Inhibition of MDR1 expression by retinol treatment increases sensitivity to etoposide (VP16) in human neoplasic cell line

Toxicology in Vitro

Volumn 22, Issue 4, 2008, Pages 873-878

  Klamt, Fábio ^a   Passos, Daniel Thompsen ^b   Castro, Mauro Antônio Alves ^a,b   Gelain, Daniel Pens ^a   Grivicich, Ivana ^b   Moreira, José Cláudio Fonseca ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

Author keywords

Chemotherapy; MDR1; Multidrug resistance; Oxidative stress; Retinol

Indexed keywords

ANTINEOPLASTIC AGENT; ETOPOSIDE; MANNITOL; MULTIDRUG RESISTANCE PROTEIN 1; RETINOL; SCAVENGER;

ADJUVANT THERAPY; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL STRAIN HT29; COLORECTAL CANCER; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG SENSITIVITY; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; LETHAL DOSE; REAL TIME POLYMERASE CHAIN REACTION;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; GENE EXPRESSION REGULATION; HT29 CELLS; HUMANS; P-GLYCOPROTEIN; POLYMERASE CHAIN REACTION; VITAMIN A;

EID: 41949141389     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.01.004     Document Type: Article

References (29)

1. Altucci L., and Gronemeyer H. Nuclear receptors in cell life and death. Trends in Endrocrinology and Metabolism 12 (2001) 460-468
2. Bartolini G., Orlandi M., Papi A., Ammar K., Guerra F., Ferreri A.M., and Rocchi P.A. Search for multidrug resistance modulators: the effects of retinoids in human colon carcinoma cells. In Vivo 20 6A (2006) 729-733
3. Blomhoff R. Vitamin A in Health and Disease (1994), Marcel Dekker, New York
4. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 162 (1987) 156-159
5. Dal-Pizzol F., Klamt F., Benfato M.S., Bernard E.A., and Moreira J.C.F. Retinol supplementation induces oxidative stress and modulates antioxidant enzyme activities in rat Sertoli cells. Free Radical Research 34 (2000) 395-404
6. Dal-Pizzol F., Klamt F., Frota Jr. M.L.C., Moraes L.F., Moreira J.C.F., and Benfato M.S. Retinol supplementation induces DNA damage and modulates iron turnover in rat Sertoli cells. Free Radical Research 33 (2000) 677-687
7. Fenaux P., Wang Z.Z., and Degos L. Treatment of acute promyelocytic leukemia by retinoids. Current Topics in Microbiology and Immunology 313 (2007) 101-128
8. Frota Jr., M.L.C., Klamt, F., Dal-Pizzol, F., Schiengold, M., Moreira, J.C.F., 2004. Retinol-induced MDR1 and MDR3 modulation in cultured rat sertoli cells is attenuated by free radical scavengers. Redox Reports 9, 161-165.
9. Gelain, D.P., Moreira, J.C.F., 2007. Evidence of increased reactive species formation by retinol, but not retinoic acid, in PC12 cells. Toxicology in Vitro, doi:10.1016/j.tiv.2007.11.007.
10. Greenwald P., Anderson N., Nelson S.A., and Taylor P.R. Clinical trials of vitamin and mineral supplements for cancer chemoprevention. American Journal of Clinical Nutrition 85 (2006) 3147S-3317S
11. Hoyos B., Imam A., Korichneva I., Levi E., Chua R., and Hammerling U. The cysteine-rich regions of the regulatory domains of Raf and Protein Kinase C as retinoid receptor. Journal of Experimental Medicine 192 (2000) 835-845
12. Kakizoe T. Chemoprevention of cancer-focusing on clinical trials. Japanese Journal of Clinical Oncology 9 (2003) 421-442
13. Klamt, F., Dal-Pizzol, F., Gelain, D.P., Dalmolin, R.S., Birnfeld de Oliveira, R., Bastiani, M., Horn, F., Fonseca Moreira, J.C., 2007. Vitamin A treatment induces apoptosis through an oxidant-dependent activation of the mitochondrial pathway. Cell Biology International, doi:10.1016/j.cellbi.2007.08.018.
14. Klamt F., Dal-Pizzol F., Ribeiro N.C., Bernard E.A., Benfato M.S., and Moreira J.C.F. Retinol-induced elevation of ornithine decarboxylase activity in cultured rat Sertoli cells is attenuated by free radical scavenger and by iron chelator. Molecular and Cellular Biochemistry 208 (2000) 71-76
15. Klamt F., Dal-Pizzol F., Roehrs R., de Oliveira R.B., Dalmolin R., Henriques J.A., de Andrades H.H., de Paula Ramos A.A., Saffi J., and Moreira J.C.F. Genotoxicity, recombinogenicity and cellular preneoplasic transformation induced by vitamin A supplementation. Mutation Research 539 (2003) 117-125
16. Krishna R., and Mayer L.D. Multidrug resistance (MDR) in cancer mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. European Journal of Pharmaceutical Sciences 11 (2001) 265-283
17. Murata M., and Kawanishi S. Oxidative DNA damage by vitamin A and its derivatives via superoxide generation. Journal of Biological Chemistry 275 (2000) 2003-2008
18. Murphy L.D., Herzog C.E., Rudick J.B., Fojo A.T., and Bates S.E. Use of the polymerase chain reaction in the quantitation of MDR1 gene expression. Biochemistry 29 (1990) 10351-10356
19. Njar V.C., Gediya L., Purushottamachar P., Chopra P., Vasaitis T.S., Khandelwal A., Mehta J., Huynh C., Belosay A., and Patel J. Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases. Bioorganic and Medicinal Chemistry 14 (2006) 4323-4340
20. Okuno M., Kojima S., Matsushima-Nishiwaki R., Tsurumi H., Muto Y., Friedman S.L., and Moriwaki H. Retinoids in cancer chemoprevention. Current Cancer Drug Targets 4 (2004) 285-298
21. Omenn G.S. Chemoprevention of lung cancers: lessons from CARET, the beta-carotene and retinol efficiency trial, and prospects for the future. European Journal of Cancer Prevention 16 (2007) 184-191
22. Ono K., and Yamada M. Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases. Neurobiology of Diseases 25 (2007) 446-454
23. Ross A.C. Cellular metabolism and activation of retinoids: roles of cellular retinoid-binding proteins. FASEB Journal 7 (1993) 317-327
24. Stouch T.R., and Gudmundsson O. Progress in understanding the structure-activity relationships of P-glycoprotein. Advanced Drug Delivery Reviews 54 (2002) 315-328
25. Takeshita A., Shinjo K., Naito K., Ohnishi K., Sugimoto Y., Yamakawa Y., Tanimoto M., Kitamura K., Naoe T., and Ohno R. Role of P-glycoprotein in all-trans retinoic acid (ATRA) resistance in acute promyelocytic leukaemia cells: analysis of intracellular concentration of ATRA. British Journal of Haematology 108 (2000) 90-92
26. Teodori E., Dei S., Scapecchi S., and Gualtieri F. The medical chemistry of multidrug resistance (MDR) reversing drugs. Farmaco 57 (2002) 385-415
27. Tsuruo T., Naito M., Tomida A., Fujita N., Mashima T., Sakamoto H., and Haga N. Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal. Cancer Science 94 (2003) 15-21
28. Varma M.V., Ashokraj Y., Dey C.S., and Panchagnula R. P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement. Pharmacological Research 48 (2003) 347-359
29. Wartenberg M., Ling F.C., Schallenberg M., Baumer A.T., Petrat K., Hescheler J., and Sauer H. Down-regulation of intrinsic P-glycoprotein expression in multicellular prostrate tumor spheroids by reactive oxygen species. Journal of Biological Chemistry 276 (2001) 17420-17428