Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase

Biochemistry

Volumn 49, Issue 37, 2010, Pages 7978-7987

  Tsai, Ping Chuan ^a   Bigley, Andrew ^a   Li, Yingchun ^a   Ghanem, Eman ^a   Cadieux, C Linn ^b   Kasten, Shane A ^b   Reeves, Tony E ^b   Cerasoli, Douglas M ^b   Raushel, Frank M ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL WARFARE; CHIRALITY; ENZYMES; HYDROLYSIS; PHOSPHORUS; PHOSPHORUS COMPOUNDS; STEREOSELECTIVITY; TOXICITY;

ACETYLCHOLINE ESTERASE; CATALYTIC HYDROLYSIS; CHEMICAL WARFARE AGENTS; COMMONLY USED; KINETIC CONSTANT; NERVE AGENTS; ORDERS OF MAGNITUDE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHOTRIESTERASES; RACEMIC MIXTURES; STEREO-SELECTIVE; WILD TYPES; WILD-TYPE ENZYMES;

ENANTIOMERS;

CYANOFENPHOS; CYCLOSARIN; MUTANT PROTEIN; ORGANOPHOSPHATE; PHOSPHOTRIESTERASE; SARIN; SOMAN; ACETYLCHOLINESTERASE; CHEMICAL WARFARE AGENT; INSECTICIDE; ORGANOPHOSPHORUS COMPOUND;

ANIMAL CELL; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; ENANTIOMER; ENZYME STRUCTURE; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; CHEMISTRY; METABOLISM; STEREOISOMERISM;

BACTERIA (MICROORGANISMS);

ACETYLCHOLINESTERASE; CATALYSIS; CHEMICAL WARFARE AGENTS; HYDROLYSIS; INSECTICIDES; ORGANOPHOSPHATES; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORIC TRIESTER HYDROLASES; STEREOISOMERISM;

EID: 77956594580     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101056m     Document Type: Article

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