Basiliximab does not increase efficacy of corticosteroids in patients with steroid-refractory ulcerative colitis

Gastroenterology

Volumn 143, Issue 2, 2012, Pages 356-364.e1

  Sands, Bruce E ^a   Sandborn, William J ^b   Creed, Tom J ^c   Dayan, Colin M ^d   Dhanda, Ashwin D ^c   Van Assche, Gert A ^e   Greguš, Miloš ^f   Sood, Ajit ^g   Choudhuri, Gourdas ^h   Stempien, Mary Jean ⁱ   Levitt, Daniel ⁱ   Probert, Christopher S ^j  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^d CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f NZZ KM Management   (Slovakia)

^g DAYANAND MEDICAL COLLEGE AND HOSPITAL   (India)

^h SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

ⁱ Cerimon Pharmaceuticals   (United States)

^j UNIVERSITY OF LIVERPOOL   (United Kingdom)

more..

Author keywords

Basiliximab; IBD; Immune Response; Randomized Clinical Trial

Indexed keywords

BASILIXIMAB; PLACEBO; PREDNISONE;

ADULT; ARTICLE; CONTROLLED STUDY; CORTICOSTEROID REFRACTORY ULCERATIVE COLITIS; CORTICOSTEROID THERAPY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ENDOSCOPY; FEMALE; GASTROINTESTINAL DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PERIPHERAL T CELL LYMPHOMA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REMISSION; TREATMENT DURATION; ULCERATIVE COLITIS;

EID: 84862741210     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.04.043     Document Type: Article

References (23)

1. W.A. Faubion Jr, E.V. Loftus Jr, W.S. Harmsen The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study Gastroenterology 121 2001 255 260 (Pubitemid 32729372)
2. S.P. Travis, J.M. Farrant, C. Ricketts Predicting outcome in severe ulcerative colitis Gut 38 1996 905 910 (Pubitemid 26231777)
3. S. Lichtiger, D.H. Present, A. Kornbluth Cyclosporine in severe ulcerative colitis refractory to steroid therapy N Engl J Med 330 1994 1841 1845 (Pubitemid 24188135)
4. P. Rutgeerts, W.J. Sandborn, B.G. Feagan Infliximab for induction and maintenance therapy for ulcerative colitis N Engl J Med 353 2005 2462 2476 (Pubitemid 41770166)
5. W.J. Sandborn Cyclosporine therapy for inflammatory bowel disease: definitive answers and remaining questions Gastroenterology 109 1995 1001 1003
6. M.Y. Choy, J.A. Walker-Smith, C.B. Williams Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis Gut 31 1990 1365 1370
7. J.C. Kam, S.J. Szefler, W. Surs Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids J Immunol 151 1993 3460 3466 (Pubitemid 23282658)
8. J.M. Ellery, P.J. Nicholls Alternate signalling pathways from the interleukin-2 receptor Cytokine Growth Factor Rev 13 2002 27 40 (Pubitemid 34436960)
9. C.A. Jamieson, K.R. Yamamoto Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling Proc Natl Acad Sci U S A 97 2000 7319 7324 (Pubitemid 30431461)
10. I. Rogatsky, S.K. Logan, M.J. Garabedian Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase Proc Natl Acad Sci U S A 95 1998 2050 2055 (Pubitemid 28145892)
11. E. Irusen, J.G. Matthews, A. Takahashi p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma J Allergy Clin Immunol 109 2002 649 657 (Pubitemid 34327193)
12. T.J. Creed, R.W. Lee, P.V. Newcomb The effects of cytokines on suppression of lymphocyte proliferation by dexamethasone J Immunol 183 2009 164 171
13. Novartis Simulect (basiliximab) drug prescribing datasheet 2005 http://www.pharma.us.novartis.com/product/pi/pdf/simulect.pdf Accessed January 10, 2012
14. S.D. Hearing, M. Norman, C.S. Probert Predicting therapeutic outcome in severe ulcerative colitis by measuring in vitro steroid sensitivity of proliferating peripheral blood lymphocytes Gut 45 1999 382 388 (Pubitemid 29400714)
15. T.J. Creed, M.R. Norman, C.S. Probert Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis Aliment Pharmacol Ther 18 2003 65 75 (Pubitemid 36897982)
16. T.J. Creed, C.S. Probert, M.N. Norman Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease Aliment Pharmacol Ther 23 2006 1435 1442
17. K.W. Schroeder, W.J. Tremaine, D.M. Ilstrup Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis A randomized study N Engl J Med 317 1987 1625 1629 (Pubitemid 18010466)
18. S.J. Pocock, R. Simon Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial Biometrics 31 1975 103 115
19. H.K. Ury, J.L. Fleiss, H.K. Ury On approximate sample sizes for comparing two independent proportions with the use of Yates' correction Biometrics 36 1980 347 351
20. G. Van Assche, W.J. Sandborn, B.G. Feagan Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial Gut 55 2006 1568 1574 (Pubitemid 44629204)
21. S.D. Hearing, M. Norman, C.M. Dayan In vitro measurement of lymphocyte steroid sensitivity: lack of agreement between whole blood culture and separated lymphocyte culture Immunopharmacol Immunotoxicol 21 1999 41 53 (Pubitemid 29173315)
22. P.L. Amlot, E. Rawlings, O.N. Fernando Prolonged action of a chimeric interleukin-2 receptor (CD25) monoclonal antibody used in cadaveric renal transplantation Transplantation 60 1995 748 756
23. J. Kovarik, P. Wolf, J.M. Cisterne Disposition of basiliximab, an interleukin-2 receptor monoclonal antibody, in recipients of mismatched cadaver renal allografts Transplantation 64 1997 1701 1705 (Pubitemid 28041703)