Histamine H4 receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation

European Journal of Immunology

Volumn 41, Issue 6, 2011, Pages 1764-1773

  Desai, Pragnya ^a   Thurmond, Robin L ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Cytokines; Histamine; Inflammation; Mast cells; Toll like receptors

Indexed keywords

DIPHENHYDRAMINE; HISTAMINE AGONIST; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR ANTAGONIST; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RAF PROTEIN; RANITIDINE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; 1 ((5 CHLORO 1H INDOL 2 YL)CARBONYL) 4 METHYLPIPERAZINE; 1-((5-CHLORO-1H-INDOL-2-YL)CARBONYL)-4-METHYLPIPERAZINE; G PROTEIN COUPLED RECEPTOR; HISTAMINE; HISTAMINE RECEPTOR; HRH4 PROTEIN, MOUSE; INDOLE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PIPERAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INFLAMMATION; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY;

ANIMALS; BONE MARROW; CELLS, CULTURED; ENZYME ACTIVATION; HISTAMINE; INDOLES; INFLAMMATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MAST CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3-KINASES; PIPERAZINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; SIGNAL TRANSDUCTION;

EID: 79957580712     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040932     Document Type: Article

References (46)

1. Zampeli, E. and Tiligada, E., The role of histamine H4 receptor in immune and inflammatory disorders. Br. J. Pharmacol. 2009. 157: 24-33.
2. 4 receptor mediates allergic airway inflammation by regulating the activation of CD4+T cells. J. Immunol. 2006. 176: 7062-7070.
3. Cowden, J. M., Riley, J. P., Ma, J. Y., Thurmond, R. L. and Dunford, P. J., Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines. Respir. Res. 2010. 11: 86.
4. 4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation. J. Invest. Dermatol. 2010. 130: 1023-1033.
5. Seike, M., Furuya, K., Omura, M., Hamada-Watanabe, K., Matsushita, A. and Ohtsu, H., Histamine H4 receptor antagonist ameliorates chronic allergic contact dermatitis induced by repeated challenge. Allergy 2010. 65: 319-326.
6. 4 receptor antagonists on experimental colitis in the rat. Eur. J. Pharmacol. 2005. 522: 130-138.
7. 4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. J. Allergy Clin. Immunol. 2007. 119: 176-183.
8. Rossbach, K., Wendorff, S., Sander, K., Stark, H., Gutzmer, R., Werfel, T., Kietzmann, M. and Baeumer, W., Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation. Exp. Dermatol. 2009. 18: 57-63.
9. Strakhova, M. I., Nikkel, A. L., Manelli, A. M., Hsieh, G. C., Esbenshade, T. A., Brioni, J. D. and Bitner, R. S., Localization of histamine H4 receptors in the central nervous system of human and rat. Brain Res. 2009. 1250: 41-48.
10. de Esch, I. J. P., Thurmond, R. L., Jongejan, A. and Leurs, R., The histamine H4 receptor as a new therapeutic target for inflammation. Trends Pharmacol. Sci. 2005. 26: 462-469.
11. Yu, F., Wolin, R. L., Wei, J., Desai, P. J., McGovern, P. M., Dunford, P. J., Karlsson, L. and Thurmond, R. L., Pharmacological characterization of oxime agonists of the histamine H4 receptor. J. Receptor Ligand Channel Res. 2010. 3: 37-49.
12. 4 receptor mediates chemotaxis and calcium mobilization of mast cells. J. Pharmacol. Exp. Ther. 2003. 305: 1212-1221.
13. 4 receptor. J. Allergy Clin. Immunol. 2007. 120: 300-307.
14. 4 receptor. Br. J. Pharmacol. 2003. 140: 1117-1127.
15. Morse, K. L., Behan, J., Laz, T. M., West, R. E., Jr., Greenfeder, S. A., Anthes, J. C., Umland, S. et al., Cloning and characterization of a novel human histamine receptor. J. Pharmacol. Exp. Ther. 2001. 296: 1058-1066.
16. 4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. J. Immunol. 2005. 174: 5224-5232.
17. Gutzmer, R., Mommert, S., Gschwandtner, M., Zwingmann, K., Stark, H. and Werfel, T., The histamine H4 receptor is functionally expressed on TH2 cells. J. Allergy Clin. Immunol. 2009. 123: 619-625.
18. 4 receptors reveals substantial pharmacological species variation. J. Pharmacol. Exp. Ther. 2001. 299: 121-130.
19. Seifert, R., Schneider, E. H., Dove, S., Brunskole, I., Neumann, D., Strasser, A. and Buschauer, A., Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: the H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Mol. Pharmacol. 2011. 79: 631-638.
20. 4-receptors in Sf9 insect cells. Naunyn Schmiedebergs Arch. Pharmacol. 2011, in press.
21. Lippert, U., Moller, A., Welker, P., Artuc, M. and Henz, B. M., Inhibition of cytokine secretion from human leukemic mast cells and basophils by H1- and H2-receptor antagonists. Exp. Dermatol. 2000. 9: 118-124.
22. Kohda, F., Koga, T., Uchi, H., Urabe, K. and Furue, M., Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes. J. Dermatol. Sci. 2002. 28: 34-41.
23. Caron, G., Delneste, Y., Roelandts, E., Duez, C., Herbault, N., Magistrelli, G., Bonnefoy, J.-Y. et al., Histamine induces CD86 expression and chemokine production by human immature dendritic cells. J. Immunol. 2001. 166: 6000-6006.
24. Triggiani, M., Gentile, M., Secondo, A., Granata, F., Oriente, A., Taglialatela, M., Annunziato, L. and Marone, G., Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors. J. Immunol. 2001. 166: 4083-4091.
25. Weimer, L. K., Gamache, D. A. and Yanni, J. M., Histamine-stimulated cytokine secretion from human conjunctival epithelial cells: inhibition by the histamine H1 antagonist emedastine. Int. Arch. Allergy Immunol. 1998. 115: 288-293.
26. 4 receptor. J. Invest. Dermatol. 2008. 128: 1696-1703.
27. 4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo. J. Pharmacol. Exp. Ther. 2003. 307: 1072-1078.
28. 4 receptor antagonist with anti-inflammatory properties. J. Pharmacol. Exp. Ther. 2004. 309: 404-413.
29. Bongers, G., Sallmen, T., Passani, M. B., Mariottini, C., Wendelin, D., Lozada, A., van Marle, A. et al., The Akt/GSK-3beta axis as a new signaling pathway of the histamine H3 receptor. J. Neurochem. 2007. 103: 248-258.
30. Drutel, G., Peitsaro, N., Karlstedt, K., Wieland, K., Smit, M. J., Timmerman, H., Panula, P. and Leurs, R., Identification of rat H3 receptor isoforms with different brain expression and signaling properties. Mol. Pharmacol. 2001. 59: 1-8.
31. Genersch, E., Hayess, K., Neuenfeld, Y. and Haller, H., Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells: involvement of Ras-dependent and -independent pathways. J. Cell Sci. 2000. 113: 4319-4330.
32. Okuma, E., Inazawa, Y., Saeki, K. and Yuo, A., Potential roles of extracellular signal-regulated kinase but not p38 during myeloid differentiation of U937 cells stimulated by cytokines. Augmentation of differentiation via prolonged activation of extracellular signal-regulated kinase. Exp. Hematol. 2002. 30: 571-581.
33. Koncz, G., Bodor, C., Kovesdi, D., Gati, R. and Sarmay, G., BCR mediated signal transduction in immature and mature B cells. Immunol. Lett. 2002. 82: 41-49.
34. Chen, J.-R., Plotkin, L. I., Aguirre, J. I., Han, L., Jilka, R. L., Kousteni, S., Bellido, T. and Manolagas, S. C., Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti- versus pro-apoptotic effects of estrogens. J. Biol. Chem. 2005. 280: 4632-4638.
35. Cagnol, S. and Chambard, J.-C., ERK and cell death: mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence. FEBS J. 2010. 277: 2-21.
36. Goel, R., Phillips-Mason, P. J., Raben, D. M. and Baldassare, J. J., alpha -thrombin induces rapid and sustained Akt phosphorylation by beta -arrestin1-dependent and -independent mechanisms, and only the sustained Akt phosphorylation is essential for G1 phase progression. J. Biol. Chem. 2002. 277: 18640-18648.
37. Moelling, K., Schad, K., Bosse, M., Zimmermann, S. and Schweneker, M., Regulation of Raf-Akt cross-talk. J. Biol. Chem. 2002. 277: 31099-31106.
38. Rommel, C., Clarke, B. A., Zimmermann, S., Nunez, L., Rossman, R., Reid, K., Moelling, K. et al., Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science 1999. 286: 1738-1741.
39. Carroll, M. P. and May, W. S., Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells. J. Biol. Chem. 1994. 269: 1249-1256.
40. Tanaka, Y., Sekiguchi, F., Hong, H. and Kawabata, A., PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells. Biochem. Biophys. Res. Commun. 2008. 377: 622-626.
41. Ganesan, L. P., Joshi, T., Fang, H., Kutala, V. K., Roda, J., Trotta, R., Lehman, A. et al., Fcgamma R-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways. Blood 2006. 108: 718-725.
42. Patrucco, E., Notte, A., Barberis, L., Selvetella, G., Maffei, A., Brancaccio, M., Marengo, S. et al., PI3K.gamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 2004. 118: 375-387.
43. 4 receptor antagonists. J. Med. Chem. 2003. 46: 3957-3960.
44. Apodaca, R., Dvorak, C. A., Xiao, W., Barbier, A. J., Boggs, J. D., Wilson, S. J., Lovenberg, T. W. and Carruthers, N. I., A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines. J. Med. Chem. 2003. 46: 3938-3944.
45. Takle, A. K., Brown, M. J. B., Davies, S., Dean, D. K., Francis, G., Gaiba, A., Hird, A. W. et al., The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg. Med. Chem. Lett. 2006. 16: 378-381.
46. Abramoff, M. D., Magelhaes, P. J. and Ram, S. J., Image processing with ImageJ. Biophotonics Int. 2004. 11: 36-42.