Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor

International Immunopharmacology

Volumn 11, Issue 4, 2011, Pages 475-479

  MacGlashan Jr , Donald ^a   Honigberg, Lee A ^b   Smith, Ashley ^b   Buggy, Joseph ^b   Schroeder, John T ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Pharmacylics Inc   (United States)

Author keywords

Atopy; Basophils; Bruton's tyrosine kinase; IgE; Signal transduction

Indexed keywords

ANTIGEN; BRUTON TYROSINE KINASE; CD11B ANTIGEN; CD203C ANTIGEN; CD63 ANTIGEN; COMPLEMENT COMPONENT C5A; FORMYLMETHIONYLLEUCYLPHENYLALANINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; INTERLEUKIN 13; INTERLEUKIN 3; INTERLEUKIN 4; LEUKOTRIENE C4; PCI 32765; PROTEIN KINASE INHIBITOR; PROTEIN KINASE SYK; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; BASOPHIL; CELL FUNCTION; CELL STIMULATION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME ACTIVATION; HISTAMINE RELEASE; HUMAN; HUMAN CELL; IC 50; LEUKOCYTE ACTIVATION; MEDIATOR; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; SIGNAL TRANSDUCTION; SUPERNATANT;

ANTIGENS, CD; BASOPHILS; BLOTTING, WESTERN; CALCIUM; CELL CULTURE TECHNIQUES; CELLS, CULTURED; FLOW CYTOMETRY; HISTAMINE RELEASE; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-13; INTERLEUKIN-4; PROTEIN-TYROSINE KINASES; PYRAZOLES; PYRIMIDINES;

EID: 79952736475     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2010.12.018     Document Type: Article

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