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Volumn 18, Issue 25, 2012, Pages 3754-3769

Trabectedin as a new chemotherapy option in the treatment of relapsed platinum sensitive ovarian cancer

Author keywords

Ovarian cancer; Pegylated liposomal doxorubicin; PLD; Trabectedin; Yondelis

Indexed keywords

ANTHRACYCLINE DERIVATIVE; APREPITANT; BRCA2 PROTEIN; CAPECITABINE; CARBOPLATIN; CISPLATIN; DEXAMETHASONE; DOCETAXEL; DOXORUBICIN; GEMCITABINE; IFOSFAMIDE; PACLITAXEL; TOPOTECAN; TRABECTEDIN;

EID: 84867525162     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212802002814     Document Type: Article
Times cited : (20)

References (116)
  • 2
    • 0026086870 scopus 로고
    • Second-line platinum therapy in patients with ovarian cancer previously treated with cisplatin
    • Markman M, Rothman R, Hakes T, et al. Second-line platinum therapy in patients with ovarian cancer previously treated with cisplatin. J Clin Oncol 1991; 9: 389-93.
    • (1991) J Clin Oncol , vol.9 , pp. 389-393
    • Markman, M.1    Rothman, R.2    Hakes, T.3
  • 3
    • 0345283114 scopus 로고    scopus 로고
    • A randomized phase II evaluation of bryostatin-1 (NSC #339555) in recurrent or persistent platinum-sensitive ovarian cancer: A Gynecologic Oncology Group Study
    • Armstrong DK, Blessing JA, Look KY, Schilder R, Nunez ER. A randomized phase II evaluation of bryostatin-1 (NSC #339555) in recurrent or persistent platinum-sensitive ovarian cancer: a Gynecologic Oncology Group Study. Invest New Drugs 2003; 21: 373-7.
    • (2003) Invest New Drugs , vol.21 , pp. 373-377
    • Armstrong, D.K.1    Blessing, J.A.2    Look, K.Y.3    Schilder, R.4    Nunez, E.R.5
  • 4
    • 40249100133 scopus 로고    scopus 로고
    • Management of partially platinum-sensitive relapsed ovarian cancer
    • Kaye S. Management of partially platinum-sensitive relapsed ovarian cancer. Eur J Canc Supplements 2008; 6: 16-21.
    • (2008) Eur J Canc Supplements , vol.6 , pp. 16-21
    • Kaye, S.1
  • 5
    • 0024522049 scopus 로고
    • Response of patients in phase II studies of chemotherapy in ovarian cancer: Implications for patient treatment and the design of phase II trials
    • Blackledge G, Lawton F, Redman C, Kelly K. Response of patients in phase II studies of chemotherapy in ovarian cancer: implications for patient treatment and the design of phase II trials. Br J Cancer 1989; 59: 650-3.
    • (1989) Br J Cancer , vol.59 , pp. 650-653
    • Blackledge, G.1    Lawton, F.2    Redman, C.3    Kelly, K.4
  • 6
    • 33846859308 scopus 로고    scopus 로고
    • Management strategies for partially platinum-sensitive ovarian cancer
    • Ledermann JA, Raja F. Management strategies for partially platinum-sensitive ovarian cancer. Am J Cancer 2006; 5: 341-54.
    • (2006) Am J Cancer , vol.5 , pp. 341-354
    • Ledermann, J.A.1    Raja, F.2
  • 7
    • 84857514950 scopus 로고    scopus 로고
    • Optimizing management of recurrent epithelial ovarian cancer with non-platinum-based chemotherapy
    • Pujade-Lauraine E, Vergote I, Pignata S, Kristensen G. Optimizing management of recurrent epithelial ovarian cancer with non-platinum-based chemotherapy. Clinical Ovarian Cancer 2008; 1: 139-40.
    • (2008) Clinical Ovarian Cancer , vol.1 , pp. 139-140
    • Pujade-Lauraine, E.1    Vergote, I.2    Pignata, S.3    Kristensen, G.4
  • 8
    • 0032910470 scopus 로고    scopus 로고
    • Extending the platinum-free interval in recurrent ovarian cancer: The role of topotecan in second-line chemotherapy
    • Bookman MA. Extending the platinum-free interval in recurrent ovarian cancer: the role of topotecan in second-line chemotherapy. Oncologist 1999; 4: 87-94.
    • (1999) Oncologist , vol.4 , pp. 87-94
    • Bookman, M.A.1
  • 9
    • 15444375395 scopus 로고    scopus 로고
    • Retrospective review: Re-treatment of patients with ovarian cancer with carboplatin after platinum resistance
    • See HT, Freedman RS, Kudelka AP, et al. Retrospective review: re-treatment of patients with ovarian cancer with carboplatin after platinum resistance. Int J Gynecol Cancer 2005; 15: 209-16.
    • (2005) Int J Gynecol Cancer , vol.15 , pp. 209-216
    • See, H.T.1    Freedman, R.S.2    Kudelka, A.P.3
  • 10
    • 35348841132 scopus 로고    scopus 로고
    • Extending the platinum-free interval with a non-platinum therapy in platinum-sensitive recurrent ovarian cancer. Results from the SOCRATES Retrospective Study
    • Pignata S, Ferrandina G, Scarfone G, et al. Extending the platinum-free interval with a non-platinum therapy in platinum-sensitive recurrent ovarian cancer. Results from the SOCRATES Retrospective Study. Oncology 2006; 71: 320-6.
    • (2006) Oncology , vol.71 , pp. 320-326
    • Pignata, S.1    Ferrandina, G.2    Scarfone, G.3
  • 11
    • 0036388148 scopus 로고    scopus 로고
    • Relapsed ovarian cancer: Challenges and management strategies for a chronic disease
    • Armstrong DK. Relapsed ovarian cancer: challenges and management strategies for a chronic disease. Oncologist 2002; 7: 20-8.
    • (2002) Oncologist , vol.7 , pp. 20-28
    • Armstrong, D.K.1
  • 12
    • 47649116971 scopus 로고    scopus 로고
    • Analysis of the pattern of hypersensitivity reactions in patients receiving carboplatin retreatment for recurrent ovarian cancer
    • Gadducci A, Tana R, Teti G, Zanca G, Fanucchi A, Genazzani AR. Analysis of the pattern of hypersensitivity reactions in patients receiving carboplatin retreatment for recurrent ovarian cancer. Int J Gynecol Cancer 2008; 18: 615-20.
    • (2008) Int J Gynecol Cancer , vol.18 , pp. 615-620
    • Gadducci, A.1    Tana, R.2    Teti, G.3    Zanca, G.4    Fanucchi, A.5    Genazzani, A.R.6
  • 13
    • 30644462055 scopus 로고    scopus 로고
    • Residual neurotoxicity in ovarian cancer patients in clinical remission after first-line chemotherapy with carboplatin and paclitaxel: The Multicenter Italian Trial in Ovarian cancer (MITO-4) retrospective study
    • Pignata S, De Placido S, Biamonte R, et al. Residual neurotoxicity in ovarian cancer patients in clinical remission after first-line chemotherapy with carboplatin and paclitaxel: the Multicenter Italian Trial in Ovarian cancer (MITO-4) retrospective study. BMC Cancer 2006; 6: 5.
    • (2006) BMC Cancer , vol.6 , pp. 5
    • Pignata, S.1    de Placido, S.2    Biamonte, R.3
  • 14
    • 34447570846 scopus 로고    scopus 로고
    • Randomized phase III trial of gemcitabine compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer
    • Mutch DG, Orlando M, Goss T,et al. Randomized phase III trial of gemcitabine compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer. J Clin Oncol 2007; 25: 2811-8.
    • (2007) J Clin Oncol , vol.25 , pp. 2811-2818
    • Mutch, D.G.1    Orlando, M.2    Goss, T.3
  • 15
    • 84856331988 scopus 로고    scopus 로고
    • Weekly paclitaxel as a single agent or in combination with carboplatin or weekly topotecan in patients with resistant ovarian cancer: The CARTAXHY randomized phase II trial from Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens (GINECO)
    • doi:10.1093/annonc/mdr149
    • Lortholary A, Largillier R, Weber B, et al. Weekly paclitaxel as a single agent or in combination with carboplatin or weekly topotecan in patients with resistant ovarian cancer: the CARTAXHY randomized phase II trial from Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens (GINECO). Ann Oncol 2011; doi:10.1093/annonc/mdr149.
    • (2011) Ann Oncol
    • Lortholary, A.1    Largillier, R.2    Weber, B.3
  • 16
    • 0037862963 scopus 로고    scopus 로고
    • Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: The ICON4/AGO-OVAR-2.2 trial
    • Parmar MK, Ledermann JA, Colombo N, du Bois A, Delaloye JF, Kristensen GB, et al. Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial. Lancet 2003; 361: 2099-106.
    • (2003) Lancet , vol.361 , pp. 2099-2106
    • Parmar, M.K.1    Ledermann, J.A.2    Colombo, N.3    du Bois, A.4    Delaloye, J.F.5    Kristensen, G.B.6
  • 17
    • 33750588670 scopus 로고    scopus 로고
    • Gemcitabine plus carboplatin compared with carboplatin in patients with platinum-sensitive recurrent ovarian cancer: An intergroup trial of the AGO-OVAR, the NCIC CTG, and the EORTC GCG
    • Pfisterer J, Plante M, Vergote I, et al. Gemcitabine plus carboplatin compared with carboplatin in patients with platinum-sensitive recurrent ovarian cancer: an intergroup trial of the AGO-OVAR, the NCIC CTG, and the EORTC GCG. J Clin Oncol 2006; 24: 4699-707.
    • (2006) J Clin Oncol , vol.24 , pp. 4699-4707
    • Pfisterer, J.1    Plante, M.2    Vergote, I.3
  • 18
    • 0030900145 scopus 로고    scopus 로고
    • Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer
    • ten Bokkel Huinink W, Gore M, Carmichael J, et al. Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer. J Clin Oncol 1997; 15: 2183-93.
    • (1997) J Clin Oncol , vol.15 , pp. 2183-2193
    • ten Bokkel, H.W.1    Gore, M.2    Carmichael, J.3
  • 19
    • 4644225190 scopus 로고    scopus 로고
    • Long-term survival advantage for women treated with pegylated liposomal doxorubicin compared with topotecan in a phase 3 randomized study of recurrent and refractory epithelial ovarian cancer
    • Gordon AN, Tonda M, Sun S, Rackoff W. Long-term survival advantage for women treated with pegylated liposomal doxorubicin compared with topotecan in a phase 3 randomized study of recurrent and refractory epithelial ovarian cancer. Gynecol Oncol 2004; 95: 1-8.
    • (2004) Gynecol Oncol , vol.95 , pp. 1-8
    • Gordon, A.N.1    Tonda, M.2    Sun, S.3    Rackoff, W.4
  • 20
    • 0035879099 scopus 로고    scopus 로고
    • Recurrent epithelial ovarian carcinoma: A randomized phase III study of pegylated liposomal doxorubicin versus topotecan
    • Gordon AN, Fleagle JT, Guthrie D, Parkin DE, Gore ME, Lacave AJ. Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan. J Clin Oncol 2001; 19: 3312-22.
    • (2001) J Clin Oncol , vol.19 , pp. 3312-3322
    • Gordon, A.N.1    Fleagle, J.T.2    Guthrie, D.3    Parkin, D.E.4    Gore, M.E.5    Lacave, A.J.6
  • 21
    • 68749121487 scopus 로고    scopus 로고
    • A randomized, phase III study of carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in relapsed platinum-sensitive ovarian cancer (OC): CALYPSO study of the Gynecologic Cancer Intergroup (GCIG)
    • ASCO Annual Meeting suppl; abstr LBA5509
    • Pujade-Lauraine E, Mahner S, Kaern J, et al. A randomized, phase III study of carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in relapsed platinum-sensitive ovarian cancer (OC): CALYPSO study of the Gynecologic Cancer Intergroup (GCIG). J Clin Oncol 2009; 27: 2009 ASCO Annual Meeting suppl; abstr LBA5509.
    • (2009) J Clin Oncol , vol.27 , pp. 2009
    • Pujade-Lauraine, E.1    Mahner, S.2    Kaern, J.3
  • 22
    • 61549104994 scopus 로고    scopus 로고
    • Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem
    • Cuevas C, Francesch A. Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem. Nat Prod Rep 2009; 26: 322-37.
    • (2009) Nat Prod Rep , vol.26 , pp. 322-337
    • Cuevas, C.1    Francesch, A.2
  • 23
    • 35048860778 scopus 로고    scopus 로고
    • Trabectedin: A review of its use in the management of soft tissue sarcoma and ovarian cancer
    • Carter NJ, Keam SJ. Trabectedin: a review of its use in the management of soft tissue sarcoma and ovarian cancer. Drugs 2007; 67: 2257-76.
    • (2007) Drugs , vol.67 , pp. 2257-2276
    • Carter, N.J.1    Keam, S.J.2
  • 24
    • 77955505177 scopus 로고    scopus 로고
    • A review of trabectedin (ET-743): A unique mechanism of action
    • D'Incalci M, Galmarini CM. A review of trabectedin (ET-743): a unique mechanism of action. Mol Cancer Ther 2010; 9: 2157-63.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2157-2163
    • D'Incalci, M.1    Galmarini, C.M.2
  • 25
    • 77955491837 scopus 로고    scopus 로고
    • Trabectedin Plus Pegylated Liposomal Doxorubicin in Recurrent Ovarian Cancer
    • Monk BJ, Herzog TJ, Kaye SB, et al. Trabectedin Plus Pegylated Liposomal Doxorubicin in Recurrent Ovarian Cancer. J Clin Oncol 2010; 28: 3107-14.
    • (2010) J Clin Oncol , vol.28 , pp. 3107-3114
    • Monk, B.J.1    Herzog, T.J.2    Kaye, S.B.3
  • 26
    • 78650325827 scopus 로고    scopus 로고
    • Trabectedin plus pegylated liposomal doxorubicin in relapsed ovarian cancer: Outcomes in the partially platinum-sensitive (platinum-free interval 6-12 months) subpopulation of OVA-301 phase III randomized trial
    • Poveda A, Vergote I, Tjulandin S, et al. Trabectedin plus pegylated liposomal doxorubicin in relapsed ovarian cancer: outcomes in the partially platinum-sensitive (platinum-free interval 6-12 months) subpopulation of OVA-301 phase III randomized trial. Ann Oncol 2010; 22: 39-48.
    • (2010) Ann Oncol , vol.22 , pp. 39-48
    • Poveda, A.1    Vergote, I.2    Tjulandin, S.3
  • 27
    • 78650312260 scopus 로고    scopus 로고
    • Trabectedin plus pegylated liposomal doxorubicin in relapsed ovarian cancer delays third-line chemotherapy and prolongs the platinum-free interval
    • Kaye SB, Colombo N, Monk BJ, et al. Trabectedin plus pegylated liposomal doxorubicin in relapsed ovarian cancer delays third-line chemotherapy and prolongs the platinum-free interval. Ann Oncol 2010; 22: 49-58.
    • (2010) Ann Oncol , vol.22 , pp. 49-58
    • Kaye, S.B.1    Colombo, N.2    Monk, B.J.3
  • 28
    • 33748035692 scopus 로고    scopus 로고
    • Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin
    • Herrero AB, Martin-Castellanos C, Marco E, Gago F, Moreno S. Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin. Cancer Res 2006; 66: 8155-62.
    • (2006) Cancer Res , vol.66 , pp. 8155-8162
    • Herrero, A.B.1    Martin-Castellanos, C.2    Marco, E.3    Gago, F.4    Moreno, S.5
  • 29
    • 0036021010 scopus 로고    scopus 로고
    • Ecteinascidin 743: A novel anticancer drug with a unique mechanism of action
    • Aune GJ, Furuta T, Pommier Y. Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action. Anticancer Drugs 2002; 13: 545-55.
    • (2002) Anticancer Drugs , vol.13 , pp. 545-555
    • Aune, G.J.1    Furuta, T.2    Pommier, Y.3
  • 30
    • 0029838307 scopus 로고    scopus 로고
    • DNA sequence-and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata
    • Pommier Y, Kohlhagen G, Bailly C, Waring M, Mazumder A, Kohn KW. DNA sequence-and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata. Biochemistry 1996; 35: 13303-9.
    • (1996) Biochemistry , vol.35 , pp. 13303-13309
    • Pommier, Y.1    Kohlhagen, G.2    Bailly, C.3    Waring, M.4    Mazumder, A.5    Kohn, K.W.6
  • 31
    • 0033566150 scopus 로고    scopus 로고
    • Ecteinascidin 743: A minor groove alkylator that bends DNA toward the major groove
    • Zewail-Foote M, Hurley LH. Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. J Med Chem 1999; 42: 2493-7.
    • (1999) J Med Chem , vol.42 , pp. 2493-2497
    • Zewail-Foote, M.1    Hurley, L.H.2
  • 32
    • 0037096739 scopus 로고    scopus 로고
    • Ecteinascidin-743 inhibits activated but not constitutive transcription
    • Friedman D, Hu Z, Kolb EA, Gorfajn B, Scotto KW. Ecteinascidin-743 inhibits activated but not constitutive transcription. Cancer Res 2002; 62: 3377-81.
    • (2002) Cancer Res , vol.62 , pp. 3377-3381
    • Friedman, D.1    Hu, Z.2    Kolb, E.A.3    Gorfajn, B.4    Scotto, K.W.5
  • 33
    • 40949130371 scopus 로고    scopus 로고
    • Platinum resistance: The role of DNA repair pathways
    • Martin LP, Hamilton TC, Schilder RJ. Platinum resistance: the role of DNA repair pathways. Clin Cancer Res 2008; 14: 1291-5.
    • (2008) Clin Cancer Res , vol.14 , pp. 1291-1295
    • Martin, L.P.1    Hamilton, T.C.2    Schilder, R.J.3
  • 34
    • 0036270039 scopus 로고    scopus 로고
    • ET-743: More than an innovative mechanism of action
    • Scotto KW. ET-743: more than an innovative mechanism of action. Anticancer Drugs 2002; 13 Suppl 1: S3-6.
    • (2002) Anticancer Drugs , vol.13 , Issue.1 SUPPL.
    • Scotto, K.W.1
  • 35
    • 41549100818 scopus 로고    scopus 로고
    • DNA repair functionality modulates the clinical outcome of patients with advanced sarcoma treated with trabectedin (ET-743)
    • Schoffski P, Casali PG, Taron M, et al. DNA repair functionality modulates the clinical outcome of patients with advanced sarcoma treated with trabectedin (ET-743). J Clin Oncol 2006; 24: 9522.
    • (2006) J Clin Oncol , vol.24 , pp. 9522
    • Schoffski, P.1    Casali, P.G.2    Taron, M.3
  • 36
    • 20044396161 scopus 로고    scopus 로고
    • Transcriptional signature of Ecteinascidin 743 (Yondelis, Trabectedin) in human sarcoma cells explanted from chemo-naive patients
    • Martinez N, Sanchez-Beato M, Carnero A, et al. Transcriptional signature of Ecteinascidin 743 (Yondelis, Trabectedin) in human sarcoma cells explanted from chemo-naive patients. Mol Cancer Ther 2005; 4: 814-23.
    • (2005) Mol Cancer Ther , vol.4 , pp. 814-823
    • Martinez, N.1    Sanchez-Beato, M.2    Carnero, A.3
  • 37
    • 17944374027 scopus 로고    scopus 로고
    • Antiproliferative activity of ecteinascidin 743 is dependent upon transcriptioncoupled nucleotide-excision repair
    • Takebayashi Y, Pourquier P, Zimonjic DB, et al. Antiproliferative activity of ecteinascidin 743 is dependent upon transcriptioncoupled nucleotide-excision repair. Nat Med 2001; 7: 961-6.
    • (2001) Nat Med , vol.7 , pp. 961-966
    • Takebayashi, Y.1    Pourquier, P.2    Zimonjic, D.B.3
  • 38
    • 0035874074 scopus 로고    scopus 로고
    • Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways
    • Damia G, Silvestri S, Carrassa L, et al. Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways. Int J Cancer 2001; 92: 583-8.
    • (2001) Int J Cancer , vol.92 , pp. 583-588
    • Damia, G.1    Silvestri, S.2    Carrassa, L.3
  • 39
    • 0035146702 scopus 로고    scopus 로고
    • Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action
    • Erba E, Bergamaschi D, Bassano L, et al. Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action. Eur J Cancer 2001; 37: 97-105.
    • (2001) Eur J Cancer , vol.37 , pp. 97-105
    • Erba, E.1    Bergamaschi, D.2    Bassano, L.3
  • 40
    • 36248974108 scopus 로고    scopus 로고
    • Dynamics of cell cycle phase perturbations by trabectedin (ET-743) in nucleotide excision repair (NER)-deficient and NER-proficient cells, unravelled by a novel mathematical simulation approach
    • Tavecchio M, Natoli C, Ubezio P, Erba E, D'Incalci M. Dynamics of cell cycle phase perturbations by trabectedin (ET-743) in nucleotide excision repair (NER)-deficient and NER-proficient cells, unravelled by a novel mathematical simulation approach. Cell Prolif 2007; 40: 885-904.
    • (2007) Cell Prolif , vol.40 , pp. 885-904
    • Tavecchio, M.1    Natoli, C.2    Ubezio, P.3    Erba, E.4    D'Incalci, M.5
  • 41
    • 40249097419 scopus 로고    scopus 로고
    • Role of homologous recombination in trabectedin-induced DNA damage
    • Tavecchio M, Simone M, Erba E, et al. Role of homologous recombination in trabectedin-induced DNA damage. Eur J Cancer 2008; 44: 609-18.
    • (2008) Eur J Cancer , vol.44 , pp. 609-618
    • Tavecchio, M.1    Simone, M.2    Erba, E.3
  • 42
    • 34548706418 scopus 로고    scopus 로고
    • Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743
    • Soares DG, Escargueil AE, Poindessous V, et al. Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743. Proc Natl Acad Sci U S A 2007; 104: 13062-7.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13062-13067
    • Soares, D.G.1    Escargueil, A.E.2    Poindessous, V.3
  • 43
    • 63049108452 scopus 로고    scopus 로고
    • Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment
    • Venkitaraman AR. Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment. Annu Rev Pathol Mech Dis 2009; 4: 461-87.
    • (2009) Annu Rev Pathol Mech Dis , vol.4 , pp. 461-487
    • Venkitaraman, A.R.1
  • 45
    • 77249139976 scopus 로고    scopus 로고
    • Correlation of RNA expression of DNA repair genes with clinical outcomes of advanced ovarian cancer (OC) pts treated with pegylated liposomal doxorubicin (PLD) vs Trabectedin (T) + PLD in the ET743-OVA-301 clinical trial
    • th ESMO European Society for Medical Oncology, september 20-24, 2009. Berlin
    • th ESMO European Society for Medical Oncology, september 20-24, 2009. Berlin): 451-2.
    • (2009) Eur J Cancer , vol.7 , Issue.SUPPL. , pp. 451-452
    • Poveda, A.1    Kaye, S.2    Herzog, T.3
  • 46
    • 20144388299 scopus 로고    scopus 로고
    • Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): Inhibition of macrophage differentiation and cytokine production
    • Allavena P, Signorelli M, Chieppa M, et al. Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production. Cancer Res 2005; 65: 2964-71.
    • (2005) Cancer Res , vol.65 , pp. 2964-2971
    • Allavena, P.1    Signorelli, M.2    Chieppa, M.3
  • 47
    • 77950231708 scopus 로고    scopus 로고
    • Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells
    • Germano G, Frapolli R, Simone M, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res; 70: 2235-44.
    • Cancer Res , vol.70 , pp. 2235-2244
    • Germano, G.1    Frapolli, R.2    Simone, M.3
  • 48
    • 0001937183 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic (PK) study of Ecteinascidin-743 (ET-743) given as a one hour infusion every 21 days
    • abstract #452
    • Bowman A, Twelves C, Koekman K, et al. Phase I clinical and pharmacokinetic (PK) study of Ecteinascidin-743 (ET-743) given as a one hour infusion every 21 days. Ann Oncol 1998; 9: 118, abstract #452.
    • (1998) Ann Oncol , vol.9 , pp. 118
    • Bowman, A.1    Twelves, C.2    Koekman, K.3
  • 49
    • 4243353028 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ET-743, a minor groove DNA binder, administrated weekly to patients with advanced cancer
    • Abstract 373
    • Forouzesh B, Hidalgo M, Denis L, et al. Phase I and pharmacokinetic study of ET-743, a minor groove DNA binder, administrated weekly to patients with advanced cancer. Proc Am Soc Clin Oncol 2001; 20: Abstract 373.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Forouzesh, B.1    Hidalgo, M.2    Denis, L.3
  • 50
    • 66149170084 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of trabectedin as a 1-or 3-hour infusion weekly in patients with advanced solid malignancies
    • Forouzesh B, Hidalgo M, Chu Q, et al. Phase I and pharmacokinetic study of trabectedin as a 1-or 3-hour infusion weekly in patients with advanced solid malignancies. Clin Cancer Res 2009; 15: 3591-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 3591-3599
    • Forouzesh, B.1    Hidalgo, M.2    Chu, Q.3
  • 51
    • 2342461682 scopus 로고    scopus 로고
    • Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy
    • Garcia-Carbonero R, Supko JG, Manola J, et al. Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy. J Clin Oncol 2004; 22: 1480-90.
    • (2004) J Clin Oncol , vol.22 , pp. 1480-1490
    • Garcia-Carbonero, R.1    Supko, J.G.2    Manola, J.3
  • 52
    • 0035127175 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies
    • Ryan DP, Supko JG, Eder JP, et al. Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies. Clin Cancer Res 2001; 7: 231-42.
    • (2001) Clin Cancer Res , vol.7 , pp. 231-242
    • Ryan, D.P.1    Supko, J.G.2    Eder, J.P.3
  • 53
    • 0036913513 scopus 로고    scopus 로고
    • A phase II and pharmacokinetic study of ecteinascidin 743 in patients with gastrointestinal stromal tumors
    • Ryan DP, Puchalski T, Supko JG, et al. A phase II and pharmacokinetic study of ecteinascidin 743 in patients with gastrointestinal stromal tumors. Oncologist 2002; 7: 531-8.
    • (2002) Oncologist , vol.7 , pp. 531-538
    • Ryan, D.P.1    Puchalski, T.2    Supko, J.G.3
  • 54
    • 0035281641 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors
    • Taamma A, Misset JL, Riofrio M, et al. Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors. J Clin Oncol 2001; 19: 1256-65.
    • (2001) J Clin Oncol , vol.19 , pp. 1256-1265
    • Taamma, A.1    Misset, J.L.2    Riofrio, M.3
  • 55
    • 0142121506 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of Yondelis (Ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours
    • Twelves C, Hoekman K, Bowman A, et al. Phase I and pharmacokinetic study of Yondelis (Ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours. Eur J Cancer 2003; 39: 1842-51.
    • (2003) Eur J Cancer , vol.39 , pp. 1842-1851
    • Twelves, C.1    Hoekman, K.2    Bowman, A.3
  • 56
    • 0034490073 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study
    • van Kesteren C, Cvitkovic E, Taamma A, et al. Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study. Clin Cancer Res 2000; 6: 4725-32.
    • (2000) Clin Cancer Res , vol.6 , pp. 4725-4732
    • van Kesteren, C.1    Cvitkovic, E.2    Taamma, A.3
  • 57
    • 0036154945 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies
    • Villalona-Calero MA, Eckhardt SG, Weiss G, et al. A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies. Clin Cancer Res 2002; 8: 75-85.
    • (2002) Clin Cancer Res , vol.8 , pp. 75-85
    • Villalona-Calero, M.A.1    Eckhardt, S.G.2    Weiss, G.3
  • 58
    • 0036387382 scopus 로고    scopus 로고
    • Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intra-venous infusion to adult patients with soft tissue sarcomas: Associations with clinical characteristics, pathophysiological variables and toxicity
    • Puchalski TA, Ryan DP, Garcia-Carbonero R, et al. Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intra-venous infusion to adult patients with soft tissue sarcomas: associations with clinical characteristics, pathophysiological variables and toxicity. Cancer Chemother Pharmacol 2002; 50: 309-19.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 309-319
    • Puchalski, T.A.1    Ryan, D.P.2    Garcia-Carbonero, R.3
  • 59
    • 0036239748 scopus 로고    scopus 로고
    • Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1-and 3-h infusion in a phase I study
    • van Kesteren C, Twelves C, Bowman A, et al. Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1-and 3-h infusion in a phase I study. Anticancer Drugs 2002; 13: 381-93.
    • (2002) Anticancer Drugs , vol.13 , pp. 381-393
    • van Kesteren, C.1    Twelves, C.2    Bowman, A.3
  • 60
    • 0035281734 scopus 로고    scopus 로고
    • Ecteinascidin-743: A marine-derived compound in advanced, pretreated sarcoma patients--preliminary evidence of activity
    • Delaloge S, Yovine A, Taamma A, et al. Ecteinascidin-743: a marine-derived compound in advanced, pretreated sarcoma patients--preliminary evidence of activity. J Clin Oncol 2001; 19: 1248-55.
    • (2001) J Clin Oncol , vol.19 , pp. 1248-1255
    • Delaloge, S.1    Yovine, A.2    Taamma, A.3
  • 62
    • 34548837518 scopus 로고    scopus 로고
    • Population pharmacokinetic meta-analysis of trabectedin (ET-743, Yondelis) in cancer patients
    • Perez-Ruixo JJ, Zannikos P, Hirankarn S, et al. Population pharmacokinetic meta-analysis of trabectedin (ET-743, Yondelis) in cancer patients. Clin Pharmacokinet 2007; 46: 867-84.
    • (2007) Clin Pharmacokinet , vol.46 , pp. 867-884
    • Perez-Ruixo, J.J.1    Zannikos, P.2    Hirankarn, S.3
  • 63
    • 33947330884 scopus 로고    scopus 로고
    • Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer
    • Beumer JH, Rademaker-Lakhai JM, Rosing H, et al. Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer. Cancer Chemother Pharmacol 2007; 59: 825-37.
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 825-837
    • Beumer, J.H.1    Rademaker-Lakhai, J.M.2    Rosing, H.3
  • 64
    • 31544458696 scopus 로고    scopus 로고
    • In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug
    • Brandon EF, Sparidans RW, Guijt KJ, et al. In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs 2006; 24: 3-14.
    • (2006) Invest New Drugs , vol.24 , pp. 3-14
    • Brandon, E.F.1    Sparidans, R.W.2    Guijt, K.J.3
  • 65
    • 33750445585 scopus 로고    scopus 로고
    • Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype
    • Beumer JH, Buckle T, Ouwehand M, et al. Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype. Invest New Drugs 2007; 25: 1-7.
    • (2007) Invest New Drugs , vol.25 , pp. 1-7
    • Beumer, J.H.1    Buckle, T.2    Ouwehand, M.3
  • 67
    • 0141731283 scopus 로고    scopus 로고
    • Complete protection by high-dose dexamethasone against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the rat
    • Donald S, Verschoyle RD, Greaves P, et al. Complete protection by high-dose dexamethasone against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the rat. Cancer Res 2003; 63: 5902-8.
    • (2003) Cancer Res , vol.63 , pp. 5902-5908
    • Donald, S.1    Verschoyle, R.D.2    Greaves, P.3
  • 68
    • 20144377216 scopus 로고    scopus 로고
    • Trabectedin for women with ovarian carcinoma after treatment with platinum and taxanes fails
    • Sessa C, De Braud F, Perotti A, et al. Trabectedin for women with ovarian carcinoma after treatment with platinum and taxanes fails. J Clin Oncol 2005; 23: 1867-74.
    • (2005) J Clin Oncol , vol.23 , pp. 1867-1874
    • Sessa, C.1    de Braud, F.2    Perotti, A.3
  • 69
    • 0000322596 scopus 로고    scopus 로고
    • Phase II evaluation of 3-hr infusion ET-743 in patients with recurrent sarcomas
    • (abstract 1628)
    • Dileo P, Casali PG, Bacci G, et al. Phase II evaluation of 3-hr infusion ET-743 in patients with recurrent sarcomas. Proc Am Soc Clin Oncol 2002; 21: 408 (abstract 1628).
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 408
    • Dileo, P.1    Casali, P.G.2    Bacci, G.3
  • 70
    • 33745161449 scopus 로고    scopus 로고
    • Steroid premedication markedly reduces liver and bone marrow toxicity of trabectedin in advanced sarcoma
    • Grosso F, Dileo P, Sanfilippo R, et al. Steroid premedication markedly reduces liver and bone marrow toxicity of trabectedin in advanced sarcoma. Eur J Cancer 2006; 42: 1484-90.
    • (2006) Eur J Cancer , vol.42 , pp. 1484-1490
    • Grosso, F.1    Dileo, P.2    Sanfilippo, R.3
  • 71
    • 14644423300 scopus 로고    scopus 로고
    • Hepatotoxicity and metabolism of trabectedin: A literature review
    • Beumer JH, Schellens JH, Beijnen JH. Hepatotoxicity and metabolism of trabectedin: a literature review. Pharmacol Res 2005; 51: 391-8.
    • (2005) Pharmacol Res , vol.51 , pp. 391-398
    • Beumer, J.H.1    Schellens, J.H.2    Beijnen, J.H.3
  • 72
    • 84862266455 scopus 로고    scopus 로고
    • Trabectedin in pretreated patients with advanced or metastatic soft tissue sarcoma: A phase II study evaluating co-treatment with dexamethasone
    • Paz-Ares L, Lopez-Pousa A, Poveda A, et al. Trabectedin in pretreated patients with advanced or metastatic soft tissue sarcoma: a phase II study evaluating co-treatment with dexamethasone. Invest New Drugs 2010; 30(2): 729-40.
    • (2010) Invest New Drugs , vol.30 , Issue.2 , pp. 729-740
    • Paz-Ares, L.1    Lopez-Pousa, A.2    Poveda, A.3
  • 73
    • 84872603432 scopus 로고    scopus 로고
    • European Medicines Agency (EMA), trabectedin. Available from, Accessed December 2010
    • ®; trabectedin. Available from: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/hu man/medicines/000773/human_med_001165.jsp&murl=menus/medicines/medicines.jsp&jsenabled=true. Accessed December 2010. 2010.
    • (2010) ®
  • 74
    • 0037757975 scopus 로고    scopus 로고
    • Effects of the neurokinin1 receptor antagonist aprepitant on the pharmacokinetics of dexamethasone and methylprednisolone
    • McCrea JB, Majumdar AK, Goldberg MR, et al. Effects of the neurokinin1 receptor antagonist aprepitant on the pharmacokinetics of dexamethasone and methylprednisolone. Clin Pharmacol Ther 2003; 74: 17-24.
    • (2003) Clin Pharmacol Ther , vol.74 , pp. 17-24
    • McCrea, J.B.1    Majumdar, A.K.2    Goldberg, M.R.3
  • 75
    • 0042878545 scopus 로고    scopus 로고
    • Effective combination of ET-743 and doxorubicin in sarcoma: Preclinical studies
    • Meco D, Colombo T, Ubezio P, et al. Effective combination of ET-743 and doxorubicin in sarcoma: preclinical studies. Cancer Chemother Pharmacol 2003; 52: 131-8.
    • (2003) Cancer Chemother Pharmacol , vol.52 , pp. 131-138
    • Meco, D.1    Colombo, T.2    Ubezio, P.3
  • 76
    • 0034786774 scopus 로고    scopus 로고
    • Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells
    • Takahashi N, Li WW, Banerjee D, Scotto KW, Bertino JR. Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells. Clin Cancer Res 2001; 7: 3251-7.
    • (2001) Clin Cancer Res , vol.7 , pp. 3251-3257
    • Takahashi, N.1    Li, W.W.2    Banerjee, D.3    Scotto, K.W.4    Bertino, J.R.5
  • 77
    • 64449085620 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer
    • Sessa C, Perotti A, Noberasco C, et al. Phase I clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer. Eur J Cancer 2009; 45: 1153-61.
    • (2009) Eur J Cancer , vol.45 , pp. 1153-1161
    • Sessa, C.1    Perotti, A.2    Noberasco, C.3
  • 78
    • 58149186082 scopus 로고    scopus 로고
    • Phase I combination study of trabectedin and doxorubicin in patients with soft-tissue sarcoma
    • Blay JY, von Mehren M, Samuels BL, et al. Phase I combination study of trabectedin and doxorubicin in patients with soft-tissue sarcoma. Clin Cancer Res 2008; 14: 6656-62.
    • (2008) Clin Cancer Res , vol.14 , pp. 6656-6662
    • Blay, J.Y.1    von Mehren, M.2    Samuels, B.L.3
  • 79
    • 53049092830 scopus 로고    scopus 로고
    • A phase I study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies
    • von Mehren M, Schilder RJ, Cheng JD, et al. A phase I study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies. Ann Oncol 2008; 19: 1802-9.
    • (2008) Ann Oncol , vol.19 , pp. 1802-1809
    • von Mehren, M.1    Schilder, R.J.2    Cheng, J.D.3
  • 81
    • 53149133906 scopus 로고    scopus 로고
    • Phase I trial of weekly trabectedin (ET-743) and gemcitabine in patients with advanced solid tumors
    • Messersmith WA, Jimeno A, Ettinger D, et al. Phase I trial of weekly trabectedin (ET-743) and gemcitabine in patients with advanced solid tumors. Cancer Chemother Pharmacol 2008; 63: 181-8.
    • (2008) Cancer Chemother Pharmacol , vol.63 , pp. 181-188
    • Messersmith, W.A.1    Jimeno, A.2    Ettinger, D.3
  • 82
    • 84872603086 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic (PK) study of sequential paclitaxel and trabectedin every 2 weeks in patients with advanced solid tumors
    • Papadopoulos KP, Chu Q, Patnaik A, et al. Phase I and pharmacokinetic (PK) study of sequential paclitaxel and trabectedin every 2 weeks in patients with advanced solid tumors. J Clin Oncol 2006; 24: 2029.
    • (2029) J Clin Oncol , vol.2006 , pp. 24
    • Papadopoulos, K.P.1    Chu, Q.2    Patnaik, A.3
  • 83
    • 67651089735 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours
    • Sessa C, Cresta S, Noberasco C, et al. Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours. Eur J Cancer 2009; 45: 2116-22.
    • (2009) Eur J Cancer , vol.45 , pp. 2116-2122
    • Sessa, C.1    Cresta, S.2    Noberasco, C.3
  • 84
    • 84872618835 scopus 로고    scopus 로고
    • Phase I clinical and pharmacological trial of trabectedin (T) in 3 hour infusion every 3 weeks (3h/q3w) in patients with advanced cancer and hepatic function disorder
    • Salazar R, Pardo B, Majem M, et al. Phase I clinical and pharmacological trial of trabectedin (T) in 3 hour infusion every 3 weeks (3h/q3w) in patients with advanced cancer and hepatic function disorder. J Clin Oncol 2006; 24: 2080.
    • (2080) J Clin Oncol , vol.2006 , pp. 24
    • Salazar, R.1    Pardo, B.2    Majem, M.3
  • 85
    • 19944426087 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of ecteinascidin-743 (Yondelis) in children with refractory solid tumors. A Children's Oncology Group study
    • Lau L, Supko JG, Blaney S, et al. A phase I and pharmacokinetic study of ecteinascidin-743 (Yondelis) in children with refractory solid tumors. A Children's Oncology Group study. Clin Cancer Res 2005; 11: 672-7.
    • (2005) Clin Cancer Res , vol.11 , pp. 672-677
    • Lau, L.1    Supko, J.G.2    Blaney, S.3
  • 86
    • 82455185410 scopus 로고    scopus 로고
    • A single-blind, placebo controlled, sequential design study evaluating the potential effects of trabectedin on the QT intervals
    • Abstract: e13096
    • Manikhas GM, Dirix L, Vermorken JB, et al. A single-blind, placebo controlled, sequential design study evaluating the potential effects of trabectedin on the QT intervals. J Clin Oncol 2010; 28: Abstract: e13096.
    • (2010) J Clin Oncol , vol.28
    • Manikhas, G.M.1    Dirix, L.2    Vermorken, J.B.3
  • 87
    • 37049038819 scopus 로고    scopus 로고
    • A Phase II study of trabectedin single agent in patients with recurrent ovarian cancer previously treated with platinum-based regimens
    • Krasner CN, McMeekin DS, Chan S, et al. A Phase II study of trabectedin single agent in patients with recurrent ovarian cancer previously treated with platinum-based regimens. Br J Cancer 2007; 17: 1618-24.
    • (2007) Br J Cancer , vol.17 , pp. 1618-1624
    • Krasner, C.N.1    McMeekin, D.S.2    Chan, S.3
  • 91
    • 84872600202 scopus 로고    scopus 로고
    • European Medicines Agency (EMA), Available from, Accessed May
    • ®-Assessment report for Yondelis. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Assessment_Report_-_Variation/human/000773/WC500059175.pdf. Accessed May 2011.
    • (2011) ®-Assessment Report For Yondelis
  • 92
    • 84872616753 scopus 로고    scopus 로고
    • European Medicines Agency (EMA), Available from, In: editor.^editors. ed
    • ®-Assesment report for Yondelis. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Assessment_Report_-_Variation/human/000773/WC500059175.pdf. In: editor.^editors. ed. p.
    • ®-Assesment Report For Yondelis
  • 93
    • 84872608610 scopus 로고    scopus 로고
    • A phase I combination study of split-dose short infusion trabectedin and doxorubicin administered every 21 days in patients with solid tumors
    • Sessa C, Braud F, Cresta S, et al. A phase I combination study of split-dose short infusion trabectedin and doxorubicin administered every 21 days in patients with solid tumors. Eur J Cancer 2005; 3: 430.
    • (2005) Eur J Cancer , vol.3 , pp. 430
    • Sessa, C.1    Braud, F.2    Cresta, S.3
  • 94
    • 77951738158 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of sequential paclitaxel and trabectedin every 2 weeks in patients with advanced solid tumors
    • Chu Q, Mita A, Forouzesh B, et al. Phase I and pharmacokinetic study of sequential paclitaxel and trabectedin every 2 weeks in patients with advanced solid tumors. Clin Cancer Res 2010; 16: 2656-65.
    • (2010) Clin Cancer Res , vol.16 , pp. 2656-2665
    • Chu, Q.1    Mita, A.2    Forouzesh, B.3
  • 95
    • 41549106488 scopus 로고    scopus 로고
    • Phase I study of trabectedin (T) in combination with docetaxel (D) in patients with advanced malignancies. Journal of Clinical Oncology, 2006
    • (June 20 Supplement)
    • Von Mehren M, Buck D, Temmer E, Elsayed YA, Cohen RB. Phase I study of trabectedin (T) in combination with docetaxel (D) in patients with advanced malignancies. Journal of Clinical Oncology, 2006 2006; ASCO Annual Meeting Proceedings Part I. Vol 24,No. 18S (June 20 Supplement): 2068.
    • (2006) ASCO Annual Meeting Proceedings Part I , vol.24 , Issue.18 S , pp. 2068
    • von Mehren, M.1    Buck, D.2    Temmer, E.3    Elsayed, Y.A.4    Cohen, R.B.5
  • 96
    • 84872616268 scopus 로고    scopus 로고
    • Phase I combination study of trabectedin (T) and capecitabine (C) in patients with advanced malignancies
    • Gore L, Rivera E, Lavallee K, et al. Phase I combination study of trabectedin (T) and capecitabine (C) in patients with advanced malignancies. J Clin Oncol 2006; 24: 2079.
    • (2079) J Clin Oncol , vol.2006 , pp. 24
    • Gore, L.1    Rivera, E.2    Lavallee, K.3
  • 97
    • 11144357506 scopus 로고    scopus 로고
    • Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
    • O'Brien ME, Wigler N, Inbar M, et al. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann Oncol 2004; 15: 440-9.
    • (2004) Ann Oncol , vol.15 , pp. 440-449
    • O'Brien, M.E.1    Wigler, N.2    Inbar, M.3
  • 98
    • 77249088752 scopus 로고    scopus 로고
    • Trabectedin: A review of its use in soft tissue sarcoma and ovarian cancer
    • Carter NJ, Keam SJ. Trabectedin: a review of its use in soft tissue sarcoma and ovarian cancer. Drugs 2010; 70: 355-76.
    • (2010) Drugs , vol.70 , pp. 355-376
    • Carter, N.J.1    Keam, S.J.2
  • 99
    • 84872615931 scopus 로고    scopus 로고
    • Docetaxel plus trabectedin appears active in recurrent or persistent ovarian and primary peritoneal cancer after up to three prior regimens: A phase II study of the Gynecologic Oncology Group
    • Monk BJ, Sill MW, Hanjani P, et al. Docetaxel plus trabectedin appears active in recurrent or persistent ovarian and primary peritoneal cancer after up to three prior regimens: A phase II study of the Gynecologic Oncology Group. Gynecol Oncol 2010.
    • (2010) Gynecol Oncol
    • Monk, B.J.1    Sill, M.W.2    Hanjani, P.3
  • 100
    • 56749178680 scopus 로고    scopus 로고
    • A phase II trial of paclitaxel poliglumex in recurrent or persistent ovarian or primary peritoneal cancer (EOC): A Gynecologic Oncology Group Study
    • Sabbatini P, Sill MW, O'Malley D, Adler L, Secord AA. A phase II trial of paclitaxel poliglumex in recurrent or persistent ovarian or primary peritoneal cancer (EOC): a Gynecologic Oncology Group Study. Gynecol Oncol 2008; 111: 455-60.
    • (2008) Gynecol Oncol , vol.111 , pp. 455-460
    • Sabbatini, P.1    Sill, M.W.2    O'Malley, D.3    Adler, L.4    Secord, A.A.5
  • 101
    • 0038121967 scopus 로고    scopus 로고
    • An international field study of the reliability and validity of a disease-specific questionnaire module (the QLQ-OV28) in assessing the quality of life of patients with ovarian cancer
    • Greimel E, Bottomley A, Cull A, et al. An international field study of the reliability and validity of a disease-specific questionnaire module (the QLQ-OV28) in assessing the quality of life of patients with ovarian cancer. Eur J Cancer 2003; 39: 1402-8.
    • (2003) Eur J Cancer , vol.39 , pp. 1402-1408
    • Greimel, E.1    Bottomley, A.2    Cull, A.3
  • 102
    • 70350001556 scopus 로고    scopus 로고
    • Health Related Quality of Life/Patient-reported Outcomes in Relapsed Ovarian Cancer: Results from a Randomized Phase III Study of Trabectedin with Pegylated Liposomal Doxorubicin (PLD) versus PLD Alone
    • Abstract 5526
    • Krasner CN, Poveda A, Herzog T, et al. Health Related Quality of Life/Patient-reported Outcomes in Relapsed Ovarian Cancer: Results from a Randomized Phase III Study of Trabectedin with Pegylated Liposomal Doxorubicin (PLD) versus PLD Alone. J Clin Oncol 2009; 27: Abstract 5526.
    • (2009) J Clin Oncol , vol.27
    • Krasner, C.N.1    Poveda, A.2    Herzog, T.3
  • 103
    • 84872621480 scopus 로고    scopus 로고
    • Patient-reported outcomes in patients with relapsed, platinum-sensitive ovarian cancer (ROC): Results from a large randomized phase III trial
    • o00458
    • Vermorken JB, Kelley J, Provencher D, et al. Patient-reported outcomes in patients with relapsed, platinum-sensitive ovarian cancer (ROC): Results from a large randomized phase III trial. Int J Gynecol Cancer 2010; 20: Abstract No00458.
    • (2010) Int J Gynecol Cancer , vol.20
    • Vermorken, J.B.1    Kelley, J.2    Provencher, D.3
  • 104
    • 35348925113 scopus 로고    scopus 로고
    • Clinical trial endpoints in ovarian cancer: Report of an FDA/ASCO/AACR Public Workshop
    • Bast RC, Thigpen JT, Arbuck SG, et al. Clinical trial endpoints in ovarian cancer: report of an FDA/ASCO/AACR Public Workshop. Gynecol Oncol 2007; 107: 173-6.
    • (2007) Gynecol Oncol , vol.107 , pp. 173-176
    • Bast, R.C.1    Thigpen, J.T.2    Arbuck, S.G.3
  • 105
    • 77956648272 scopus 로고    scopus 로고
    • A phase II study of combination chemotherapy in early relapsed epithelial ovarian cancer using gemcitabine and pegylated liposomal doxorubicin
    • Mirza MR, Lund B, Lindegaard JC,et al. A phase II study of combination chemotherapy in early relapsed epithelial ovarian cancer using gemcitabine and pegylated liposomal doxorubicin. Gynecol Oncol 2010; 119: 26-31.
    • (2010) Gynecol Oncol , vol.119 , pp. 26-31
    • Mirza, M.R.1    Lund, B.2    Lindegaard, J.C.3
  • 106
    • 33847304901 scopus 로고    scopus 로고
    • Second-line chemotherapy with pegylated liposomal doxorubicin and carboplatin is highly effective in patients with advanced ovarian cancer in late relapse: A GINECO phase II trial
    • Ferrero JM, Weber B, Geay JF, et al. Second-line chemotherapy with pegylated liposomal doxorubicin and carboplatin is highly effective in patients with advanced ovarian cancer in late relapse: a GINECO phase II trial. Ann Oncol 2007; 18: 263-8.
    • (2007) Ann Oncol , vol.18 , pp. 263-268
    • Ferrero, J.M.1    Weber, B.2    Geay, J.F.3
  • 107
    • 70349246454 scopus 로고    scopus 로고
    • Phase II study of pegylated liposomal doxorubicin and carboplatin in patients with platinum-sensitive and partially platinum-sensitive metastatic ovarian cancer
    • Rapoport BL, Vorobiof DA, Slabber C, Alberts AS, Hlophe HS, Mohammed C. Phase II study of pegylated liposomal doxorubicin and carboplatin in patients with platinum-sensitive and partially platinum-sensitive metastatic ovarian cancer. Int J Gynecol Cancer 2009; 19: 1137-41.
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 1137-1141
    • Rapoport, B.L.1    Vorobiof, D.A.2    Slabber, C.3    Alberts, A.S.4    Hlophe, H.S.5    Mohammed, C.6
  • 108
    • 67651149486 scopus 로고    scopus 로고
    • Efficacy of pegylated liposomal doxorubicin (PLD) plus carboplatin in ovarian cancer patients who recur within six to twelve months: A phase II study
    • Power P, Stuart G, Oza A, et al. Efficacy of pegylated liposomal doxorubicin (PLD) plus carboplatin in ovarian cancer patients who recur within six to twelve months: a phase II study. Gynecol Oncol 2009; 114: 410-4.
    • (2009) Gynecol Oncol , vol.114 , pp. 410-414
    • Power, P.1    Stuart, G.2    Oza, A.3
  • 109
    • 77954726606 scopus 로고    scopus 로고
    • Pegylated liposomal Doxorubicin and Carboplatin compared with Paclitaxel and Carboplatin for patients with platinum-sensitive ovarian cancer in late relapse
    • Pujade-Lauraine E, Wagner U, Aavall-Lundqvist E, et al. Pegylated liposomal Doxorubicin and Carboplatin compared with Paclitaxel and Carboplatin for patients with platinum-sensitive ovarian cancer in late relapse. J Clin Oncol 2010; 28: 3323-9.
    • (2010) J Clin Oncol , vol.28 , pp. 3323-3329
    • Pujade-Lauraine, E.1    Wagner, U.2    Aavall-Lundqvist, E.3
  • 110
    • 78650392836 scopus 로고    scopus 로고
    • A GCIG randomized phase III study of carboplatin (C) & pegylated liposomal doxorubicin (PLD) (C-D) vs carboplatin (C) & paclitaxel (P) (C-P): CALYPSO results in partially platinum-sensitive ovarian cancer (OC) patients
    • Vasey P, Largillier R, Gropp M, et al. A GCIG randomized phase III study of carboplatin (C) & pegylated liposomal doxorubicin (PLD) (C-D) vs carboplatin (C) & paclitaxel (P) (C-P): CALYPSO results in partially platinum-sensitive ovarian cancer (OC) patients. Eur J Cancer Supplements 2009; 7: 11.
    • (2009) Eur J Cancer Supplements , vol.7 , pp. 11
    • Vasey, P.1    Largillier, R.2    Gropp, M.3
  • 111
    • 77950349922 scopus 로고    scopus 로고
    • Changing the paradigm in the treatment of platinum-sensitive recurrent ovarian cancer: From platinum doublets to nonplatinum doublets and adding antiangiogenesis compounds
    • Monk BJ, Coleman RL. Changing the paradigm in the treatment of platinum-sensitive recurrent ovarian cancer: from platinum doublets to nonplatinum doublets and adding antiangiogenesis compounds. Int J Gynecol Cancer 2009; 19 Suppl 2: S63-7.
    • (2009) Int J Gynecol Cancer , vol.19 , Issue.2 SUPPL.
    • Monk, B.J.1    Coleman, R.L.2
  • 112
    • 33646726747 scopus 로고    scopus 로고
    • Management of platinum-sensitive recurrent ovarian cancer
    • Pfisterer J, Ledermann JA. Management of platinum-sensitive recurrent ovarian cancer. Semin Oncol 2006; 33: S12-6.
    • (2006) Semin Oncol , vol.33
    • Pfisterer, J.1    Ledermann, J.A.2
  • 113
    • 3242686319 scopus 로고    scopus 로고
    • The role of topotecan for extending the platinum-free interval in recurrent ovarian cancer: An in vitro model
    • Horowitz NS, Hua J, Gibb RK, Mutch DG, Herzog TJ. The role of topotecan for extending the platinum-free interval in recurrent ovarian cancer: an in vitro model. Gynecol Oncol 2004; 94: 67-73.
    • (2004) Gynecol Oncol , vol.94 , pp. 67-73
    • Horowitz, N.S.1    Hua, J.2    Gibb, R.K.3    Mutch, D.G.4    Herzog, T.J.5
  • 114
    • 34848917530 scopus 로고    scopus 로고
    • Treatment of recurrent ovarian cancer relapsing 6-12 months post platinum-based chemotherapy
    • Colombo N, Gore M. Treatment of recurrent ovarian cancer relapsing 6-12 months post platinum-based chemotherapy. Crit Rev Oncol Hematol 2007; 64: 129-138.
    • (2007) Crit Rev Oncol Hematol , vol.64 , pp. 129-138
    • Colombo, N.1    Gore, M.2
  • 115
    • 0029067168 scopus 로고
    • Carboplatin reinduction after taxane in patients with platinum-refractory epithelial ovarian cancer
    • Kavanagh J, Tresukosol D, Edwards C, et al. Carboplatin reinduction after taxane in patients with platinum-refractory epithelial ovarian cancer. J Clin Oncol 1995; 13: 1584-8.
    • (1995) J Clin Oncol , vol.13 , pp. 1584-1588
    • Kavanagh, J.1    Tresukosol, D.2    Edwards, C.3
  • 116
    • 40249100133 scopus 로고    scopus 로고
    • Management of partially platinum-sensitive relapsed ovarian cancer
    • Kaye S. Management of partially platinum-sensitive relapsed ovarian cancer. Eur J Canc Supplements 2008; 6: 16-21.
    • (2008) Eur J Canc Supplements , vol.6 , pp. 16-21
    • Kaye, S.1


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