Regulation exerted by miRNAs in the promoter and UTR sequences: MDR1/P-gp expression as a particular case

DNA and Cell Biology

Volumn 31, Issue 8, 2012, Pages 1358-1364

  Toscano Garibay, Julia D ^a   Aquino Jarquin, Guillermo ^b  

^a HOSPITAL JUÁREZ DE MÉXICO   (Mexico)

^b Children's Hospital of Mexico Federico Gomez   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE 2 PROTEIN; DOUBLE STRANDED DNA; DOUBLE STRANDED RNA; GLYCOPROTEIN P; MICRORNA; MICRORNA 125B; MICRORNA 21; MULTIDRUG RESISTANCE PROTEIN 1; SMALL INTERFERING RNA;

3' UNTRANSLATED REGION; ARTICLE; BASE PAIRING; BIOGENESIS; CANCER CELL; DOWN REGULATION; GENE EXPRESSION REGULATION; HUMAN; LEUKEMIA CELL; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RNA ANALYSIS; RNA HYBRIDIZATION; RNA SEQUENCE; RNA STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ANIMALS; DRUG RESISTANCE, MULTIPLE; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; P-GLYCOPROTEIN; PROMOTER REGIONS, GENETIC; UNTRANSLATED REGIONS;

EID: 84864629063     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.2012.1703     Document Type: Article

References (49)

1. Ahlenstiel, C.L., Lim, H.G., Cooper, D.A., Ishida, T., Kelleher, A.D., and Suzuki, K. (2012). Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells. Nucleic Acids Res 40, 1579-1595.
2. Allen, K.E., and Weiss, G.J. (2010). Resistance may not be futile: MicroRNA biomarkers for chemoresistance and potential therapeutics. Mol Cancer Ther 9, 3126-3136.
3. Asangani, I.A., Rasheed, S.A., Nikolova, D.A., Leupold, J.H., Colburn, N.H., Post, S., and Allgayer, H. (2008). MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27, 2128-2136.
4. Ayel, E., and Escude, C. (2010). In vitro selection of oligonucleotides that bind double-stranded DNA in the presence of triplex- stabilizing agents. Nucleic Acids Res 38, e31.
5. Bartel, D.P. (2004). MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
6. Betel, D., Wilson, M., Gabow, A., Marks, D.S., and Sander, C. (2008). The microRNA.org resource: Targets and expression. Nucleic Acids Res 36, D149-D153.
7. Blackburn, E.H. (2005). Telomeres and telomerase: Their mechanisms of action and the effects of altering their functions. FEBS Lett 579, 859-862.
8. Bourguignon, L.Y., Spevak, C.C., Wong, G., Xia, W., and Gilad, E. (2009). Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. J Biol Chem 284, 26533-26546.
9. Bousquet, M., Harris, M.H., Zhou, B., and Lodish, H.F. (2010). MicroRNA miR-125b causes leukemia. Proc Natl Acad Sci USA 107, 21558-21563.
10. Castelli, E.C., Moreau, P., Oya e Chiromatzo, A., Mendes-Junior, C.T., Veiga-Castelli, L.C., Yaghi, L., Giuliatti, S., Carosella, E.D., and Donadi, E.A. (2009). In silico analysis of microRNAS targeting the HLA-G 3¢ untranslated region alleles and haplotypes. Hum Immunol 70, 1020-1025.
11. Cornwell, M.M., and Smith, D.E. (1993). A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase. J Biol Chem 268, 15347-15350.
12. Cullen, B.R. (2004). Transcription and processing of human microRNA precursors. Mol Cell 16, 861-865.
13. Feng, D.D., Zhang, H., Zhang, P., Zheng, Y.S., Zhang, X.J., Han, B.W., Luo, X.Q., Xu, L., Zhou, H., Qu, L.H., and Chen, Y.Q. (2011). Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia. J Cell Mol Med 15, 2164-2175.
14. Gregory, R.I., Yan, K.P., Amuthan, G., Chendrimada, T., Doratotaj, B., Cooch, N., and Shiekhattar, R. (2004). The Microprocessor complex mediates the genesis of microRNAs. Nature 432, 235-240.
15. Guo, C., Ding, J., Yao, L., Sun, L., Lin, T., Song, Y., and Fan, D. (2005). Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1. Int J Cancer 116, 155-160.
16. Hofmann, M.H., Heinrich, J., Radziwill, G., and Moelling, K. (2009). A short hairpin DNA analogous to miR-125b inhibits C-Raf expression, proliferation, and survival of breast cancer cells. Mol Cancer Res 7, 1635-1644.
17. Kelly, E.J., and Russell, S.J. (2009). MicroRNAs and the regulation of vector tropism. Mol Ther 17, 409-416.
18. Kovalchuk, O., Filkowski, J., Meservy, J., Ilnytskyy, Y., Tryndyak, V.P., Chekhun, V.F., and Pogribny, I.P. (2008). Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther 7, 2152-2159.
19. Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., and Tuschl, T. (2002). Identification of tissue-specific microRNAs from mouse. Curr Biol 12, 735-739.
20. Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A.O., Landthaler, M., Lin, C., Socci, N.D., Hermida, L., Fulci, V., Chiaretti, S., Foa, R., Schliwka, J., Fuchs, U., Novosel, A., Muller, R.U., Schermer, B., Bissels, U., Inman, J., Phan, Q., Chien, M., Weir, D.B., Choksi, R., De Vita, G., Frezzetti, D., Trompeter, H.I., Hornung, V., Teng, G., Hartmann, G., Palkovits, M., Di Lauro, R., Wernet, P., Macino, G., Rogler, C.E., Nagle, J.W., Ju, J., Papavasiliou, F.N., Benzing, T., Lichter, P., Tam, W., Brownstein, M.J., Bosio, A., Borkhardt, A., Russo, J.J., Sander, C., Zavolan, M., and Tuschl, T. (2007). A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129, 1401-1414.
21. Lee, I., Ajay, S.S., Yook, J.I., Kim, H.S., Hong, S.H., Kim, N.H., Dhanasekaran, S.M., Chinnaiyan, A.M., and Athey, B.D. (2009). New class of microRNA targets containing simultaneous 5¢-UTR and 3¢-UTR interaction sites. Genome Res 19, 1175-1183.
22. Lewin, B. (2008). Genes IX, 9th edition ( Jones and Bartlett Publishers, Sudbury, Mass
23. Liang, Y., Ridzon, D., Wong, L., and Chen, C. (2007). Characterization of microRNA expression profiles in normal human tissues. BMC Genomics 8, 166.
24. Liu, Y.P., and Berkhout, B. (2011). miRNA cassettes in viral vectors: Problems and solutions. Biochim Biophys Acta 1809, 732-745.
25. Lytle, J.R., Yario, T.A., and Steitz, J.A. (2007). Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5¢ UTR as in the 3¢ UTR. Proc Natl Acad Sci USA 104, 9667-9672.
26. Ma, J., Dong, C., and Ji, C. (2010). MicroRNA and drug resistance. Cancer Gene Ther 17, 523-531.
27. Nobili, S., Landini, I., Giglioni, B., and Mini, E. (2006). Pharmacological strategies for overcoming multidrug resistance. Curr Drug Targets 7, 861-879.
28. Nobili, S., Landini, I., Mazzei, T., and Mini, E. (2011). Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression. Med Res Rev [Epub ahead of print]; DOI: 10.1002/med.20239.
29. Orom, U.A., Nielsen, F.C., and Lund, A.H. (2008). MicroRNA- 10a binds the 5¢UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell 30, 460-471.
30. Ouellet, D.L., Perron, M.P., Gobeil, L.A., Plante, P., and Provost, P. (2006). MicroRNAs in gene regulation: When the smallest governs it all. J Biomed Biotechnol 2006, 69616.
31. Rand, T.A., Petersen, S., Du, F., and Wang, X. (2005). Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell 123, 621-629.
32. Sarkar, F.H., Li, Y., Wang, Z., Kong, D., and Ali, S. (2010). Implication of microRNAs in drug resistance for designing novel cancer therapy. Drug Resist Updat 13, 57-66.
33. Sontheimer, E.J. (2005). Assembly and function of RNA silencing complexes. Nat Rev Mol Cell Biol 6, 127-138.
34. Sorrentino, A., Liu, C.G., Addario, A., Peschle, C., Scambia, G., and Ferlini, C. (2008). Role of microRNAs in drug-resistant ovarian cancer cells. Gynecol Oncol 111, 478-486.
35. Soukup, G.A., Ellington, A.D., and Maher, L.J., 3rd. (1996). Selection of RNAs that bind to duplex DNA at neutral pH. J Mol Biol 259, 216-228.
36. Suzuki, K., Juelich, T., Lim, H., Ishida, T., Watanebe, T., Cooper, D.A., Rao, S., and Kelleher, A.D. (2008). Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region. J Biol Chem 283, 23353-23363.
37. Suzuki, K., and Kelleher, A.D. (2009). Transcriptional regulation by promoter targeted RNAs. Curr Top Med Chem 9, 1079-1087.
38. Ueda, K. (2011). ABC proteins protect the human body and maintain optimal health. Biosci Biotechnol Biochem 75, 401-409.
39. Weber, M.J. (2005). New human and mouse microRNA genes found by homology search. FEBS J 272, 59-73.
40. Weinmann, L., Hock, J., Ivacevic, T., Ohrt, T., Mutze, J., Schwille, P., Kremmer, E., Benes, V., Urlaub, H., and Meister, G. (2009). Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Cell 136, 496-507.
41. Woodahl, E.L., and Ho, R.J. (2004). The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function. Curr Drug Metab 5, 11-19.
42. Yang, H.S., Cho, M.H., Zakowicz, H., Hegamyer, G., Sonenberg, N., and Colburn, N.H. (2004). A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol 24, 3894-3906.
43. Yi, R., Qin, Y., Macara, I.G., and Cullen, B.R. (2003). Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 17, 3011-3016.
44. Zhang, H., Li, M., Han, Y., Hong, L., Gong, T., Sun, L., and Zheng, X. (2010). Down-regulation of miR-27a might reverse multidrug resistance of esophageal squamous cell carcinoma. Dig Dis Sci 55, 2545-2551.
45. Zhao, X., Yang, L., Hu, J., and Ruan, J. (2010). miR-138 might reverse multidrug resistance of leukemia cells. Leuk Res 34, 1078-1082.
46. Zheng, T., Wang, J., Chen, X., and Liu, L. (2010). Role of microRNA in anticancer drug resistance. Int J Cancer 126, 2-10.
47. Zhou, J., Peng, C., Li, B., Wang, F., Zhou, C., Hong, D., Ye, F., Cheng, X., Lu, W., and Xie, X. (2012). Transcriptional gene silencing of HPV16 E6/E7 induces growth inhibition via apoptosis in vitro and in vivo. Gynecol Oncol 124, 296-302.
48. Zhu, H., Wu, H., Liu, X., Evans, B.R., Medina, D.J., Liu, C.G., and Yang, J.M. (2008). Role of MicroRNA miR-27a and miR- 451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol 76, 582-588.
49. Zimmerman, A.L., and Wu, S. (2011). MicroRNAs, cancer and cancer stem cells. Cancer Lett 300, 10-19.