Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

Nucleic Acids Research

Volumn 37, Issue 4, 2009, Pages 1152-1159

  Ng, Laura J ^a,b   Cropley, Jennifer E ^a,b   Pickett, Hilda A ^c   Reddel, Roger R ^c   Suter, Catherine M ^a,b  

^a VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; RNA; TELOMERASE; TELOMERIC REPEAT CONTAINING RNA; UNCLASSIFIED DRUG;

ALTERNATIVE LENGTHENING OF TELOMERE; ARTICLE; CANCER CELL CULTURE; CHROMOSOME 18P; CHROMOSOME 2P; CHROMOSOME 4P; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ENZYME ACTIVITY; EPIGENETICS; GENE SILENCING; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SUBTELOMERIC METHYLATION; TELOMERE; TRANSCRIPTION REGULATION; UMBILICAL CORD BLOOD;

CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELLS, CULTURED; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; TELOMERASE; TELOMERE; TRANSCRIPTION, GENETIC;

MUS;

EID: 62549122535     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn1030     Document Type: Article

References (29)

1. Hayflick,L. (1965) The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res., 37, 614-636.
2. Harley,C.B., Futcher,A.B. and Greider,C.W. (1990) Telomeres shorten during ageing of human fibroblasts. Nature, 345, 458-460.
3. Kim,N.W., Piatyszek,M.A., Prowse,K.R., Harley,C.B., West,M.D., Ho,P.L., Coviello,G.M., Wright,W.E., Weinrich,S.L. and Shay,J.W. (1994) Specific association of human telomerase activity with immortal cells and cancer. Science, 266, 2011-2015.
4. Hanahan,D. and Weinberg,R.A. (2000) The hallmarks of cancer. Cell, 100, 57-70.
5. Wright,W.E., Piatyszek,M.A., Rainey,W.E., Byrd,W. and Shay,J.W. (1996) Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet., 18, 173-179.
6. Shay,J.W. and Bacchetti,S. (1997) A survey of telomerase activity in human cancer. Eur. J. Cancer, 33, 787-791.
7. Bryan,T.M., Englezou,A., Dalla-Pozza,L., Dunham,M.A. and Reddel,R.R. (1997) Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat. Med., 3, 1271-1274.
8. Murnane,J.P., Sabatier,L., Marder,B.A. and Morgan,W.F. (1994) Telomere dynamics in an immortal human cell line. EMBO J., 13, 4953-4962.
9. Yeager,T.R., Neumann,A.A., Englezou,A., Huschtscha,L.I., Noble,J.R. and Reddel,R.R. (1999) Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res., 59, 4175-4179.
10. Cesare,A.J. and Griffith,J.D. (2004) Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops. Mol. Cell Biol., 24, 9948-9957.
11. Grewal,S.I. and Jia,S. (2007) Heterochromatin revisited. Nat. Rev. Genet., 8, 35-46.
12. Garcia-Cao,M., O'Sullivan,R., Peters,A.H., Jenuwein,T. and Blasco,M.A. (2004) Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat. Genet., 36, 94-99.
13. Wolffe,A.P. and Matzke,M.A. (1999) Epigenetics: Regulation through repression. Science, 286, 481-486.
14. Brock,G.J., Charlton,J. and Bird,A. (1999) Densely methylated sequences that are preferentially localized at telomere-proximal regions of human chromosomes. Gene, 240, 269-277.
15. de Lange,T., Shiue,L., Myers,R.M., Cox,D.R., Naylor,S.L., Killery,A.M. and Varmus,H.E. (1990) Structure. Mol. Cell Biol., 10, 518-527.
16. Benetti,R., Garcia-Cao,M. and Blasco,M.A. (2007) Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat. Genet., 39, 243-250.
17. Gonzalo,S., Jaco,I., Fraga,M.F., Chen,T., Li,E., Esteller,M. and Blasco,M.A. (2006) DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat. Cell Biol., 8 416-424.
18. Vera,E., Canela,A., Fraga,M.F., Esteller,M. and Blasco,M.A. (2008) Epigenetic regulation of telomeres in human cancer. Oncogene, 27, 6817-6833.
19. Dunham,M.A., Neumann,A.A., Fasching,C.L. and Reddel,R.R. (2000) Telomere maintenance by recombination in human cells. Nat. Genet., 26 447-450.
20. Kovacheva,V.P., Mellott,T.J., Davison,J.M., Wagner,N., Lopez-Coviella,I., Schnitzler,A.C. and Blusztajn,J.K. (2007) Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. J. Biol. Chem., 282, 31777-31788.
21. Frenck,R.W. Jr, Blackburn,E.H. and Shannon,K.M. (1998) The rate of telomere sequence loss in human leukocytes varies with age. Proc. Natl Acad. Sci. USA, 95, 5607-5610.
22. Jones,P.A. and Laird,P.W. (1999) Cancer-epigenetics comes of age. Nat. Genet., 21, 163-167.
23. Ehrlich,M. (2006) Cancer-linked DNA hypomethylation and its relationship to hypermethylation. Curr. Top Microbiol. Immunol., 310, 251-274.
24. Suter,C.M., Martin,D.I. and Ward,R.L. (2004) Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int. J. Colorectal. Dis., 19, 95-101.
25. Reddel,R.R., Bryan,T.M., Colgin,L.M., Perrem,K.T. and Yeager,T.R. (2001) Alternative lengthening of telomeres in human cells. Radiat. Res., 155, 194-200.
26. Perrem,K., Colgin,L.M., Neumann,A.A., Yeager,T.R. and Reddel,R.R. (2001) Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol. Cell Biol., 21, 3862-3875.
27. Azzalin,C.M., Reichenbach,P., Khoriauli,L., Giulotto,E. and Lingner,J. (2007) Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science, 318, 798-801.
28. Schoeftner,S. and Blasco,M.A. (2008) Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat. Cell Biol., 10, 228-236.
29. Yehezkel,S., Segev,Y., Viegas-Pequignot,E., Skorecki,K. and Selig,S. (2008) Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions. Hum. Mol. Genet., 17, 2776-2789.