Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding

European Journal of Neuroscience

Volumn 8, Issue 12, 1996, Pages 2447-2458

  Johansson, Björn ^a   Georgiev, Vasil ^a,b   Kuosmanen, Tarja ^a   Fredholm, Bertil B ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b INSTITUTE OF PHYSIOLOGY   (Bulgaria)

Author keywords

Adenosine receptors; Autoradiography; Benzodiazepines; Caffeine; Epilepsy; Immediate early genes; In situ hybridization

Indexed keywords

ADENOSINE RECEPTOR; BENZODIAZEPINE RECEPTOR; BICUCULLINE; CAFFEINE; METHYLXANTHINE DERIVATIVE; PARAXANTHINE; PENTETRAZOLE; THEOBROMINE; THEOPHYLLINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; MALE; MOUSE; NONHUMAN; ONCOGENE C FOS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RECEPTOR DENSITY; SEIZURE;

ANIMALS; AUTORADIOGRAPHY; BEHAVIOR, ANIMAL; BICUCULLINE; BRAIN; CAFFEINE; DISEASE SUSCEPTIBILITY; MALE; MICE; MICE, INBRED STRAINS; PENTYLENETETRAZOLE; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, GABA-A; RECEPTORS, PURINERGIC P1; RNA, MESSENGER; SEIZURES; TIME FACTORS; XANTHINES;

EID: 0030475564     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1996.tb01539.x     Document Type: Article

References (50)

1. Arnaud, M. J. (1993) Metabolism of caffeine and other components of coffee. In Garattini, S. (ed.), Caffeine, Coffee and Health. Raven Press, New York, pp. 43-95.
2. Boulenger, J.-P. and Marangos, P. J. (1989) Caffeine withdrawal affects central adenosine receptors but not benzodiazepine receptors. J. Neural Transm., 78, 9-19.
3. Boulenger, J.-P., Marangos, P. J., Zander, K. J. and Hanson, J. (1986) Stress and caffeine: effects on central adenosine receptors. Clin. Neuropharmacol., 9, 79-83.
4. 2A receptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 353, 261-271.
5. Dragunow, M. (1988) Purinergic mechanisms in epilepsy. Prog. Neurobiol., 31, 85-108.
6. Dunwiddie, T. V. (1985) The physiological role of adenosine in the central nervous system. Int. Rev. Neurobiol., 27, 63-139.
7. Dunwiddie, T. V. and Worth, T. (1982) Sedative and anticonvulsant actions of adenosine analogues in mouse and rat. J. Pharmacol. Exp. Ther., 220, 70-76.
8. 1-receptors in rat brain, as revealed by autoradiography. Neuroscience, 34, 759-769.
9. 1-receptors and 5′-nucleotidase in the brain of some commonly used experimental animals. Neuroscience, 22, 813-826.
10. Fredholm, B. B. (1980) Are methylxanthine effects due to antagonism of endogenous adenosine? Trends Pharmacol. Sci., 1, 129-132.
11. Fredholm, B. B. (1982) Adenosine actions and adenosine receptors after 1 week treatment with caffeine. Acta Physiol. Scand., 115, 283-286.
12. Fredholm, B. B. (1995) Adenosine, adenosine receptors and the actions of caffeine. Pharmacol. Toxicol., 76, 93-101.
13. Fredholm, B. B. and Dunwiddie, T. V. (1988) How does adenosine inhibit transmitter release? Trends Pharmacol. Sci., 9, 130-134.
14. Fredholm, B. B., Herrera-Marschitz, M., Jonzon, B., Lindström, K. and Ungerstedt, U. (1983) On the mechanism by which methylxanthines enhance apomorphine-induced rotation behaviour in the rat. Pharmacol. Biochem. Behav., 19, 535-541.
15. Fredholm, B. B., Abbracchio, M. P., Burnstock, G., Daly, J. W., Harden, T. K., Jacobson, K. A., Leff, P. and Williams, M. (1994) Nomenclature and classification of purinoceptors. Pharmacol. Rev., 46, 143-156.
16. Gale, K., Maggio, R., Halonen, T., Lanaud, P. and Grayson, D. (1992) Regional changes in immediate-early gene expression following focally-evoked limbic motor seizures. Epilepsy Res., 9, Suppl., 361-369.
17. Georgiev, V. and Petkova-Radkova, B. (1976) Effect of isopropyl-noradrenaline, adenosine, cyclic 3′,5′-AMP and d,b-cyclic 3′,5′-AMP on the picrotoxin convulsive seizure threshold. Interaction with GABA. Acta Physiol. Pharmacol. Bulg., 2, 51-58.
18. 1 receptor number. Brain Res., 612, 271-277.
19. Herdegen, T., Sandkühler, J., Gass, P., Kiessling, M., Bravo, R. and Zimmerman, M: (1993) JUN, FOS, KROX, and CREB transcription factor proteins in the rat cortex: basal expression and induction by spreading depression and epileptic seizures. J. Comp. Neurol., 333, 271-288.
20. Holtzman, S. G., Mante, S. and Minneman, K. P. (1991) Role of adenosine receptors in caffeine tolerance. J. Pharmacol. Exp. Ther., 256, 62-68.
21. Hughes, P. and Dragunow, M. (1995) Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol. Rev., 47, 133-178.
22. 3H]CGS 21680. Eur. J. Pharmacol., 168, 243-246.
23. 3H]CGS 21680 to rat cortex differs from its binding to rat striatum. Eur. J. Pharmacol. Mol. Pharmacol. Sect., 247, 103-110.
24. Johansson, B., Lindström, K. and Fredholm, B. B. (1994) Differences in the regional and cellular localization of c-fos mRNA induced by amphetamine, cocaine and caffeine in the rat. Neuroscience, 59, 837-849.
25. 1 adenosine receptor binding. J. Pharmacol. Exp. Ther., 266, 1563-1572.
26. Kaplan, G. B., Greenblatt, D. J., Leduc, B. W., Thompson, M. L. and Shader, R. I. (1989) Relationship of plasma and brain concentrations of caffeine and metabolites to benzodiazepine receptor binding and locomotor activity. J. Pharmacol. Exp. Ther., 248, 1078-1083.
27. Kaplan, G. B., Tai, N. T., Greenblatt, D. J. and Shader, R. I. (1990) Caffeine-induced behavioural stimulation is dose- and concentration-dependent. Br. J. Pharmacol., 100, 435-440.
28. Lin, Y. and Phillis, J. W. (1990) Chronic caffeine exposure reduces the excitant action of acetylcholine on cerebral cortical neurons. Brain Res., 524, 316-318.
29. Mally, J. (1989) Aminophylline and essential tremor (Letter). Lancet, 2, 278-279.
30. Marangos, P. J., Boulenger, J. P. and Patel, J. (1984) Effects of chronic caffeine on brain adenosine receptors: regional and ontogenetic studies. Life Sci., 34, 899-907.
31. Morgan, J. I., Cohen, D. R., Hempstead, J. L. and Curran, T. (1987) Mapping patterns of c-fos expression in the central nervous system after seizure. Science, 237, 192-197.
32. Nakajima, T., Daval, J. L., Morgan, P. F., Post, R. M. and Marangos, P. J. (1989) Adenosinergic modulation of caffeine-induced c-fos mRNA expression in mouse brain. Brain Res., 501, 307-314.
33. A receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J. Chem. Neuroanat., 3, 59-76.
34. 3H]-CGS 21680 as a ligand. Naunyn-Schmiedeberg's Arch. Pharmacol., 342, 85-89.
35. 1 receptors: a complicating factor in quantitative autoradiography. J. Neurochem., 58, 941-950.
36. 2A receptors and nitrobenzylthioinosine-sensitive transporters in gerbil brain: no changes following long-term treatment with the adenosine transport inhibitor propentofylline. Neuropharmacology, 35, 79-89.
37. Paxinos, G. and Watson, W. (1986) The Rat Brain in Stereotaxic Coordinates, 2nd edition. Academic Press, London.
38. Rauca, C. and Rüthrich, H.-L. (1995) Moderate hypoxia reduces pentylenetetrazol-induced seizures. Naunyn-Schmiedeberg's Arch. Pharmacol., 351, 261-267.
39. Saffen, D. W., Cole, A. J., Worley, P. F., Christy, B. A., Ryder, K. and Baraban, J. M. (1988) Convulsant-induced increase in transcription factor mRNAs in rat brain. Proc. Natl Acad. Sci. USA, 85, 7795-7799.
40. 1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats. Neurosci. Lett., 101, 325-330.
41. Schrader, J., Wahl, M., Kuschinsky, W. and Kreutzberg, G. W. (1980) Increase of adenosine content in cerebral cortex of the cat during bicuculline-induced seizure. Pflügers Arch., 387, 245-251.
42. Shi, D., Nikodijevic, O., Jacobson, K. A. and Daly, J. W. (1993) Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain. Cell Mol. Neurobiol., 13, 247-261.
43. 3H]Ro 15-4513: a biochemical and autoradiographic study. J. Neurochem., 48, 46-52.
44. Smeyne, R. J., Schilling, K., Robertson, L., Luk, D., Oberdick, J., Curran, T. and Morgan, J. I. (1992) Fos-lac Z transgenic mice: mapping sites of gene induction in the central nervous system. Neuron, 8, 18-23.
45. Svenningsson, P., Nomikos, G. G. and Fredholm, B. B. (1995) Biphasic changes in locomotor behavior and in expression of mRNA for NGFI-A and NGFI-B in rat striatum following acute caffeine administration. J. Neurosci., 15, 7612-7624.
46. 1-adenosine receptors associated with reduced sensitivity to convulsants. Neuropharmacology, 26, 1173-1180.
47. 1 receptor agonist and antagonist: effect on receptor density and N-methyl-D-aspartate induced seizures in mice. Eur. J. Pharmacol., 253, 95-99.
48. 3H]8-cyclopentyl-1,3-dipropylxanthine. J. Neurochem., 54, 1344-1353.
49. 3H]diazepam binding sites in chronic caffeine treated rats. Brain Res., 294, 186-198.
50. Zhang, G., Franklin, P. H. and Murray, T. F. (1993) Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility. J. Pharmacol. Exp. Ther., 264, 1415-1424.