Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells

Leukemia and Lymphoma

Volumn 53, Issue 7, 2012, Pages 1383-1389

  Cheng, Zhiyong ^a   Yang, Ning ^a   Liang, Wentong ^a   Yan, Xiaoyan ^a   Li, Lin ^a   Pan, Ling ^b  

^a First (No 1) Hospital of Baoding   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

leukemia; multidrug resistance; PI3K Akt; PTEN

Indexed keywords

ADENOVIRUS VECTOR; ANTINEOPLASTIC AGENT; CYTARABINE; DOXORUBICIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA CELL; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; CELL SURVIVAL; CYTARABINE; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, LEUKEMIC; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; K562 CELLS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; OXIDES; P-GLYCOPROTEIN; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSFECTION;

EID: 84862736573     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.650695     Document Type: Article

References (22)

1. Enokida H, Gotanda T, Oku S, et al. Reversal of P-glycoprotein-mediated paclitaxel resistance by new synthetic isoprenoids in human bladder cancer cell line. Jpn J Cancer Res 2002;93:1037-1046. (Pubitemid 35154271)
2. Calatozzolo C, Gelati M, Ciusani E, et al. Expression of drugresistance proteins P-gp, MRP1, MRP3, MRP5 and GST-pi in human glioma. J Neurooncol 2005;74:113-121. (Pubitemid 41478906)
3. Myers MP, Stolarov JP, Eng C, et al. PTEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci USA 1997;94:9052-9057.
4. Xu Q, Simpson SE, Scialla TJ, et al. Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 2003;102:972-980. (Pubitemid 36917792)
5. Dahia PL, Aguiar RC, Alberta J, et al. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in hematological malignancies. Hum Mol Genet 1999;8:185-193. (Pubitemid 29054260)
6. Wang S, Cheng Z, Deng K, et al. Effect of wild type PTEN gene on proliferation and invasion of multiple myeloma. Int J Hematol 2010;92:83-94.
7. Zhiyong C, Wentong L, Xiaoyang Y, et al. PTEN's regulation of VEGF and VEGFR1 expression and its clinical significance in myeloid leukemia. Med Oncol 2011 Mar 1. [Epub ahead of print]
8. Jotta PY, Ganazza MA, Silva A, et al. Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia. Leukemia 2010;24:239-242.
9. Liu TC, Lin PM, Chang JG, et al. Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia. Am J Hematol 2000;63:170-175.
10. Yang J, Liu J, Zheng J, et al. A reappraisal by quantitative flow cytometry analysis of PTEN expression in acute leukemia. Leukemia 2007;21:2072-2074. (Pubitemid 47299993)
11. Montiel-Duarte C, Cordeu L, Agirre X, et al. Resistance to imatinib mesylate-induced apoptosis in acute lymphoblastic leukemia is associated with PTEN down-regulation due to promoter hypermethylation. Leuk Res 2008;32:709-716. (Pubitemid 351330173)
12. Zhang J, Grindley JC, Yin T, et al. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 2006;441:518-522. (Pubitemid 44050154)
13. Yilmaz OH, Valdez R, Th eisen BK, et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 2006;441:475-482. (Pubitemid 44050144)
14. Guo W, Lasky JL, Chang CJ, et al. Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature 2008;453:529-533. (Pubitemid 351733319)
15. Vasudevan KM, Gurvmunhy S, Rangnekar VM. Suppression of PTEN expression by NF-kappaB prevents apoptosis. Mol Cell Biol 2004;24:1007-1021. (Pubitemid 38112166)
16. Grandage VL, Gale RE, Linch DC, et al. PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. Leukemia 2005;19:586-594. (Pubitemid 40521164)
17. Cheng ZY, Guo XL, Yang XY, et al. PTEN and rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway. J Exp Clin Cancer Res 2008;27:87.
18. Tabellini G, Cappellini A, Tazzari PL, et al. Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells. J Cell Physiol 2005;202:623-634. (Pubitemid 40041333)
19. Tabellini G, Tazzari PL, Bortul R, et al. Novel 2′-substituted, 3′-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway. Br J Haematol 2004;126:574-582. (Pubitemid 39093101)
20. Han Z, Hong L, Han Y, et al. Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax. J Exp Clin Cancer Res 2007;26:261-268. (Pubitemid 47025290)
21. Yang H, Kong W, He L, et al. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res 2008;68:425-433. (Pubitemid 351380068)
22. Zhou M, Gu L, Findley HW, et al. PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells. Cancer Res 2003;63:6357-6362. (Pubitemid 37255184)