, C.; Chen, Q.; Han, X. Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma. Exp. Hematol. 2011, 39 (5), 558-569.
-
(2011)
Exp. Hematol
, vol.39
, Issue.5
, pp. 558-569
-
-
Shen, H.1
Xu, W.2
Luo, W.3
Zhou, L.4
Yong, W.5
Chen, F.6
Wu, C.7
Chen, Q.8
Han, X.9
-
49
-
-
34447321311
-
Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein
-
Katayama, K.; Yoshioka, S.; Tsukahara, S.; Mitsuhashi, J.; Sugimoto, Y. Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein. Mol. Cancer Ther. 2007, 6 (7), 2092-2102.
-
(2007)
Mol. Cancer Ther
, vol.6
, Issue.7
, pp. 2092-2102
-
-
Katayama, K.1
Yoshioka, S.2
Tsukahara, S.3
Mitsuhashi, J.4
Sugimoto, Y.5
-
50
-
-
62649113168
-
Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells
-
Stratford, A. L.; Fry, C. J.; Desilets, C.; Davies, A. H.; Cho, Y. Y.; Li, Y.; Dong, Z.; Berquin, I. M.; Roux, P. P.; Dunn, S. E. Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells. Breast Cancer Res. 2008, 10 (6), R99.
-
(2008)
Breast Cancer Res
, vol.10
, Issue.6
-
-
Stratford, A.L.1
Fry, C.J.2
Desilets, C.3
Davies, A.H.4
Cho, Y.Y.5
Li, Y.6
Dong, Z.7
Berquin, I.M.8
Roux, P.P.9
Dunn, S.E.10
-
51
-
-
84857197449
-
Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment
-
Akiyama, K.; Ohga, N.; Hida, Y.; Kawamoto, T.; Sadamoto, Y.; Ishikawa, S.; Maishi, N.; Akino, T.; Kondoh, M.; Matsuda, A.; Inoue, N.; Shindoh, M.; Hida, K. Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment. Am. J. Pathol. 2012, 180 (3), 1283-1293.
-
(2012)
Am. J. Pathol
, vol.180
, Issue.3
, pp. 1283-1293
-
-
Akiyama, K.1
Ohga, N.2
Hida, Y.3
Kawamoto, T.4
Sadamoto, Y.5
Ishikawa, S.6
Maishi, N.7
Akino, T.8
Kondoh, M.9
Matsuda, A.10
Inoue, N.11
Shindoh, M.12
Hida, K.13
-
52
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza, G. L. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010, 29 (5), 625-634.
-
(2010)
Oncogene
, vol.29
, Issue.5
, pp. 625-634
-
-
Semenza, G.L.1
-
53
-
-
79957534572
-
Targeting hypoxia in cancer therapy
-
Wilson, W. R.; Hay, M. P. Targeting hypoxia in cancer therapy. Nat. Rev. Cancer 2011, 11 (6), 393-410.
-
(2011)
Nat. Rev. Cancer
, vol.11
, Issue.6
, pp. 393-410
-
-
Wilson, W.R.1
Hay, M.P.2
-
54
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G. L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003, 3 (10), 721-732.
-
(2003)
Nat. Rev. Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
55
-
-
84870197971
-
Therapeutic delivery of siRNA silencing HIF-1 alpha with micellar nanoparticles inhibits hypoxic tumor growth
-
Liu, X. Q.; Xiong, M. H.; Shu, X. T.; Tang, R. Z.; Wang, J. Therapeutic delivery of siRNA silencing HIF-1 alpha with micellar nanoparticles inhibits hypoxic tumor growth. Mol. Pharm. 2012, 9 (10), 2863-2874.
-
(2012)
Mol. Pharm
, vol.9
, Issue.10
, pp. 2863-2874
-
-
Liu, X.Q.1
Xiong, M.H.2
Shu, X.T.3
Tang, R.Z.4
Wang, J.5
-
56
-
-
78650797956
-
Zinc downregulates HIF-1alpha and inhibits its activity in tumor cells in vitro and in vivo
-
Nardinocchi, L.; Pantisano, V.; Puca, R.; Porru, M.; Aiello, A.; Grasselli, A.; Leonetti, C.; Safran, M.; Rechavi, G.; Givol, D.; Farsetti, A.; D'Orazi, G. Zinc downregulates HIF-1alpha and inhibits its activity in tumor cells in vitro and in vivo. PLoS One 2010, 5 (12), e15048.
-
(2010)
PLoS One
, vol.5
, Issue.12
-
-
Nardinocchi, L.1
Pantisano, V.2
Puca, R.3
Porru, M.4
Aiello, A.5
Grasselli, A.6
Leonetti, C.7
Safran, M.8
Rechavi, G.9
Givol, D.10
Farsetti, A.11
D'Orazi, G.12
-
57
-
-
69949108875
-
Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha
-
Nardinocchi, L.; Puca, R.; Sacchi, A.; Rechavi, G.; Givol, D.; D'Orazi, G. Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha. PLoS One 2009, 4 (8), e6819.
-
(2009)
PLoS One
, vol.4
, Issue.8
-
-
Nardinocchi, L.1
Puca, R.2
Sacchi, A.3
Rechavi, G.4
Givol, D.5
D'Orazi, G.6
-
58
-
-
80053049211
-
Various doses of fractioned irradiation modulates multidrug resistance 1 expression differently through hypoxia-inducible factor 1alpha in esophageal cancer cells
-
Zhang, G. J.; Gao, R.; Wang, J. S.; Fu, J. K.; Zhang, M. X.; Jin, X. Various doses of fractioned irradiation modulates multidrug resistance 1 expression differently through hypoxia-inducible factor 1alpha in esophageal cancer cells. Dis. Esophagus 2011, 24 (7), 481-488.
-
(2011)
Dis. Esophagus
, vol.24
, Issue.7
, pp. 481-488
-
-
Zhang, G.J.1
Gao, R.2
Wang, J.S.3
Fu, J.K.4
Zhang, M.X.5
Jin, X.6
-
59
-
-
84862818535
-
Recent advances in hypoxiainducible factor (HIF)-1 inhibitors
-
Xia, Y.; Choi, H. K.; Lee, K. Recent advances in hypoxiainducible factor (HIF)-1 inhibitors. Eur. J. Med. Chem. 2012, 49, 24-40.
-
(2012)
Eur. J. Med. Chem
, vol.49
, pp. 24-40
-
-
Xia, Y.1
Choi, H.K.2
Lee, K.3
-
60
-
-
34250795145
-
Post-transcriptional regulation of P-glycoprotein expression in cancer cell lines
-
Gomez-Martinez, A.; Garcia-Morales, P.; Carrato, A.; Castro-Galache, M. D.; Soto, J. L.; Carrasco-Garcia, E.; Garcia-Bautista, M.; Guaraz, P.; Ferragut, J. A.; Saceda, M. Post-transcriptional regulation of P-glycoprotein expression in cancer cell lines. Mol. Cancer Res. 2007, 5 (6), 641-653.
-
(2007)
Mol. Cancer Res
, vol.5
, Issue.6
, pp. 641-653
-
-
Gomez-Martinez, A.1
Garcia-Morales, P.2
Carrato, A.3
Castro-Galache, M.D.4
Soto, J.L.5
Carrasco-Garcia, E.6
Garcia-Bautista, M.7
Guaraz, P.8
Ferragut, J.A.9
Saceda, M.10
-
61
-
-
0031861729
-
Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y
-
Jin, S.; Scotto, K. W. Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. Mol. Cell Biol. 1998, 18 (7), 4377-4384.
-
(1998)
Mol. Cell Biol
, vol.18
, Issue.7
, pp. 4377-4384
-
-
Jin, S.1
Scotto, K.W.2
-
62
-
-
78650176650
-
Up-regulation of ABCB1/P-glycoprotein by escaping promoter hypermethylation indicates poor prognosis in hematologic malignancy patients with and without bone marrow transplantation
-
Shi, C. J.; Wang, F.; Ren, M. F.; Mi, Y. J.; Yan, Y. Y.; To, K. K.; Dai, C. L.; Wang, Y. S.; Chen, L. M.; Tong, X. Z.; Liang, Y. J.; Fu, L. W. Up-regulation of ABCB1/P-glycoprotein by escaping promoter hypermethylation indicates poor prognosis in hematologic malignancy patients with and without bone marrow transplantation. Leuk. Res. 2011, 35 (1), 73-79.
-
(2011)
Leuk. Res
, vol.35
, Issue.1
, pp. 73-79
-
-
Shi, C.J.1
Wang, F.2
Ren, M.F.3
Mi, Y.J.4
Yan, Y.Y.5
To, K.K.6
Dai, C.L.7
Wang, Y.S.8
Chen, L.M.9
Tong, X.Z.10
Liang, Y.J.11
Fu, L.W.12
-
63
-
-
84860652628
-
Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance
-
Wilting, R. H.; Dannenberg, J. H. Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance. Drug Resist. Updat. 2012, 15 (1-2), 21-38.
-
(2012)
Drug Resist. Updat
, vol.15
, Issue.1-2
, pp. 21-38
-
-
Wilting, R.H.1
Dannenberg, J.H.2
-
64
-
-
84866183997
-
Dual regulation of P-glycoprotein expression by trichostatin A in cancer cell lines
-
Balaguer, T. M.; Gomez-Martinez, A.; Garcia-Morales, P.; Lacueva, J.; Calpena, R.; Reverte, L. R.; Riquelme, N. L.; Martinez-Lacaci, I.; Ferragut, J. A.; Saceda, M. Dual regulation of P-glycoprotein expression by trichostatin A in cancer cell lines. BMC Mol. Biol. 2012, 13, 25.
-
(2012)
BMC Mol. Biol
, vol.13
, pp. 25
-
-
Balaguer, T.M.1
Gomez-Martinez, A.2
Garcia-Morales, P.3
Lacueva, J.4
Calpena, R.5
Reverte, L.R.6
Riquelme, N.L.7
Martinez-Lacaci, I.8
Ferragut, J.A.9
Saceda, M.10
-
65
-
-
79952932076
-
Histone deacetylase inhibitors: Molecular mechanisms of action and clinical trials as anti-cancer drugs
-
Kim, H. J.; Bae, S. C. Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs. Am. J. Transl. Res. 2011, 3 (2), 166-179.
-
(2011)
Am. J. Transl. Res
, vol.3
, Issue.2
, pp. 166-179
-
-
Kim, H.J.1
Bae, S.C.2
-
66
-
-
34547864236
-
Histone deacetylase inhibitors: Molecular mechanisms of action
-
Xu, W. S.; Parmigiani, R. B.; Marks, P. A. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 2007, 26 (37), 5541-5552.
-
(2007)
Oncogene
, vol.26
, Issue.37
, pp. 5541-5552
-
-
Xu, W.S.1
Parmigiani, R.B.2
Marks, P.A.3
-
67
-
-
78649905409
-
Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions
-
Marks, P. A. Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions. Biochim. Biophys. Acta 2010, 1799 (10-12), 717-725.
-
(2010)
Biochim. Biophys. Acta
, vol.1799
, Issue.10-12
, pp. 717-725
-
-
Marks, P.A.1
-
68
-
-
77957705615
-
UHRF1 inhibits MDR1 gene transcription and sensitizes breast cancer cells to anticancer drugs
-
Jin, W.; Liu, Y.; Xu, S. G.; Yin, W. J.; Li, J. J.; Yang, J. M.; Shao, Z. M. UHRF1 inhibits MDR1 gene transcription and sensitizes breast cancer cells to anticancer drugs. Breast Cancer Res. Treat. 2010, 124 (1), 39-48.
-
(2010)
Breast Cancer Res. Treat
, vol.124
, Issue.1
, pp. 39-48
-
-
Jin, W.1
Liu, Y.2
Xu, S.G.3
Yin, W.J.4
Li, J.J.5
Yang, J.M.6
Shao, Z.M.7
-
69
-
-
79951487862
-
Genetic and epigenetic changes in human prostate cancer
-
Koochekpour, S. Genetic and epigenetic changes in human prostate cancer. Iran. Red Crescent Med. J. 2011, 13 (2), 80-98.
-
(2011)
Iran. Red Crescent Med. J
, vol.13
, Issue.2
, pp. 80-98
-
-
Koochekpour, S.1
-
70
-
-
35848939204
-
Cobalamin potentiates vinblastine cytotoxicity through downregulation of mdr-1 gene expression in HepG2 cells
-
Marguerite, V.; Beri-Dexheimer, M.; Ortiou, S.; Gueant, J. L.; Merten, M. Cobalamin potentiates vinblastine cytotoxicity through downregulation of mdr-1 gene expression in HepG2 cells. Cell. Physiol. Biochem. 2007, 20 (6), 967-976.
-
(2007)
Cell. Physiol. Biochem
, vol.20
, Issue.6
, pp. 967-976
-
-
Marguerite, V.1
Beri-Dexheimer, M.2
Ortiou, S.3
Gueant, J.L.4
Merten, M.5
-
71
-
-
84867441742
-
Dysregulation of microRNAs in cancer
-
Chen, P. S.; Su, J. L.; Hung, M. C. Dysregulation of microRNAs in cancer. J. Biomed. Sci. 2012, 19, 90.
-
(2012)
J. Biomed. Sci
, vol.19
, pp. 90
-
-
Chen, P.S.1
Su, J.L.2
Hung, M.C.3
-
72
-
-
84872745556
-
MicroRNA-145 post-transcriptionally regulates the expression and function of P-glycoprotein in intestinal epithelial cells
-
Ikemura, K.; Yamamoto, M.; Miyazaki, S.; Mizutani, H.; Iwamoto, T.; Okuda, M. MicroRNA-145 post-transcriptionally regulates the expression and function of P-glycoprotein in intestinal epithelial cells. Mol. Pharmacol. 2013, 83 (2), 399-405.
-
(2013)
Mol. Pharmacol
, vol.83
, Issue.2
, pp. 399-405
-
-
Ikemura, K.1
Yamamoto, M.2
Miyazaki, S.3
Mizutani, H.4
Iwamoto, T.5
Okuda, M.6
-
73
-
-
84861591908
-
Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298
-
Bao, L.; Hazari, S.; Mehra, S.; Kaushal, D.; Moroz, K.; Dash, S. Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298. Am. J. Pathol. 2012, 180 (6), 2490-2503.
-
(2012)
Am. J. Pathol
, vol.180
, Issue.6
, pp. 2490-2503
-
-
Bao, L.1
Hazari, S.2
Mehra, S.3
Kaushal, D.4
Moroz, K.5
Dash, S.6
-
74
-
-
84864629063
-
Regulation exerted by miRNAs in the promoter and UTR sequences: MDR1/P-gp expression as a particular case
-
Toscano-Garibay, J. D.; Aquino-Jarquin, G. Regulation exerted by miRNAs in the promoter and UTR sequences: MDR1/P-gp expression as a particular case. DNA Cell Biol. 2012, 31 (8), 1358-1364.
-
(2012)
DNA Cell Biol
, vol.31
, Issue.8
, pp. 1358-1364
-
-
Toscano-Garibay, J.D.1
Aquino-Jarquin, G.2
-
75
-
-
78650491562
-
Resistance may not be futile: MicroRNA biomarkers for chemoresistance and potential therapeutics
-
Allen, K. E.; Weiss, G. J. Resistance may not be futile: microRNA biomarkers for chemoresistance and potential therapeutics. Mol. Cancer Ther. 2010, 9 (12), 3126-3136.
-
(2010)
Mol. Cancer Ther
, vol.9
, Issue.12
, pp. 3126-3136
-
-
Allen, K.E.1
Weiss, G.J.2
-
76
-
-
34748865948
-
Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells
-
Masuyama, H.; Nakatsukasa, H.; Takamoto, N.; Hiramatsu, Y. Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells. Mol. Pharmacol. 2007, 72 (4), 1045-1053.
-
(2007)
Mol. Pharmacol
, vol.72
, Issue.4
, pp. 1045-1053
-
-
Masuyama, H.1
Nakatsukasa, H.2
Takamoto, N.3
Hiramatsu, Y.4
-
77
-
-
44149109915
-
Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: Studies with anti-human immunodeficiency virus protease inhibitors
-
Gupta, A.; Mugundu, G. M.; Desai, P. B.; Thummel, K. E.; Unadkat, J. D. Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors. Drug Metab. Dispos. 2008, 36 (6), 1172-1180.
-
(2008)
Drug Metab. Dispos
, vol.36
, Issue.6
, pp. 1172-1180
-
-
Gupta, A.1
Mugundu, G.M.2
Desai, P.B.3
Thummel, K.E.4
Unadkat, J.D.5
-
78
-
-
84862813487
-
Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters
-
Chen, Y.; Tang, Y.; Guo, C.; Wang, J.; Boral, D.; Nie, D. Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. Biochem. Pharmacol. 2012, 83 (8), 1112-1126.
-
(2012)
Biochem. Pharmacol
, vol.83
, Issue.8
, pp. 1112-1126
-
-
Chen, Y.1
Tang, Y.2
Guo, C.3
Wang, J.4
Boral, D.5
Nie, D.6
-
79
-
-
84868497825
-
Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response
-
Pondugula, S. R.; Mani, S. Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response. Cancer Lett. 2013, 328 (1), 1-9.
-
(2013)
Cancer Lett
, vol.328
, Issue.1
, pp. 1-9
-
-
Pondugula, S.R.1
Mani, S.2
-
80
-
-
0042591363
-
Transcription factor c-Jun activation represses mdr-1 gene expression
-
Miao, Z. H.; Ding, J. Transcription factor c-Jun activation represses mdr-1 gene expression. Cancer Res. 2003, 63 (15), 4527-4532.
-
(2003)
Cancer Res
, vol.63
, Issue.15
, pp. 4527-4532
-
-
Miao, Z.H.1
Ding, J.2
-
81
-
-
73949094806
-
Immunosuppressors as multidrug resistance reversal agents
-
Morjani, H.; Madoulet, C. Immunosuppressors as multidrug resistance reversal agents. Methods Mol. Biol. 2010, 596, 433-446.
-
(2010)
Methods Mol. Biol
, vol.596
, pp. 433-446
-
-
Morjani, H.1
Madoulet, C.2
-
82
-
-
77951890193
-
PSC833, cyclosporine analogue, downregulates MDR1 expression by activating JNK/c-Jun/AP-1 and suppressing NF-kappaB
-
Bark, H.; Choi, C. H. PSC833, cyclosporine analogue, downregulates MDR1 expression by activating JNK/c-Jun/AP-1 and suppressing NF-kappaB. Cancer Chemother. Pharmacol. 2010, 65 (6), 1131-1136.
-
(2010)
Cancer Chemother. Pharmacol
, vol.65
, Issue.6
, pp. 1131-1136
-
-
Bark, H.1
Choi, C.H.2
-
83
-
-
84860622188
-
The proteasome inhibitor bortezomib reverses Pglycoprotein-mediated leukemia multi-drug resistance through the NF-kappaB pathway
-
Wang, H.; Wang, X.; Li, Y.; Liao, A.; Fu, B.; Pan, H.; Liu, Z.; Yang, W. The proteasome inhibitor bortezomib reverses Pglycoprotein-mediated leukemia multi-drug resistance through the NF-kappaB pathway. Pharmazie 2012, 67 (2), 187-192.
-
(2012)
Pharmazie
, vol.67
, Issue.2
, pp. 187-192
-
-
Wang, H.1
Wang, X.2
Li, Y.3
Liao, A.4
Fu, B.5
Pan, H.6
Liu, Z.7
Yang, W.8
-
84
-
-
84855208681
-
Oroxylin A reverses multi-drug resistance of human hepatoma BEL7402/5-FU cells via downregulation of P-glycoprotein expression by inhibiting NF-kappaB signaling pathway
-
Yang, H. Y.; Zhao, L.; Yang, Z.; Zhao, Q.; Qiang, L.; Ha, J.; Li, Z. Y.; You, Q. D.; Guo, Q. L. Oroxylin A reverses multi-drug resistance of human hepatoma BEL7402/5-FU cells via downregulation of P-glycoprotein expression by inhibiting NF-kappaB signaling pathway. Mol. Carcinog. 2012, 51 (2), 185-195.
-
(2012)
Mol. Carcinog
, vol.51
, Issue.2
, pp. 185-195
-
-
Yang, H.Y.1
Zhao, L.2
Yang, Z.3
Zhao, Q.4
Qiang, L.5
Ha, J.6
Li, Z.Y.7
You, Q.D.8
Guo, Q.L.9
-
85
-
-
36849021582
-
Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway
-
Choi, B. H.; Kim, C. G.; Lim, Y.; Shin, S. Y.; Lee, Y. H. Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway. Cancer Lett. 2008, 259 (1), 111-118.
-
(2008)
Cancer Lett
, vol.259
, Issue.1
, pp. 111-118
-
-
Choi, B.H.1
Kim, C.G.2
Lim, Y.3
Shin, S.Y.4
Lee, Y.H.5
-
86
-
-
84865282157
-
Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-kappaB signaling pathway in a human breast cancer cell line
-
Lin, X.; Zhang, X.; Wang, Q.; Li, J.; Zhang, P.; Zhao, M.; Li, X. Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-kappaB signaling pathway in a human breast cancer cell line. Neoplasma 2012, 59 (3), 248-256.
-
(2012)
Neoplasma
, vol.59
, Issue.3
, pp. 248-256
-
-
Lin, X.1
Zhang, X.2
Wang, Q.3
Li, J.4
Zhang, P.5
Zhao, M.6
Li, X.7
-
87
-
-
79551489371
-
Metformin inhibits P-glycoprotein expression via the NF-kappaB pathway and CRE transcriptional activity through AMPK activation
-
Kim, H. G.; Hien, T. T.; Han, E. H.; Hwang, Y. P.; Choi, J. H.; Kang, K. W.; Kwon, K. I.; Kim, B. H.; Kim, S. K.; Song, G. Y.; Jeong, T. C.; Jeong, H. G. Metformin inhibits P-glycoprotein expression via the NF-kappaB pathway and CRE transcriptional activity through AMPK activation. Br. J. Pharmacol. 2011, 162 (5), 1096-1108.
-
(2011)
Br. J. Pharmacol
, vol.162
, Issue.5
, pp. 1096-1108
-
-
Kim, H.G.1
Hien, T.T.2
Han, E.H.3
Hwang, Y.P.4
Choi, J.H.5
Kang, K.W.6
Kwon, K.I.7
Kim, B.H.8
Kim, S.K.9
Song, G.Y.10
Jeong, T.C.11
Jeong, H.G.12
-
88
-
-
77954633764
-
Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMPactivated protein kinase in breast cancer MCF-7/adr cells
-
Hien, T. T.; Kim, H. G.; Han, E. H.; Kang, K. W.; Jeong, H. G. Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMPactivated protein kinase in breast cancer MCF-7/adr cells. Mol. Nutr. Food Res. 2010, 54 (7), 918-928.
-
(2010)
Mol. Nutr. Food Res
, vol.54
, Issue.7
, pp. 918-928
-
-
Hien, T.T.1
Kim, H.G.2
Han, E.H.3
Kang, K.W.4
Jeong, H.G.5
-
89
-
-
9144271181
-
AMPactivated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
-
Zang, M.; Zuccollo, A.; Hou, X.; Nagata, D.; Walsh, K.; Herscovitz, H.; Brecher, P.; Ruderman, N. B.; Cohen, R. A. AMPactivated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J. Biol. Chem. 2004, 279 (46), 47898-47905.
-
(2004)
J. Biol. Chem
, vol.279
, Issue.46
, pp. 47898-47905
-
-
Zang, M.1
Zuccollo, A.2
Hou, X.3
Nagata, D.4
Walsh, K.5
Herscovitz, H.6
Brecher, P.7
Ruderman, N.B.8
Cohen, R.A.9
-
90
-
-
34248186686
-
Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells
-
Yu, S. T.; Chen, T. M.; Tseng, S. Y.; Chen, Y. H. Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells. Biochem. Biophys. Res. Commun 2007, 358 (1), 79-84.
-
(2007)
Biochem. Biophys. Res. Commun
, vol.358
, Issue.1
, pp. 79-84
-
-
Yu, S.T.1
Chen, T.M.2
Tseng, S.Y.3
Chen, Y.H.4
-
91
-
-
71949120643
-
Cyclo-oxygenase 2 modulates chemoresistance in breast cancer cells involving NF-kappaB
-
Zatelli, M. C.; Mole, D.; Tagliati, F.; Minoia, M.; Ambrosio, M. R.; degli Uberti, E. Cyclo-oxygenase 2 modulates chemoresistance in breast cancer cells involving NF-kappaB. Cell. Oncol. 2009, 31 (6), 457-465.
-
(2009)
Cell. Oncol
, vol.31
, Issue.6
, pp. 457-465
-
-
Zatelli, M.C.1
Mole, D.2
Tagliati, F.3
Minoia, M.4
Ambrosio, M.R.5
degli Uberti, E.6
-
92
-
-
77951912375
-
Cyclo-oxygenase 2 up-regulates the effect of multidrug resistance
-
Liu, B.; Qu, L.; Tao, H. Cyclo-oxygenase 2 up-regulates the effect of multidrug resistance. Cell Biol. Int. 2010, 34 (1), 21-25.
-
(2010)
Cell Biol. Int
, vol.34
, Issue.1
, pp. 21-25
-
-
Liu, B.1
Qu, L.2
Tao, H.3
-
93
-
-
33644673861
-
Cyclooxygenaseindependent down-regulation of multidrug resistance-associated protein-1 expression by celecoxib in human lung cancer cells
-
Kang, H. K.; Lee, E.; Pyo, H.; Lim, S. J. Cyclooxygenaseindependent down-regulation of multidrug resistance-associated protein-1 expression by celecoxib in human lung cancer cells. Mol. Cancer Ther. 2005, 4 (9), 1358-1363.
-
(2005)
Mol. Cancer Ther
, vol.4
, Issue.9
, pp. 1358-1363
-
-
Kang, H.K.1
Lee, E.2
Pyo, H.3
Lim, S.J.4
-
94
-
-
78751615758
-
Preventing chemoresistance of human breast cancer cell line, MCF-7 with celecoxib
-
Chen, C.; Shen, H. L.; Yang, J.; Chen, Q. Y.; Xu, W. L. Preventing chemoresistance of human breast cancer cell line, MCF-7 with celecoxib. J. Cancer Res. Clin. Oncol. 2011, 137 (1), 9-17.
-
(2011)
J. Cancer Res. Clin. Oncol
, vol.137
, Issue.1
, pp. 9-17
-
-
Chen, C.1
Shen, H.L.2
Yang, J.3
Chen, Q.Y.4
Xu, W.L.5
-
95
-
-
70350422423
-
Insights into the reactivation of cobalamin-dependent methionine synthase
-
Koutmos, M.; Datta, S.; Pattridge, K. A.; Smith, J. L.; Matthews, R. G. Insights into the reactivation of cobalamin-dependent methionine synthase. Proc. Natl. Acad. Sci. USA, 2009, 106 (44), 18527-18532.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, Issue.44
, pp. 18527-18532
-
-
Koutmos, M.1
Datta, S.2
Pattridge, K.A.3
Smith, J.L.4
Matthews, R.G.5
-
96
-
-
41949141389
-
Inhibition of MDR1 expression by retinol treatment increases sensitivity to etoposide (VP16) in human neoplasic cell line
-
Klamt, F.; Passos, D. T.; Castro, M. A.; Gelain, D. P.; Grivicich, I.; Moreira, J. C. Inhibition of MDR1 expression by retinol treatment increases sensitivity to etoposide (VP16) in human neoplasic cell line. Toxicol. In Vitro 2008, 22 (4), 873-878.
-
(2008)
Toxicol. In Vitro
, vol.22
, Issue.4
, pp. 873-878
-
-
Klamt, F.1
Passos, D.T.2
Castro, M.A.3
Gelain, D.P.4
Grivicich, I.5
Moreira, J.C.6
-
97
-
-
33646840483
-
Suppression of P-glycoprotein expression by antipsychotics trifluoperazine in adriamycin-resistant L1210 mouse leukemia cells
-
Shin, S. Y.; Choi, B. H.; Kim, J. R.; Kim, J. H.; Lee, Y. H. Suppression of P-glycoprotein expression by antipsychotics trifluoperazine in adriamycin-resistant L1210 mouse leukemia cells. Eur. J. Pharm. Sci. 2006, 28 (4), 300-306.
-
(2006)
Eur. J. Pharm. Sci
, vol.28
, Issue.4
, pp. 300-306
-
-
Shin, S.Y.1
Choi, B.H.2
Kim, J.R.3
Kim, J.H.4
Lee, Y.H.5
-
98
-
-
44449121844
-
Effect of the novel antipsychotic drug perospirone on P-glycoprotein function and expression in Caco-2 cells
-
Zhou, Y. G.; Li, K. Y.; Li, H. D. Effect of the novel antipsychotic drug perospirone on P-glycoprotein function and expression in Caco-2 cells. Eur. J. Clin. Pharmacol. 2008, 64 (7), 697-703.
-
(2008)
Eur. J. Clin. Pharmacol
, vol.64
, Issue.7
, pp. 697-703
-
-
Zhou, Y.G.1
Li, K.Y.2
Li, H.D.3
-
99
-
-
54049144205
-
Cantharidin reverses multidrug resistance of human hepatoma HepG2/ADM cells via down-regulation of P-glycoprotein expression
-
Zheng, L. H.; Bao, Y. L.; Wu, Y.; Yu, C. L.; Meng, X.; Li, Y. X. Cantharidin reverses multidrug resistance of human hepatoma HepG2/ADM cells via down-regulation of P-glycoprotein expression. Cancer Lett. 2008, 272 (1), 102-109.
-
(2008)
Cancer Lett
, vol.272
, Issue.1
, pp. 102-109
-
-
Zheng, L.H.1
Bao, Y.L.2
Wu, Y.3
Yu, C.L.4
Meng, X.5
Li, Y.X.6
-
100
-
-
77956178476
-
Reversal of P-glycoproteinmediated multidrug resistance in vitro by milbemycin compounds in adriamycin-resistant human breast carcinoma (MCF-7/adr) cells
-
Xiang, W.; Gao, A.; Liang, H.; Li, C.; Gao, J.; Wang, Q.; Shuang, B.; Zhang, J.; Yan, Y.; Wang, X. Reversal of P-glycoproteinmediated multidrug resistance in vitro by milbemycin compounds in adriamycin-resistant human breast carcinoma (MCF-7/adr) cells. Toxicol. In Vitro 2010, 24 (6), 1474-1481.
-
(2010)
Toxicol. In Vitro
, vol.24
, Issue.6
, pp. 1474-1481
-
-
Xiang, W.1
Gao, A.2
Liang, H.3
Li, C.4
Gao, J.5
Wang, Q.6
Shuang, B.7
Zhang, J.8
Yan, Y.9
Wang, X.10
-
101
-
-
33749453246
-
Reversal of drug resistance in P-glycoprotein-expressing T-cell acute lymphoblastic CEM leukemia cells by copper N-(2-hydroxy acetophenone) glycinate and oxalyl bis (N-phenyl) hydroxamic acid
-
Majumder, S.; Dutta, P.; Mukherjee, P.; Datta, E. R.; Efferth, T.; Bhattacharya, S.; Choudhuri, S. K. Reversal of drug resistance in P-glycoprotein-expressing T-cell acute lymphoblastic CEM leukemia cells by copper N-(2-hydroxy acetophenone) glycinate and oxalyl bis (N-phenyl) hydroxamic acid. Cancer Lett. 2006, 244 (1), 16-23.
-
(2006)
Cancer Lett
, vol.244
, Issue.1
, pp. 16-23
-
-
Majumder, S.1
Dutta, P.2
Mukherjee, P.3
Datta, E.R.4
Efferth, T.5
Bhattacharya, S.6
Choudhuri, S.K.7
-
102
-
-
77955505177
-
A review of trabectedin (ET-743): A unique mechanism of action
-
D'Incalci, M.; Galmarini, C. M. A review of trabectedin (ET-743): a unique mechanism of action. Mol. Cancer Ther. 2010, 9 (8), 2157-2163.
-
(2010)
Mol. Cancer Ther
, vol.9
, Issue.8
, pp. 2157-2163
-
-
D'Incalci, M.1
Galmarini, C.M.2
-
103
-
-
72949084796
-
Trabectedin: An anticancer drug from the sea
-
Ganjoo, K. N.; Patel, S. R. Trabectedin: an anticancer drug from the sea. Expert. Opin. Pharmacother. 2009, 10 (16), 2735-2743.
-
(2009)
Expert. Opin. Pharmacother
, vol.10
, Issue.16
, pp. 2735-2743
-
-
Ganjoo, K.N.1
Patel, S.R.2
-
104
-
-
77952921894
-
Wide-spectrum characterization of trabectedin: Biology, clinical activity and future perspectives
-
Vincenzi, B.; Napolitano, A.; Frezza, A. M.; Schiavon, G.; Santini, D.; Tonini, G. Wide-spectrum characterization of trabectedin: biology, clinical activity and future perspectives. Pharmacogenomics 2010, 11 (6), 865-878.
-
(2010)
Pharmacogenomics
, vol.11
, Issue.6
, pp. 865-878
-
-
Vincenzi, B.1
Napolitano, A.2
Frezza, A.M.3
Schiavon, G.4
Santini, D.5
Tonini, G.6
-
105
-
-
84880025072
-
Complete remission of recurrent ovarian clear cell carcinoma by chemotherapy with bevacizumab, trabectedin and oxaliplatin
-
Takano, M.; Ikeda, Y.; Kudoh, K.; Kita, T.; Sasaki, N.; Kikuchi, Y. Complete remission of recurrent ovarian clear cell carcinoma by chemotherapy with bevacizumab, trabectedin and oxaliplatin. J. Obstet. Gynaecol. Res. 2013, 39 (4), 872-875.
-
(2013)
J. Obstet. Gynaecol. Res
, vol.39
, Issue.4
, pp. 872-875
-
-
Takano, M.1
Ikeda, Y.2
Kudoh, K.3
Kita, T.4
Sasaki, N.5
Kikuchi, Y.6
-
106
-
-
84867525162
-
Trabectedin as a new chemotherapy option in the treatment of relapsed platinum sensitive ovarian cancer
-
Monk, B. J.; Dalton, H.; Benjamin, I.; Tanovic, A. Trabectedin as a new chemotherapy option in the treatment of relapsed platinum sensitive ovarian cancer. Curr. Pharm. Des. 2012, 18 (25), 3754-3769.
-
(2012)
Curr. Pharm. Des
, vol.18
, Issue.25
, pp. 3754-3769
-
-
Monk, B.J.1
Dalton, H.2
Benjamin, I.3
Tanovic, A.4
-
107
-
-
84867533023
-
Advances in epithelial ovarian cancer therapy
-
Kroep, J. R. Advances in epithelial ovarian cancer therapy. Curr. Pharm. Des. 2012, 18 (25), 3735-3740.
-
(2012)
Curr. Pharm. Des
, vol.18
, Issue.25
, pp. 3735-3740
-
-
Kroep, J.R.1
-
108
-
-
84862099775
-
Efficacy of trabectedin in patients with advanced or metastatic alveolar soft-part sarcoma
-
Pink, D.; Bertz-Lepel, J.; Busemann, C.; Bitz, U.; Reichardt, P. Efficacy of trabectedin in patients with advanced or metastatic alveolar soft-part sarcoma. Onkologie 2012, 35 (5), 249-252.
-
(2012)
Onkologie
, vol.35
, Issue.5
, pp. 249-252
-
-
Pink, D.1
Bertz-Lepel, J.2
Busemann, C.3
Bitz, U.4
Reichardt, P.5
-
109
-
-
84255167300
-
Clinical and pharmacokinetic evaluation of trabectedin for the treatment of soft-tissue sarcoma
-
Cioffi, A.; Italiano, A. Clinical and pharmacokinetic evaluation of trabectedin for the treatment of soft-tissue sarcoma. Expert Opin. Drug Metab. Toxicol. 2012, 8 (1), 113-122.
-
(2012)
Expert Opin. Drug Metab. Toxicol
, vol.8
, Issue.1
, pp. 113-122
-
-
Cioffi, A.1
Italiano, A.2
-
110
-
-
84455194180
-
Trabectedin registry
-
Kubackova, K.; Finek, J.; Vyzula, R.; Zvarikova, M.; Vocka, M.; Batko, S.; Dreslerova, J.; Lazarov, P. P.; Lysy, M.; Ptatkova, Z.; Benesova, V.; Bortlicek, Z.; Kandrnal, V. [Trabectedin registry]. Klin. Onkol. 2011, 24 (6), 470-474.
-
(2011)
Klin. Onkol
, vol.24
, Issue.6
, pp. 470-474
-
-
Kubackova, K.1
Finek, J.2
Vyzula, R.3
Zvarikova, M.4
Vocka, M.5
Batko, S.6
Dreslerova, J.7
Lazarov, P.P.8
Lysy, M.9
Ptatkova, Z.10
Benesova, V.11
Bortlicek, Z.12
Kandrnal, V.13
-
111
-
-
84860688652
-
Overcoming multidrug resistance in cancer: 35 years after the discovery of ABCB1
-
Gillet, J. P.; Gottesman, M. M. Overcoming multidrug resistance in cancer: 35 years after the discovery of ABCB1. Drug Resist. Updat. 2012, 15 (1-2), 2-4.
-
(2012)
Drug Resist. Updat
, vol.15
, Issue.1-2
, pp. 2-4
-
-
Gillet, J.P.1
Gottesman, M.M.2
|