메뉴 건너뛰기




Volumn 293, Issue 6, 2007, Pages

Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice

Author keywords

11 hydroxysteroid dehydrogenase type 1; Agouti; Low density lipoprotein receptor; Obesity

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE 1; CARBENOXOLONE; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

EID: 37149046570     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00522.2007     Document Type: Article
Times cited : (62)

References (61)
  • 3
    • 17844363297 scopus 로고    scopus 로고
    • The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans
    • Andrew R, Westerbacka J, Wahren J, Yki-Jarvinen H, Walker BR. The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans. Diabetes 54: 1364-1370, 2005.
    • (2005) Diabetes , vol.54 , pp. 1364-1370
    • Andrew, R.1    Westerbacka, J.2    Wahren, J.3    Yki-Jarvinen, H.4    Walker, B.R.5
  • 4
    • 0037238379 scopus 로고    scopus 로고
    • Effects of the 11β-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes
    • Andrews RC, Rooyackers O, Walker BR. Effects of the 11β-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes. J Clin Endocrinol Metab 88: 285-291, 2003.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 285-291
    • Andrews, R.C.1    Rooyackers, O.2    Walker, B.R.3
  • 5
    • 0034569866 scopus 로고    scopus 로고
    • Obesity: Preventing and managing the global epidemic. Report of a WHO consultation
    • Anonymous. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 894: i-xii, 1-253, 2000.
    • (2000) World Health Organ Tech Rep Ser , vol.894
    • Anonymous1
  • 6
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Anonymous. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285: 2486-2497, 2001.
    • (2001) JAMA , vol.285 , pp. 2486-2497
    • Anonymous1
  • 8
    • 34249775822 scopus 로고    scopus 로고
    • Depot-specific modulation of rat intra-abdominal adipose tissue lipid metabolism by pharmacologic inhibition of 11β-hydroxysteroid dehydrogenase type 1
    • Berthiaume M, Laplante M, Festuccia W, Gelinas Y, Poulin S, Lalonde J, Joanisse DR, Thieringer R, Deshaies Y. Depot-specific modulation of rat intra-abdominal adipose tissue lipid metabolism by pharmacologic inhibition of 11β-hydroxysteroid dehydrogenase type 1. Endocrinology 148: 2391-2397, 2007.
    • (2007) Endocrinology , vol.148 , pp. 2391-2397
    • Berthiaume, M.1    Laplante, M.2    Festuccia, W.3    Gelinas, Y.4    Poulin, S.5    Lalonde, J.6    Joanisse, D.R.7    Thieringer, R.8    Deshaies, Y.9
  • 10
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect "Cushing's disease of the omentum"?
    • Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect "Cushing's disease of the omentum"? Lancet 349: 1210-1213, 1997.
    • (1997) Lancet , vol.349 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    Stewart, P.M.3
  • 11
    • 33847393688 scopus 로고    scopus 로고
    • Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue
    • Coenen KR, Gruen ML, Chait A, Hasty AH. Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue. Diabetes 56: 564-573, 2007.
    • (2007) Diabetes , vol.56 , pp. 564-573
    • Coenen, K.R.1    Gruen, M.L.2    Chait, A.3    Hasty, A.H.4
  • 12
    • 34547645772 scopus 로고    scopus 로고
    • Obesity potentiates development of fatty liver and insulin resistance, but not atherosclerosis, in high-fat diet-fed agouti LDLR-deficient mice
    • Coenen KR, Hasty AH. Obesity potentiates development of fatty liver and insulin resistance, but not atherosclerosis, in high-fat diet-fed agouti LDLR-deficient mice. Am J Physiol Endocrinol Metab 293: E492-E499, 2007.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Coenen, K.R.1    Hasty, A.H.2
  • 13
    • 0023795464 scopus 로고
    • Glycyrrhetinic acid derivatives: A novel class of inhibitors of gap-junctional intercellular communication. Structure-activity relationships
    • Davidson JS, Baumgarten IM. Glycyrrhetinic acid derivatives: a novel class of inhibitors of gap-junctional intercellular communication. Structure-activity relationships. J Pharmacol Exp Ther 246: 1104-1107, 1988.
    • (1988) J Pharmacol Exp Ther , vol.246 , pp. 1104-1107
    • Davidson, J.S.1    Baumgarten, I.M.2
  • 14
    • 1642545652 scopus 로고    scopus 로고
    • Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone
    • Dolinsky VW, Douglas DN, Lehner R, Vance DE. Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochem J 378: 967-974, 2004.
    • (2004) Biochem J , vol.378 , pp. 967-974
    • Dolinsky, V.W.1    Douglas, D.N.2    Lehner, R.3    Vance, D.E.4
  • 15
    • 0037307922 scopus 로고    scopus 로고
    • TNF-α plus IFN-γ induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses
    • Eugenin EA, Branes MC, Berman JW, Saez JC. TNF-α plus IFN-γ induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J Immunol 170: 1320-1328, 2003.
    • (2003) J Immunol , vol.170 , pp. 1320-1328
    • Eugenin, E.A.1    Branes, M.C.2    Berman, J.W.3    Saez, J.C.4
  • 17
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385: 165-168, 1997.
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 18
    • 0141818124 scopus 로고    scopus 로고
    • Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion
    • Gilham D, Ho S, Rasouli M, Martres P, Vance DE, Lehner R. Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion. FASEB J 17: 1685-1687, 2003.
    • (2003) FASEB J , vol.17 , pp. 1685-1687
    • Gilham, D.1    Ho, S.2    Rasouli, M.3    Martres, P.4    Vance, D.E.5    Lehner, R.6
  • 19
    • 0031821520 scopus 로고    scopus 로고
    • Understanding adipocyte differentiation
    • Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol Rev 78: 783-809, 1998.
    • (1998) Physiol Rev , vol.78 , pp. 783-809
    • Gregoire, F.M.1    Smas, C.M.2    Sul, H.S.3
  • 21
    • 13344296494 scopus 로고
    • Studies on rat adipose tissue in vitro. 7. Effects of adrenal cortical hormones
    • Jeanrenaud B, Renold AE. Studies on rat adipose tissue in vitro. 7. Effects of adrenal cortical hormones. J Biol Chem 235: 2217-2223, 1960.
    • (1960) J Biol Chem , vol.235 , pp. 2217-2223
    • Jeanrenaud, B.1    Renold, A.E.2
  • 22
    • 4544260173 scopus 로고    scopus 로고
    • Overexpression of 11β-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: Studies in young adult monozygotic twins
    • Kannisto K, Pietilainen KH, Ehrenborg E, Rissanen A, Kaprio J, Hamsten A, Yki-Jarvinen H. Overexpression of 11β-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. J Clin Endocrinol Metab 89: 4414-4421, 2004.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4414-4421
    • Kannisto, K.1    Pietilainen, K.H.2    Ehrenborg, E.3    Rissanen, A.4    Kaprio, J.5    Hamsten, A.6    Yki-Jarvinen, H.7
  • 23
    • 15944394711 scopus 로고    scopus 로고
    • Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity
    • Kershaw EE, Morton NM, Dhillon H, Ramage L, Seckl JR, Flier JS. Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity. Diabetes 54: 1023-1031, 2005.
    • (2005) Diabetes , vol.54 , pp. 1023-1031
    • Kershaw, E.E.1    Morton, N.M.2    Dhillon, H.3    Ramage, L.4    Seckl, J.R.5    Flier, J.S.6
  • 25
    • 0026485210 scopus 로고
    • Effects of carbenoxolone administered acutely to adrenalectomized rats (in vivo) on renal and hepatic handling of corticosterone by 11β-hydroxysteroid dehydrogenase
    • Latif SA, Semafuko WE, Morris DJ. Effects of carbenoxolone administered acutely to adrenalectomized rats (in vivo) on renal and hepatic handling of corticosterone by 11β-hydroxysteroid dehydrogenase. Steroids 57: 494-501, 1992.
    • (1992) Steroids , vol.57 , pp. 494-501
    • Latif, S.A.1    Semafuko, W.E.2    Morris, D.J.3
  • 27
    • 0034519393 scopus 로고    scopus 로고
    • Mechanisms of dysregulation of 11β-hydroxysteroid dehydrogenase type 1 in obese Zucker rats
    • Livingstone DE, Kenyon CJ, Walker BR. Mechanisms of dysregulation of 11β-hydroxysteroid dehydrogenase type 1 in obese Zucker rats. J Endocrinol 167: 533-539, 2000.
    • (2000) J Endocrinol , vol.167 , pp. 533-539
    • Livingstone, D.E.1    Kenyon, C.J.2    Walker, B.R.3
  • 28
    • 0037374775 scopus 로고    scopus 로고
    • Is 11β-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats
    • Livingstone DE, Walker BR. Is 11β-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats. J Pharmacol Exp Ther 305: 167-172, 2003.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 167-172
    • Livingstone, D.E.1    Walker, B.R.2
  • 29
    • 1542675142 scopus 로고    scopus 로고
    • Tissue-specific glucocorticoid reactivating enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) - a promising drug target for the treatment of metabolic syndrome
    • Masuzaki H, Flier JS. Tissue-specific glucocorticoid reactivating enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) - a promising drug target for the treatment of metabolic syndrome. Curr Drug Targets Immune Endocr Metabol Disord 3: 255-262, 2003.
    • (2003) Curr Drug Targets Immune Endocr Metabol Disord , vol.3 , pp. 255-262
    • Masuzaki, H.1    Flier, J.S.2
  • 32
    • 0026538832 scopus 로고
    • Localization of an 11β- hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney
    • Mercer WR, Krozowski ZS. Localization of an 11β- hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney. Endocrinology 130: 540-543, 1992.
    • (1992) Endocrinology , vol.130 , pp. 540-543
    • Mercer, W.R.1    Krozowski, Z.S.2
  • 33
    • 0027414683 scopus 로고
    • The forms and functions of 11β-hydroxysteroid dehydrogenase
    • Monder C. The forms and functions of 11β-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol 45: 161-165, 1993.
    • (1993) J Steroid Biochem Mol Biol , vol.45 , pp. 161-165
    • Monder, C.1
  • 34
    • 0035798621 scopus 로고    scopus 로고
    • Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice
    • Morton NM, Holmes MC, Fievet C, Staels B, Tailleux A, Mullins JJ, Seckl JR. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem 276: 41293-41300, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 41293-41300
    • Morton, N.M.1    Holmes, M.C.2    Fievet, C.3    Staels, B.4    Tailleux, A.5    Mullins, J.J.6    Seckl, J.R.7
  • 36
    • 0032959823 scopus 로고    scopus 로고
    • Communication via gap junctions modulates bile secretion in the isolated perfused rat liver
    • Nathanson MH, Rios-Velez L, Burgstahler AD, Mennone A. Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. Gastroenterology 116: 1176-1183, 1999.
    • (1999) Gastroenterology , vol.116 , pp. 1176-1183
    • Nathanson, M.H.1    Rios-Velez, L.2    Burgstahler, A.D.3    Mennone, A.4
  • 39
    • 33646182383 scopus 로고    scopus 로고
    • Quantitation and cellular localization of 11β-HSD1 expression in murine thymus
    • Nuotio-Antar AM, Hasty AH, Kovacs WJ. Quantitation and cellular localization of 11β-HSD1 expression in murine thymus. J Steroid Biochem Mol Biol 99: 93-99, 2006.
    • (2006) J Steroid Biochem Mol Biol , vol.99 , pp. 93-99
    • Nuotio-Antar, A.M.1    Hasty, A.H.2    Kovacs, W.J.3
  • 44
    • 0024422086 scopus 로고
    • Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7α-hydroxylase
    • Princen HM, Meijer P, Hofstee B. Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7α-hydroxylase. Biochem J 262: 341-348, 1989.
    • (1989) Biochem J , vol.262 , pp. 341-348
    • Princen, H.M.1    Meijer, P.2    Hofstee, B.3
  • 45
    • 0038306946 scopus 로고    scopus 로고
    • Hypertension and the cortisol-cortisone shuttle
    • Quinkler M, Stewart PM. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 88: 2384-2392, 2003.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2384-2392
    • Quinkler, M.1    Stewart, P.M.2
  • 47
    • 0038495546 scopus 로고    scopus 로고
    • Inhibition of 11β-hydroxysteroid dehydrogenase type 1 lowers intraocular pressure in patients with ocular hypertension
    • Rauz S, Cheung CM, Wood PJ, Coca-Prados M, Walker EA, Murray PI, Stewart PM. Inhibition of 11β-hydroxysteroid dehydrogenase type 1 lowers intraocular pressure in patients with ocular hypertension. QJM 96: 481-490, 2003.
    • (2003) QJM , vol.96 , pp. 481-490
    • Rauz, S.1    Cheung, C.M.2    Wood, P.J.3    Coca-Prados, M.4    Walker, E.A.5    Murray, P.I.6    Stewart, P.M.7
  • 48
    • 0026649567 scopus 로고
    • Effect of chronic stress and exogenous glucocorticoids on regional fat distribution and metabolism
    • Rebuffe-Scrive M, Walsh UA, McEwen B, Rodin J. Effect of chronic stress and exogenous glucocorticoids on regional fat distribution and metabolism. Physiol Behav 52: 583-590, 1992.
    • (1992) Physiol Behav , vol.52 , pp. 583-590
    • Rebuffe-Scrive, M.1    Walsh, U.A.2    McEwen, B.3    Rodin, J.4
  • 49
    • 0029065303 scopus 로고
    • Glucocorticoid receptor, mineralocorticoid receptors, 11β-hydroxysteroid dehydrogenase-1 and -2 expression in rat brain and kidney: In situ studies
    • Roland BL, Krozowski ZS, Funder JW. Glucocorticoid receptor, mineralocorticoid receptors, 11β-hydroxysteroid dehydrogenase-1 and -2 expression in rat brain and kidney: in situ studies. Mol Cell Endocrinol 111: R1-R7, 1995.
    • (1995) Mol Cell Endocrinol , vol.111
    • Roland, B.L.1    Krozowski, Z.S.2    Funder, J.W.3
  • 50
    • 13544261520 scopus 로고    scopus 로고
    • Determination of corticosteroids in tissue samples by liquid chromatography-tandem mass spectrometry
    • Ronquist-Nii Y, Edlund PO. Determination of corticosteroids in tissue samples by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 37: 341-350, 2005.
    • (2005) J Pharm Biomed Anal , vol.37 , pp. 341-350
    • Ronquist-Nii, Y.1    Edlund, P.O.2
  • 51
    • 14644388141 scopus 로고    scopus 로고
    • Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone
    • Sandeep TC, Andrew R, Homer NZ, Andrews RC, Smith K, Walker BR. Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes 54: 872-879, 2005.
    • (2005) Diabetes , vol.54 , pp. 872-879
    • Sandeep, T.C.1    Andrew, R.2    Homer, N.Z.3    Andrews, R.C.4    Smith, K.5    Walker, B.R.6
  • 52
    • 33746098574 scopus 로고    scopus 로고
    • The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages
    • Saraswathi V, Hasty AH. The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages. J Lipid Res 47: 1406-1415, 2006.
    • (2006) J Lipid Res , vol.47 , pp. 1406-1415
    • Saraswathi, V.1    Hasty, A.H.2
  • 53
    • 0022367312 scopus 로고
    • Acute stimulation by glucocorticoids of gluconeogenesis from lactate/pyruvate in isolated hepatocytes from normal and adrenalectomized rats
    • Sistare FD, Haynes RC Jr. Acute stimulation by glucocorticoids of gluconeogenesis from lactate/pyruvate in isolated hepatocytes from normal and adrenalectomized rats. J Biol Chem 260: 12754-12760, 1985.
    • (1985) J Biol Chem , vol.260 , pp. 12754-12760
    • Sistare, F.D.1    Haynes Jr., R.C.2
  • 55
    • 0020565483 scopus 로고
    • Plasma lipoproteins, lipolytic enzymes, and very low density lipoprotein triglyceride turnover in Cushing's syndrome
    • Taskinen MR, Nikkila EA, Pelkonen R, Sane T. Plasma lipoproteins, lipolytic enzymes, and very low density lipoprotein triglyceride turnover in Cushing's syndrome. J Clin Endocrinol Metab 57: 619-626, 1983.
    • (1983) J Clin Endocrinol Metab , vol.57 , pp. 619-626
    • Taskinen, M.R.1    Nikkila, E.A.2    Pelkonen, R.3    Sane, T.4
  • 57
    • 0026441301 scopus 로고
    • Mineralocorticoid excess and inhibition of 11β-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome
    • Walker BR, Campbell JC, Fraser R, Stewart PM, Edwards CR. Mineralocorticoid excess and inhibition of 11β-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome. Clin Endocrinol (Oxf) 37: 483-492, 1992.
    • (1992) Clin Endocrinol (Oxf) , vol.37 , pp. 483-492
    • Walker, B.R.1    Campbell, J.C.2    Fraser, R.3    Stewart, P.M.4    Edwards, C.R.5
  • 58
    • 0028839840 scopus 로고
    • Carbenoxolone increases hepatic insulin sensitivity in man: A novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation
    • Walker BR, Connacher AA, Lindsay RM, Webb DJ, Edwards CR. Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab 80: 3155-3159, 1995.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3155-3159
    • Walker, B.R.1    Connacher, A.A.2    Lindsay, R.M.3    Webb, D.J.4    Edwards, C.R.5
  • 60
    • 34247368931 scopus 로고    scopus 로고
    • Gap-junctional communication is required for mitotic clonal expansion during adipogenesis
    • Yanagiya T, Tanabe A, Hotta K. Gap-junctional communication is required for mitotic clonal expansion during adipogenesis. Obesity (Silver Spring) 15: 572-582, 2007.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 572-582
    • Yanagiya, T.1    Tanabe, A.2    Hotta, K.3
  • 61
    • 2442477510 scopus 로고    scopus 로고
    • Regulation of hepatic apolipoprotein B-lipoprotein assembly and secretion by the availability of fatty acids. I. Differential response to the delivery of fatty acids via albumin or remnant-like emulsion particles
    • Zhang YL, Hernandez-Ono A, Ko C, Yasunaga K, Huang LS, Ginsberg HN. Regulation of hepatic apolipoprotein B-lipoprotein assembly and secretion by the availability of fatty acids. I. Differential response to the delivery of fatty acids via albumin or remnant-like emulsion particles. J Biol Chem 279: 19362-19374, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 19362-19374
    • Zhang, Y.L.1    Hernandez-Ono, A.2    Ko, C.3    Yasunaga, K.4    Huang, L.S.5    Ginsberg, H.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.