Engineering V-type nerve agents detoxifying enzymes using computationally focused libraries

ACS Chemical Biology

Volumn 8, Issue 11, 2013, Pages 2394-2403

  Cherny, Izhack ^a   Greisen, Per ^b   Ashani, Yacov ^a   Khare, Sagar D ^b   Oberdorfer, Gustav ^b   Leader, Haim ^a   Baker, David ^b   Tawfik, Dan S ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; PHOSPHOTRIESTERASE; CHEMICAL WARFARE AGENT; CHOLINESTERASE INHIBITOR; PEPTIDE LIBRARY; PHOSPHOROTHIOIC ACID DERIVATIVE;

ARTICLE; BIOLOGY; BREVUNDIMONAS DIMINUTA; CATALYST; COLORIMETRY; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVE SITE; ENZYME ENGINEERING; HIGH THROUGHPUT SCREENING; HYDROLYSIS; ISOMER; MATHEMATICAL MODEL; MOLECULAR LIBRARY; PRIORITY JOURNAL; STATIC ELECTRICITY; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG SCREENING; PEPTIDE LIBRARY; PROTEIN ENGINEERING;

BINDING SITES; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOTHIOPHOSPHORUS COMPOUNDS; PEPTIDE LIBRARY; PROTEIN ENGINEERING;

EID: 84887892532     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb4004892     Document Type: Article

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