Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298

American Journal of Pathology

Volumn 180, Issue 6, 2012, Pages 2490-2503

  Bao, Lili ^a   Hazari, Sidhartha ^a   Mehra, Smriti ^b   Kaushal, Deepak ^b   Moroz, Krzysztof ^a   Dash, Srikanta ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; FIREFLY LUCIFERASE; GLYCOPROTEIN P; MICRORNA 298; SMALL UNTRANSLATED RNA; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CYTOPLASM; CYTOTOXICITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

3' UNTRANSLATED REGIONS; ANTIBIOTICS, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; RNA, NEOPLASM; TUMOR CELLS, CULTURED;

EID: 84861591908     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.02.024     Document Type: Article

References (40)

1. G. Szakacs, J.K. Paterson, J.A. Ludwig, C. Booth-Genthe, M.M. Gottesman Targeting multidrug resistance in cancer Nat Rev Drug Discov 5 2006 219 234
2. M. Lehnert Chemotherapy resistance in breast cancer Anticancer Res 18 1998 2225 2226
3. M.M. Gottesman, T. Fojo, S.E. Bates Multidrug resistance in cancer: role of ATP-dependent transporters Nature Rev Cancer 2 2002 48 58
4. G.D. Leonard, T. Fojo, S.E. Bates The role of ABC transporters in clinical medicine Oncologist 8 2003 411 424
5. T. Fojo Multiple paths to a drug resistance phenotype: mutations, translations, deletions and amplification of coding genes or promoter regions, epigenetics changes and microRNAs Drug Resist Update 10 2007 59 67
6. M. Dean, Y. Hamon, G. Chimini The human ATP-binding cassette (ABC) transporter superfamily J Lipid Res 42 2001 1007 1017
7. Dong Xu, Dongjiu Ye, Michael Fisher, R.L. Juliano Selective inhibition of P-glycoprotein expression in multidrug-resistance tumor cells by a designed transcriptional tegulator J Pharmacol Exp Ther 302 2002 963 971
8. Hao Wu, William Hait, Jin-ming Yang Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells Cancer Res 63 2003 1515 1519
9. I.F. Faneyte, P.M. Kristel, M. Maliepaard, G.L. Scheffer, R.J. Scheper, J.H. Schellens, M.J. van de Vijver Expression of the breast cancer resistance protein (BCRP) in breast cancer Clin Cancer Res 8 2002 1068 1074
10. K.J. Bailey-Dell, B. Hassel, L.A. Doyle, D.D. Ross Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene Biochim Biophys Acta 1520 2001 234 241
11. A. Abolhoda, A.E. Wilson, H. Ross, P.V. Danenberg, M. Burt, K.W. Scotto Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin Clin Cancer Res 5 1999 3352 3356
12. P.M. Chaudhary, I.B. Roninson Induction of multidrug resistance in human cancer cells by transient exposure to different chemotherapy drugs J Natl Cancer Inst 85 1993 632 639
13. K.V. Chin, S.S. Chauhan, I. Pastan, M.M. Gottesman Regulation of MDR RNA levels in response to cytotoxic drugs in rodent cells Cell Growth Differ 1 1990 361 365
14. K.V. Chin, S. Tanaka, G. Darlington, I. Pastan, M.M. Gottesman Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells J Biol Chem 265 1990 221 226
15. Z. Hu, S. Jin, K.W. Scotto Transcriptional activation of the MDR1 gene by UV irradiation Role of NF-Y and SP-1 J Biol Chem 275 2000 2979 2985
16. T. Uchiumi, K. Kohno, H. Tanimura, K. Matsuo, S. Sato, Y. Uchida, M. Kuwano Enhanced expression of the human multidrug resistance 1 gene in response to UV light irradiation Cell Growth Differ 4 1993 147 157
17. J.M. Yang, A.D. Vassil, W.N. Hait Activation of phospholipase C induces the expression of the multidrug resistance (MDR1) gene through Raf-MAPK pathway Mol Pharmacol 60 2001 674 680
18. W. Jin, K.W. Scotto, W.N. Hait, J.M. Yang Involvement of CtBP1 in the transcriptional activation of the MDR1 gene in human multidrug resistant cancer cells Biochem Pharmacol 74 2007 851 859
19. R.M. Glasspool, J.M. Teodoridis, R. Brown Epigenetics as a mechanism driving polygenic clinical drug resistance Br J Cancer 94 2006 1087 1092
20. Y. Iwasa, M.A. Nowak, F. Michor Evolution of resistance during clonal expansion Genetics 172 2006 2557 2566
21. M.R. Matarazzo, S. Boyle, M. D'Esposito, W.A. Bickmore Chromosome territory reorganization in human disease with altered DNA methylation Proc Natl Acad Sci U S A 104 2007 16546 16551
22. E.C. Lai MicroRNAs are complementary to 3′ UTR sequence motif that mediate negative post-transcriptional regulation Nat Genet 30 2002 363 364
23. H. Robins, W.H. Press Human microRNAs target functionally distinct population of genes with AT-rich 3′ UTRs Proc Natl Acad Sci U S A 102 2005 15557 15562
24. A. Stark, J. Brennecke, N. Bushati, R.B. Russell, S.M. Cohen Animal microRNAs confer rubustness to gene expression and have a significant impact on 3′UTR evolution Cell 123 2005 1133 1146
25. M. Sun, L.D. Hurst, G.G. Carmichael, J. Chen Evidence for preferential targeting of 3′-UTRs by cis-encoded natural antisense transcripts Nucleic Acids Res 33 2005 5533 5543
26. Y. Lee, M. Kim, J. Han, K.H. Yeom, S. Lee, S.H. Baek, V.N. Kim MicroRNA genes are transcribed by RNA polymerase II EMBO J 23 2004 4051 4060
27. A.M. Denli, B.B. Tops, R.H. Plasterk, R.F. Ketting, G.J. Hannon Processing of primary microRNAs by the microprocessor complex Nature 432 2004 231 235
28. R.I. Gregory, K.P. Yan, G. Amuthan, T. Chendrimada, B. Doratotaj, N. Cooch, R. Shiekhattar Microprocessor complex mediates the genesis of microRNAs Nature 432 2004 235 240
29. R. Yi, Y. Qin, I.G. macara, B.R. Cullen Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs Genes Dev 17 2003 3011 3016
30. E. Lund, S. Guttinger, A. Calado, J.E. Dahlberg, U. Kutay Nucelar export of microRNA precursors Science 303 2004 95 98
31. L. Bao, A. Haque, K. Jackson, S. Hazari, K. Moroz, R. Jetley, S. Dash Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in 4T1 metastatic breast cancer model Am J Pathol 178 2011 838 852
32. R.-M. Laberge, R. Ambadipudi, E. Georges P-glycoprotein (ABCB1) modulates collateral sensitivity of a multidrug resistant cell line to verapamil Arch Bioch Biophys 491 2009 53 60
33. H. Bark, C.H. Choi PSC833, cyclosporine analogue, downregulates MDR1 expression by activating JNK/c-Jun/AP-1 and suppressing NF-kB Cancer Chemother Pharmacol 65 2010 1131 1136
34. D. Betel, M. Wilson, A. Gabow, D.S. Marks, C. Sander The microRNA.org resource: targets and expression Nucleic Acids Res 36 2008 D149 D153 (Database issue)
35. O. Kovalchuk, J. Filkowski, J. Meservy, Y. Ilnytskyy, V.P. Tryndyak, V.F. Chekhun, I.P. Pogribny Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin Mol Cancer Ther 7 2008 2152 2159
36. H. Zhu, H. Wu, X. Liu, B.R. Evans, D.J. Medina, C.G. Liu, J.M. Yang Role of microRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells Biochem Pharmacol 76 2008 582 588
37. K.E. Allen, G.J. Weiss Resistance may not be futile: microRNA biomarkers for chemoresistance and potential therapeutics Mol Cancer Ther 9 2010 3126 3136
38. Z. Linag, H. Wu, J. Xia, Y. Li, Y. Zhang, K. Huang, N. Wagar, Y. Yoon, H.T. Cho, S. Scala, H. Shim Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1 Biochem Pharmacol 79 2010 817 824
39. Y.Z. Pan, M.E. Morris, A.M. Yu MicroRNA-328 negatively regulates the expression of breast cancer resistant protein (BCRP/ABCG2) in human cancer cells Mol Pharmacol 75 2009 1374 1379
40. K.J. Dedes, R. Natrajan, M.B. Lambros, F.C. Geyer, M.A. Lopez-Garcia, K. Savage, R.L. Jones, J.S. Reis-Filho Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer Eur J Cancer 47 2011 138 150