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Volumn , Issue , 2012, Pages 77-96

Coffee and Alzheimer's Disease: Animal and Cellular Evidence

Author keywords

Caffeine in coffee; Cellular, animal models; Coffee and AD; Cognitive decline; MAPT phosphorylated; Neuroprotective effects

Indexed keywords


EID: 84886036601     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781119949893.ch4     Document Type: Chapter
Times cited : (4)

References (123)
  • 1
    • 84885993917 scopus 로고    scopus 로고
    • National Center for Health Statistics. Leading causes of death. (accessed August 11)
    • National Center for Health Statistics. Leading causes of death. http://www.cdc.gov/nchs/fastats/ lcod.htm (accessed August 11, 2010)
    • (2010)
  • 2
    • 58849083195 scopus 로고    scopus 로고
    • Midlife coffee and tea drinking and the risk of late-life dementia: A populationbased CAIDE study
    • Eskelinen, M. H., et al. Midlife coffee and tea drinking and the risk of late-life dementia: A populationbased CAIDE study. J. Alzheimers Dis. 2009, 16, 85-91.
    • (2009) J. Alzheimers Dis. , vol.16 , pp. 85-91
    • Eskelinen, M.H.1
  • 3
    • 0036046427 scopus 로고    scopus 로고
    • Does caffeine intake protect from Alzheimer's disease
    • Maia, L., de Mendonca, A. Does caffeine intake protect from Alzheimer's disease. Eur. J. Neurol. 2002, 9, 377-382.
    • (2002) Eur. J. Neurol. , vol.9 , pp. 377-382
    • Maia, L.1    de Mendonca, A.2
  • 4
    • 33846983228 scopus 로고    scopus 로고
    • Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE study
    • van Gelder, B. M., et al. Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE study. Eur. J. Clin. Nutr. 2007, 61, 226-232.
    • (2007) Eur. J. Clin. Nutr. , vol.61 , pp. 226-232
    • van Gelder, B.M.1
  • 5
    • 34548433951 scopus 로고    scopus 로고
    • The neuroprotective effects of caffeine: a prospective population study (the Three City Study)
    • Ritchie, K., et al. The neuroprotective effects of caffeine: a prospective population study (the Three City Study). Neurology 2007, 69, 536-545.
    • (2007) Neurology , vol.69 , pp. 536-545
    • Ritchie, K.1
  • 6
    • 77956224301 scopus 로고    scopus 로고
    • Caffeine intake is associated with a lower risk of cognitive decline: a cohort study from Portugal
    • Santos, C., et al. Caffeine intake is associated with a lower risk of cognitive decline: a cohort study from Portugal. J. Alzheimers Dis. 2010, 20, S175-S185.
    • (2010) J. Alzheimers Dis. , vol.20
    • Santos, C.1
  • 8
    • 0000293742 scopus 로고
    • Uber eine eigenartige Erkankung der Hirnrinde
    • Alzheimer, A. Uber eine eigenartige Erkankung der Hirnrinde. Psychiatr. 1907, 64, 146.
    • (1907) Psychiatr , vol.64 , pp. 146
    • Alzheimer, A.1
  • 9
    • 0028856460 scopus 로고
    • An English translation of Alzheimer's 1907 paper "Uber eine eigenartige Erkankung der Hirnrinde"
    • Alzheimer, A., Stelzmann, R. A., Schnitzlein, H. N., Murtagh, F. R. An English translation of Alzheimer's 1907 paper, "Uber eine eigenartige Erkankung der Hirnrinde". Clin. Anat. 1995, 8, 429-431.
    • (1995) Clin. Anat. , vol.8 , pp. 429-431
    • Alzheimer, A.1    Stelzmann, R.A.2    Schnitzlein, H.N.3    Murtagh, F.R.4
  • 10
    • 29144508843 scopus 로고    scopus 로고
    • Global prevalence of dementia: a Delphi consensus study
    • Ferri, C. P., et al. Global prevalence of dementia: a Delphi consensus study. Lancet 2005, 366, 2112-2117.
    • (2005) Lancet , vol.366 , pp. 2112-2117
    • Ferri, C.P.1
  • 11
    • 77950362845 scopus 로고    scopus 로고
    • Neuronutrition and Alzheimer's disease
    • Ramesh, B. N., et al. Neuronutrition and Alzheimer's disease. J. Alzheimers Dis. 2010, 19, 1123-1139.
    • (2010) J. Alzheimers Dis. , vol.19 , pp. 1123-1139
    • Ramesh, B.N.1
  • 12
    • 80052726642 scopus 로고    scopus 로고
    • Personality changes in Alzheimer's disease: a systematic review
    • Wahlin, T. R., Byrne, G. J. Personality changes in Alzheimer's disease: a systematic review. Int. J. Geriatr. Psych. 2011, 26, 1019-1029.
    • (2011) Int. J. Geriatr. Psych. , vol.26 , pp. 1019-1029
    • Wahlin, T.R.1    Byrne, G.J.2
  • 13
    • 79953244313 scopus 로고    scopus 로고
    • Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer's disease
    • Karttunen, K., et al. Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer's disease. Int. J. Geriatr. Psych. 2010, 26, 473-482.
    • (2010) Int. J. Geriatr. Psych. , vol.26 , pp. 473-482
    • Karttunen, K.1
  • 14
    • 0029887389 scopus 로고
    • The spectrum of behavioral changes in Alzheimer's disease
    • Mega, M. S., Cummings, J. L., Fiorello, T., Gornbein, J. The spectrum of behavioral changes in Alzheimer's disease. Neurology 1995, 46, 130-135.
    • (1995) Neurology , vol.46 , pp. 130-135
    • Mega, M.S.1    Cummings, J.L.2    Fiorello, T.3    Gornbein, J.4
  • 15
    • 20844432210 scopus 로고    scopus 로고
    • Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment
    • Kalbe, E., et al. Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment. Dement. Geriatr. Cogn. Disord. 2005, 19, 349-356.
    • (2005) Dement. Geriatr. Cogn. Disord. , vol.19 , pp. 349-356
    • Kalbe, E.1
  • 16
    • 75649135280 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer's disease
    • Perl, D. P. Neuropathology of Alzheimer's disease. Mt. Sinai J. Med. 2010, 77, 32-42.
    • (2010) Mt. Sinai J. Med. , vol.77 , pp. 32-42
    • Perl, D.P.1
  • 17
    • 31544481443 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer's disease
    • Mott, R. T., Hulette, C. M. Neuropathology of Alzheimer's disease. Neuroimag. Clin. N. Am. 2005, 15, 755-765.
    • (2005) Neuroimag. Clin. N. Am. , vol.15 , pp. 755-765
    • Mott, R.T.1    Hulette, C.M.2
  • 18
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
    • Terry, R. D., et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 1991, 30, 572-580.
    • (1991) Ann. Neurol. , vol.30 , pp. 572-580
    • Terry, R.D.1
  • 19
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer-related changes
    • Braak, H., Braak, E. Neuropathological staging of Alzheimer-related changes. Acta. Neuropathol. 1991, 82, 239-259.
    • (1991) Acta. Neuropathol. , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 20
    • 0020607502 scopus 로고
    • Phosphorylation of microtubule-associated proteins regulates their interaction with actin filaments
    • Selden, S. C., Polard, T. D. Phosphorylation of microtubule-associated proteins regulates their interaction with actin filaments. J. Biol. Chem. 1983, 258, 7064-7071.
    • (1983) J. Biol. Chem. , vol.258 , pp. 7064-7071
    • Selden, S.C.1    Polard, T.D.2
  • 21
    • 77953808475 scopus 로고    scopus 로고
    • Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease
    • Dawson, H. N., et al. Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. Neuroscience 2010, 169, 516-531.
    • (2010) Neuroscience , vol.169 , pp. 516-531
    • Dawson, H.N.1
  • 22
    • 33750705653 scopus 로고    scopus 로고
    • A century of Alzheimer's disease
    • Goedert, M., Spillantini, M. G. A century of Alzheimer's disease. Science 2006, 314, 777-781.
    • (2006) Science , vol.314 , pp. 777-781
    • Goedert, M.1    Spillantini, M.G.2
  • 23
    • 0026743110 scopus 로고
    • Neurofibrillary tangles and not senile plaques parallel duration and severity of Alzheimer's disease
    • Arriagada, P. V., Growdon, J. H., Hedley-White, T., Hyman, B. T. Neurofibrillary tangles and not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992, 42, 1681-1688.
    • (1992) Neurology , vol.42 , pp. 1681-1688
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-White, T.3    Hyman, B.T.4
  • 24
    • 0028861585 scopus 로고
    • Neurofibrillary tangles correlate with dementia severity in Alzheimer's disease
    • Hof, P. R., et al. Neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch. Neurol. 1995, 52, 81-88.
    • (1995) Arch. Neurol. , vol.52 , pp. 81-88
    • Hof, P.R.1
  • 25
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • Kang, J., et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987, 325, 733-736.
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1
  • 26
    • 0033595706 scopus 로고    scopus 로고
    • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
    • Vassar, R., et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999, 286, 735-741.
    • (1999) Science , vol.286 , pp. 735-741
    • Vassar, R.1
  • 27
    • 0029933153 scopus 로고    scopus 로고
    • The role of APP processing and trafficking pathways in the formation of amyloid beta-protein
    • Selkoe, D. J., et al. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Ann. NY Acad. Sci. 1996, 777, 57-64.
    • (1996) Ann. NY Acad. Sci. , vol.777 , pp. 57-64
    • Selkoe, D.J.1
  • 28
    • 0023684537 scopus 로고
    • Differences between vascular and plaque core amyloid in Alzheimer's disease
    • Prelli, F., Castano, E., Glenner, C. G., Frangione, B. Differences between vascular and plaque core amyloid in Alzheimer's disease. J. Neurochem. 1988, 51, 648-651.
    • (1988) J. Neurochem. , vol.51 , pp. 648-651
    • Prelli, F.1    Castano, E.2    Glenner, C.G.3    Frangione, B.4
  • 29
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy, J., Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297, 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 30
    • 34248547813 scopus 로고    scopus 로고
    • Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases
    • Ferreira, S. T., Vieira, M. N. N., De Felice, F. G. Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases. Life 2007, 59, 332-345.
    • (2007) Life , vol.59 , pp. 332-345
    • Ferreira, S.T.1    Vieira, M.N.N.2    De Felice, F.G.3
  • 31
    • 0034923434 scopus 로고    scopus 로고
    • Oxidative damage is the earliest event in Alzheimer's disease
    • Nunomura, A., et al. Oxidative damage is the earliest event in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 2001, 60, 759-767.
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 759-767
    • Nunomura, A.1
  • 32
    • 33645775687 scopus 로고    scopus 로고
    • Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau
    • Castellani, R. J., Lee, H. G., Perry, G., Smith, M. A. Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau. Am. J. Alzheimers Dis. Other Demen. 2006, 21, 126-130.
    • (2006) Am. J. Alzheimers Dis. Other Demen. , vol.21 , pp. 126-130
    • Castellani, R.J.1    Lee, H.G.2    Perry, G.3    Smith, M.A.4
  • 33
    • 0029787599 scopus 로고    scopus 로고
    • Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils
    • El Khoury, J., et al. Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature 1996, 382, 716-719.
    • (1996) Nature , vol.382 , pp. 716-719
    • El Khoury, J.1
  • 34
    • 0034814056 scopus 로고    scopus 로고
    • Microglial chemotaxis, activation, and phagocytosis of amyloid β-peptide as linked phenomena in Alzheimer's disease
    • Rogers, J., Lue, L. F. Microglial chemotaxis, activation, and phagocytosis of amyloid β-peptide as linked phenomena in Alzheimer's disease. Neurochem. Int. 2001, 39, 333-340.
    • (2001) Neurochem. Int. , vol.39 , pp. 333-340
    • Rogers, J.1    Lue, L.F.2
  • 35
    • 0031753157 scopus 로고    scopus 로고
    • Alzheimer's beta-amyloid peptide 1-42 induces a phagocytic response in murine microglia
    • Kopek, K. K., Caroll, R. T. Alzheimer's beta-amyloid peptide 1-42 induces a phagocytic response in murine microglia. J. Neurochem. 1998, 71, 2123-2131.
    • (1998) J. Neurochem. , vol.71 , pp. 2123-2131
    • Kopek, K.K.1    Caroll, R.T.2
  • 36
    • 0026783591 scopus 로고
    • Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils
    • Frackowiak, J., et al. Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol. 1992, 84, 225-233.
    • (1992) Acta Neuropathol , vol.84 , pp. 225-233
    • Frackowiak, J.1
  • 37
    • 0032521111 scopus 로고    scopus 로고
    • Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of select population of neurons in the rat CNS in vivo
    • Weldon, D. T., et al. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of select population of neurons in the rat CNS in vivo. J. Neurosci. 1998, 18, 2161-2173.
    • (1998) J. Neurosci. , vol.18 , pp. 2161-2173
    • Weldon, D.T.1
  • 38
    • 4944258716 scopus 로고    scopus 로고
    • The role of inflammation in Alzheimer's disease
    • Tuppo, E. E., Arias, H. R. The role of inflammation in Alzheimer's disease. Int. J. Biochem. Cell Biol. 2005, 37, 289-305.
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 289-305
    • Tuppo, E.E.1    Arias, H.R.2
  • 39
    • 0019410162 scopus 로고
    • Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis
    • Whitehouse, P. J., et al. Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann. Neurol. 1981, 10, 122-126.
    • (1981) Ann. Neurol. , vol.10 , pp. 122-126
    • Whitehouse, P.J.1
  • 40
    • 0018078940 scopus 로고
    • Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia
    • Perry, E. K., et al. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br. Med. J. 1978, 2, 1457-1459.
    • (1978) Br. Med. J. , vol.2 , pp. 1457-1459
    • Perry, E.K.1
  • 41
    • 34548555711 scopus 로고    scopus 로고
    • Genetics of Alzheimer's disease: a rapidly evolving field
    • Serretti, A., Olgiati, P., de Ronchi, D. Genetics of Alzheimer's disease: a rapidly evolving field. J. Alzheimers Dis. 2007, 12, 73-92.
    • (2007) J. Alzheimers Dis. , vol.12 , pp. 73-92
    • Serretti, A.1    Olgiati, P.2    de Ronchi, D.3
  • 42
    • 78349246723 scopus 로고    scopus 로고
    • Age-related progressive synaptic dysfunction: the critical role of presenilin 1
    • Auffret, A., Mariani, J., Rovira, C. Age-related progressive synaptic dysfunction: the critical role of presenilin 1. Rev. Neurosci. 2010, 21, 239-250.
    • (2010) Rev. Neurosci. , vol.21 , pp. 239-250
    • Auffret, A.1    Mariani, J.2    Rovira, C.3
  • 43
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad, E., et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995, 269, 973-977.
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1
  • 44
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindred with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev, E. I., et al. Familial Alzheimer's disease in kindred with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1995, 376, 775-778.
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1
  • 45
    • 0027407565 scopus 로고
    • Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
    • Strittmatter, W. J., et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 1993, 90, 1977-1981.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1
  • 46
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease
    • McKhann, G., et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984, 34, 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1
  • 47
    • 0842304328 scopus 로고
    • American Psychiatric, Association
    • 4th edition Text Revision Washington, DC: American Psychiatric Association;
    • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision, Washington, DC: American Psychiatric Association; 1994.
    • (1994) Diagnostic and Statistical Manual of Mental Disorders
  • 49
    • 84885969072 scopus 로고    scopus 로고
    • Tacrine in the treatment of Alzheimer's disease
    • Summers, W. K. Tacrine in the treatment of Alzheimer's disease. Med. Sentinel 2000, 5, 15-18.
    • (2000) Med. Sentinel , vol.5 , pp. 15-18
    • Summers, W.K.1
  • 50
    • 78651395271 scopus 로고    scopus 로고
    • Investigational medications for treatment of patients with Alzheimer disease
    • Potter, P. E. Investigational medications for treatment of patients with Alzheimer disease. J. Am. Osteopath. Assoc. 2010, 110(9 Suppl 8), S27-S36.
    • (2010) J. Am. Osteopath. Assoc. , vol.110 , Issue.9 SUPPL 8
    • Potter, P.E.1
  • 52
    • 33750503415 scopus 로고    scopus 로고
    • Drug discovery in dementia: the role of rodent models
    • van Dam, D., de Deyn, P. P. Drug discovery in dementia: the role of rodent models. Nat. Rev. Drug Discov. 2006, 5, 956-970.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 956-970
    • van Dam, D.1    de Deyn, P.P.2
  • 53
    • 45749151056 scopus 로고    scopus 로고
    • Animal models of Alzheimer's disease and frontotemporal dementia
    • Götz, J., Ittner, L. M. Animal models of Alzheimer's disease and frontotemporal dementia. Nat. Rev. Neurosci. 2008, 9, 532-544.
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 532-544
    • Götz, J.1    Ittner, L.M.2
  • 54
    • 0033180601 scopus 로고    scopus 로고
    • Neuroprotective approaches in experimental models of β-amyloid neurotoxicity: relevance to Alzheimer's disease
    • Harkany, T., et al. Neuroprotective approaches in experimental models of β-amyloid neurotoxicity: relevance to Alzheimer's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 1999, 23, 963- 1008.
    • (1999) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.23
    • Harkany, T.1
  • 55
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid β protein inhibit hippocampal long-term potentiation in vivo
    • Walsh, D. M., et al. Naturally secreted oligomers of amyloid β protein inhibit hippocampal long-term potentiation in vivo. Nature 2002, 416, 535-539.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1
  • 56
    • 0030896787 scopus 로고    scopus 로고
    • Senescence-accelerated mouse (SAM): a novel murine model of senescence
    • Kakeda, T., Hosokawa, M., Higuchi, K. Senescence-accelerated mouse (SAM): a novel murine model of senescence. Exp. Gerontol. 1998, 32, 105-109.
    • (1998) Exp. Gerontol. , vol.32 , pp. 105-109
    • Kakeda, T.1    Hosokawa, M.2    Higuchi, K.3
  • 57
    • 33646126924 scopus 로고    scopus 로고
    • A decade of modeling Alzheimer's disease in transgenic mice
    • McGowen, E., Eriksen, J., Hutton, M. A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet. 2006, 22, 281-289.
    • (2006) Trends Genet , vol.22 , pp. 281-289
    • McGowen, E.1    Eriksen, J.2    Hutton, M.3
  • 58
    • 33645238792 scopus 로고    scopus 로고
    • Total and specific fluid consumption as determinants of bladder cancer risk
    • Villanueva, C. M., et al. Total and specific fluid consumption as determinants of bladder cancer risk. Int. J. Cancer 2006, 118, 2040-2047.
    • (2006) Int. J. Cancer , vol.118 , pp. 2040-2047
    • Villanueva, C.M.1
  • 59
    • 0345718662 scopus 로고
    • Pharmacology of Uighur
    • Wulumaqi China: Xinjiang People's Publishing House;
    • Liu, Y. M., Shawuti, Y. Pharmacology of Uighur. Wulumaqi, China: Xinjiang People's Publishing House; 1985, p. 267.
    • (1985) , pp. 267
    • Liu, Y.M.1    Shawuti, Y.2
  • 60
    • 33750984544 scopus 로고    scopus 로고
    • Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain β-amyloid production
    • Arendash, G. W., et al. Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain β-amyloid production. Neuroscience 2006, 142, 941-952.
    • (2006) Neuroscience , vol.142 , pp. 941-952
    • Arendash, G.W.1
  • 61
    • 70350277695 scopus 로고    scopus 로고
    • Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees
    • Chu, Y., et al. Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees. J. Agric. Food Chem. 2009, 57, 9801-9808.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 9801-9808
    • Chu, Y.1
  • 62
    • 58549107784 scopus 로고    scopus 로고
    • Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals
    • Cho, E. S., et al. Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals. Mutat. Res. 2009, 661, 18-24.
    • (2009) Mutat. Res. , vol.661 , pp. 18-24
    • Cho, E.S.1
  • 63
    • 0017373876 scopus 로고
    • The effects of prolonged coffee intake on genetically identical mice
    • Bauer, A. R., et al. The effects of prolonged coffee intake on genetically identical mice. Life Sci. 1977, 21, 63-70.
    • (1977) Life Sci , vol.21 , pp. 63-70
    • Bauer, A.R.1
  • 64
    • 1642421843 scopus 로고    scopus 로고
    • Inhibitory effect of coffee on hepatoma proliferation and invasion in culture and on tumor growth, metastasis and abnormal lipoprotein profiles in hepatomabearing rats
    • Miura, Y., Ono, K., Okauchi, R., Yagasaki, K. Inhibitory effect of coffee on hepatoma proliferation and invasion in culture and on tumor growth, metastasis and abnormal lipoprotein profiles in hepatomabearing rats. J. Nutr. Sci. Vitaminol. 2004, 50, 38-44.
    • (2004) J. Nutr. Sci. Vitaminol. , vol.50 , pp. 38-44
    • Miura, Y.1    Ono, K.2    Okauchi, R.3    Yagasaki, K.4
  • 65
    • 0028869586 scopus 로고
    • Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats
    • Hasegawa, R., et al. Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. Food Chem. Toxicol. 1995, 33, 15-20.
    • (1995) Food Chem. Toxicol. , vol.33 , pp. 15-20
    • Hasegawa, R.1
  • 66
    • 33748253471 scopus 로고    scopus 로고
    • Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease
    • Green, K. N., et al. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J. Neurosci. 2006, 26, 9047-9056.
    • (2006) J. Neurosci. , vol.26 , pp. 9047-9056
    • Green, K.N.1
  • 67
    • 0037206650 scopus 로고    scopus 로고
    • Modulation of the stress response by coffee: an in vivo microdialysis study of hippocampal serotonin and dopamine levels in rat
    • Yamato, T., et al. Modulation of the stress response by coffee: an in vivo microdialysis study of hippocampal serotonin and dopamine levels in rat. Neurosci. Lett. 2002, 332, 87-90.
    • (2002) Neurosci. Lett. , vol.332 , pp. 87-90
    • Yamato, T.1
  • 68
    • 0025914533 scopus 로고
    • Coffee contains cholinomimetic compound distinct from caffeine I: purification and chromatographic analysis
    • Tse, S. Y. Coffee contains cholinomimetic compound distinct from caffeine. I: purification and chromatographic analysis. J. Pharm. Sci. 1991, 80, 665-669.
    • (1991) J. Pharm. Sci. , vol.80 , pp. 665-669
    • Tse, S.Y.1
  • 69
    • 0026796053 scopus 로고
    • Cholinomimetic compound distinct from caffeine contained in coffee II: Muscarinic actions
    • Tse, S. Y. Cholinomimetic compound distinct from caffeine contained in coffee. II: Muscarinic actions. J. Pharm. Sci. 1992, 81, 449-452.
    • (1992) J. Pharm. Sci. , vol.81 , pp. 449-452
    • Tse, S.Y.1
  • 70
    • 77950961183 scopus 로고    scopus 로고
    • The influence of beverage composition on delivery of phenolic compounds from coffee and tea
    • Ferruzzi, M. G. The influence of beverage composition on delivery of phenolic compounds from coffee and tea. Physiol. Behav. 2010, 100, 33-41.
    • (2010) Physiol. Behav. , vol.100 , pp. 33-41
    • Ferruzzi, M.G.1
  • 71
    • 24644504314 scopus 로고    scopus 로고
    • Caffeine
    • Leiberman, H. R., Kanarek, R. B., Prasad, C., eds. Boca Raton: CRC Press
    • Smith, A. Caffeine. In: Nutritional Neuroscience. Leiberman, H. R., Kanarek, R. B., Prasad, C., eds. Boca Raton: CRC Press; 2005, pp. 341-356.
    • (2005) Nutritional Neuroscience , pp. 341-356
    • Smith, A.1
  • 72
    • 33644551294 scopus 로고    scopus 로고
    • Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers
    • Ciruela, F., et al. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. J. Neurosci. 2006, 26, 2080-2087.
    • (2006) J. Neurosci. , vol.26 , pp. 2080-2087
    • Ciruela, F.1
  • 73
    • 0345561561 scopus 로고    scopus 로고
    • Actions of caffeine in the brain with special reference to factors that contribute to its widespread use
    • Fredholm, B. B., et al. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol. Rev. 1999, 51, 83-133.
    • (1999) Pharmacol. Rev. , vol.51 , pp. 83-133
    • Fredholm, B.B.1
  • 74
    • 56249109097 scopus 로고    scopus 로고
    • Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice
    • Björklund, O., et al. Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice. Physiol. Behav. 2008, 95, 668-676.
    • (2008) Physiol. Behav. , vol.95 , pp. 668-676
    • Björklund, O.1
  • 75
    • 70349653486 scopus 로고    scopus 로고
    • The role of adenosine in Alzheimer's disease
    • Rahman, A. The role of adenosine in Alzheimer's disease. Curr. Neuropharm. 2009, 7, 207-216.
    • (2009) Curr. Neuropharm. , vol.7 , pp. 207-216
    • Rahman, A.1
  • 76
    • 0030987603 scopus 로고    scopus 로고
    • Caffeine stimulates amyloid β-peptide release from β-amyloid precursor protein-transfected HEK293 cells
    • Querfurth, H. W., Jiang, J., Geiger, J. D., Selkoe, D. J. Caffeine stimulates amyloid β-peptide release from β-amyloid precursor protein-transfected HEK293 cells. J. Neurochem. 1997, 69, 1580- 1591.
    • (1997) J. Neurochem. , vol.69
    • Querfurth, H.W.1    Jiang, J.2    Geiger, J.D.3    Selkoe, D.J.4
  • 77
    • 0038415954 scopus 로고    scopus 로고
    • Neuroprotection by caffeine and adenosine A2A receptor blockade of β-amyloid neurotoxicity
    • Dall'Igna, O. P., et al. Neuroprotection by caffeine and adenosine A2A receptor blockade of β-amyloid neurotoxicity. Brit. J. Pharmacol. 2003, 138, 1207-1209.
    • (2003) Brit. J. Pharmacol. , vol.138 , pp. 1207-1209
    • Dall'Igna, O.P.1
  • 79
    • 38449097509 scopus 로고    scopus 로고
    • Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies
    • Takahashi, R. N., Pamplona, F. A., Prediger, R. D. Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies. Front. Biosci. 2008, 13, 2614-2632.
    • (2008) Front. Biosci. , vol.13 , pp. 2614-2632
    • Takahashi, R.N.1    Pamplona, F.A.2    Prediger, R.D.3
  • 80
    • 77956180469 scopus 로고    scopus 로고
    • Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet
    • Prasanthi, J. R. P., et al. Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic. Biol. Med. 2010, 49, 1212-1220.
    • (2010) Free Radic. Biol. Med. , vol.49 , pp. 1212-1220
    • Prasanthi, J.R.P.1
  • 81
    • 13844254130 scopus 로고    scopus 로고
    • Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats involvement of adenosine A1 and A2A receptors
    • Prediger, R. D. S., Batista, L. C., Takahashi, R. N. Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats involvement of adenosine A1 and A2A receptors. Neurobiol. Aging 2005, 26, 957-964.
    • (2005) Neurobiol. Aging , vol.26 , pp. 957-964
    • Prediger, R.D.S.1    Batista, L.C.2    Takahashi, R.N.3
  • 82
    • 67849083449 scopus 로고    scopus 로고
    • Caffeine reverses cognitive impairment and decreases brain amyloid-β levels in aged Alzheimer's disease mice
    • Arendash, G. W., et al. Caffeine reverses cognitive impairment and decreases brain amyloid-β levels in aged Alzheimer's disease mice. J. Alzheimers Dis. 2009, 17, 661-680.
    • (2009) J. Alzheimers Dis. , vol.17 , pp. 661-680
    • Arendash, G.W.1
  • 83
    • 67849104997 scopus 로고    scopus 로고
    • Caffeine suppresses amyloid-β levels in plasma and brain of Alzheimer's disease transgenic mice
    • Cao, C., et al. Caffeine suppresses amyloid-β levels in plasma and brain of Alzheimer's disease transgenic mice. J. Alzheimers Dis. 2009, 17, 681-697.
    • (2009) J. Alzheimers Dis. , vol.17 , pp. 681-697
    • Cao, C.1
  • 84
    • 0030475564 scopus 로고    scopus 로고
    • Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice Relationship to c-fos expression and receptor binding
    • Johansson, B., Georgiev, V., Kuosmanen, T., Fredholm, B. Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding. Eur. J. Neurosci. 1996, 8, 2447-2458.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 2447-2458
    • Johansson, B.1    Georgiev, V.2    Kuosmanen, T.3    Fredholm, B.4
  • 85
    • 77956195944 scopus 로고    scopus 로고
    • Caffeine and coffee as therapeutics against Alzheimer's disease
    • Arendash, G.W., Cao, C. Caffeine and coffee as therapeutics against Alzheimer's disease. J. Alzheimers Dis. 2010, 20, S117-S126.
    • (2010) J. Alzheimers Dis. , vol.20
    • Arendash, G.W.1    Cao, C.2
  • 86
    • 77954537925 scopus 로고    scopus 로고
    • Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline
    • Cunha, R. A., Agostinho, P. M. Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline. J. Alzheimers Dis. 2010, 20, S95-S116.
    • (2010) J. Alzheimers Dis. , vol.20
    • Cunha, R.A.1    Agostinho, P.M.2
  • 87
    • 33645760745 scopus 로고    scopus 로고
    • Characterization by LC-MS(n) of four new classes of chlorogenic acids in green coffee beans: dimethoxycnnamoylquinic acids, diferuloylquinic acids, caffeoyldimethoxycinnamoylquinic acids, and feruloyl-dimethoxycinnamoylquinic acids
    • Clifford, M. N., et al. Characterization by LC-MS(n) of four new classes of chlorogenic acids in green coffee beans: dimethoxycnnamoylquinic acids, diferuloylquinic acids, caffeoyldimethoxycinnamoylquinic acids, and feruloyl-dimethoxycinnamoylquinic acids. J. Agric. Food Chem. 2006, 54, 1957-1969.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 1957-1969
    • Clifford, M.N.1
  • 88
    • 33644631621 scopus 로고    scopus 로고
    • Coffee and health: a review of recent human research
    • Higdon, J. V., Frei, B. Coffee and health: a review of recent human research. Crit. Rev. Food Sci. Nutr. 2006, 46, 101-123.
    • (2006) Crit. Rev. Food Sci. Nutr. , vol.46 , pp. 101-123
    • Higdon, J.V.1    Frei, B.2
  • 89
    • 0024793872 scopus 로고
    • Occurrence and content of hydroxycinnamic and hydroxybenzoic acid compounds in foods
    • Herrmann, K. Occurrence and content of hydroxycinnamic and hydroxybenzoic acid compounds in foods. Crit. Rev. Food Sci. Nutr. 1989, 28, 315-347.
    • (1989) Crit. Rev. Food Sci. Nutr. , vol.28 , pp. 315-347
    • Herrmann, K.1
  • 90
    • 0021399390 scopus 로고
    • Chlorogenic acid composition of instant coffees
    • Trugo, L. C., Macrae, R. Chlorogenic acid composition of instant coffees. Analyst. 1984, 109, 263-266.
    • (1984) Analyst , vol.109 , pp. 263-266
    • Trugo, L.C.1    Macrae, R.2
  • 91
    • 67649224315 scopus 로고    scopus 로고
    • Role of roasting conditions in the level of chlorogenic acid content in coffee beans: correlation with coffee acidity
    • Moon, J. K., Yoo, H. S., Shibamoto, T. Role of roasting conditions in the level of chlorogenic acid content in coffee beans: correlation with coffee acidity. J. Agric. Food Chem. 2009, 57, 5365- 5369.
    • (2009) J. Agric. Food Chem. , vol.57
    • Moon, J.K.1    Yoo, H.S.2    Shibamoto, T.3
  • 92
    • 0034657786 scopus 로고    scopus 로고
    • Chlorogenic acids and other cinnamates: nature, occurrence, dietary burden, absorption and metabolism
    • Clifford, M. N. Chlorogenic acids and other cinnamates: nature, occurrence, dietary burden, absorption and metabolism. J. Sci. Food Agric. 2000, 80, 1033-1043.
    • (2000) J. Sci. Food Agric. , vol.80 , pp. 1033-1043
    • Clifford, M.N.1
  • 93
    • 0037409121 scopus 로고    scopus 로고
    • Antioxidant capacity of phenolic phytochemicals from various cultivars of plums
    • Kim, D. O., Jeong, S. W., Lee, C. Y. Antioxidant capacity of phenolic phytochemicals from various cultivars of plums. Food Chem. 2003, 81, 321-326.
    • (2003) Food Chem , vol.81 , pp. 321-326
    • Kim, D.O.1    Jeong, S.W.2    Lee, C.Y.3
  • 94
    • 33845271866 scopus 로고    scopus 로고
    • Chlorogenic acid is poorly absorbed, independently of the food matrix: a Caco-2 cells and rat chronic absorption study
    • Dupas, C., et al. Chlorogenic acid is poorly absorbed, independently of the food matrix: a Caco-2 cells and rat chronic absorption study. Mol. Nutr. Food. Res. 2006, 50, 1053-1060.
    • (2006) Mol. Nutr. Food. Res. , vol.50 , pp. 1053-1060
    • Dupas, C.1
  • 95
    • 0038653491 scopus 로고    scopus 로고
    • Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats
    • Gonthier, M., et al. Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. J. Nutr. 2003, 133, 1853-1859.
    • (2003) J. Nutr. , vol.133 , pp. 1853-1859
    • Gonthier, M.1
  • 96
    • 41549100684 scopus 로고    scopus 로고
    • Chlorogenic acid and its metabolite m-coumaric acid evoke neurite outgrowth in hippocampal neuronal cells
    • Ito, H., et al. Chlorogenic acid and its metabolite m-coumaric acid evoke neurite outgrowth in hippocampal neuronal cells. Biotechnol. Biochem. 2008, 72, 885-888.
    • (2008) Biotechnol. Biochem. , vol.72 , pp. 885-888
    • Ito, H.1
  • 97
    • 20444482037 scopus 로고    scopus 로고
    • Neuroprotective effects of 3,5-dicaffeolylquinic acid on hydrogen peroxide-induced cell death in SH-SY5Y cells
    • Kim, S. S., et al. Neuroprotective effects of 3,5-dicaffeolylquinic acid on hydrogen peroxide-induced cell death in SH-SY5Y cells. Phytother. Res. 2005, 19, 243-245.
    • (2005) Phytother. Res. , vol.19 , pp. 243-245
    • Kim, S.S.1
  • 98
    • 33845670452 scopus 로고    scopus 로고
    • Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions
    • Nakajima,Y., Shimazawa,M., Mishima, S., Hara, H.Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions. Life Sci. 2007, 80, 370-377.
    • (2007) Life Sci , vol.80 , pp. 370-377
    • Nakajima, Y.1    Shimazawa, M.2    Mishima, S.3    Hara, H.4
  • 99
    • 77955920306 scopus 로고    scopus 로고
    • Chlorogenic acid attenuates adhesion molecules upregulation in IL-1β-treated endothelial cells
    • Chang, W., et al. Chlorogenic acid attenuates adhesion molecules upregulation in IL-1β-treated endothelial cells. Eur. J. Nutr. 2010, 49, 267-275.
    • (2010) Eur. J. Nutr. , vol.49 , pp. 267-275
    • Chang, W.1
  • 100
    • 79954610780 scopus 로고    scopus 로고
    • Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression
    • Boettler, U., et al. Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. J. Nutr. Biochem. 2010, 22, 426-440.
    • (2010) J. Nutr. Biochem. , vol.22 , pp. 426-440
    • Boettler, U.1
  • 101
    • 34548612956 scopus 로고    scopus 로고
    • Chlorogenic acid, a polyphenol and Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects
    • Bouayed, J., et al. Chlorogenic acid, a polyphenol and Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects. J. Neur. Sci. 2007, 262, 77-84.
    • (2007) J. Neur. Sci. , vol.262 , pp. 77-84
    • Bouayed, J.1
  • 102
    • 78049316797 scopus 로고    scopus 로고
    • Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice
    • Kwon, S., et al. Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice. Behav. Pharmacol. 2010, 649, 210-217.
    • (2010) Behav. Pharmacol. , vol.649 , pp. 210-217
    • Kwon, S.1
  • 103
    • 0029888128 scopus 로고    scopus 로고
    • Structure-antioxidant activity relationships of flavonoids and phenolic acids
    • Rice-Evans, C. A., Miller, M. J., Paganga, G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 1996, 20, 933-956.
    • (1996) Free Radic. Biol. Med. , vol.20 , pp. 933-956
    • Rice-Evans, C.A.1    Miller, M.J.2    Paganga, G.3
  • 104
    • 78650175025 scopus 로고    scopus 로고
    • In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid
    • Sato, Y., et al. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int. J. Pharm. 2011, 403, 136-138.
    • (2011) Int. J. Pharm. , vol.403 , pp. 136-138
    • Sato, Y.1
  • 105
    • 0031172471 scopus 로고    scopus 로고
    • Effect of caffeic acid dietary supplementation on the antioxidant defense system in rat: an in vivo study
    • Nardini, M., et al. Effect of caffeic acid dietary supplementation on the antioxidant defense system in rat: an in vivo study. Arch. Biochem. Biophys. 1997, 342, 157-160.
    • (1997) Arch. Biochem. Biophys. , vol.342 , pp. 157-160
    • Nardini, M.1
  • 106
    • 0023662410 scopus 로고
    • The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma
    • Wayner, D. D. M., et al. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochim. Biophys. Acta. 1987, 924, 408-419.
    • (1987) Biochim. Biophys. Acta. , vol.924 , pp. 408-419
    • Wayner, D.D.M.1
  • 107
    • 10944237949 scopus 로고    scopus 로고
    • Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells
    • Huang, J., de Paulis, T., May, J. M. Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells. J. Nutr. Biochem. 2004, 15, 722-729.
    • (2004) J. Nutr. Biochem. , vol.15 , pp. 722-729
    • Huang, J.1    de Paulis, T.2    May, J.M.3
  • 108
    • 0037053071 scopus 로고    scopus 로고
    • Dicinnamoylquinides in roasted coffee inhibit the human adenosine transporter
    • de Paulis, T., et al. Dicinnamoylquinides in roasted coffee inhibit the human adenosine transporter. Eur. J. Pharmacol. 2002, 442, 215-223.
    • (2002) Eur. J. Pharmacol. , vol.442 , pp. 215-223
    • de Paulis, T.1
  • 109
    • 0037180987 scopus 로고    scopus 로고
    • Alkylpyridiniums: 1 Formation and model systems via thermal degradation of trigonelline
    • Stadler, R. H., et al. Alkylpyridiniums: 1. Formation and model systems via thermal degradation of trigonelline. J. Agric. Food. Chem. 2002a, 50, 1200-1206.
    • (2002) J. Agric. Food. Chem. , vol.50 , pp. 1200-1206
    • Stadler, R.H.1
  • 110
    • 0037180987 scopus 로고    scopus 로고
    • Alkylpyridiniums: 2 Isolation and quantification in roasted and ground coffees
    • Stadler, R. H., et al. Alkylpyridiniums: 2. Isolation and quantification in roasted and ground coffees. J. Agric. Food. Chem. 2002b, 50, 1200-1206.
    • (2002) J. Agric. Food. Chem. , vol.50 , pp. 1200-1206
    • Stadler, R.H.1
  • 111
    • 58949096676 scopus 로고    scopus 로고
    • Quantitative investigation of trigonelline, nicotinic acid, and nicotinamide in foods, urine, and plasma by means of LC-MS/MS and stable isotope dilution analysis
    • Lang, R., Yagar, E. F., Eggers, R., Hofmann, T. Quantitative investigation of trigonelline, nicotinic acid, and nicotinamide in foods, urine, and plasma by means of LC-MS/MS and stable isotope dilution analysis. J. Agric. Food. Chem. 2008, 56, 11114-11121.
    • (2008) J. Agric. Food. Chem. , vol.56 , pp. 11114-11121
    • Lang, R.1    Yagar, E.F.2    Eggers, R.3    Hofmann, T.4
  • 112
    • 0032779216 scopus 로고    scopus 로고
    • Trigonelline-induced neurite outgrowth in human neuroblastoma SK-N-SH cells
    • Tohda, C., Nakamura, N., Komatsu, K., Hattori, M. Trigonelline-induced neurite outgrowth in human neuroblastoma SK-N-SH cells. Biol. Pharm. Bull. 1999, 22, 679-682.
    • (1999) Biol. Pharm. Bull. , vol.22 , pp. 679-682
    • Tohda, C.1    Nakamura, N.2    Komatsu, K.3    Hattori, M.4
  • 113
    • 20944450901 scopus 로고    scopus 로고
    • Search for natural products related to regeneration of the neuronal network
    • Tohda, C., Kuboyama, T., Komatsu, K. Search for natural products related to regeneration of the neuronal network. Neurosignals 2004, 14, 34-45.
    • (2004) Neurosignals , vol.14 , pp. 34-45
    • Tohda, C.1    Kuboyama, T.2    Komatsu, K.3
  • 114
    • 0030752316 scopus 로고    scopus 로고
    • The cholesterol-raising factor from coffee beans
    • Urgert, R., Katan, M. B. The cholesterol-raising factor from coffee beans. Annu. Rev. Nutr. 1997, 17, 305-324.
    • (1997) Annu. Rev. Nutr. , vol.17 , pp. 305-324
    • Urgert, R.1    Katan, M.B.2
  • 115
    • 0030932986 scopus 로고    scopus 로고
    • Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver aminotransferases
    • Urgert, R., et al. Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver aminotransferases. Am. J. Clin. Nutr. 1997, 65, 519-524.
    • (1997) Am. J. Clin. Nutr. , vol.65 , pp. 519-524
    • Urgert, R.1
  • 116
    • 34548471732 scopus 로고    scopus 로고
    • Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage
    • Lee, K. J., Jeong, H. G. Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage. Toxicol. Lett. 2007, 173, 80-87.
    • (2007) Toxicol. Lett. , vol.173 , pp. 80-87
    • Lee, K.J.1    Jeong, H.G.2
  • 117
    • 46749135955 scopus 로고    scopus 로고
    • The coffee diterpenes kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress
    • Hwang, Y. P., Jeong, H. G. The coffee diterpenes kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress. FEBS Letters 2008, 582, 2655-2662.
    • (2008) FEBS Letters , vol.582 , pp. 2655-2662
    • Hwang, Y.P.1    Jeong, H.G.2
  • 118
    • 3042646706 scopus 로고    scopus 로고
    • Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages
    • Kim, J.Y., Jung, K. S., Jeong, H. G. Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages. FEBS Letters. 2004, 569, 321-326.
    • (2004) FEBS Letters , vol.569 , pp. 321-326
    • Kim, J.Y.1    Jung, K.S.2    Jeong, H.G.3
  • 119
    • 75149138360 scopus 로고    scopus 로고
    • Cafestol, a coffee-specific diterpenes, is a novel extracellular signal regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages
    • Shen, T., et al. Cafestol, a coffee-specific diterpenes, is a novel extracellular signal regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol. Pharm. Bull. 2010, 33, 128-132.
    • (2010) Biol. Pharm. Bull. , vol.33 , pp. 128-132
    • Shen, T.1
  • 120
    • 77951543964 scopus 로고    scopus 로고
    • Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an Nrf2-dependent mechanism
    • Trinh, K., et al. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an Nrf2-dependent mechanism. J. Neurosci. 2010, 30, 5525-5532.
    • (2010) J. Neurosci. , vol.30 , pp. 5525-5532
    • Trinh, K.1
  • 121
    • 78951482261 scopus 로고    scopus 로고
    • Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of β-amyloid peptide toxicity
    • Dostal, V., Roberts, C. M., Link, C. D. Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of β-amyloid peptide toxicity. Genetics 2010, 186, 857-866.
    • (2010) Genetics , vol.186 , pp. 857-866
    • Dostal, V.1    Roberts, C.M.2    Link, C.D.3
  • 122
    • 33746584028 scopus 로고    scopus 로고
    • Capillary electrophoresis for caffeine and pyroglutamate determination in coffees Study of the in vivo effect on learning and locomotor activity in mice
    • Maeso, N., et al. Capillary electrophoresis for caffeine and pyroglutamate determination in coffees Study of the in vivo effect on learning and locomotor activity in mice. J. Pharm. Biomed. Anal. 2006, 41, 1095-1100.
    • (2006) J. Pharm. Biomed. Anal. , vol.41 , pp. 1095-1100
    • Maeso, N.1
  • 123
    • 0021350693 scopus 로고
    • Pyroglutamic acid administration modifies the electrocorticogram and increases the release of acetylcholine and CABA from the guinea-pig cerebral cortex
    • Antonelli, T., et al. Pyroglutamic acid administration modifies the electrocorticogram and increases the release of acetylcholine and CABA from the guinea-pig cerebral cortex. Pharmacol. Res. Commun. 1984, 16, 189-197.
    • (1984) Pharmacol. Res. Commun. , vol.16 , pp. 189-197
    • Antonelli, T.1


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