Is 11β-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 305, Issue 1, 2003, Pages 167-172

  Livingstone, Dawn E W ^a   Walker, Brian R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1; CARBENOXOLONE; CORTICOSTERONE; GLUCOCORTICOID; INSULIN; ISOENZYME; STEROID 5BETA REDUCTASE; UNCLASSIFIED DRUG; HSD11B1 PROTEIN, HUMAN; HYDROXYSTEROID DEHYDROGENASE; LIPID; OXIDOREDUCTASE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG EFFECT; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INACTIVATION; HORMONE ACTION; INSULIN SENSITIVITY; LEAN BODY WEIGHT; LIPID BLOOD LEVEL; MALE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN TARGETING; RAT; SKELETAL MUSCLE; ANIMAL; BLOOD; DRUG ANTAGONISM; EATING; ENZYMOLOGY; GLUCOSE TOLERANCE TEST; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; PATHOPHYSIOLOGY; WEIGHT GAIN; ZUCKER RAT;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; CARBENOXOLONE; EATING; GLUCOSE TOLERANCE TEST; HYDROXYSTEROID DEHYDROGENASES; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LIPIDS; OBESITY; OXIDOREDUCTASES; PITUITARY-ADRENAL SYSTEM; RATS; RATS, ZUCKER; WEIGHT GAIN;

EID: 0037374775     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.044842     Document Type: Article

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