Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity

British Journal of Pharmacology

Volumn 167, Issue 2, 2012, Pages 393-406

  Huang, Fong Chun ^a   Chang, Cheng Chung ^b   Wang, Jing Min ^a   Chang, Ta Chau ^c   Lin, Jing Jer ^a,d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c INSTITUTE OF ATOMIC AND MOLECULAR SCIENCES   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

c myc; carbazole; G quadruplex; senescence; telomerase; telomere

Indexed keywords

3,6 BIS(4 METHYL 2 VINYLPYRAZINIUM IODIDE)CARBAZOLE; ATM PROTEIN; CARBAZOLE DERIVATIVE; TELOMERASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SENESCENCE; TELOMERE HOMEOSTASIS;

ANTINEOPLASTIC AGENTS; CARBAZOLES; CELL AGING; CELL LINE, TUMOR; DNA DAMAGE; G-QUADRUPLEXES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; HUMANS; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PYRAZINES; TELOMERASE;

EID: 84865437096     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01997.x     Document Type: Article

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