Metyrapone is a competitive inhibitor of 11β-hydroxysteroid dehydrogenase type 1 reductase

Journal of Steroid Biochemistry and Molecular Biology

Volumn 62, Issue 2-3, 1997, Pages 195-199

  Sampath Kumar, R ^a   Yu, M ^a   Khalil, M W ^a   Yang, K ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTISONE; HYDROCORTISONE; ISOENZYME; METYRAPONE;

ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; IN VITRO STUDY; KIDNEY MICROSOME; LIVER MICROSOME; NONHUMAN; RADIOMETRY; SHEEP; STEROIDOGENESIS;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; BINDING, COMPETITIVE; ENZYME INHIBITORS; HYDROXYSTEROID DEHYDROGENASES; KIDNEY; METYRAPONE; MICROSOMES; MICROSOMES, LIVER; SHEEP;

ANIMALIA; OVIS ARIES;

EID: 0030661601     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(97)00027-7     Document Type: Article

References (31)

1. Chart J. J., Sheppard H., Allen M. J., Bencze W. L. and Gaunt R., New amphenone analogs as adrenocortical inhibitors. Experientia 14 (1958) 151-152.
2. Dollery, C., Therapeutic Drugs. Churchill Livingstone, Edinburgh, 1991.
3. Carballeira A., Fishman L. M. and Jacobi J. D., Dual sites of inhibition by metyrapone of human adrenal steroidogenesis: correlation of in vivo and in vitro studies. Journal of Clinical Endocrinology and Metabolism 42 (1976) 687-697.
4. Liddle G. W., Island D., Lance E. M. and Harris A. P., Alterations of adrenal steroid patterns in man resulting from treatment with a chemical inhibitor of 11β-hydroxylation. Journal of Clinical Endocrinology and Metabolism 18 (1958) 906.
5. Jenkins J. S., Meakin J. W., Nelson D. H. and Thorn G. W., Inhibition of adrenal steroid 11-oxygenation in the dog. Science 128 (1958) 478-480.
6. Lye S. J. and Challis J. R., In vivo adrenocorticotropin (1-24)-induced accumulation of cyclic adenosine monophosphate by ovine fetal adrenal cells is inhibited by concomitant infusion of metopirone. Endocrinology 115 (1984) 1584-1587.
7. Sparks L. L., Smilo R. P., Pavlatos F. C. and Forsham P. H., Experience with a rapid oral metyrapone test and the plasma ACTH content in determining the cause of Cushing's syndrome. Metabolism 18 (1969) 175-192.
8. Loriaux, D. L. and Cutler, G. B., Diseases of the adrenal glands. In Clinical Endocrinology, ed. P. O. Kohler. John Wiley and Sons, New York, 1986, pp. 167-238.
9. Murphy B. E. P., Treatment of major depression with steroid suppressive drugs. Journal of Steroid Biochemistry and Molecular Biology 39 (1991) 239-244.
10. O'Dwyer A.-M., Lightman S. L., Marks M. N. and Checkley S. A., Treatment of major depression with metyrapone and hydrocortisone. Journal of Affective Disorders 33 (1995) 123-128.
11. Raven P. W., Checkley S. A. and Taylor N. F., Extra-adrenal effects of metyrapone include inhibition of the 11-oxoreductase activity of 11β-hydroxysteroid dehydrogenase: a model for 11-HSD I deficiency. Clinical Endocrinology (Oxford) 43 (1995) 637-644.
12. Monder C. and White P. C., 11β-hydroxysteroid dehydrogenase. Vitamins and Hormones 47 (1993) 187-271.
13. Maser E. and Bannenberg G, 11β-Hydroxysteroid dehydrogenase mediates reductive metabolism of xenobiotic carbonyl compounds. Biochemical Pharmacology 47 (1994) 1805-1812.
14. Funder J. W., 11β-Hydroxysteroid dehydrogenase: new answers, new questions. European Journal of Endocrinology 134 (1996) 267-268.
15. Monder C., The forms and functions of 11β-hydroxysteroid dehydrogenase. Journal of Steroid Biochemistry and Molecular Biology 45 (1993) 161-165.
16. Rusvai E. and Naray Fejes Toth A., A new isoform of 11β-hydroxysteroid dehydrogenase in aldosterone target cells. Journal of Biological Chemistry 268 (1993) 10717-10720.
17. Albiston A. L., Obeyesekere V., Smith R. and Krozowski Z. S., Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Molecular and Cellular Endocrinology 105 (1994) R11-R17.
18. Agarwal A. K., Mune T., Monder C. and White P. C., NAD-dependent isoform of 11β-hydroxysteroid dehydrogenase. Journal of Biological Chemistry 269 (1994) 25959-25962.
19. Yang K., Smith C. L., Dales D., Hammond G. L. and Challis J. R., Cloning of an ovine 11β-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development. Endocrinology 131 (1992) 2120-2126.
20. Campbell L. E., Yu M. and Yang K., Ovine 11β-hydroxysteroid dehydrogenase type 2 gene predicts a protein distinct from that deduced by the cloned kidney cDNA at the C-terminus. Molecular and Cellular Endocrinology 119 (1996) 113-118.
21. Yang K. and Yu M., Evidence for distinct isoforms of 11β-hydroxysteroid dehydrogenase in the ovine liver and kidney. Journal of Steroid Biochemistry and Molecular Biology 49 (1994) 245-250.
22. Raven P. W., O'Dwyer A.-M., Taylor N. F. and Checkley S. A., The relationship between the effects of metyrapone treatment on depressed mood and urinary steroid profiles. Psychoneuroendocrinology 21 (1996) 277-286.
23. Blichert-Toft M., Folke K. and Nielsen M. L., Effects of metyrapone and corticotropin infusion on cortisol disappearance rate in man. Journal of Clinical Endocrinology and Metabolism 35 (1972) 59-62.
24. Levin J., Zumoff B. and Fukushima D. F., Extra-adrenal effects of metyrapone in man. Journal of Clinical Endocrinology and Metabolism 47 (1978) 845-849.
25. Jubiz M. D., Matsukura S., Meikle A. W., Harada G., West C. D. and Tyler F. H., Plasma metyrapone, adrenocorticotropic hormone, cortisol, and deoxycortisol levels. Archives of Internal Medicine 125 (1970) 468-472.
26. Meikle A. W., Radioimmunoassay of metyrapone and reduced metyrapone. Methods in Enzymology 84 (1982) 585-595.
27. Challis J. R., Huhtanen D., Sprague C., Mitchell B. F. and Lye S. J., Modulation by cortisol of adrenocorticotropin-induced activation of adrenal function in fetal sheep. Endocrinology 116 (1985) 2267-2272.
28. Vilos G. A., Challis J. R., Pliagas G. A., Lye S. L., Possmayer F. and Harding P. G., Propranolol inhibits the maturational effect of adrenocorticotropin in the fetal sheep lung. American Journal of Obstetrics and Gynecology 153 (1985) 472-477.
29. Challis J. R., Nancekievill E. A. and Lye S. J., Possible role of cortisol in the stimulation of cortisol-binding capacity in the plasma of fetal sheep. Endocrinology 116 (1985) 1139-1144.
30. Monder C., Stewart P. M., Lakshmi V., Valentino R., Burt D. Edwards C. R., Licorice inhibits corticosteroid 11β-dehydrogenase of rat kidney and liver: in vivo and in vitro studies. Endocrinology 125 (1989) 1046-1053.
31. Edwards C. R. and Walker B. R., Cortisol and hypertension: what was not so apparent about "apparent mineralocorticoid excess". Journal of Laboratory and Clinical Medicine 122 (1993) 632-635.