Mast cells and basophils are essential for allergies: Mechanisms of allergic inflammation and a proposed procedure for diagnosis

Acta Pharmacologica Sinica

Volumn 34, Issue 10, 2013, Pages 1270-1283

  He, Shao Heng ^a,c   Zhang, Hui Yun ^b   Zeng, Xiao Ning ^c   Chen, Dong ^a   Yang, Ping Chang ^d  

^a JINZHOU MEDICAL UNIVERSITY   (China)

^b HAINAN MEDICAL UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^d MCMASTER UNIVERSITY   (Canada)

Author keywords

Allergy; Basophil; Basophil activation test; IgE; IgG; Mast cell; Pseudo allergic reaction; Specific allergen challenge test

Indexed keywords

ADRENALIN; ALLERGEN; ANTIHISTAMINIC AGENT; CD123 ANTIGEN; CD4 ANTIGEN; CD63 ANTIGEN; CHEMOKINE RECEPTOR CCR3; CHYMASE; FOOD ALLERGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEPARIN; HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; INTERLEUKIN 13; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 25; INTERLEUKIN 3; INTERLEUKIN 31; INTERLEUKIN 33; INTERLEUKIN 4; INTERLEUKIN 5; LEUKOTRIENE C4; STEM CELL FACTOR RECEPTOR; STEROID; THYMIC STROMAL LYMPHOPOIETIN; TRANSCRIPTION FACTOR FOXP3; TRYPTASE;

ALLERGIC ASTHMA; ALLERGIC CONJUNCTIVITIS; ALLERGIC DISEASE; ALLERGIC REACTION; ALLERGIC RHINITIS; ALLERGIC URTICARIA; ALLERGY; ALLERGY TEST; ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ANTIGEN PRESENTING CELL; ANTIGENICITY; B LYMPHOCYTE; BASOPHIL; BRONCHOSPASM; CELL MEMBRANE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EFFECTOR CELL; EOSINOPHIL; EPITHELIUM CELL; HISTAMINE RELEASE; HOUSE DUST ALLERGY; HUMAN; IMMUNOPATHOGENESIS; INSECT ALLERGY; LABORATORY TEST; MAST CELL; MOLECULAR WEIGHT; NEUTROPHIL; NONHUMAN; PNEUMONIA; POLLEN ALLERGY; PRICK TEST; PROVOCATION TEST; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT ALLERGY; REVIEW; T LYMPHOCYTE; TH17 CELL; TH2 CELL; TRANSDERMAL PATCH;

ALLERGENS; ANIMALS; BASOPHILS; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INFLAMMATION; MAST CELLS;

EID: 84887371851     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.88     Document Type: Review

References (156)

1. Warner JO, Kaliner MA, Crisci CD, Del Giacco S, Frew AJ, Liu GH, et al. Allergy practice worldwide: a report by the world allergy organization specialty and training council. Int Arch Allergy Immunol 2006; 139: 166-74. (Pubitemid 43177330)
2. Barnes PJ. Pathophysiology of allergic inflammation. In: Adkinson NF Jr, Bochner BS, Busse WW, Holgate ST, Lemanske RF Jr, Simons FER. Middleton's Allergy, Principles and Practice Edition 7. Mosby: Elsevier; 2009. p455-72.
3. Bernardini R, Novembre E, Lombardi E, Monaco MG, Monte MT, Pucci N, et al. Pseudoallergies. Pediatr Med Chir 2001; 23: 9-16.
4. Hamilton RG. Clinical laboratory assessment of immediate-type hypersensitivity. J Allergy Clin Immunol 2010; 125 Suppl 2: S284-96.
5. Wang RQ, Zhang HY. Analysis of 215,210 allergen specific IgE tests in Beijing Union Hospital. Workshop of Allergy; 2011; Nanjing, China.
6. He S, Zhang H, Zeng X, Yang P. Self-amplification mechanisms of mast cell activation: a new look in allergy. Curr Mol Med 2012; 12: 1329-39.
7. Platts-Mills TAE. Indoor allergens. In: Adkinson NF Jr, Bochner BS, Busse WW, Holgate ST, Lemanske RF Jr, Simons FER. Middleton's Allergy, Principles and Practice Edition 7. Mosby: Elsevier; 2009. p539-55.
8. Ohman JL Jr, Lowell FC, Bloch KJ, Kendall S. Allergens of mammalian origin V. Properties of extracts derived from the domestic cat. Clin Allergy 1976; 6: 419-28.
9. Chapman MD, Platts-Mills TA. Purification and characterization of the major allergen from Dermatophagoides pteronyssinus-antigen P1. J Immunol 1980; 125: 587-92. (Pubitemid 10045631)
10. Zhang N, Holtappels G, Gevaert P, Patou J, Dhaliwal B, Gould H, et al. Mucosal tissue polyclonal IgE is functional in response to allergen and SEB. Allergy 2011; 66: 141-8.
11. Marone G, Rossi FW, Detoraki A, Granata F, Marone G, Genovese A, et al. Role of superallergens in allergic disorders. Chem Immunol Allergy 2007; 93: 195-213. (Pubitemid 46924879)
12. Schuurman J, Perdok GJ, Mueller GA, Aalberse RC. Complementation of Der P 2-induced histamine release from human basophils sensitized with monoclonal IgE: not only by IgE, but also by IgG antibodies directed to a nonoverlapping epitope of Der p 2. J Allergy Clin Immunol 1998; 101: 404-9. (Pubitemid 28146362)
13. Woolhiser MR, Brockow K, Metcalfe DD. Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a. Clin Immunol 2004; 110: 172-80. (Pubitemid 38296707)
14. Ali H. Regulation of human mast cell and basophil function by anaphylatoxins C3a and C5a. Immunol Lett 2010; 128: 36-45.
15. Heimbach L, Li Z, Berkowitz P, Zhao M, Li N, Rubenstein DS, et al. The C5a receptor on mast cells is critical for the autoimmune skin-blistering disease bullous pemphigoid. J Biol Chem 2011; 286: 15003-9.
16. Warkentin TE, Greinacher A. Heparin-induced anaphylactic and anaphylactoid reactions: two distinct but overlapping syndromes. Expert Opin Drug Saf 2009; 8: 129-44.
17. Peavy RD, Metcalfe DD. Understanding the mechanisms of anaphylaxis. Curr Opin Allergy Clin Immunol 2008; 8: 310-5.
18. Idée JM, Pinès E, Prigent P, Corot C. Allergy-like reactions to iodinated contrast agents. A critical analysis. Fundam Clin Pharmacol 2005; 19: 263-81. (Pubitemid 40769449)
19. Barnes PJ. Pathophysiology of allergic inflammation. Immunol Rev 2011; 242: 31-50.
20. Incorvaia C, Frati F, Sensi L, Riario-Sforza GG, Marcucci F. Allergic inflammation and the oral mucosa. Recent Pat Inflamm Allergy Drug Discov 2007; 1: 35-8.
21. Willart MA, Hammad H. Alarming dendritic cells for allergic sensitization. Allergol Int 2010; 59: 95-103.
22. Maurer D, Fiebiger S, Ebner C, Reininger B, Fischer GF, Wichlas S, et al. Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. J Immunol 1996; 157: 607-16. (Pubitemid 26231362)
23. Lewkowich IP, Lajoie S, Clark JR, Herman NS, Sproles AA, Wills-Karp M. Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice. PLoS One 2008; 3: e3879.
24. Till SJ, Jacobson MR, O'Brien F, Durham SR, Klein Jan A, Fokkens WJ, et al. Recruitment of CD1a+ Langerhans cells to the nasal mucosa in seasonal allergic rhinitis and effects of topical corticosteroid therapy. Allergy 2001; 56: 126-31. (Pubitemid 32115762)
25. Novak N, Bieber T, Kraft S. Immunoglobulin E-bearing antigen-presenting cells in atopic dermatitis. Curr Allergy Asthma Rep 2004; 4: 263-9. (Pubitemid 39359527)
26. Koyasu S, Moro K. Type 2 innate immune responses and the natural helper cell. Immunology 2011; 132: 475-81.
27. Schroeder JT, Chichester KL, Bieneman AP. Human basophils secrete IL-3: evidence of autocrine priming for phenotypic and functional responses in allergic disease. J Immunol 2009; 182: 2432-8.
28. Ricci M, Matucci A, Rossi O. IL-4 as a key factor influencing the development of allergen-specific Th2-like cells in atopic individuals. J Investig Allergol Clin Immunol 1997; 7: 144-50 (Pubitemid 27344626)
29. Allahverdian S, Harada N, Singhera GK, Knight DA, Dorscheid DR. Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF. Am J Respir Cell Mol Biol 2008; 38: 153-60. (Pubitemid 351162836)
30. Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med 2009; 180: 720-30.
31. Ozdemir C, Akdis M, Akdis CA. T-cell response to allergens. Chem Immunol Allergy 2010; 95: 22-44.
32. Cosmi L, Liotta F, Maggi E, Romagnani S, Annunziato F. Th17 cells: new players in asthma pathogenesis. Allergy 2011; 66: 989-98.
33. Shen Y, Hu GH, Yang YC, Ke X, Tang XY, Hong SL. Allergen induced Th17 response in the peripheral blood mononuclear cells (PBMCs) of patients with nasal polyposis. Int Immunopharmacol 2011; 12: 235-40.
34. Venuprasad K, Kong YC, Farrar MA. Control of Th2-mediated inflammation by regulatory T cells. Am J Pathol 2010; 177: 525-31.
35. Akdis M. The cellular orchestra in skin allergy; are differences to lung and nose relevant? Curr Opin Allergy Clin Immunol 2010; 10: 443-51.
36. Palomares O, Yaman G, Azkur AK, Akkoc T, Akdis M, Akdis CA. Role of Treg in immune regulation of allergic diseases. Eur J Immunol 2010; 40: 1232-40.
37. Robinson DS. Regulatory T cells and asthma. Clin Exp Allergy 2009; 39: 1314-23.
38. Jelinek DF. Regulation of B lymphocyte differentiation. Ann Allergy Asthma Immunol 2000; 84: 375-85.
39. Chung CH, Mirakhur B, Chan E, Le QT, Berlin J, Morse M, et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3- galactose. N Engl J Med 2008; 358: 1109-17. (Pubitemid 351398485)
40. Savilahti EM, Saarinen KM, Savilahti E. Duration of clinical reactivity in cow's milk allergy is associated with levels of specific immunoglobulin G4 and immunoglobulin A antibodies to beta-lactoglobulin. Clin Exp Allergy 2010; 40: 251-6.
41. Choi GS, Park HJ, Hur GY, Choi SJ, Shin SY, Ye YM, et al. Vascular endothelial growth factor in allergen-induced nasal inflammation. Clin Exp Allergy 2009; 39: 655-61.
42. Tschopp CM, Spiegl N, Didichenko S, Lutmann W, Julius P, Virchow JC, et al. Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. Blood 2006; 108: 2290-9. (Pubitemid 44497512)
43. Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, et al. IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. J Immunol 2009; 182: 2835-41.
44. Andersen HB, Holm M, Hetland TE, Dahl C, Junker S, Schiøtz PO, et al. Comparison of short term in vitro cultured human mast cells from different progenitors - Peripheral blood-derived progenitors generate highly mature and functional mast cells. J Immunol Methods 2008; 336: 166-7
45. Laidlaw TM, Steinke JW, Tiñana AM, Feng C, Xing W, Lam BK, et al. Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcεRI. J Allergy Clin Immunol 2011; 127: 815-22.
46. Lee HN, Kim CH, Song GG, Cho SW. Effects of IL-3 and SCF on histamine production kinetics and cell phenotype in rat bone marrow-derived mast cells. Immune Netw 2010; 10: 15-25.
47. Law M, Morales JL, Mottram LF, Iyer A, Peterson BR, August A. Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2. Int J Biochem Cell Biol 2011; 43: 1228-39.
48. Spiegl N, Didichenko S, McCaffery P, Langen H, Dahinden CA. Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid. Blood 2008; 112: 3762-71.
49. Kraft D. Regulation of IgE synthesis. Wien Klin Wochenschr 1993; 105: 669-71. (Pubitemid 24011300)
50. Romagnani S. Regulation of the development of type 2 T-helper cells in allergy. Curr Opin Immunol 1994; 6: 838-46.
51. Baraniuk JN. Pathogenesis of allergic rhinitis. J Allergy Clin Immunol 1997; 99: S763-72. (Pubitemid 27091593)
52. Zhang H, Yang H, He S. TNF increases expression of IL-4 and PARs in mast cells. Cell Physiol Biochem 2010; 26: 327-36.
53. Smithgall MD, Comeau MR, Yoon BR, Kaufman D, Armitage R, Smith DE. IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells. Int Immunol 2008; 20: 1019-30.
54. Molfino NA, Gossage D, Kolbeck R, Parker JM, Geba GP. Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor. Clin Exp Allergy 2012; 42: 712-37.
55. Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, et al. Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J Immunol 2010; 184: 4159-69.
56. Wang YH, Liu YJ. Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses. Clin Exp Allergy 2009; 39: 798-806.
57. Wisniewski JA, Borish L. Novel cytokines and cytokine-producing T cells in allergic disorders. Allergy Asthma Proc 2011; 32: 83-94.
58. Siegle JS, Hansbro N, Dong C, Angkasekwinai P, Foster PS, Kumar RK. Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma. Clin Exp Immunol 2011; 165: 19-28.
59. Cornelissen C, Lüscher-Firzlaff J, Baron JM, Lüscher B. Signaling by IL-31 and functional consequences. Eur J Cell Biol 2012; 91: 552-66.
60. Castellani ML, Felaco P, Galzio RJ, Tripodi D, Toniato E, De Lutiis MA, et al. IL-31a Th2 cytokine involved in immunity and inflammation. Int J Immunopathol Pharmacol 2010; 23: 709-13.
61. Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, et al. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J Immunol 2010; 184: 3526-34.
62. Eiwegger T, Akdis CA. IL-33 links tissue cells, dendritic cells and Th2 cell development in a mouse model of asthma. Eur J Immunol 2011; 41: 1535-8.
63. Schneider E, Thieblemont N, De Moraes ML, Dy M. Basophils: new players in the cytokine network. Eur Cytokine Netw 2010; 21: 142-53.
64. Okayama Y, Okumura S, Sagara H, Yuki K, Sasaki T, Watanabe N, et al. FcepsilonRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells. Eur Respir J 2009; 34: 425-35.
65. Wodnar-Filipowicz A, Heusser CH, Moroni C. Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation. Nature 1989; 339: 150-2. (Pubitemid 19122273)
66. Romagnani S. The role of lymphocytes in allergic disease. J Allergy Clin Immunol 2000; 105: 399-408. (Pubitemid 30169893)
67. Zhang H, Yang H, Zhang L, Yang X, Zhang Z, Lin Q, et al. Induction of IL-4 release and upregulated expression of protease activated receptors by GM-CSF in P815 cells. Cytokine 2009; 48: 196-202.
68. Lampinen M, Carlson M, Håkansson LD, Venge P. Cytokine-regulated accumulation of eosinophils in inflammatory disease. Allergy 2004; 59: 793-805. (Pubitemid 39005818)
69. Bischoff SC, Ulmer FA. Eosinophils and allergic diseases of the gastrointestinal tract. Best Pract Res Clin Gastroenterol 2008; 22: 455-79. (Pubitemid 351676811)
70. Marone G, Triggiani M, Genovese A, De Paulis A. Role of human mast cells and basophils in bronchial asthma. Adv Immunol 2005; 88: 97-160. (Pubitemid 41437913)
71. Yu CK, Chen CL. Activation of mast cells is essential for development of house dust mite Dermatophagoides farinae-induced allergic airway inflammation in mice. J Immunol 2003; 171: 3808-15.
72. Vliagoftis H, Befus AD. Rapidly changing perspectives about mast cells at mucosal surfaces. Immunol Rev 2005; 206: 190-203. (Pubitemid 41105171)
73. Kalesnikoff J, Galli SJ. Anaphylaxis: mechanisms of mast cell activation. Chem Immunol Allergy 2010; 95: 45-66.
74. Hennino A, Bérard F, Guillot I, Saad N, Rozières A, Nicolas JF. Patho-physiology of urticaria. Clin Rev Allergy Immunol 2006; 30: 3-11.
75. 2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. Nat Rev Drug Discov 2007; 6: 313-25. (Pubitemid 46505882)
76. Iwaki S, Tkaczyk C, Metcalfe DD, Gilfillan AM. Roles of adaptor molecules in mast cell activation. Chem Immunol Allergy 2005; 87: 43-58. (Pubitemid 43093179)
77. Holgate ST. The role of mast cells and basophils in inflammation. Clin Exp Allergy 2000; 30: 28-32. (Pubitemid 30341374)
78. Bradding P, Walls AF, Holgate ST. The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol 2006; 117: 1277-84. (Pubitemid 43795741)
79. Yu M, Tsai M, Tam SY, Jones C, Zehnder J, Galli SJ. Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest 2006; 116: 1633-41.
80. Munitz A, Bachelet I, Levi-Schaffer F. Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a. J Allergy Clin Immunol 2006; 118: 1082-9. (Pubitemid 44666985)
81. He S, Walls AF. Human mast cell tryptase: a stimulus of micro-vascular leakage and mast cell activation. Eur J Pharmacol 1997; 328: 89-97. (Pubitemid 27241401)
82. Caron G, Delneste Y, Roelandts E, Duez C, Bonnefoy JY, Pestel J, et al. Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells. J Immunol 2001; 167: 3682-6. (Pubitemid 32910811)
83. Foster AP, Cunningham FM. Histamine-induced adherence and migration of equine eosinophils. Am J Vet Res 1998; 59: 1153-9. (Pubitemid 128472441)
84. Desai P, Thurmond RL. Histamine H4 receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation. Eur J Immunol 2011; 41: 1764-73.
85. He S, Peng Q, Walls AF. Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase: selective enhancement of eosinophil recruitment by histamine. J Immunol 1997; 159: 6216-25. (Pubitemid 127471563)
86. Vliagoftis H, Lacy P, Luy B, Adamko D, Hollenberg M, Befus D, et al. Mast cell tryptase activates peripheral blood eosinophils to release granule-associated enzymes. Int Arch Allergy Immunol 2004; 135: 196-204. (Pubitemid 39664091)
87. Meyer MC, Creer MH, McHowat J. Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium. Am J Physiol Cell Physiol 2005; 289: C1485-91. (Pubitemid 41636353)
88. He S, Walls AF. Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells in vivo. Br J Pharmacol 1998; 125: 1491-500. (Pubitemid 28548562)
89. Terakawa M, Tomimori Y, Goto M, Hayashi Y, Oikawa S, Fukuda Y. Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway. Biochem Biophys Res Commun 2005; 332: 969-75. (Pubitemid 40798182)
90. He S, Zheng J. Stimulation of mucin release from airway epithelial cells by mast cell chymase. Acta Pharmacol Sin 2004; 25: 827-32. (Pubitemid 38736113)
91. Pejler G, Knight SD, Henningsson F, Wernersson S. Novel insights into the biological function of mast cell carboxypeptidase A. Trends Immunol 2009; 30: 401-8.
92. Dias-Baruffi M, Pereira-da-Silva G, Jamur MC, Roque-Barreira MC. Heparin potentiates in vivo neutrophil migration induced by IL-8. Glycoconj J 1998; 15: 523-6. (Pubitemid 28295022)
93. Oschatz C, Maas C, Lecher B, Jansen T, Björkqvist J, Tradler T, et al. Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo. Immunity 2011; 34: 258-68.
94. Rönnberg E, Melo FR, Pejler G. Mast cell proteoglycans. J Histochem Cytochem 2012; 60: 950-62.
95. Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM. Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. Am J Respir Cell Mol Biol 1997; 17: 519-28. (Pubitemid 127500985)
96. Devi NS, Doble M. Leukotriene c4 synthase: upcoming drug target for inflammation. Curr Drug Targets 2012; 13: 1107-18.
97. 2 receptors DP and CRTH2 in the pathogenesis of asthma. Curr Mol Med 2008; 8: 365-75.
98. Kasperska-Zajac A, Brzoza Z, Rogala B. Platelet activating factor as a mediator and therapeutic approach in bronchial asthma. Inflammation 2008; 31: 112-20.
99. Nilsson G, Metcalfe DD, Taub DD. Demonstration that platelet-activating factor is capable of activating mast cells and inducing a chemotactic response. Immunology 2000; 99: 314-9. (Pubitemid 30093679)
100. Mustafa FB, Ng FS, Nguyen TH, Lim LH. Honeybee venom secretory phospholipase A2 induces leukotriene production but not histamine release from human basophils. Clin Exp Immunol 2008; 151: 94-100. (Pubitemid 350230993)
101. He S, Zhang H, Chen H, Yang H, Huang T, Chen Y, et al. Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29. Allergy 2010; 65: 1234-41.
102. Theoharides TC, Kempuraj D, Tagen M, Conti P, Kalogeromitros D. Differential release of mast cell mediators and the pathogenesis of inflammation. Immunol Rev 2007; 217: 65-78. (Pubitemid 46718152)
103. Yang YJ, Chen W, Carrigan SO, Chen WM, Roth K, Akiyama T, et al. TRAF6 specifically contributes to FcepsilonRI-mediated cytokine production but not mast cell degranulation. J Biol Chem 2008; 283: 32110-8.
104. Hart PH. Regulation of the inflammatory response in asthma by mast cell products. Immunol Cell Biol 2001; 79: 149-53. (Pubitemid 32281086)
105. Misiak-Tłoczek A, Brzeziłska-Błaszczyk E. IL-6, but not IL-4, stimulates chemokinesis and TNF stimulates chemotaxis of tissue mast cells: involvement of both mitogen-activated protein kinases and phosphatidylinositol 3-kinase signalling pathways. APMIS 2009; 117: 558-67.
106. Olsson N, Taub DD, Nilsson G. Regulation of mast cell migration by T and T cytokines: identification of tumour necrosis factor-alpha and interleukin-4 as mast cell chemotaxins. Scand J Immunol 2004; 59: 267-72. (Pubitemid 38429293)
107. Brzeziłska-Błaszczyk E, Pietrzak A, Misiak-Tłoczek AH. Tumor necrosis factor (TNF) is a potent rat mast cell chemoattractant. J Interferon Cytokine Res 2007; 27: 911-9. (Pubitemid 350223111)
108. Toru H, Kinashi T, Ra C, Nonoyama S, Yata J, Nakahata T. Inter-leukin-4 induces homotypic aggregation of human mast cells by promoting LFA-1/ICAM-1 adhesion molecules. Blood 1997; 89: 3296-302.
109. Muñoz NM, Meliton AY, Lambertino, Boetticher E, Learoyd J, Sultan F, et al. Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. J Immunol 2006; 177: 574-82. (Pubitemid 43939171)
110. 2 in the skin. Am J Pathol 2010; 176: 227-37.
111. Knol EF, Mul FP, Jansen H, Calafat J, Roos D. Monitoring human basophil activation via CD63 monoclonal antibody 435. J Allergy Clin Immunol 1991; 88: 328-38.
112. Schäfer T, Starkl P, Allard C, Wolf RM, Schweighoffer T. A granular variant of CD63 is a regulator of repeated human mast cell degranulation. Allergy 2010; 65: 1242-55
113. Wedi B, Kapp A. Cellular in-vitro assays. Applicability in daily routine. Hautarzt 2010; 61: 954-60.
114. Sturm EM, Kranzelbinder B, Heinemann A, Groselj-Strele A, Aberer W, Sturm GJ. CD203c-based basophil activation test in allergy diagnosis: characteristics and differences to CD63 upregulation. Cytometry B Clin Cytom 2010; 78: 308-18.
115. Kinhult J, Egesten A, Uddman R, Cardell LO. PACAP enhances the expression of CD11b, CD66b and CD63 in human neutrophils. Peptides 2002; 23: 1735-9. (Pubitemid 35279831)
116. Bellemare-Pelletier A, Tremblay J, Beaulieu S, Boulassel MR, Routy JP, Massie B, et al. HLA-DO transduced in human monocyte-derived dendritic cells modulates MHC class II antigen processing. J Leukoc Biol 2005; 78: 95-105. (Pubitemid 40979948)
117. Pfistershammer K, Majdic O, Stöckl J, Zlabinger G, Kirchberger S, Steinberger P, et al. CD63 as an activation-linked T cell costimulatory element. J Immunol 2004; 173: 6000-8. (Pubitemid 39487754)
118. Mahmudi-Azer S, Downey GP, Moqbel R. Translocation of the tetraspanin CD63 in association with human eosinophil mediator release. Blood 2002; 99: 4039-47. (Pubitemid 35332045)
119. Hausmann OV, Gentinetta T, Fux M, Ducrest S, Pichler WJ, Dahinden CA. Robust expression of CCR3 as a single basophil selection marker in flow cytometry. Allergy 2011; 66: 85-91.
120. Korosec P, Mavsar N, Bajrovic N, Silar M, Mrhar A, Kosnik M. Basophil responsiveness and clinical picture of acetylsalicylic acid intolerance. Int Arch Allergy Immunol 2011; 155: 257-62.
121. + progenitors. Clin Exp Allergy 2003; 33: 640-8. (Pubitemid 36629689)
122. Morokata T, Suzuki K, Masunaga Y, Taguchi K, Morihira K, Sato I, et al. A novel, selective, and orally available antagonist for CC chemokine receptor 3. J Pharmacol Exp Ther 2006; 317: 244-50.
123. + dendritic cells in the nasal mucosa. Int Arch Allergy Immunol 2011; 155: 234-42.
124. Carlson JA, Perlmutter A, Tobin E, Richardson D, Rohwedder A. Adverse antibiotic-induced eruptions associated with epstein barr virus infection and showing Kikuchi-Fujimoto disease-like histology. Am J Dermatopathol 2006; 28: 48-55. (Pubitemid 44366182)
125. Chirumbolo S, Conforti A, Ortolani R, Vella A, Marzotto M, Bellavite P. Stimulus-specific regulation of CD63 and CD203c membrane expression in human basophils by the flavonoid quercetin. Int Immunopharmacol 2010; 10: 183-92.
126. Wanich N, Nowak-Wegrzyn A, Sampson HA, Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol 2009; 123: 789-94.
127. Kraft S, Fleming T, Billingsley JM, Lin SY, Jouvin MH, Storz P, et al. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J Exp Med 2005; 201: 385-96. (Pubitemid 40229413)
128. Hauswirth AW, Sonneck K, Florian S, Krauth MT, Bohm A, Sperr WR, et al. Interleukin-3 promotes the expression of E-NPP3/CD203C on human blood basophils in healthy subjects and in patients with birch pollen allergy. Int J Immunopathol Pharmacol 2007; 20: 267-78. (Pubitemid 47104847)
129. Boumiza R, Monneret G, Forissier MF, Savoye J, Gutowski MC, Powell WS, et al. Marked improvement of the basophil activation test by detecting CD203c instead of CD63. Clin Exp Allergy 2003; 33: 259-65. (Pubitemid 36241385)
130. Ono E, Taniguchi M, Higashi N, Mita H, Kajiwara K, Yamaguchi H, et al. CD203c expression on human basophils is associated with asthma exacerbation. J Allergy Clin Immunol 2010; 125: 483-9.
131. Sturm GJ, Kranzelbinder B, Sturm EM, Heinemann A, Groselj-Strele A, Aberer W. The basophil activation test in the diagnosis of allergy: technical issues and critical factors. Allergy 2009; 64: 1319-26.
132. Gernez Y, Tirouvanziam R, Yu G, Ghosn EE, Reshamwala N, Nguyen T, et al. Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Int Arch Allergy Immunol 2011; 154: 318-27.
133. Özdemir SK, Gülǒlu D, Sin BA, Elhan AH, Ikinciǒullari{dotless} A, Mi{dotless}si{dotless}rli{dotless}gil Z. Reliability of basophil activation test using CD203c expression in diagnosis of pollen allergy. Am J Rhinol Allergy 2011; 25: e225-31.
134. Ebo DG, Bridts CH, Hagendorens MM, Mertens CH, De Clerck LS, Stevens WJ. Flow-assisted diagnostic management of anaphylaxis from rocuronium bromide. Allergy 2006; 61: 935-9. (Pubitemid 44024890)
135. Frezzolini A, Cadoni S, De Pità O. Usefulness of the CD63 basophil activation test in detecting Anisakis hypersensitivity in patients with chronic urticaria: diagnosis and follow-up. Clin Exp Dermatol 2010; 35: 765-70.
136. Gentinetta T, Pecaric-Petkovic T, Wan D, Falcone FH, Dahinden CA, Pichler WJ, et al. Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria. J Allergy Clin Immunol 2011; 128: 1227-34.
137. MacGlashan D Jr. Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes. Clin Exp Allergy 2010; 40: 1365-77.
138. Lundberg K, Greiff L, Borrebaeck CA, Lindstedt M. FcεRI levels and frequencies of peripheral blood dendritic cell populations in allergic rhinitis. Hum Immunol 2010; 71: 931-3.
139. Iikura M, Yamaguchi M, Hirai K, Miyamasu M, Yamada H, Nakajima T, et al. Regulation of surface FcepsilonRI expression on human eosinophils by IL-4 and IgE. Int Arch Allergy Immunol 2001; 124: 470-7. (Pubitemid 32429690)
140. Kojima T, Obata K, Mukai K, Sato S, Takai T, Minegishi Y, et al. Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. J Immunol 2007; 179: 7093-100.
141. Valent P, Cerny-Reiterer S, Herrmann H, Mirkina I, George TI, Sotlar K, et al. Phenotypic heterogeneity, novel diagnostic markers, and target expression profiles in normal and neoplastic human mast cells. Best Pract Res Clin Haematol 2010; 23: 369-78.
142. Miettinen M, Lasota J. KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol 2005; 13: 205-20. (Pubitemid 41209013)
143. Sabato V, Verweij MM, Bridts CH, Levi-Schaffer F, Gibbs BF, De Clerck LS, et al. CD300a is expressed on human basophils and seems to inhibit IgE/FcεRI-dependent anaphylactic degranulation. Cytometry B Clin Cytom 2012; 82: 132-8.
144. Akiyama K, Pruzansky JJ, Patterson R. Hapten-modified basophils: a model of human immediate hypersensitivity that can be elicited by IgG antibody. J Immunol 1984; 133: 3286-90. (Pubitemid 15216506)
145. Szebeni J. Complement activation-related pseudoallergy caused by liposomes, micellar carriers of intravenous drugs, and radiocontrast agents. Crit Rev Ther Drug Carrier Syst 2001; 18: 567-606. (Pubitemid 34024397)
146. Mertes PM, Demoly P, Malinovsky JM. Hypersensitivity reactions in the anesthesia setting/allergic reactions to anesthetics. Curr Opin Allergy Clin Immunol 2012; 12: 361-8.
147. Ring J, Brockow K, Behrendt H. History and classification of anaphylaxis. Novartis Found Symp 2004; 257: 6-16.
148. Ring J, Behrendt H, de Weck A. History and classification of anaphylaxis. Chem Immunol Allergy 2010; 95: 1-11.
149. Urisu A, Ebisawa M, Mukoyama T, Morikawa A, Kondo N. Japanese Society of Allergology. Japanese guideline for food allergy. Allergol Int 2011; 60: 221-36.
150. Sanz ML, Gamboa PM, De Weck AL. Cellular tests in the diagnosis of drug hypersensitivity. Curr Pharm Des 2008; 14: 2803-8.
151. Lieberman JA, Sicherer SH. The diagnosis of food allergy. Am J Rhinol Allergy 2010; 24: 439-43.
152. Kim JH, An S, Kim JE, Choi GS, Ye YM, Park HS. Beef-induced anaphylaxis confirmed by the basophil activation test. Allergy Asthma Immunol Res 2010; 2: 206-8.
153. Soundararajan S, Kikuchi Y, Joseph K, Kaplan AP. Functional assessment of pathogenic IgG subclasses in chronic autoimmune urticaria. J Allergy Clin Immunol 2005; 115: 815-21. (Pubitemid 40460859)
154. MacGlashan D Jr, Honigberg LA, Smith A, Buggy J, Schroeder JT. Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor. Int Immunopharmacol 2011; 11: 475-9.
155. Nakahira M, Nakanishi K. Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells. Int Immunol 2011; 23: 761-72.
156. Croft M, Duan W, Choi H, Eun SY, Madireddi S, Mehta A. TNF super-family in inflammatory disease: translating basic insights. Trends Immunol 2012; 33: 144-52.