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Volumn 19, Issue 2, 2013, Pages 125-133

Telomerase and the search for the end of cancer

Author keywords

Cancer; Gene therapy; Immunotherapy; Small molecule inhibitors; Targeted therapy; Telomerase; Telomere; TERT

Indexed keywords

[2 (3 NAPHTHALENE 2 YL BUT 2 ENOYLAMINO)BENZOIC ACID]; BETA CATENIN; BEVACIZUMAB; BRACO 19; DOCETAXEL; ETOPOSIDE; FLUCYTOSINE; GEMCITABINE; IMETELSTAT; MESSENGER RNA; PACLITAXEL; PROTEIN BAX; QUARFLOXIN; SINGLE WALLED NANOTUBE; TELOMERASE; TELOMESTATIN; TERTOMOTIDE; TRANSCRIPTASE; TRASTUZUMAB; UNCLASSIFIED DRUG; WNT PROTEIN; ZD 2767P;

EID: 84873170179     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2012.11.006     Document Type: Review
Times cited : (106)

References (95)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 1961, 25:585-621.
    • (1961) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 3
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar A.G., et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998, 279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1
  • 4
    • 0013462065 scopus 로고
    • A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
    • Moyzis R.K., et al. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. U.S.A. 1988, 85:6622-6626.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 6622-6626
    • Moyzis, R.K.1
  • 5
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn E.H. Switching and signaling at the telomere. Cell 2001, 106:661-673.
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 6
    • 71149093724 scopus 로고    scopus 로고
    • How telomeres solve the end-protection problem
    • de Lange T. How telomeres solve the end-protection problem. Science 2009, 326:948-952.
    • (2009) Science , vol.326 , pp. 948-952
    • de Lange, T.1
  • 8
    • 0024978857 scopus 로고
    • A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
    • Greider C.W., Blackburn E.H. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 1989, 337:331-337.
    • (1989) Nature , vol.337 , pp. 331-337
    • Greider, C.W.1    Blackburn, E.H.2
  • 9
    • 79952017845 scopus 로고    scopus 로고
    • Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
    • Martinez P., Blasco M.A. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat. Rev. Cancer 2011, 11:161-176.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 161-176
    • Martinez, P.1    Blasco, M.A.2
  • 11
    • 0036137878 scopus 로고    scopus 로고
    • Telomere shortening and cell fates in mouse models of neoplasia
    • Artandi S.E. Telomere shortening and cell fates in mouse models of neoplasia. Trends Mol. Med. 2002, 8:44-47.
    • (2002) Trends Mol. Med. , vol.8 , pp. 44-47
    • Artandi, S.E.1
  • 12
    • 39749163359 scopus 로고    scopus 로고
    • Telomerase and cancer therapeutics
    • Harley C.B. Telomerase and cancer therapeutics. Nat. Rev. Cancer 2008, 8:167-179.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 167-179
    • Harley, C.B.1
  • 13
    • 33745679352 scopus 로고    scopus 로고
    • Telomerase therapeutics for cancer: challenges and new directions
    • Shay J.W., Wright W.E. Telomerase therapeutics for cancer: challenges and new directions. Nat. Rev. Drug Discov. 2006, 5:577-584.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 577-584
    • Shay, J.W.1    Wright, W.E.2
  • 14
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco M.A., et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997, 91:25-34.
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1
  • 15
    • 34247581288 scopus 로고    scopus 로고
    • Short telomeres limit tumor progression in vivo by inducing senescence
    • Feldser D.M., Greider C.W. Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell 2007, 11:461-469.
    • (2007) Cancer Cell , vol.11 , pp. 461-469
    • Feldser, D.M.1    Greider, C.W.2
  • 16
    • 0343228751 scopus 로고    scopus 로고
    • Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
    • Gonzalez-Suarez E., et al. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat. Genet. 2000, 26:114-117.
    • (2000) Nat. Genet. , vol.26 , pp. 114-117
    • Gonzalez-Suarez, E.1
  • 17
    • 0035355340 scopus 로고    scopus 로고
    • Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    • Gonzalez-Suarez E., et al. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 2001, 20:2619-2630.
    • (2001) EMBO J. , vol.20 , pp. 2619-2630
    • Gonzalez-Suarez, E.1
  • 18
    • 0037062454 scopus 로고    scopus 로고
    • Constitutive telomerase expression promotes mammary carcinomas in aging mice
    • Artandi S.E., et al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:8191-8196.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 8191-8196
    • Artandi, S.E.1
  • 19
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim N.W., et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 266:2011-2015.
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1
  • 20
    • 0038359431 scopus 로고    scopus 로고
    • Evolving views of telomerase and cancer
    • Blasco M.A., Hahn W.C. Evolving views of telomerase and cancer. Trends Cell Biol. 2003, 13:289-294.
    • (2003) Trends Cell Biol. , vol.13 , pp. 289-294
    • Blasco, M.A.1    Hahn, W.C.2
  • 21
    • 0030958176 scopus 로고    scopus 로고
    • Telomerase activity in ordinary meningiomas predicts poor outcome
    • Langford L.A., et al. Telomerase activity in ordinary meningiomas predicts poor outcome. Hum. Pathol. 1997, 28:416-420.
    • (1997) Hum. Pathol. , vol.28 , pp. 416-420
    • Langford, L.A.1
  • 22
    • 0031442702 scopus 로고    scopus 로고
    • Telomerase activity and survival of patients with node-positive breast cancer
    • Clark G.M., et al. Telomerase activity and survival of patients with node-positive breast cancer. J. Natl. Cancer Inst. 1997, 89:1874-1881.
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 1874-1881
    • Clark, G.M.1
  • 23
    • 84862183505 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis
    • Mocellin S., et al. Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis. J. Natl. Cancer Inst. 2012, 104:840-854.
    • (2012) J. Natl. Cancer Inst. , vol.104 , pp. 840-854
    • Mocellin, S.1
  • 24
    • 0035045477 scopus 로고    scopus 로고
    • Telomerase activation, cellular immortalization and cancer
    • Hahn W.C., Meyerson M. Telomerase activation, cellular immortalization and cancer. Ann. Med. 2001, 33:123-129.
    • (2001) Ann. Med. , vol.33 , pp. 123-129
    • Hahn, W.C.1    Meyerson, M.2
  • 25
    • 80052855877 scopus 로고    scopus 로고
    • Breast field cancerization: isolation and comparison of telomerase-expressing cells in tumor and tumor adjacent, histologically normal breast tissue
    • Trujillo K.A., et al. Breast field cancerization: isolation and comparison of telomerase-expressing cells in tumor and tumor adjacent, histologically normal breast tissue. Mol. Cancer Res. 2011, 9:1209-1221.
    • (2011) Mol. Cancer Res. , vol.9 , pp. 1209-1221
    • Trujillo, K.A.1
  • 26
    • 77955845914 scopus 로고    scopus 로고
    • Telomeres and telomerase in normal and cancer stem cells
    • Shay J.W., Wright W.E. Telomeres and telomerase in normal and cancer stem cells. FEBS Lett. 2010, 584:3819-3825.
    • (2010) FEBS Lett. , vol.584 , pp. 3819-3825
    • Shay, J.W.1    Wright, W.E.2
  • 27
    • 0037148327 scopus 로고    scopus 로고
    • Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy?
    • Kyo S., Inoue M. Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy?. Oncogene 2002, 21:688-697.
    • (2002) Oncogene , vol.21 , pp. 688-697
    • Kyo, S.1    Inoue, M.2
  • 28
    • 0031939872 scopus 로고    scopus 로고
    • Telomerase activity, cell proliferation, and cancer
    • Greider C.W. Telomerase activity, cell proliferation, and cancer. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:90-92.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 90-92
    • Greider, C.W.1
  • 29
    • 3042778750 scopus 로고    scopus 로고
    • Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma
    • Gertler R., et al. Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma. J. Clin. Oncol. 2004, 22:1807-1814.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1807-1814
    • Gertler, R.1
  • 30
    • 0030934745 scopus 로고    scopus 로고
    • Shortened telomere length and increased telomerase activity in hamster pancreatic duct adenocarcinomas and cell lines
    • Kobitsu K., et al. Shortened telomere length and increased telomerase activity in hamster pancreatic duct adenocarcinomas and cell lines. Mol. Carcinog. 1997, 18:153-159.
    • (1997) Mol. Carcinog. , vol.18 , pp. 153-159
    • Kobitsu, K.1
  • 31
    • 77956635152 scopus 로고    scopus 로고
    • DNA damage repair and telomere length in normal breast, preneoplastic lesions, and invasive cancer
    • Raynaud C.M., et al. DNA damage repair and telomere length in normal breast, preneoplastic lesions, and invasive cancer. Am. J. Clin. Oncol. 2010, 33:341-345.
    • (2010) Am. J. Clin. Oncol. , vol.33 , pp. 341-345
    • Raynaud, C.M.1
  • 32
    • 0030873789 scopus 로고    scopus 로고
    • Relative contribution of normal and neoplastic cells determines telomerase activity and telomere length in primary cancers of the prostate, colon, and sarcoma
    • Engelhardt M., et al. Relative contribution of normal and neoplastic cells determines telomerase activity and telomere length in primary cancers of the prostate, colon, and sarcoma. Clin. Cancer Res. 1997, 3:1849-1857.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 1849-1857
    • Engelhardt, M.1
  • 33
    • 18544364628 scopus 로고    scopus 로고
    • Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate
    • Pascolo E., et al. Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J. Biol. Chem. 2002, 277:15566-15572.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15566-15572
    • Pascolo, E.1
  • 34
    • 4243937106 scopus 로고    scopus 로고
    • A highly selective telomerase inhibitor limiting human cancer cell proliferation
    • Damm K., et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J. 2001, 20:6958-6968.
    • (2001) EMBO J. , vol.20 , pp. 6958-6968
    • Damm, K.1
  • 35
    • 13544268344 scopus 로고    scopus 로고
    • Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532
    • El-Daly H., et al. Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532. Blood 2005, 105:1742-1749.
    • (2005) Blood , vol.105 , pp. 1742-1749
    • El-Daly, H.1
  • 36
    • 84860211280 scopus 로고    scopus 로고
    • Searching drug-like anti-cancer compound(s) based on G-quadruplex ligands
    • Li Q., et al. Searching drug-like anti-cancer compound(s) based on G-quadruplex ligands. Curr. Pharm. Des. 2012, 18:1973-1983.
    • (2012) Curr. Pharm. Des. , vol.18 , pp. 1973-1983
    • Li, Q.1
  • 37
    • 76349122184 scopus 로고    scopus 로고
    • Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer
    • Neidle S. Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer. FEBS J. 2010, 277:1118-1125.
    • (2010) FEBS J. , vol.277 , pp. 1118-1125
    • Neidle, S.1
  • 38
    • 36849081775 scopus 로고    scopus 로고
    • Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action
    • De Cian A., et al. Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:17347-17352.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 17347-17352
    • De Cian, A.1
  • 39
    • 0037070575 scopus 로고    scopus 로고
    • Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex
    • Kim M.Y., et al. Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex. J. Am. Chem. Soc. 2002, 124:2098-2099.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 2098-2099
    • Kim, M.Y.1
  • 40
    • 33746916385 scopus 로고    scopus 로고
    • The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells
    • Gomez D., et al. The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer Res. 2006, 66:6908-6912.
    • (2006) Cancer Res. , vol.66 , pp. 6908-6912
    • Gomez, D.1
  • 41
    • 0041353443 scopus 로고    scopus 로고
    • Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways
    • Tauchi T., et al. Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways. Oncogene 2003, 22:5338-5347.
    • (2003) Oncogene , vol.22 , pp. 5338-5347
    • Tauchi, T.1
  • 42
    • 13944272246 scopus 로고    scopus 로고
    • The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function
    • Burger A.M., et al. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 2005, 65:1489-1496.
    • (2005) Cancer Res. , vol.65 , pp. 1489-1496
    • Burger, A.M.1
  • 43
    • 84857775773 scopus 로고    scopus 로고
    • Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb
    • Miyazaki T., et al. Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb. Clin. Cancer Res. 2012, 18:1268-1280.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1268-1280
    • Miyazaki, T.1
  • 44
    • 33646872017 scopus 로고    scopus 로고
    • Biopharmaceutical characterization of the telomerase inhibitor BRACO19
    • Taetz S., et al. Biopharmaceutical characterization of the telomerase inhibitor BRACO19. Pharm. Res. 2006, 23:1031-1037.
    • (2006) Pharm. Res. , vol.23 , pp. 1031-1037
    • Taetz, S.1
  • 45
    • 34247208639 scopus 로고    scopus 로고
    • Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism
    • Phatak P., et al. Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. Br. J. Cancer 2007, 96:1223-1233.
    • (2007) Br. J. Cancer , vol.96 , pp. 1223-1233
    • Phatak, P.1
  • 46
    • 70350220557 scopus 로고    scopus 로고
    • Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis
    • Drygin D., et al. Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis. Cancer Res. 2009, 69:7653-7661.
    • (2009) Cancer Res. , vol.69 , pp. 7653-7661
    • Drygin, D.1
  • 47
    • 11844265528 scopus 로고    scopus 로고
    • Part I: Vaccines for solid tumours
    • Mocellin S., et al. Part I: Vaccines for solid tumours. Lancet Oncol. 2004, 5:681-689.
    • (2004) Lancet Oncol. , vol.5 , pp. 681-689
    • Mocellin, S.1
  • 48
    • 78650574270 scopus 로고    scopus 로고
    • Therapeutic cancer vaccines: are we there yet?
    • Klebanoff C.A., et al. Therapeutic cancer vaccines: are we there yet?. Immunol. Rev. 2011, 239:27-44.
    • (2011) Immunol. Rev. , vol.239 , pp. 27-44
    • Klebanoff, C.A.1
  • 49
    • 75349112400 scopus 로고    scopus 로고
    • Telomerase in cancer immunotherapy
    • Liu J.P., et al. Telomerase in cancer immunotherapy. Biochim. Biophys. Acta 2010, 1805:35-42.
    • (2010) Biochim. Biophys. Acta , vol.1805 , pp. 35-42
    • Liu, J.P.1
  • 50
    • 0033151591 scopus 로고    scopus 로고
    • The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes
    • Vonderheide R.H., et al. The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. Immunity 1999, 10:673-679.
    • (1999) Immunity , vol.10 , pp. 673-679
    • Vonderheide, R.H.1
  • 51
    • 32544432871 scopus 로고    scopus 로고
    • Telomerase-specific T-cells kill pancreatic tumor cells in vitro and in vivo
    • Schmidt J., et al. Telomerase-specific T-cells kill pancreatic tumor cells in vitro and in vivo. Cancer 2006, 106:759-764.
    • (2006) Cancer , vol.106 , pp. 759-764
    • Schmidt, J.1
  • 52
    • 0033826798 scopus 로고    scopus 로고
    • Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells
    • Nair S.K., et al. Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells. Nat. Med. 2000, 6:1011-1017.
    • (2000) Nat. Med. , vol.6 , pp. 1011-1017
    • Nair, S.K.1
  • 53
    • 77955172418 scopus 로고    scopus 로고
    • A vaccine targeting telomerase enhances survival of dogs affected by B-cell lymphoma
    • Peruzzi D., et al. A vaccine targeting telomerase enhances survival of dogs affected by B-cell lymphoma. Mol. Ther. 2010, 18:1559-1567.
    • (2010) Mol. Ther. , vol.18 , pp. 1559-1567
    • Peruzzi, D.1
  • 54
    • 80455140226 scopus 로고    scopus 로고
    • Telomerase peptide vaccination in NSCLC: a phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial
    • Brunsvig P.F., et al. Telomerase peptide vaccination in NSCLC: a phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial. Clin. Cancer Res. 2011, 17:6847-6857.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6847-6857
    • Brunsvig, P.F.1
  • 55
    • 33750557230 scopus 로고    scopus 로고
    • A phase I study of the optimized cryptic peptide TERT(572y) in patients with advanced malignancies
    • Mavroudis D., et al. A phase I study of the optimized cryptic peptide TERT(572y) in patients with advanced malignancies. Oncology 2006, 70:306-314.
    • (2006) Oncology , vol.70 , pp. 306-314
    • Mavroudis, D.1
  • 56
    • 20144364773 scopus 로고    scopus 로고
    • Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer
    • Su Z., et al. Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer. J. Immunol. 2005, 174:3798-3807.
    • (2005) J. Immunol. , vol.174 , pp. 3798-3807
    • Su, Z.1
  • 57
    • 79959769072 scopus 로고    scopus 로고
    • HTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes
    • Suso E.M., et al. hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes. Cancer Immunol. Immunother. 2011, 60:809-818.
    • (2011) Cancer Immunol. Immunother. , vol.60 , pp. 809-818
    • Suso, E.M.1
  • 58
    • 35948955903 scopus 로고    scopus 로고
    • Telomerase-specific T-cell immunity in breast cancer: effect of vaccination on tumor immunosurveillance
    • Domchek S.M., et al. Telomerase-specific T-cell immunity in breast cancer: effect of vaccination on tumor immunosurveillance. Cancer Res. 2007, 67:10546-10555.
    • (2007) Cancer Res. , vol.67 , pp. 10546-10555
    • Domchek, S.M.1
  • 59
    • 84856709105 scopus 로고    scopus 로고
    • Immunological responses in cancer patients after vaccination with the therapeutic telomerase-specific vaccine Vx-001
    • Vetsika E.K., et al. Immunological responses in cancer patients after vaccination with the therapeutic telomerase-specific vaccine Vx-001. Cancer Immunol. Immunother. 2012, 61:157-168.
    • (2012) Cancer Immunol. Immunother. , vol.61 , pp. 157-168
    • Vetsika, E.K.1
  • 60
    • 77953963578 scopus 로고    scopus 로고
    • A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma
    • Greten T.F., et al. A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma. BMC Cancer 2010, 10:209.
    • (2010) BMC Cancer , vol.10 , pp. 209
    • Greten, T.F.1
  • 61
    • 79954602211 scopus 로고    scopus 로고
    • Telomerase-specific GV1001 peptide vaccination fails to induce objective tumor response in patients with cutaneous T cell lymphoma
    • Schlapbach C., et al. Telomerase-specific GV1001 peptide vaccination fails to induce objective tumor response in patients with cutaneous T cell lymphoma. J. Dermatol. Sci. 2011, 62:75-83.
    • (2011) J. Dermatol. Sci. , vol.62 , pp. 75-83
    • Schlapbach, C.1
  • 62
    • 79751506542 scopus 로고    scopus 로고
    • Gene therapy finds its niche
    • Sheridan C. Gene therapy finds its niche. Nat. Biotechnol. 2011, 29:121-128.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 121-128
    • Sheridan, C.1
  • 63
    • 84867495468 scopus 로고    scopus 로고
    • New gene therapy strategies for cancer treatment: a review of recent patents
    • Ortiz R., et al. New gene therapy strategies for cancer treatment: a review of recent patents. Recent Pat. Anticancer Drug Discov. 2012, 7:297-312.
    • (2012) Recent Pat. Anticancer Drug Discov. , vol.7 , pp. 297-312
    • Ortiz, R.1
  • 64
    • 84864392111 scopus 로고    scopus 로고
    • Suicide gene therapy in cancer: where do we stand now?
    • Duarte S., et al. Suicide gene therapy in cancer: where do we stand now?. Cancer Lett. 2012, 324:160-170.
    • (2012) Cancer Lett. , vol.324 , pp. 160-170
    • Duarte, S.1
  • 65
    • 79952180081 scopus 로고    scopus 로고
    • Promise and challenge of RNA interference-based therapy for cancer
    • Petrocca F., Lieberman J. Promise and challenge of RNA interference-based therapy for cancer. J. Clin. Oncol. 2011, 29:747-754.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 747-754
    • Petrocca, F.1    Lieberman, J.2
  • 66
    • 24744446474 scopus 로고    scopus 로고
    • In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor
    • Dikmen Z.G., et al. In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res. 2005, 65:7866-7873.
    • (2005) Cancer Res. , vol.65 , pp. 7866-7873
    • Dikmen, Z.G.1
  • 67
    • 47549118123 scopus 로고    scopus 로고
    • Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo
    • Shammas M.A., et al. Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo. Leukemia 2008, 22:1410-1418.
    • (2008) Leukemia , vol.22 , pp. 1410-1418
    • Shammas, M.A.1
  • 68
    • 33748340023 scopus 로고    scopus 로고
    • Delivery of telomerase reverse transcriptase small interfering RNA in complex with positively charged single-walled carbon nanotubes suppresses tumor growth
    • Zhang Z., et al. Delivery of telomerase reverse transcriptase small interfering RNA in complex with positively charged single-walled carbon nanotubes suppresses tumor growth. Clin. Cancer Res. 2006, 12:4933-4939.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4933-4939
    • Zhang, Z.1
  • 69
    • 0034775290 scopus 로고    scopus 로고
    • Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells
    • Saretzki G., et al. Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells. Cancer Gene Ther. 2001, 8:827-834.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 827-834
    • Saretzki, G.1
  • 70
    • 33744799396 scopus 로고    scopus 로고
    • Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer
    • Hochreiter A.E., et al. Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer. Clin. Cancer Res. 2006, 12:3184-3192.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 3184-3192
    • Hochreiter, A.E.1
  • 71
    • 23444453219 scopus 로고    scopus 로고
    • Lipid modification of GRN163, an N3'→P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
    • Herbert B.S., et al. Lipid modification of GRN163, an N3'→P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene 2005, 24:5262-5268.
    • (2005) Oncogene , vol.24 , pp. 5262-5268
    • Herbert, B.S.1
  • 72
    • 78549257138 scopus 로고    scopus 로고
    • The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines
    • Joseph I., et al. The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines. Cancer Res. 2010, 70:9494-9504.
    • (2010) Cancer Res. , vol.70 , pp. 9494-9504
    • Joseph, I.1
  • 73
    • 74949143829 scopus 로고    scopus 로고
    • The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth
    • Marian C.O., et al. The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clin. Cancer Res. 2010, 16:154-163.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 154-163
    • Marian, C.O.1
  • 74
    • 34250375517 scopus 로고    scopus 로고
    • Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2
    • Schepelmann S., et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 2007, 67:4949-4955.
    • (2007) Cancer Res. , vol.67 , pp. 4949-4955
    • Schepelmann, S.1
  • 75
    • 84858708337 scopus 로고    scopus 로고
    • Noninvasive and real-time monitoring of the therapeutic response of tumors in vivo with an optimized hTERT promoter
    • Yu S.T., et al. Noninvasive and real-time monitoring of the therapeutic response of tumors in vivo with an optimized hTERT promoter. Cancer 2012, 118:1884-1893.
    • (2012) Cancer , vol.118 , pp. 1884-1893
    • Yu, S.T.1
  • 76
    • 77953027875 scopus 로고    scopus 로고
    • In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy
    • Kojima T., et al. In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy. Ann. Surg. 2010, 251:1079-1086.
    • (2010) Ann. Surg. , vol.251 , pp. 1079-1086
    • Kojima, T.1
  • 77
    • 41949104575 scopus 로고    scopus 로고
    • Direct and distant antitumor effects of a telomerase-selective oncolytic adenoviral agent, OBP-301, in a mouse prostate cancer model
    • Huang P., et al. Direct and distant antitumor effects of a telomerase-selective oncolytic adenoviral agent, OBP-301, in a mouse prostate cancer model. Cancer Gene Ther. 2008, 15:315-322.
    • (2008) Cancer Gene Ther. , vol.15 , pp. 315-322
    • Huang, P.1
  • 78
    • 76349086193 scopus 로고    scopus 로고
    • A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors
    • Nemunaitis J., et al. A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors. Mol. Ther. 2010, 18:429-434.
    • (2010) Mol. Ther. , vol.18 , pp. 429-434
    • Nemunaitis, J.1
  • 79
    • 33847390325 scopus 로고    scopus 로고
    • Telomerase-specific oncolytic virotherapy for human cancer with the hTERT promoter
    • Fujiwara T., et al. Telomerase-specific oncolytic virotherapy for human cancer with the hTERT promoter. Curr. Cancer Drug Targets 2007, 7:191-201.
    • (2007) Curr. Cancer Drug Targets , vol.7 , pp. 191-201
    • Fujiwara, T.1
  • 80
    • 77951637673 scopus 로고    scopus 로고
    • Telomerase-based therapies emerging slowly
    • Brower V. Telomerase-based therapies emerging slowly. J. Natl. Cancer Inst. 2010, 102:520-521.
    • (2010) J. Natl. Cancer Inst. , vol.102 , pp. 520-521
    • Brower, V.1
  • 81
    • 14344265993 scopus 로고    scopus 로고
    • Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells
    • Folini M., et al. Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells. Eur. J. Cancer 2005, 41:624-634.
    • (2005) Eur. J. Cancer , vol.41 , pp. 624-634
    • Folini, M.1
  • 82
    • 42549092132 scopus 로고    scopus 로고
    • HTERT-targeted RNA interference inhibits tumorigenicity and motility of HCT116 cells
    • Shen Y., et al. hTERT-targeted RNA interference inhibits tumorigenicity and motility of HCT116 cells. Cancer Biol. Ther. 2008, 7:228-236.
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 228-236
    • Shen, Y.1
  • 83
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann M.T., et al. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001, 107:67-77.
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1
  • 84
    • 14544287303 scopus 로고    scopus 로고
    • Combination of telomerase antisense oligonucleotides simultaneously targeting hTR and hTERT produces synergism of inhibition of telomerase activity and growth in human colon cancer cell line
    • Fu X.H., et al. Combination of telomerase antisense oligonucleotides simultaneously targeting hTR and hTERT produces synergism of inhibition of telomerase activity and growth in human colon cancer cell line. World J. Gastroenterol. 2005, 11:785-790.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 785-790
    • Fu, X.H.1
  • 85
    • 84857370161 scopus 로고    scopus 로고
    • Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in vitro and in vivo
    • Xia W., et al. Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in vitro and in vivo. J. Control. Release 2012, 157:427-436.
    • (2012) J. Control. Release , vol.157 , pp. 427-436
    • Xia, W.1
  • 86
    • 78449304076 scopus 로고    scopus 로고
    • Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner
    • Tamakawa R.A., et al. Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner. Cancer Res. 2010, 70:8684-8694.
    • (2010) Cancer Res. , vol.70 , pp. 8684-8694
    • Tamakawa, R.A.1
  • 87
    • 33745190090 scopus 로고    scopus 로고
    • Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: preclinical evaluation of chemovirotherapy
    • Fujiwara T., et al. Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: preclinical evaluation of chemovirotherapy. Int. J. Cancer 2006, 119:432-440.
    • (2006) Int. J. Cancer , vol.119 , pp. 432-440
    • Fujiwara, T.1
  • 88
    • 67649764432 scopus 로고    scopus 로고
    • SiRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells
    • Dong X., et al. siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells. BMC Cancer 2009, 9:133.
    • (2009) BMC Cancer , vol.9 , pp. 133
    • Dong, X.1
  • 89
    • 67651176018 scopus 로고    scopus 로고
    • The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel
    • Goldblatt E.M., et al. The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel. Mol. Cancer Ther. 2009, 8:2027-2035.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2027-2035
    • Goldblatt, E.M.1
  • 90
    • 70349918608 scopus 로고    scopus 로고
    • Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab
    • Goldblatt E.M., et al. Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab. Breast Cancer Res. Treat. 2009, 118:21-32.
    • (2009) Breast Cancer Res. Treat. , vol.118 , pp. 21-32
    • Goldblatt, E.M.1
  • 91
    • 79953758016 scopus 로고    scopus 로고
    • Comparative analysis of various tumor-associated antigen-specific T-cell responses in patients with hepatocellular carcinoma
    • Mizukoshi E., et al. Comparative analysis of various tumor-associated antigen-specific T-cell responses in patients with hepatocellular carcinoma. Hepatology 2011, 53:1206-1216.
    • (2011) Hepatology , vol.53 , pp. 1206-1216
    • Mizukoshi, E.1
  • 92
    • 44849109968 scopus 로고    scopus 로고
    • Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization
    • Agarwal M., et al. Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization. Cancer Res. 2008, 68:3370-3378.
    • (2008) Cancer Res. , vol.68 , pp. 3370-3378
    • Agarwal, M.1
  • 93
    • 0142084745 scopus 로고    scopus 로고
    • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • Hacein-Bey-Abina S., et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 2003, 302:415-419.
    • (2003) Science , vol.302 , pp. 415-419
    • Hacein-Bey-Abina, S.1
  • 94
    • 34548667973 scopus 로고    scopus 로고
    • Telomere length, stem cells and aging
    • Blasco M.A. Telomere length, stem cells and aging. Nat. Chem. Biol. 2007, 3:640-649.
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 640-649
    • Blasco, M.A.1
  • 95
    • 81155148297 scopus 로고    scopus 로고
    • The aging effect of chemotherapy on cultured human mesenchymal stem cells
    • Buttiglieri S., et al. The aging effect of chemotherapy on cultured human mesenchymal stem cells. Exp. Hematol. 2011, 39:1171-1181.
    • (2011) Exp. Hematol. , vol.39 , pp. 1171-1181
    • Buttiglieri, S.1


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