A granular variant of CD63 is a regulator of repeated human mast cell degranulation

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 65, Issue 10, 2010, Pages 1242-1255

  Schafer T ^a   Starkl, P ^a   Allard, C ^a   Wolf, R M ^a   Schweighoffer, T ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

CD63; mast cell; repeated degranulation; tetraspanin

Indexed keywords

CD63 ANTIGEN; CYSTEINE; FC EPSILON RECEPTOR 1; FC RECEPTOR; IMMUNOGLOBULIN E; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD63; TETRASPANIN; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ARTICLE; CELL ACTIVATION; CELL SURVIVAL; CROSS REACTION; DISULFIDE BOND; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MAST CELL; MAST CELL DEGRANULATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, CD; BIOLOGICAL MARKERS; CELL DEGRANULATION; FETAL BLOOD; HUMANS; MAST CELLS; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, IGE;

EID: 77956439040     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2010.02350.x     Document Type: Article

References (44)

1. Bischoff SC. Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol 2007 7 : 93 104.
2. Marshall JS. Mast cell responses to pathogens. Nat Rev Immunol 2004 4 : 787 799.
3. Galli SJ, Nakae S, Tsai M. Mast cells in the development of adaptive immune responses. Nat Immunol 2005 6 : 135 142.
4. Gilfillan AM, Tkaczyk C. Integrated signalling pathways for mast-cell activation. Nat Rev Immunol 2006 6 : 218 230.
5. Nishida K, Yamasaki S, Ito Y, Kabu K, Hattori K, Tezuka T et al. FcεRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol 2005 170 : 115 126.
6. Puri N, Kruhlak MJ, Whiteheart SW, Roche PA. Mast Cell Degranulation Requires N-Ethylmaleimide-Sensitive Factor-Mediated SNARE Disassembly. J Immunol 2003 171 : 5345 5352.
7. Blank U, Rivera J. The ins and outs of IgE-dependent mast-cell exocytosis. Trends Immunol 2004 25 : 266 273.
8. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007 9 : 654 659.
9. Kunder CA, St. John AL, Li G, Leong KW, Berwin B, Staats HF et al. Mast cell-derived particles deliver peripheral signals to remote lymph nodes. J Exp Med 2009 206 : 2455 2647.
10. Burwen SJ. Recycling of mast cells following degranulation in vitro: an ultrastructural study. Tissue Cell 1982 14 : 125 134.
11. Dvorak AM, Schleimer RP, Schulman ES, Lichtenstein LM. Human mast cells use conservation and condensation mechanisms during recovery from degranulation. In vitro studies with mast cells purified from human lungs. Lab Invest 1986 54 : 663 678.
12. Xiang Z, Block M, Lofman C, Nilsson G. IgE-mediated mast cell degranulation and recovery monitored by time-lapse photography. J Allergy Clin Immunol 2001 108 : 116 121.
13. Garcia-Espana A, Chung PJ, Sarkar IN, Stiner E, Sun TT, DeSalle R. Appearance of new tetraspanin genes during vertebrate evolution. Genomics 2008 91 : 326 334.
14. Hemler ME. Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu Rev Cell Dev Biol 2003 19 : 397 422.
15. Stipp CS, Kolesnikova TV, Hemler ME. Functional domains in tetraspanin proteins. Trends Biochem Sci 2003 28 : 106 112.
16. Jung KK, Liu XW, Chirco R, Fridman R, Kim HR. Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. EMBO J 2006 25 : 3934 3942.
17. Latysheva N, Muratov G, Rajesh S, Padgett M, Hotchin NA, Overduin M et al. Syntenin-1 Is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63. Mol Cell Biol 2006 26 : 7707 7718.
18. Yoshida T, Kawano Y, Sato K, Ando Y, Aoki J, Miura Y et al. A CD63 mutant inhibits T-cell tropic HIV-1 entry by disrupting CXCR4 trafficking to the plasma membrane. Traffic 2008 9 : 540 558.
19. Metzelaar MJ, Wijngaard PL, Peters PJ, Sixma JJ, Nieuwenhuis HK, Clevers HC. CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. J Biol Chem 1991 266 : 3239 3245.
20. Nishibori M, Cham B, McNicol A, Shalev A, Jain N, Gerrard JM. The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin. J Clin Invest 1993 91 : 1775 1782.
21. Eberlein-Konig B, Varga R, Mempel M, Darsow U, Behrendt H, Ring J. Comparison of basophil activation tests using CD63 or CD203c expression in patients with insect venom allergy. Allergy 2006 61 : 1084 1085.
22. Ebo DG, Lechkar B, Schuerwegh AJ, Bridts CH, De Clerck LS, Stevens WJ. Validation of a two-color flow cytometric assay detecting in vitro basophil activation for the diagnosis of IgE-mediated natural rubber latex allergy. Allergy 2002 57 : 706 712.
23. Sturm GJ, Bohm E, Trummer M, Weiglhofer I, Heinemann A, Aberer W. The CD63 basophil activation test in Hymenoptera venom allergy: a prospective study. Allergy 2004 59 : 1110 1117.
24. Rous BA, Reaves BJ, Ihrke G, Briggs JAG, Gray SR, Stephens DJ et al. Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes. Mol Biol Cell 2002 13 : 1071 1082.
25. Kempuraj D, Saito H, Kaneko A, Fukagawa K, Nakayama M, Toru H et al. Characterization of mast cell-committed progenitors present in human umbilical cord blood. Blood 1999 93 : 3338 3346.
26. Schernthaner GH, Hauswirth AW, Baghestanian M, Agis H, Ghannadan M, Worda C et al. Detection of differentiation- and activation-linked cell surface antigens on cultured mast cell progenitors. Allergy 2005 60 : 1248 1255.
27. Dahl C, Saito H, Nielsen HV, Schiotz PO. The establishment of a combined serum-free and serum-supplemented culture method of obtaining functional cord blood-derived human mast cells. J Immunol Methods 2002 262 : 137 143.
28. Kitadokoro K, Ponassi M, Galli G, Petracca R, Falugi F, Grandi G et al. Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. Biol Chem 2002 383 : 1447 1452.
29. Canutescu AA, Shelenkov AA, Dunbrack RL Jr. A graph-theory algorithm for rapid protein side-chain prediction. Protein Sci 2003 12 : 2001 2014.
30. Laskowski RA, MacArthur MW, Moss DS, Thornton JM. Procheck: a program to check the stereochemical quality of protein structures. J Appl Crystallogr 1993 26 : 283 291.
31. Grutzkau A, Smorodchenko A, Lippert U, Kirchhof L, Artuc M, Henz BM. LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells. Cytometry A 2004 61 : 62 68.
32. Hotta H, Ross AH, Huebner K, Isobe M, Wendeborn S, Chao MV et al. Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. Cancer Res 1988 48 : 2955 2962.
33. Logozzi M, De MA, Lugini L, Borghi M, Calabro L, Spada M et al. High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. PLoS ONE 2009 4 : e5219.
34. Engering A, Kuhn L, Fluitsma D, Hoefsmit E, Pieters J. Differential post-translational modification of CD63 molecules during maturation of human dendritic cells. FEBS J 2003 270 : 2412 2420.
35. Smith DA, Monk PN, Partridge LJ. Antibodies against human CD63 activate transfected rat basophilic leukemia (RBL-2H3) cells. Mol Immunol 1995 32 : 1339 1344.
36. Kraft S, Fleming T, Billingsley JM, Lin SY, Jouvin MH, Storz P et al. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J Exp Med 2005 201 : 385 396.
37. Gordon JR, Galli SJ. Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. Nature 1990 346 : 274 276.
38. Bischoff SC, Lorentz A, Schwengberg S, Weier G, Raab R, Manns MP. Mast cells are an important cellular source of tumour necrosis factor alpha in human intestinal tissue. Gut 1999 44 : 643 652.
39. Rajotte D, Stearns CD, Kabcenell AK. Isolation of mast cell secretory lysosomes using flow cytometry. Cytometry A 2003 55 : 94 101.
40. Laffargue M, Calvez R, Finan P, Trifilieff A, Barbier M, Altruda F et al. Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function. Immunity 2002 16 : 441 451.
41. Kallquist L, Hansson M, Persson AM, Janssen H, Calafat J, Tapper H et al. The tetraspanin CD63 is involved in granule targeting of neutrophil elastase. Blood 2008 112 : 3444 3454.
42. Welker P, Grabbe J, Henz BM. Differential expression of mast cell characteristics in human myeloid cell lines. Exp Dermatol 2004 13 : 535 542.
43. Schwartz LB, Austen KF. Structure and function of the chemical mediators of mast cells. Prog Allergy 1984 34 : 271 325.
44. Forsberg E, Pejler G, Ringvall M, Lunderius C, Tomasini-Johansson B, Kusche-Gullberg M et al. Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme. Nature 1999 400 : 773 776.