메뉴 건너뛰기




Volumn 32, Issue 1, 2004, Pages 371-379

Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing

Author keywords

[No Author keywords available]

Indexed keywords

BRACO 19; GUANINE; LIGAND 12459; TELOMERASE; TELOMERASE INHIBITOR; TELOMERASE REVERSE TRANSCRIPTASE; TELOMESTATIN; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 1242342930     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh181     Document Type: Article
Times cited : (201)

References (29)
  • 5
    • 0036562687 scopus 로고    scopus 로고
    • Telomere maintenance as a target for anticancer drug discovery
    • Neidle,S. and Parkinson,G. (2002) Telomere maintenance as a target for anticancer drug discovery. Nature Rev. Drug Discov., 1, 383-393.
    • (2002) Nature Rev. Drug Discov. , vol.1 , pp. 383-393
    • Neidle, S.1    Parkinson, G.2
  • 8
    • 0037096736 scopus 로고    scopus 로고
    • Detection of telomerase inhibitors based on G-quadruplex ligands by a modified telomeric repeat amplification protocol assay
    • Gomez,D., Mergny,J.L. and Riou,J.F. (2002) Detection of telomerase inhibitors based on G-quadruplex ligands by a modified telomeric repeat amplification protocol assay. Cancer Res., 62, 3365-3368.
    • (2002) Cancer Res. , vol.62 , pp. 3365-3368
    • Gomez, D.1    Mergny, J.L.2    Riou, J.F.3
  • 10
    • 0036241599 scopus 로고    scopus 로고
    • A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity
    • Gowan,S.M., Harrison,J.R., Patterson,L., Valenti,M., Read,M.A., Neidle,S. and Kelland,L.R. (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol. Pharmacol, 61, 1154-1162.
    • (2002) Mol. Pharmacol. , vol.61 , pp. 1154-1162
    • Gowan, S.M.1    Harrison, J.R.2    Patterson, L.3    Valenti, M.4    Read, M.A.5    Neidle, S.6    Kelland, L.R.7
  • 11
    • 0035793647 scopus 로고    scopus 로고
    • Fluorescence resonance energy transfer as a probe for G-quartet formation by a telomeric repeat
    • Mergny,J.L. and Maurizot,J.C. (2001) Fluorescence resonance energy transfer as a probe for G-quartet formation by a telomeric repeat. Chembiochem, Eur. J. Chem. Biol., 2. 124-132.
    • (2001) Chembiochem. Eur. J. Chem. Biol. , vol.2 , pp. 124-132
    • Mergny, J.L.1    Maurizot, J.C.2
  • 12
    • 0032508468 scopus 로고    scopus 로고
    • Following G-quartet formation by UV-spectroscopy
    • Mergny,J.L., Phan,A.T. and Lacroix,L. (1998) Following G-quartet formation by UV-spectroscopy. FEBS Lett., 435, 74-78.
    • (1998) FEBS Lett. , vol.435 , pp. 74-78
    • Mergny, J.L.1    Phan, A.T.2    Lacroix, L.3
  • 13
    • 10744226178 scopus 로고    scopus 로고
    • Resistance to the short-term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration
    • Gomez,D., Aouali,N., Londono-Vallejo,A., Lacroix,L., Megnin-Chanet,F., Lemarteleur,T., Douarre,C., Shin-ya,K., Mailliet,P., Trentesaux,C. et al. (2003) Resistance to the short-term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration. J. Biol. Chem., 278, 5055-50562.
    • (2003) J. Biol. Chem. , vol.278 , pp. 5055-50562
    • Gomez, D.1    Aouali, N.2    Londono-Vallejo, A.3    Lacroix, L.4    Megnin-Chanet, F.5    Lemarteleur, T.6    Douarre, C.7    Shin-ya, K.8    Mailliet, P.9    Trentesaux, C.10
  • 14
    • 0035584117 scopus 로고    scopus 로고
    • Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells
    • Yi,X., Shay,J.W. and Wright,W.E. (2001) Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res., 29, 4818-4825.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 4818-4825
    • Yi, X.1    Shay, J.W.2    Wright, W.E.3
  • 15
    • 0033577876 scopus 로고    scopus 로고
    • Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
    • Wick,M., Zubov,D. and Hagen,G. (1999) Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene, 232, 97-106.
    • (1999) Gene , vol.232 , pp. 97-106
    • Wick, M.1    Zubov, D.2    Hagen, G.3
  • 16
    • 0037070575 scopus 로고    scopus 로고
    • Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex
    • Kim,M.Y., Vankayalapati,H., Shin-Ya,K., Wierzba,K. and Hurley,L.H. (2002) Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. J. Am. Chem. Soc., 124, 2098-2099.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 2098-2099
    • Kim, M.Y.1    Vankayalapati, H.2    Shin-Ya, K.3    Wierzba, K.4    Hurley, L.H.5
  • 18
    • 0036849582 scopus 로고    scopus 로고
    • Human telomeric DNA: G-quadruples, i-motif and Watson-Crick double helix
    • Phan,A.T. and Mergny,J.L. (2002) Human telomeric DNA: G-quadruples, i-motif and Watson-Crick double helix. Nucleic Acids Res., 30, 4618-4625.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 4618-4625
    • Phan, A.T.1    Mergny, J.L.2
  • 19
    • 0037731436 scopus 로고    scopus 로고
    • The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular g-quadrplex structures
    • Kim,M.Y., Gleason-Guzman,M., Izbicka,E., Nishioka,D. and Hurley,L.H. (2003) the different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular g-quadrplex structures. Cancer Res., 63, 3247-3256.
    • (2003) Cancer Res. , vol.63 , pp. 3247-3256
    • Kim, M.Y.1    Gleason-Guzman, M.2    Izbicka, E.3    Nishioka, D.4    Hurley, L.H.5
  • 20
    • 0037889841 scopus 로고    scopus 로고
    • Telomere inhibition and telomere disruption as processes for drug targeting
    • Rezler,E.M., Bearss,D.J. and Hurley,L.H. (2003) Telomere inhibition and telomere disruption as processes for drug targeting. Annu. Rev. Pharmacol. Toxicol., 43, 359-379.
    • (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 359-379
    • Rezler, E.M.1    Bearss, D.J.2    Hurley, L.H.3
  • 21
    • 0037015078 scopus 로고    scopus 로고
    • Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
    • Siddiqui-Jain,A., Grand,C.L., Bearss,D.J. and Hurley,L.H. (2002) Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc. Natl Acad. Sci. USA, 99, 11593-11598.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 11593-11598
    • Siddiqui-Jain, A.1    Grand, C.L.2    Bearss, D.J.3    Hurley, L.H.4
  • 22
    • 0035900649 scopus 로고    scopus 로고
    • Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
    • Darnell,J.C., Jensen,K.B., Jin,P., Brown,V., Warren,S.T. and Darnell,R.B. (2001) Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell, 107, 489-499.
    • (2001) Cell , vol.107 , pp. 489-499
    • Darnell, J.C.1    Jensen, K.B.2    Jin, P.3    Brown, V.4    Warren, S.T.5    Darnell, R.B.6
  • 23
    • 0141925805 scopus 로고    scopus 로고
    • A single IRES containing a G-quartet RNA structure drives FGF-2 gene expression at four alternative translation initiation codons
    • Bonnal,S., Schaeffer,C., Créancier,L., Clamens,S., Moine,H., Prats,A.C. and Vagner,S. (2003) A single IRES containing a G-quartet RNA structure drives FGF-2 gene expression at four alternative translation initiation codons. J. Biol. Chem., 278, 39330-39336.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39330-39336
    • Bonnal, S.1    Schaeffer, C.2    Créancier, L.3    Clamens, S.4    Moine, H.5    Prats, A.C.6    Vagner, S.7
  • 24
    • 0029022901 scopus 로고
    • An intronic (A/U)GGG repeat enhances the splicing of an alternative intron of the chicken β-tropomyosin pre-mRNA
    • Sirand-Pugnet,P., Durosay,P., Brody,E. and Marie,J. (1995) An intronic (A/U)GGG repeat enhances the splicing of an alternative intron of the chicken β-tropomyosin pre-mRNA. Nucleic Acids Res., 23, 3501-3507.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 3501-3507
    • Sirand-Pugnet, P.1    Durosay, P.2    Brody, E.3    Marie, J.4
  • 27
    • 0034640507 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonucleoprotein A1 and UP1 protect mammalian telomeric repeats and modulate telomere replication in vitro
    • Dallaire,F., Dupuis,S., Fiset,S. and Chabot,B. (2000) Heterogeneous nuclear ribonucleoprotein A1 and UP1 protect mammalian telomeric repeats and modulate telomere replication in vitro. J. Biol. Chem., 275, 14509-14516.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14509-14516
    • Dallaire, F.1    Dupuis, S.2    Fiset, S.3    Chabot, B.4
  • 29
    • 0242349126 scopus 로고    scopus 로고
    • The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n
    • Weisman-Shomer,P., Cohen,E., Hershco,I., Khateb,S., Wolfovitz-Barchad,O., Hurley,L. and Fry,M. (2003) The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n. Nucleic Acids Res., 31, 3963-3970.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 3963-3970
    • Weisman-Shomer, P.1    Cohen, E.2    Hershco, I.3    Khateb, S.4    Wolfovitz-Barchad, O.5    Hurley, L.6    Fry, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.