Fortification of Foods with Omega-3 Polyunsaturated Fatty Acids

Critical Reviews in Food Science and Nutrition

Volumn 54, Issue 1, 2014, Pages 98-114

  Ganesan, Balasubramanian ^a   Brothersen, Carl ^a   McMahon, Donald J ^a  

^a UTAH STATE UNIVERSITY   (United States)

Author keywords

3 fatty acid; DHA; EPA; fishy flavor; PUFA

Indexed keywords

CONSUMER ACCEPTANCE; DHA; EICOSAPENTAENOIC ACID (EPA) AND DOCOSAHEXAENOIC ACID (DHA); EPA; NUTRITIONAL SUPPLEMENTS; OMEGA-3 POLYUNSATURATED FATTY ACIDS; PUFA; VOLATILE SULFUR COMPOUNDS;

COMMERCE; DIETARY SUPPLEMENTS; FATTY ACIDS; HEALTH; METABOLISM; NUTRITION; OILS AND FATS; PHYSIOLOGY; POLYUNSATURATED FATTY ACIDS; SULFUR COMPOUNDS;

FLAVOR COMPOUNDS;

DOCOSAHEXAENOIC ACID; EDIBLE OIL; FISH OIL; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; UNSATURATED FATTY ACID;

ANALYSIS; ANIMAL; ARTIFICIAL MILK; CHEMISTRY; DAIRY PRODUCT; DIET; DIET SUPPLEMENTATION; DRUG STABILITY; HEALTH PROMOTION; HUMAN; INFANT; MEAT; METABOLISM; ODOR; SEA FOOD; REVIEW;

ANIMALS; DAIRY PRODUCTS; DIET; DIETARY FATS, UNSATURATED; DOCOSAHEXAENOIC ACIDS; DRUG STABILITY; EICOSAPENTAENOIC ACID; FATTY ACIDS, OMEGA-3; FATTY ACIDS, UNSATURATED; FISH OILS; FOOD, FORTIFIED; HEALTH PROMOTION; HUMANS; INFANT; INFANT FORMULA; MEAT; ODORS; SEAFOOD;

EID: 84887028252     PISSN: 10408398     EISSN: 15497852     Source Type: Journal    
DOI: 10.1080/10408398.2011.578221     Document Type: Article

References (166)

1. Ackman, R. G. 2000. " Fatty acids in fish and shellfish ". In Fatty Acids in Foods and Their Health Implications, Edited by: Chow, C. K. 153 - 174. New York: Marcel Drekker, Inc.
2. Ackroff, K., Lucas, F. and Sclafani, A. 2005. Flavor preference conditioning as a function of fat source. Physiol. Behav., 85 (4): 448 - 460.
3. Agostoni, C. 2008. Role of long-chain polyunsaturated fatty acids in the first year of life. J. Pediatr. Gastroenterol Nutr., 47 (Suppl. 2): S41 - S44.
4. Aguedo, M., Hanon, E., Danthine, S., Paquot, M., Lognay, G. Thomas, A. 2008. Enrichment of anhydrous milk fat in polyunsaturated fatty acid residues from linseed and rapeseed oils through enzymatic interesterification. J. Agric. Food Chem., 56: 1757 - 1765.
5. Ailhaud, G., Massiera, F., Weill, P., Legrand, P., Alessandri, J. M. and Guesnet, P. 2006. Temporal changes in dietary fats: Role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity. Prog. Lipid. Res., 45 (3): 203 - 236.
6. Aldini, G., Dalle-Donne, I., Facino, R. M., Milzani, A. and Carini, M. 2007. Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls. Med. Res. Rev., 27 (6): 817 - 868.
7. Allred, S. L., Dhiman, T. R., Brennand, C. P., Khanal, R. C., McMahon, D. J. and Luchini, N. D. 2006. Milk and cheese from cows fed calcium salts of palm and fish oil alone or in combination with soybean products. J. Dairy Sci., 89 (1): 234 - 248.
8. Anderson, G. H., Aziz, A. and Abou Samra, R. 2006. Physiology of food intake regulation: Interaction with dietary components. Nestle Nutr. Workshop Ser. Pediatr. Program, 58: 133 - 143. discussion 143-135
9. Anonymous. 2007. Methylmercury in sport fish: information for fish consumers. Available from http://oehha.ca.gov/fish/hg/index.html. Accessed January 30, 2013.
10. Arterburn, L. M., Hall, E. B. and Oken, H. 2006. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am. J. Clin. Nutr., 83 (Suppl. 6): 1467S - 1476S.
11. Ayadi, M. A., Grati-Kamoun, N. and Attia, H. 2009. Physico-chemical change and heat stability of extra virgin olive oils flavoured by selected Tunisian aromatic plants. Food Chem. Toxicol., 47 (10): 2613 - 2619.
12. Bingham, C. O. 3rd and Austen, K. F. 1999. Phospholipase A2 enzymes in eicosanoid generation. Proc. Assoc. Am. Physicians, 111 (6): 516 - 524.
13. Borga, K., Fisk, A. T., Hoekstra, P. E. and Muir, D. C. 2004. Biological and chemical factors of importance in the bioaccumulation and trophic transfer of persistent organochlorine contaminants in Arctic marine food webs. Environ. Toxicol. Chem., 23 (10): 2367 - 2385.
14. Bourre, J. M. 2005. Effect of increasing the omega-3 fatty acid in the diets of animals on the animal products consumed by humans. Med. Sci. (Paris), 21 (8-9): 773 - 779.
15. Bourre, J. M. and Paquotte, P. 2008. Seafood (wild and farmed) for the elderly: Contribution to the dietary intakes of iodine, selenium, DHA and vitamins B12 and D. J. Nutr. Health Aging, 12 (3): 186 - 192.
16. Brennand, C. P., Ha, J. K. and Lindsay, R. C. 1989. Aroma properties and thresholds of some branched-chain and other minor volatile fatty acids occurring in milkfat and meat lipids. J. Sens. Stud., 4 (2): 105 - 120.
17. Brenner, R. R. 1984. Effect of unsaturated acids on membrane structure and enzyme kinetics. Prog. Lipid Res., 23 (2): 69 - 96.
18. Brewer, M. S. 2009. Irradiation effects on meat flavor: A review. Meat Sci., 81: 1 - 14.
19. Brown, S. A. 2008. Oxidative stress and chronic kidney disease. Vet. Clin. North Am. Small Anim. Pract., 38 (1): 157 - 166. vi
20. Burdge, G. C. 2006. Metabolism of alpha-linolenic acid in humans. Prostag. Leukot. Essent. Fatty Acids, 75 (3): 161 - 168.
21. Calder, P. C. and Grimble, R. F. 2002. Polyunsaturated fatty acids, inflammation and immunity. Eur. J. Clin. Nutr., 56 (Suppl. 3): S14 - S19.
22. Calviello, G., Palozza, P., Maggiano, N., Piccioni, E., Franceschelli, P. Frattucci, A. 1999. Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa. Lipids, 34 (6): 599 - 604.
23. Cantor, A. H., Decker, E. A. and Collins, V. P. 2000. " Fatty acids in poultry and egg products ". In Fatty Acids in Foods and Their Health Implications, Edited by: Chow, C. K. 153 - 174. New York: Marcel Drekker, Inc.
24. Carlier, H., Bernard, A. and Caselli, C. 1991. Digestion and absorption of polyunsaturated fatty acids. Reprod. Nutr. Dev., 31 (5): 475 - 500.
25. Certik, M. and Shimizu, S. 1999. Biosynthesis and regulation of microbial polyunsaturated fatty acid production. J. Biosci. Bioeng., 87 (1): 1 - 14.
26. Chaiyasit, W., Elias, R. J., McClements, D. J. and Decker, E. A. 2007. Role of physical structures in bulk oils on lipid oxidation. Crit. Rev. Food Sci. Nutr., 47 (3): 299 - 317.
27. Chaiyasit, W., McClements, D. J., Weiss, J. and Decker, E. A. 2008. Impact of surface-active compounds on physicochemical and oxidative properties of edible oil. J. Agric. Food Chem., 56 (2): 550 - 556.
28. Chen, C. T., Green, J. T., Orr, S. K. and Bazinet, R. P. 2008. Regulation of brain polyunsaturated fatty acid uptake and turnover. Prostag. Leukot. Essent. Fatty Acids, 79 (3-5): 85 - 91.
29. Childs, C. E., Romeu-Nadal, M., Burdge, G. C. and Calder, P. C. 2008. Gender differences in the n-3 fatty acid content of tissues. Proc. Nutr. Soc., 67 (1): 19 - 27.
30. Chin, H.-W. and Lindsay, R. C. 1994. Ascorbate and transition-metal mediation of methanethiol oxidation to dimethyl disulfide and dimethyl trisulfide. Food Chem., 49 (4): 387 - 392.
31. Choe, E. and Min, D. B. 2007. Chemistry of deep-fat frying oils. J. Food Sci., 72 (5): R77 - R86.
32. Christensen, B., Kjær, A. and Madsen, J. 1981. Volatile sulfur compounds and other headspace constituents of north sea fish oils. Journal of the American Oil Chemists' Society, 58 (12): 1053 - 1057.
33. Christensen, K. R. and Reineccius, G. A. 1992. Gas chromatographic analysis of volatile sulfur compounds from heated milk using static headspace sampling. J. Dairy Sci., 75 (8): 2098 - 2104.
34. Christie, W. W. 1995. " Composition and structure of milk lipids ". In Advances in Dairy Chemistry, Lipids, Edited by: Fox, P. F. Vol. 2, 1 - 36. London: Chapman and Hall.
35. Conklin, K. A. 2002. Dietary polyunsaturated fatty acids: Impact on cancer chemotherapy and radiation. Altern. Med. Rev., 7 (1): 4 - 21.
36. De Vizia, B., Raia, V., Spano, C., Pavlidis, C., Coruzzo, A. and Alessio, M. 2003. Effect of an 8-month treatment with omega-3 fatty acids (eicosapentaenoic and docosahexaenoic) in patients with cystic fibrosis. JPEN J. Parenter Enteral. Nutr., 27 (1): 52 - 57.
37. Diez, S. 2009. Human health effects of methylmercury exposure. Rev. Environ. Contam. Toxicol., 198: 111 - 132.
38. Douaud, C. 2006. First DHA/ARA-fortified organic baby formula launched. Available from www.nutraingredients-usa.com/Industry/First-DHA-ARA-fortified-organic-baby-formula-launched. Accessed January 30, 2013.
39. Dyerberg, J., Eskesen, D. C., Andersen, P. W., Astrup, A., Buemann, B. Christensen, J. H. 2004. Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study. Eur. J. Clin. Nutr., 58: 1062 - 1070.
40. El Abed, M. M., Marzouk, B., Medhioub, M. N., Helal, A. N. and Medhioub, A. 2008. Microalgae: A potential source of polyunsaturated fatty acids. Nutr. Health, 19 (3): 221 - 226.
41. Ervin, R. W. J., Wang, C. and Kennedy-Stephenson, J. 2004. Dietary intake of fats and fatty acids for the United States population: 1999-2000. Adv. Data Vital Health Stat., 348: 1 - 6. ([DHHS publication no. (PHS) 2005-1250 04-0565.])
42. Eunok, C. and David, B. M. 2006. Mechanisms and factors for edible oil oxidation. Comprehen. Rev. Food Sci. Food Safety, 5 (4): 169 - 186.
43. FDA. 2004. Available from www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2004/ucm108351.htm. Accessed January 30, 2013.
44. Fellers, D. A. and Bean, M. M. 1977. Storage stability of wheat based foods: A review. J. Food Sci, 42: 1143 - 1147.
45. Fewtrell, M. S. 2006. Long-chain polyunsaturated fatty acids in early life: Effects on multiple health outcomes. A critical review of current status, gaps and knowledge. Nestle Nutr. Workshop Ser. Pediatr. Program, 57: 203 - 214. discussion 215-221
46. Frankel, E. N., Satue-Gracia, T., Meyer, A. S. and German, J. B. 2002. Oxidative stability of fish and algae oils containing long-chain polyunsaturated fatty acids in bulk and in oil-in-water emulsions. J. Agric. Food Chem., 50 (7): 2094 - 2099.
47. Fritsche, K., Irons, R., Pompos, L., Janes, J., Zheng, Z. and Brown, C. 2005. Omega-3 polyunsaturated fatty acid impairment of early host resistance against Listeria monocytogenes infection is independent of neutrophil infiltration and function. Cell Immunol., 235 (1): 65 - 71.
48. Funk, C. D. 2001. Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science, 294 (5548): 1871 - 1875.
49. Galobart, J., Barroeta, A. C., Baucells, M. D., Codony, R. and Ternes, W. 2001. Effect of dietary supplementation with rosemary extract and alpha-tocopheryl acetate on lipid oxidation in eggs enriched with omega3-fatty acids. Poult. Sci., 80 (4): 460 - 467.
50. Ganeko, N., Shoda, M., Hirohara, I., Bhadra, A., Ishida, T. Matsuda, H. 2008. Analysis of volatile flavor compounds of sardine (Sardinops melanostica) by solid phase microextraction. J. Food Sci., 73: S83 - S88.
51. Gao, S., Mooberry, E. S. and Steele, J. L. 1998. Use of 13C nuclear magnetic resonance and gas chromatography to examine methionine catabolism by lactococci. Appl. Environ. Microbiol., 64 (12): 4670 - 4675.
52. Garter, B., Zhou, S. and Brown, A. 2008. Method for suppression of fishy aromas in food products by proteins. Patent issued to Kellogg Company by USPTO
53. German, O. L., Insua, M. F., Gentili, C., Rotstein, N. P. and Politi, L. E. 2006. Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway. J. Neurochem., 98 (5): 1507 - 1520.
54. Giamarellos-Bourboulis, E. J., Grecka, P., Asteriou, A. D., Grammatikou, M. and Giamarellou, H. 1994. Do Escherichia coli susceptibilities to various antibiotics decrease in the presence of polyunsaturated fatty acids? A preliminary report. J. Chemother., 6 (1): 39 - 43.
55. GISSI. 1999. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet, 354 (9177): 447 - 455.
56. Goburdhun, D. and Jhurree, B. 1995. Effect of deep-fat frying on fat oxidation in soybean oil. Int. J. Food Sci. Nutr., 46 (4): 363 - 371.
57. Graham, D. Y. and Sackman, J. W. 1983. Solubility of calcium soaps of long-chain fatty acids in simulated intestinal environment. Digestive Diseases and Sciences, 28 (8): 733 - 736.
58. Gudipati, V., Sandra, S., McClements, D. J. and Decker, E. A. 2010. Oxidative stability and in vitro digestibility of fish oil-in-water emulsions containing multilayered membranes. J. Agric. Food Chem., 58: 8093-8099
59. Guiotto, A., Calderan, A., Ruzza, P. and Borin, G. 2005. Carnosine and carnosine-related antioxidants: A review. Curr. Med. Chem., 12 (20): 2293 - 2315.
60. Gunstone, F. D. 1996. Fatty Acid and Lipid Chemistry, Glasgow, UK: Blackie Academic and Professional.
61. Hack, D. M., Bordi, P. L. Jr. and Hessert, S. W. Jr. 2009. Nutrition, sensory evaluation, and performance analysis of hydrogenated frying oils. Int. J. Food Sci. Nutr., 60: 1 - 15.
62. Harris, W. S., Mozaffarian, D., Lefevre, M., Toner, C. D., Colombo, J. Cunnane, S. C. 2009. Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids. J. Nutr., 139: 804S - 819S.
63. Harwood, J. L. 1988. Fatty acid metabolism. Ann. Rev. Plant Physiol. Plant Molecular Biol., 39 (1): 101 - 138.
64. Hauswirth, C. B., Scheeder, M. R. and Beer, J. H. 2004. High omega-3 fatty acid content in alpine cheese: The basis for an alpine paradox. Circulation, 109 (1): 103 - 107.
65. Herrera, E. 2002. Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development-A review. Placenta, 23 (Suppl. A): S9 - S19.
66. Herrera, E., Amusquivar, E., Lopez-Soldado, I. and Ortega, H. 2006. Maternal lipid metabolism and placental lipid transfer. Horm. Res., 65 (Suppl. 3): 59 - 64.
67. HHS and USDA. 2005. Dietary guidelines for Americans Available from www.health.gov/DietaryGuidelines/dga2005/. Accessed January 30, 2013.
68. Hill, B. G., Haberzettl, P., Ahmed, Y., Srivastava, S. and Bhatnagar, A. 2008. Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells. Biochem. J., 410 (3): 525 - 534.
69. Hogan, S. A., O'Riordan, E. D. and O'Sullivan, M. 2003. Microencapsulation and oxidative stability of spray-dried fish oil emulsions. J. Microencapsul, 20 (5): 675 - 688.
70. Hogstrom, M., Nordstrom, P. and Nordstrom, A. 2007. n-3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: The NO2 Study. Am. J. Clin. Nutr., 85 (3): 803 - 807.
71. Holian, O. and Nelson, R. 1992. Action of long-chain fatty acids on protein kinase C activity: Comparison of omega-6 and omega-3 fatty acids. Anticancer Res., 12 (3): 975 - 980.
72. Honkatukia, M., Reese, K., Preisinger, R., Tuiskula-Haavisto, M., Weigend, S. Roito, J. 2005. Fishy taint in chicken eggs is associated with a substitution within a conserved motif of the FMO3 gene. Genomics, 86: 225 - 232.
73. Hulbert, A. J., Turner, N., Storlien, L. H. and Else, P. L. 2005. Dietary fats and membrane function: Implications for metabolism and disease. Biol. Rev. Camb. Philos. Soc., 80 (1): 155 - 169.
74. Hwang, D. and Rhee, S. H. 1999. Receptor-mediated signaling pathways: Potential targets of modulation by dietary fatty acids. Am. J. Clin. Nutr., 70 (4): 545 - 556.
75. ICIS. 2009. Dietary Guidelines for Americans. Available from www.icis.com. Accessed on January 30, 2013.
76. Im, S. and Kurata, T. 2003. Volatile off-flavor compounds in porcine liver. J. Japan. Soc. Food Sci. Technol. (Nippon Shokuhin Kagaku Kogaku Kaishi), 50: 574 - 577.
77. Innis, S. M., Sprecher, H., Hachey, D., Edmond, J. and Anderson, R. E. 1999. Neonatal polyunsaturated fatty acid metabolism. Lipids, 34 (2): 139 - 149.
78. Jacobsen, C, Adler, N. J., Meyer, A. S., Hartvigsen, S. A. and Lmer, K. 2000. Oxidation in Fish-Oil-Enriched Mayonnaise: 2. Assessment of the Efficacy of Different Tocopherol Antioxidant Systems by Discriminant Partial Least Squares Regression Analysis Volume, 13-30 European Food Research and Technology, 210
79. Jacobsen, C., Adler-Nissen, J. and Meyer, A. S. 1999. Effect of ascorbic acid on iron release from the emulsifier interface and on the oxidative flavor deterioration in fish oil enriched mayonnaise. J. Agric. Food Chem., 47 (12): 4917 - 4926.
80. Jacobsen, C., Hartvigsen, K., Lund, P., Meyer, A. S., Adler-Nissen, J. Holstborg, J. 1999. Oxidation in fish-oil-enriched mayonnaise 1. Assessment of propyl gallate as an antioxidant by discriminant partial least squares regression analysis. Eur. Food Res. Technol., 210 (1): 13 - 30.
81. Jacobsen, C., Hartvigsen, K., Lund, P., Thomsen, M. K., Skibsted, L. H. Hølmer, G. 2001. Oxidation in fish oil-enriched mayonnaise: 4. Effect of tocopherol concentration on oxidative deterioration. Eur. Food Res. Technol, 212: 308 - 318.
82. Jacobsen, C., Let, M. B., Nielsen, N. S. and Meyer, A. S. 2008. Antioxidant strategies for preventing oxidative flavour deterioration of foods enriched with n-3 polyunsaturated lipids: A comparative evaluation. Trends Food Sci. Technol., 19 (2): 76 - 93.
83. Jensen, R. G., Ferris, A. M. and Lammi-Keefe, C. J. 1992. Lipids in human milk and infant formulas. Annu. Rev. Nutr., 12: 417 - 441.
84. Jump, D. B. and Clarke, S. D. 1999. Regulation of gene expression by dietary fat. Annu. Rev. Nutr., 19: 63 - 90.
85. Kankaanpaa, P. E., Salminen, S. J., Isolauri, E. and Lee, Y. K. 2001. The influence of polyunsaturated fatty acids on probiotic growth and adhesion. FEMS Microbiol. Lett., 194 (2): 149 - 153.
86. Kanwar, R. K., Macgibbon, A. K., Black, P. N., Kanwar, J. R., Rowan, A. Vale, M. 2008. Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice. Clin. Exp. Allergy, 38: 208 - 218.
87. Katsuda, M. S., McClements, D. J., Miglioranza, L. H. and Decker, E. A. 2008. Physical and oxidative stability of fish oil-in-water emulsions stabilized with beta-lactoglobulin and pectin. J. Agric. Food Chem., 56 (14): 5926 - 5931.
88. Ke, S., Huang, Y., Decker, E. A. and Hultin, H. O. 2008. Impact of citric acid on the tenderness, microstructure and oxidative stability of beef muscle. Meat Sci., 82 (1): 113-118
89. Kellerby, S. S., McClements, D. J. and Decker, E. A. 2006. Role of proteins in oil-in-water emulsions on the stability of lipid hydroperoxides. J. Agric. Food Chem., 54 (20): 7879 - 7884.
90. Khanapure, S. P., Garvey, D. S., Janero, D. R. and Letts, L. G. 2007. Eicosanoids in inflammation: Biosynthesis, pharmacology, and therapeutic frontiers. Curr. Top Med. Chem., 7 (3): 311 - 340.
91. Khosla, P. and Hayes, K. C. 1996. Dietary trans-monounsaturated fatty acids negatively impact plasma lipids in humans: Critical review of the evidence. J. Am. Coll. Nutr., 15 (4): 325 - 339.
92. Kocchar, S. P. 1995. " Oxidative Pathways to the Formation of Off-Flavours ". In Food Taints and Off-Flavours, 2nd ed., Glasgow, UK: pp. 168-225. Blackie Academic and Professional.
93. Kolanowski, W. and Weißbrodt, J. 2008. Possibilities of fisherman's friend type lozenges fortification with omega-3 LC PUFA by addition of microencapsulated fish oil. J. American Oil Chemists' Soc., 85 (4): 339 - 345.
94. Komprda, T., Zelenka, J., Fajmonova, E., Fialova, M. and Kladroba, D. 2005. Arachidonic acid and long-chain n-3 polyunsaturated fatty acid contents in meat of selected poultry and fish species in relation to dietary fat sources. J. Agric. Food Chem., 53 (17): 6804 - 6812.
95. Kris-Etherton, P. M. and Hill, A. M. 2008. N-3 fatty acids: Food or supplements?. J. Am. Diet. Assoc., 108 (7): 1125 - 1130.
96. Laignelet, B. and Dumas, C. 1984. Lipid oxidation and distribution of oxidized lipids during the mixing of a dough of bread wheat flour. Lebensmittel-Wissenschaft und -Technologie, 17 (4): 226 - 230.
97. Lauritzen, I., Blondeau, N., Heurteaux, C., Widmann, C., Romey, G. and Lazdunski, M. 2000. Polyunsaturated fatty acids are potent neuroprotectors. EMBO J., 19 (8): 1784 - 1793.
98. Lee, J. Y., Kim, Y. S. and Shin, D. H. 2002. Antimicrobial synergistic effect of linolenic acid and monoglyceride against Bacillus cereus and Staphylococcus aureus. J. Agric. Food Chem., 50 (7): 2193 - 2199.
99. Let, M. B., Jacobsen, C. and Meyer, A. S. 2007. Lipid oxidation in milk, yoghurt, and salad dressing enriched with neat fish oil or pre-emulsified fish oil. J. Agric. Food Chem., 55 (19): 7802 - 7809.
100. Lock, A. L. and Bauman, D. E. 2004. Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health. Lipids, 39 (12): 1197 - 1206.
101. Lombardi, F. and Terranova, P. 2007. Anti-arrhythmic properties of N-3 poly-unsaturated fatty acids (n-3 PUFA). Curr. Med. Chem., 14 (19): 2070 - 2080.
102. Lunden, A., Gustafsson, V., Imhof, M., Gauch, R. and Bosset, J. O. 2002. High trimethylamine concentration in milk from cows on standard diets is expressed as fishy off-flavour. J. Dairy Res., 69 (3): 383 - 390.
103. MacGibbon, A. K. H. and Taylor, M. W. 2006. " Composition and Structure of Bovine Milk Lipids ". In Advances in Dairy Chemistry, Lipids, Edited by: Fox, P. F. and McSWeeney, P. L. H. Volume 2, 1 - 42. New York: Springer Science+Business Media.
104. Maia, M. R., Chaudhary, L. C., Figueres, L. and Wallace, R. J. 2007. Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen. Antonie Van Leeuwenhoek, 91 (4): 303 - 314.
105. Martini, S., Thurgood, J. E., Brothersen, C., Ward, R. and McMahon, D. J. 2009. Fortification of reduced-fat Cheddar cheese with n-3 fatty acids: Effect on off-flavor generation. J. Dairy Sci., 92 (5): 1876 - 1884.
106. Masanetz, C., Guth, H. and Grosch, W. 1998. Fishy and hay-like off-flavours of dry spinach. Zeitschrift für Lebensmitteluntersuchung und -Forschung A, 206 (2): 108 - 113.
107. Masoro, E. J. 1977. Lipids and lipid metabolism. Annu. Rev. Physiol., 39: 301 - 321.
108. McCann, J. C. and Ames, B. N. 2005. Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am. J. Clin. Nutr., 82 (2): 281 - 295.
109. Meijboom, P. W. and Stronk, J. B. A. 1972. 2-trans,4-cis,7-cis-decatrienal, the fishy off-flavour occurring in strongly autoxidized oils containing linolenic acid or 3,6,9,etc., fatty acids. J. Am. Oil Chemists' Society, 49 (10): 555-558
110. Miller, L. E., Luhadiya, A. P. and Mehansho, H. 2007. Concentrated and odorless omega-3 fatty acids. Patent issued by International Bureau to The Procter and Gamble Company, Cincinnati, OH
111. Nakamura, M. T., Cheon, Y., Li, Y. and Nara, T. Y. 2004. Mechanisms of regulation of gene expression by fatty acids. Lipids, 39 (11): 1077 - 1083.
112. Nam, K. C. and Ahn, D. U. 2003. Use of antioxidants to reduce lipid oxidation and off-odor volatiles of irradiated pork homogenates and patties. Meat Sci., 63 (1): 1 - 8.
113. NCBI. 2009. Fish oil MedlinePlus supplements. Available from www.nlm.nih.gov/medlineplus/druginfo/natural/patient-fishoil.html. Accessed on August 1, 2012
114. Nelson, K. A. S. and Martini, S. 2009. Increasing omega fatty acid content in cow's milk through diet manipulation: Effect on milk flavor. J. Dairy Sci, 92 (4): 1378 - 1386.
115. Nfon, E., Cousins, I. T. and Broman, D. 2008. Biomagnification of organic pollutants in benthic and pelagic marine food chains from the Baltic Sea. Sci. Total Environ., 397 (1-3): 190 - 204.
116. Nodari, S., Metra, M., Milesi, G., Manerba, A., Cesana, B. M. Gheorghiade, M. 2009. The role of n-3 PUFAs in preventing the arrhythmic risk in patients with idiopathic dilated cardiomyopathy. Cardiovasc Drugs Ther., 23: 5 - 15.
117. Nutting, D. F., Kumar, N. S., Siddiqi, S. A. and Mansbach, C. M. 2nd. 2002. Nutrient absorption. Curr. Opin. Gastroenterol, 18 (2): 168 - 175.
118. Ohta, S., Chang, T., Kawashima, A., Nagate, T., Murase, M. Nakanishi, H. 1994. Anti methicillin-resistant Staphylococcus aureus (MRSA) activity by linolenic acid isolated from the marine microalga Chlorococcum HS-101. Bull Environ. Contam. Toxicol., 52: 673 - 680.
119. Passorn, S., Laoteng, K., Rachadawong, S., Tanticharoen, M. and Cheevadhanarak, S. 1999. Heterologous expression of Mucor rouxii delta(12)-desaturase gene in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun., 263 (1): 47 - 51.
120. Patrignani, P. 2001. Oxidized lipids. Ital. Heart J., 2 (12): 873 - 877.
121. Perez-Mateos, M., Boyd, L. and Lanier, T. 2004. Stability of omega-3 fatty acids in fortified surimi seafoods during chilled storage. J. Agric. Food Chem., 52 (26): 7944 - 7949.
122. Prentice, A. M. 2005. Macronutrients as sources of food energy. Public Health Nutr., 8 (7A): 932 - 939.
123. Prentki, M. and Madiraju, S. R. 2008. Glycerolipid metabolism and signaling in health and disease. Endocr. Rev., 29 (6): 647 - 676.
124. Quinn, P. J., Joo, F. and Vigh, L. 1989. The role of unsaturated lipids in membrane structure and stability. Prog. Biophys. Mol. Biol., 53 (2): 71 - 103.
125. Ramaswamy, N., Baer, R. J., Schingoethe, D. J., Hippen, A. R., Kasperson, K. M. and Whitlock, L. A. 2001. Composition and flavor of milk and butter from cows fed fish oil, extruded soybeans, or their combination. J. Dairy Sci., 84 (10): 2144 - 2151.
126. Refsgaard, H. H., Brockhoff, P. M. and Jensen, B. 2000. Free polyunsaturated fatty acids cause taste deterioration of salmon during frozen storage. J. Agric. Food Chem., 48 (8): 3280 - 3285.
127. Ren, J., Han, E. J. and Chung, S. H. 2007. In vivo and in vitro anti-inflammatory activities of alpha-linolenic acid isolated from Actinidia polygama fruits. Arch. Pharm. Res., 30 (6): 708 - 714.
128. Rhee, K. S. 2000. " Fatty Acids in Meats and Meat Products ". In Fatty Acids in Foods and Their Health Implications, Edited by: Chow, C. K. 153 - 174. New York: Marcel Drekker, Inc.
129. Ruxton, C. H., Reed, S. C., Simpson, M. J. and Millington, K. J. 2004. The health benefits of omega-3 polyunsaturated fatty acids: A review of the evidence. J. Hum. Nutr. Diet., 17 (5): 449 - 459.
130. Rymer, C. and Givens, D. I. 2005. n-3 fatty acid enrichment of edible tissue of poultry: A review. Lipids, 40 (2): 121 - 130.
131. Rymer, C. and Givens, D. I. 2006. Effect of species and genotype on the efficiency of enrichment of poultry meat with n-3 polyunsaturated fatty acids. Lipids, 41 (5): 445 - 451.
132. Saris, W. H., Asp, N. G., Bjorck, I., Blaak, E., Bornet, F. Brouns, F. 1998. Functional food science and substrate metabolism. Br. J. Nutr., 80 (Suppl. 1): S47 - S75.
133. Serhan, C. N. 2005. Novel eicosanoid and docosanoid mediators: Resolvins, docosatrienes, and neuroprotectins. Curr. Opin. Clin. Nutr. Metab. Care, 8 (2): 115 - 121.
134. Serna-Saldivar, S. O., Zorrilla, R., De La Parra, C., Stagnitti, G. and Abril, R. 2006. Effect of DHA containing oils and powders on baking performance and quality of white pan bread. Plant Foods Hum. Nutr., 61 (3): 121 - 129.
135. Shaw, L. A., McClements, D. J. and Decker, E. A. 2007. Spray-dried multilayered emulsions as a delivery method for omega-3 fatty acids into food systems. J. Agric. Food Chem., 55 (8): 3112 - 3119.
136. Sheppard, A. J., Iverson, J. L. and Weihrauch, J. L. 1978. " Composition of selected dietary fats, oils, margarine, and butter ". In Fatty Acids and Glycerides, Edited by: Kuksis, A. Volume 1, 314-379 New York: Plenum Press.
137. Shin, S. Y., Bajpai, V. K., Kim, H. R. and Kang, S. C. 2007. Antibacterial activity of bioconverted eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) against foodborne pathogenic bacteria. Int. J. Food Microbiol, 113: 233-236
138. Sinclair, A. J., Attar-Bashi, N. M. and Li, D. 2002. What is the role of alpha-linolenic acid for mammals?. Lipids, 37 (12): 1113 - 1123.
139. Spector, A. A. and Yorek, M. A. 1985. Membrane lipid composition and cellular function. J. Lipid. Res., 26 (9): 1015 - 1035.
140. Spolaore, P., Joannis-Cassan, C., Duran, E. and Isambert, A. 2006. Commercial applications of microalgae. J. Biosci. Bioeng., 101 (2): 87 - 96.
141. Starling, S. 2008. Omega-3 in infant formula world first Available from www.nutraingredients.com/Industry/Omega-3-in-infant-formula-world-first. Accessed January 20, 2013.
142. Surh, J., Gu, Y. S., Decker, E. A. and McClements, D. J. 2005. Influence of environmental stresses on stability of O/W emulsions containing cationic droplets stabilized by SDS-fish gelatin membranes. J. Agric. Food Chem., 53 (10): 4236 - 4244.
143. Takahata, K., Monobe, K., Tada, M. and Weber, P. C. 1998. The benefits and risks of n-3 polyunsaturated fatty acids. Biosci. Biotechnol. Biochem., 62 (11): 2079 - 2085.
144. Tamura, Y., Hirai, A., Terano, T. and Saitoh, H. 1992. Anti-thrombotic and anti-atherogenic action of eicosapentaenoic acid. Nippon. Rinsho., 50 (2): 403 - 407.
145. Tapiero, H., Ba, G. N., Couvreur, P. and Tew, K. D. 2002. Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies. Biomed. Pharmacother., 56 (5): 215 - 222.
146. Tataranni, P. A. and Ravussin, E. 1997. Effect of fat intake on energy balance. Ann. N Y Acad. Sci., 819: 37 - 43.
147. Theurer, M. L., Block, E., Sanchez, W. K. and McGuire, M. A. 2009. Calcium salts of polyunsaturated fatty acids deliver more essential fatty acids to the lactating dairy cow. J. Dairy Sci., 92 (5): 2051 - 2056.
148. Tong, L. M., Sasaki, S., McClements, D. J. and Decker, E. A. 2000. Mechanisms of the antioxidant activity of a high molecular weight fraction of whey. J. Agric. Food Chem., 48 (5): 1473 - 1478.
149. Trumbo, P., Schlicker, S., Yates, A. A. and Poos, M. 2002. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J. Am. Dietetic Assoc., 102 (11): 1621 - 1630.
150. USDA. 2005. Production, supply, and distribution online. Available from www.fas.usda.gov. Accessed on February 8, 2013.
151. Valentine, R. C. and Valentine, D. L. 2004. Omega-3 fatty acids in cellular membranes: A unified concept. Prog. Lipid Res., 43 (5): 383 - 402.
152. Venkateshwarlu, G., Let, M. B., Meyer, A. S. and Jacobsen, C. 2004a. Chemical and olfactometric characterization of volatile flavor compounds in a fish oil enriched milk emulsion. J. Agr. Food Chem., 52 (2): 311 - 317.
153. Venkateshwarlu, G., Let, M. B., Meyer, A. S. and Jacobsen, C. 2004b. Modeling the sensory impact of defined combinations of volatile lipid oxidation products on fishy and metallic off-flavors. J. Agric. Food Chem., 52 (6): 1635 - 1641.
154. Vuksan, V., Whitham, D., Sievenpiper, J. L., Jenkins, A. L., Rogovik, A. L. Bazinet, R. P. 2007. Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: Results of a randomized controlled trial. Diabetes Care, 30: 2804 - 2810.
155. Waddington, E. I., Croft, K. D., Sienuarine, K., Latham, B. and Puddey, I. B. 2003. Fatty acid oxidation products in human atherosclerotic plaque: An analysis of clinical and histopathological correlates. Atherosclerosis, 167 (1): 111 - 120.
156. Wang, C., Chung, M., Balk, E., Kupelnick, B., DeVine, D. Lawrence, A. 2004. " Evidence report/technology assessment no. 94 (Prepared by Tufts-New England Medical Center Evidence-based Practice Center, under contract no. 290-02-0022) ". In Effects of omega-3 fatty acids on cardiovascular disease, Rockville, MD: Agency for Healthcare Research and Quality. Volume AHRQ publication no. 04-E009-2
157. Wang, G. and Wang, T. 2008. Oxidative stability of egg and soy lecithin as affected by transition metal ions and pH in emulsion. J. Agric. Food Chem., 56 (23): 11424 - 11431.
158. Wassall, S. R. and Stillwell, W. 2009. Polyunsaturated fatty acid-cholesterol interactions: Domain formation in membranes. Biochim. Biophys. Acta, 1788 (1): 24 - 32.
159. Whelan, J. 1996. Antagonistic effects of dietary arachidonic acid and n-3 polyunsaturated fatty acids. J. Nutr., 126 (Suppl. 4): 1086S - 1091S.
160. Whelan, J. and Rust, C. 2006. Innovative dietary sources of n-3 fatty acids. Annu. Rev. Nutr., 26: 75 - 103.
161. Willie, H. J. and Gonus, P. Preparation of fish oil for dietary applications, Belgirate, Italy Paper presented at the NATO Advanced Research workshop on Dietary omega-3 and omega-6 fatty acids: Biological effects and Nitritional essentiality
162. Yaqoob, P. and Calder, P. C. 2007. Fatty acids and immune function: new insights into mechanisms. Br. J. Nutr., 98 (Suppl. 1): S41 - S45.
163. Yavin, E., Brand, A. and Green, P. 2002. Docosahexaenoic acid abundance in the brain: A biodevice to combat oxidative stress. Nutr. Neurosci., 5 (3): 149 - 157.
164. Yep, Y. L., Li, D., Mann, N. J., Bode, O. and Sinclair, A. J. 2002. Bread enriched with microencapsulated tuna oil increases plasma docosahexaenoic acid and total omega-3 fatty acids in humans. Asia Pac. J. Clin. Nutr., 11 (4): 285 - 291.
165. Zamaria, N. 2004. Alteration of polyunsaturated fatty acid status and metabolism in health and disease. Reprod. Nutr. Dev., 44 (3): 273 - 282.
166. Zhou, L. and Nilsson, A. 2001. Sources of eicosanoid precursor fatty acid pools in tissues. J. Lipid Res., 42 (10): 1521 - 1542.